BERKELEY

A group of 18 scientists and ethicists today warned that a revolutionary new tool to cut and splice DNA should be used cautiously when attempting to fix human genetic disease, and strongly discouraged any attempts at making changes to the human genome that could be passed on to offspring.

Among the authors of this warning is Jennifer Doudna, the co-inventor of the technology, called CRISPR-Cas9, which is driving a new interest in gene therapy, or genome engineering. She and colleagues co-authored a perspective piece that appears in the March 20 issue of Science, based on discussions at a meeting that took place in Napa on Jan. 24. The same issue ofSciencefeatures a collection of recent research papers, commentary and news articles on CRISPR and its implications.

Given the speed with which the genome engineering field is evolving, our group concluded that there is an urgent need for open discussion of the merits and risks of human genome modification by a broad cohort of scientists, clinicians, social scientists, the general public and relevant public entities and interest groups, the authors wrote.

Doudna, director of UC Berkeleys Innovative Genomics Initiative, was joined by five current and two former UC Berkeley scientists, plus David Baltimore, a Nobel laureate and president emeritus of the California Institute of Technology, Stanford Nobelist Paul Berg and eminent scientists from UC San Francisco, Stanford, Harvard and the universities of Wisconsin and Utah. Several of these scientists are currently involved in gene therapy to cure inherited diseases.

Such warnings have been issued numerous times since the dawn of genetic engineering in 1975, but until now the technology to actually fix genetic defects was hard to use.

However, this limitation has been upended recently by the rapid development and widespread adoption of a simple, inexpensive and remarkably effective genome engineering method known as CRISPR-Cas9, the scientists wrote. The simplicity of the CRISPR-Cas9 system enables any researcher with knowledge of molecular biology to modify genomes, making feasible many experiments that were previously difficult or impossible to conduct.

Correcting genetic defects

Scientists today are changing DNA sequences to correct genetic defects in animals as well as cultured tissues generated from stem cells, strategies that could eventually be used to treat human disease. The technology can also be used to engineer animals with genetic diseases mimicking human disease, which could lead to new insights into previously enigmatic disorders.

The CRISPR-Cas9 tool is still being refined to ensure that genetic changes are precisely targeted, Doudna said. Nevertheless, the authors met to initiate an informed discussion of the uses of genome engineering technology, and to identify proactively those areas where current action is essential to prepare for future developments. We recommend taking immediate steps toward ensuring that the application of genome engineering technology is performed safely and ethically.

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Scientists urge caution in using new CRISPR technology to treat human genetic disease

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IMAGE:Violence and Gender is the only peer-reviewed journal focusing on the understanding, prediction, and prevention of acts of violence. Through research papers, roundtable discussions, case studies, and other... view more

Credit: Mary Ann Liebert, Inc., publishers

New Rochelle, NY, March 18, 2015-Who intentionally seeks to kill a policeman and why? In 2014 the rate of policemen purposely killed in the line of duty in the U.S. was nearly 1.5 times greater than in 2013. These incidents and what may have motivated the killers is the focus of an in-depth article in the peer-reviewed journal Violence and Gender, from Mary Ann Liebert, Inc., publishers. The article is available free on the Violence and Gender website until April 18, 2015.

In the article "Men Who Kill Policemen," Michael Stone, MD, Columbia College of Physicians and Surgeons (New York, NY) and Mid-Hudson Forensic Psychiatric Hospital (Goshen, NY), reviews details of the intentional killings of police in the line of duty in 2013-2014. All the killers were male, and most used a gun. Dr. Stone describes whether the perpetrators were killed or committed suicide during the incidents, or were actively involved in a crime at the time of the killing. He examines a variety of possible motivations for intentional killing of a policeman, including belonging to a "cop-hating" group, mental illness, or intoxication. He also discusses societal factors that may lead to higher or lower rates of policemen killing in different social or minority groups.

"This unique study by Dr. Michael Stone, an Associate Editor of Violence and Gender, could not be more timely and relevant," says Editor-in-Chief Mary Ellen O'Toole, PhD, Director, Forensic Science Program, George Mason University; Forensic Behavioral Consultant; and Senior FBI Profiler/Criminal Investigative Analyst (ret.).

"Dr. Stone looked at all the police officers intentionally killed in the line of duty in the United States between 2013 and 2014," Dr. O'Toole continues. "He found that all of the 66 cop-killers were males, and their choice of weapon was a firearm. Dr. Stone identifies factors that led up to and contributed to these murders, and based on his experience and expertise as a world-renowned psychiatrist he offers the opinion that only a minority of these men likely suffered from a mental illness at the time of these murders. In the study of violence it is quite rare that research is so quickly available on contemporary issues, and this study exemplifies Dr. Stone's and the Journal's commitment to bring headline topics to our readers in scholarly and insightful ways."

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About the Journal

Violence and Gender is the only peer-reviewed journal focusing on the understanding, prediction, and prevention of acts of violence. Through research papers, roundtable discussions, case studies, and other original content, the Journal critically examines biological, genetic, behavioral, psychological, racial, ethnic, and cultural factors as they relate to the gender of perpetrators of violence. Led by Editor-in-Chief Mary Ellen O'Toole, PhD, Forensic Behavioral Consultant and Senior FBI Profiler/Criminal Investigative Analyst (ret.), Violence and Gender explores the difficult issues that are vital to threat assessment and prevention of the epidemic of violence. Violence and Gender is published quarterly online with Open Access options and in print, and is the official journal of The Avielle Foundation. Tables of content and a sample issue may be viewed on the Violence and Gender website.

About the Publisher

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What motivates men who kill police?

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If wine tends to give you a hangover, science may have a solution, and it starts with a "genome knife." The phrase refers to an enzyme called RNA-guided Cas9 nuclease that's able to knock down a longstanding hurdle to genetic engineering in fermented foods, a researcher at the University of Illinois explains in a press release.

It's a little complicated, but the strains of yeast that ferment wine (along with beer and bread) are "polyploid" strains. Those strains "contain multiple copies of genes in the genome," says Yong-Su Jin, whose study was published in Applied and Environmental Microbiology.

The difficulty comes into play when you try to alter a gene in one copy of the genome. Essentially, you can't: "An unaltered copy would correct the one that had been changed." The enzyme fixes that problem.

It allows the genetic engineering of polyploid strains, specifically Saccharomyces cerevisiaewhich you're more likely to know as baker's yeast, Jove notes. Researchers are calling the engineered result a "jailbreaking" yeast.

Engineered yeast could make wine healthier by boosting the amount of a nutrient called resveratrol "by 10 times or more," Jin notes. As for post-booze headaches, the "genome knife" could act on what's known as malolactic fermentation, which can result in hangover-inducing toxic substances.

That's good news, though Medical Daily reports that the variety of factors leading to hangovers likely means such a product wouldn't get rid of them completely.

(It's not just the genetics involved in winemaking that affect your hangover risk: Your own genes do, too, according to research last year.)

This article originally appeared on Newser: Scientists Find a Way to Cut Wine Hangovers

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Researchers find a way to cut wine hangovers

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Mutants Genetics Gladiators Ultimas Luchas Del Evento Nu Roma
Gracias por todo Lindo Dia Y Espero este contentos con mi trabajo.

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Lot 700 - McCabe Genetics Bred Heifers
Description.

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The Sim 3 | Perfect Genetics Challenge #2
The hunt for a man begins! Poorly! There are mullets...and mooches...and some more getting to know Azkadellia! Founder Sim: Azkadellia Ideal Challenge Rules: --------- Perfect Genetics Challenge...

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The Sim 3 | Perfect Genetics Challenge #2 - Video

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Victor McKusick (Human Genetics)
The following is an interview with Victor A. McKusick, University Professor of Medical Genetics, Johns Hopkins University School of Medicine, Baltimore. The interview was conducted by his student,...

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Victor McKusick (Human Genetics) - Video

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LA CONFIDENTIAL DNA Genetics weed grow report Trichome World
A quick review what you can see in our full cannabis grow report (+300 pics) Review for medical users weed plant lovers http://trichome-world.com/category/strains-test/dna-genetics/la-confident...

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LA CONFIDENTIAL DNA Genetics weed grow report Trichome World - Video

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Minecraft ARTIFACTS SMP #39;LEARNING HOW TO FLY (Advanced Genetics) #39; Ep 10
Enjoy this video? Help me out and share it with your friends on twitter, facebook and any other social media site! Friends - https://www.youtube.com/user/joyceANDcarlo https://www.youtube.com/use...

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Minecraft ARTIFACTS SMP 'LEARNING HOW TO FLY (Advanced Genetics)' Ep 10 - Video

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The Sims 3 - Perfect Genetics Challenge - Pt9 - Meet Belle
If you like this video please leave a thumbs up, it really helps Open fully for *NEW SCHEDULE* info and social media links Weekly Schedule (Subject to change) Monday - Disney...

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Boston, MA (PRWEB) March 18, 2015

In the vast flow of new scientific research, discoveries, and information, it is not uncommon for important scientific advances to go unappreciated, or even just unnoticed, for surprisingly long periods of time. The Boston stem cell medicine technology start-up company, Asymmetrex is working to make sure that its growing portfolio of adult tissue stem cell technology patents obtains wide notice, appreciation, and investment.

In late 2014, the company started a digital media campaign to achieve greater visibility for its patented technologies that address the major barriers to greater progress in stem cell medicine. These include technologies for identifying, counting, and mass-producing adult tissue stem cells. The two presentations scheduled for the 5th World Congress on Cell and Stem Cell Research in Chicago continue Asymmetrexs efforts to better inform medical, research, and industrial communities focused on advancing stem cell medicine of the companys vision for implementation of its unique technologies.

Asymmetrex holds patents for the only method described for routine production of natural human tissue stem cells that retain their normal function. The company also holds patents for biomarkers that can be used to count tissue stem cells for the first time. The companys most recently developed technology was invented with computer-simulation leader, AlphaSTAR Corporation. In partnership, the two companies created a first-of-its-kind method for monitoring adult tissue stem cell number and function for any human tissue that can be cultured. This advance is the basis for the two companies AlphaSTEM technology for detecting adult tissue stem cell-toxic drug candidates before conventional preclinical testing in animals or clinical trials. Asymmetrex and AlphaSTAR plan to market the new technology to pharmaceutical companies. The implementation of AlphaSTEM technology would accelerate drug development and reduce adverse drug events for volunteers and patients. At full capacity use, AlphaSTEM could reduce U.S. drug development costs by $4-5 billion each year.

About Asymmetrex (http://asymmetrex.com/)

Asymmetrex, LLC is a Massachusetts life sciences company with a focus on developing technologies to advance stem cell medicine. Asymmetrexs founder and director, James L. Sherley, M.D., Ph.D. is an internationally recognized expert on the unique properties of adult tissue stem cells. The companys patent portfolio contains biotechnologies that solve the two main technical problems production and quantification that have stood in the way of successful commercialization of human adult tissue stem cells for regenerative medicine and drug development. In addition, the portfolio includes novel technologies for isolating cancer stem cells and producing induced pluripotent stem cells for disease research purposes. Currently, Asymmetrexs focus is employing its technological advantages to develop facile methods for monitoring adult stem cell number and function in clinically important human tissues.

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Boston Stem Cell Biotech Start-up Asymmetrex Will Present Essential Technologies for Stem Cell Medical Engineering at ...

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HACKENSACK, N.J.and PETACH TIKVAH, Israel, March 18, 2015 /PRNewswire/ --BrainStorm Cell Therapeutics Inc. (NASDAQ: BCLI), a leading developer of adult stem cell technologies for neurodegenerative diseases, announced today that CEO Tony Fiorino, MD, PhD, will present at the 3rd Annual Regen Med Investor Day to be held Wednesday, March 25, 2015 in New York City.

Organized by the Alliance for Regenerative Medicine (ARM) and co-hosted with Piper Jaffray, this one-day investor meeting provides institutional, strategic and venture investors with unique insight into the financing hypothesis for advanced therapies-based treatment and tools. The program includes clinical and commercial experts who are on-hand to address specific questions regarding the outlook for these products, as well as offer insight into how advanced therapies could impact the standard of care in key therapeutic areas. In addition to presentations by more than 30 leading companies from across the globe, the event includes dynamic, interactive panels featuring research analysts covering the space, key clinical opinion leaders and top company CEOs. These discussions will explore themes specific to cell and gene therapy such as commercialization, market access and pricing for breakthrough technologies, gene therapy delivery and upcoming milestones in the adoptive T-cell therapy space.

The following are specific details regarding BrainStorm's presentation:

Event:

ARM's Regen Med Investor Day

Date:

March 25, 2015

Time:

4:20 PM EST

Location:

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BrainStorm Cell Therapeutics to Present at 3rd Annual Regen Med Investor Day on March 25 in New York

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The human gut is a remarkable thing. Every week the intestines regenerate a new lining, sloughing off the equivalent surface area of a studio apartment and refurbishing it with new cells. For decades, researchers have known that the party responsible for this extreme makeover were intestinal stem cells, but it wasn't until this year that Scott Magness, PhD, associate professor of medicine, cell biology and physiology, and biomedical engineering, figured out a way to isolate and grow thousands of these elusive cells in the laboratory at one time. This high throughput technological advance now promises to give scientists the ability to study stem cell biology and explore the origins of inflammatory bowel disease, intestinal cancers, and other gastrointestinal disorders.

But it didn't come easy.

One Step Forward . . .

When Magness and his team first began working with intestinal stem cells some years ago, they quickly found themselves behind the eight ball. Their first technique involved using a specific molecule or marker on the surface of stem cells to make sure they could distinguish stem cells from other intestinal cells. Then Magness's team would fish out only the stem cells from intestinal tissues and grow the cells in Petri dishes. But there was a problem. Even though all of the isolated cells had the same stem cell marker, only one out of every 100 could "self-renew" and differentiate into specialized cells like a typical stem cell should. (Stem cells spawn cells that have specialized functions necessary for any organ to work properly.)

"The question was: why didn't the 99 others behave like stem cells?" Magness said. "We thought it was probably because they're not all the same, just like everybody named Judy doesn't look the same. There are all kinds of differences, and we've been presuming that these cells are all the same based on this one name, this one molecular marker. That's been a problem. But the only way to solve it so we could study these cells was to look at intestinal stem cells at the single cell level, which had never been done before."

Magness is among a growing contingent of researchers who recognize that many of the biological processes underlying health and disease are driven by a tiny fraction of the 37 trillion cells that make up the human body. Individual cells can replenish aging tissues, develop drug resistance, and become vehicles for viral infections. And yet the effects of these singular actors are often missed in biological studies that focus on pooled populations of thousands of seemingly "identical" cells.

Distinguishing between the true intestinal stem cells and their cellular look-a-likes would require isolating tens of thousands of stem cells and tracking the behavior of each individual cell over time. But Magness had no idea how to accomplish that feat. Enter Nancy Allbritton, PhD, chair of the UNC/NCSU Joint Department of Biomedical Engineering. The two professors met one day to discuss Magness joining the biomedical engineering department as an adjunct faculty member. And they did discuss it. And Magness did join. But the meeting quickly turned into collaboration. One of Allbritton's areas of expertise is microfabrication -- the ability to squeeze large devices into very small footprints. During their meeting, Allbritton showed Magness her latest creation, a device smaller than a credit card dotted with 15,000 tiny wells for culturing cells.

"It was like a light bulb went off, and I realized I was looking at the answer to a billion of our problems," Magness said.

Micro Magic

Each microwell is as thick as a strand of hair. By placing individual stem cells into the microwells, Magness and postdoctoral fellow Adam Gracz, PhD, could watch the cells grow into fully developed tissue structures known as mini-guts. Each microwell could be stamped with a specific address, which would allow researchers to track stem cells that were behaving as expected and those that weren't.

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A Single-Cell Breakthrough: newly developed technology dissects properties of single stem cells

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CAR T-Cell Therapy - Nebraska Medicine
It #39;s the fifth most common type of cancer in U.S. adults. For years, traditional therapies to treat non-Hodgkin #39;s lymphoma (NHL) have included chemotherapy, radiation and a stem cell/bone...

By: Nebraska Medicine

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CAR T-Cell Therapy - Nebraska Medicine - Video

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Stem Cell Therapy- Sci Video2
Created using PowToon -- Free sign up at http://www.powtoon.com/join -- Create animated videos and animated presentations for free. PowToon is a free tool that allows you to develop cool...

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Stem Cell Therapy- Sci Video2 - Video

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DNA Genetics -- Best people. Best pig. Best genetic option.

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DNA Genetics -- Best people. Best pig. Best genetic option. - Video

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Outdoor organic experiment (TGA Genetics)
Had popped some new seeds, didnt have room so I thought I would let them finish outside . . It is not the right time of year to flower here and they only got around 6 hours of sunlight.. In...

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Genetics of eating disorders - Video abstract 55776
Video abstract of review paper "Genetics and epigenetics of eating disorders" published in the open access journal Advances in Genomics and Genetics by Yilmaz Z, Hardaway JA, and Bulik CM....

By: dovepress

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Genetics of eating disorders - Video abstract 55776 - Video

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Janet Rowley (Cancer Genetics)
The following is an interview with Janet D. Rowley, MD, Blum-Riese Professor of Medicine and Human Genetics at The University of Chicago. The interview was conducted by her friend and colleague,.

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Janet Rowley (Cancer Genetics) - Video

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DALLAS, March 17, 2015 /PRNewswire/ --

According to a new market research report"Global Animal Genetics Market, By Product (Canine, Equine, Poultry, Porcine, Bovine, and Genetic Material), by testing services (DNA Sexing, DNA Typing, Genetic Disease Test, and Others) - Global Forecast to 2020", published by MarketsandMarkets, The global Animal Genetics Market is estimated to be worth around $2.5 Billion in 2014 and $4 Billion in 2020, to grow at a CAGR of 8-9% during the forecast period of 2014 to 2020.

Browse96market data Tables and27Figures spread through200Pages and in-depth TOC on "Global Animal Genetics Market" http://www.marketsandmarkets.com/Market-Reports/animal-genetic-market-12462093.html

Early buyers will receive 10% customization on this report.

The Animal Genetics Market witnessed healthy growth during the last decade, primarily attributed to the increasing animal protein consumption by and increasingly urban global population. To cater the rising demand of animal proteins, farmers are increasingly adopting advanced genetic technologies for larger-scale production and quality breeds. In addition, growing awareness about veterinary genetic diseases and disorders; increase in the population of livestock animals, especially in emerging markets; implementation of animal welfare acts in developed countries; and development of cutting-edge technologies in animal genetic testing are further driving this market. However, stringent regulations regarding animal genetic engineering, expensive and time-consuming R&D activities, high cost of animal testing, and insufficient number of skilled professionals in animal genetics are restraining the growth of animal genetics market during the forecast period of 2014 to 2020.

Inquiry before Buying:http://www.marketsandmarkets.com/Enquiry_Before_Buying.asp?id=12462093

In this report, the animal genetics market is segmented by products, testing services, and region. Based on type of product, the market is mainly segmented into live animals and genetic materials. The live animal segment is further subsegmented into canine, equine, poultry, porcine, bovine, and others. On the other hand, the genetic material segment is subsegmented into semen and embryo. Animal genetics market is segmented into various testing services such as DNA sexing, DNA typing, genetic disease tests, and others in the report.

In 2014, the live segment accounted for the largest share of the market. Growing population, increasing urbanization, and rising demand of animal derived products have contributed to the growth of the live animal market. In addition, increase in the population of livestock animals especially in emerging markets and implementation of animal welfare acts are further fueling the growth of live animal market.

North America represented the largest regional market in 2014, followed by Europe, Asia-Pacific, and ROW. The Asia-Pacific region represents the fastest-growing market for the animal genetics market, primarily due to the increasing population, rapid urbanization, and rising demand of animal products in this region. In addition, increased awareness towards animal welfare in developing countries and development of cutting-edge technologies in animal genetic testing are further driving the market in this region.

Major players in the global animal genetics market are Animal Genetics, Inc. (U.S.), Genus Plc (U.K.), Topigs (Netherlands), Harlan Laboratories, Inc. (U.S.), Hendrix Genetics BV (Netherlands), Aviagen Group (U.S.), Neogen Corporation (U.S.), Alta Genetics (Canada), VetGen (U.S.), and Zoetis, Inc.(U.S.) among others.

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Global Animal Genetics Market Worth Around $4 Billion by 2020

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Gene Therapy Respiratory Insight: Trends and Challenges Analysed in Research Report
Gene Therapy Respiratory Insight: Pipeline Assessment, Market Trend, Technology and Competitive Landscape provides in depth insights into the Respiratory gene therapy. It has covered 5+...

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Gene Therapy Respiratory Insight: Trends and Challenges Analysed in Research Report - Video

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SCOAN 15/03/15: Spinal Cord Injury Knee Problem Healed At Prayer Line. Emmanuel TV
SCOAN Live Sunday Service 15 March 2015 Testimony Time Emmanuel TV.

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The Ethics of Stem Cells
In this video produced by ConnectEd California, Professor Charis Thompson from UC Berkeley explains the ethics debate surrounding stem cell research and what...

By: California Institute for Regenerative Medicine

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The Ethics of Stem Cells - Video

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Dr. Nathan Newman - Stem Cell Therapy and Regenerative Medicine
Dr. Nathan Newman is a Board Certified Dermatologist, a Cosmetic Surgeon, and a pioneer in stem cell therapy and Regenerative Medicine. He is world-renowned for his ground-breaking Stem Cell...

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Dr. Nathan Newman - Stem Cell Therapy and Regenerative Medicine - Video

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Orange, California (PRWEB) March 17, 2015

The top stem cell therapy clinics in California, Telehealth, are now offering treatment for nonhealing wounds at three locations. The stem cell therapy for wound healing is being offered by Board Certified doctors at three separate locations in Orange, La Jolla and Upland. Call (888) 828-4575 for more information and scheduling.

Patients with diabetes, neuropathy and autoimmune disorders often find it difficult to heal even minor wounds. This may lead to diabetic ulcers and infections in the soft tissue and/or bone. At times, even the most rigorous conventional wound care fails to heal wounds sufficiently.

At Telehealth, stem cell therapy for nonhealing wounds has been showing exceptional results. Wounds that had basically been unresponsive to traditional methods have displayed quick results with healing when the procedures are performed. The regenerative medicine treatments involve either bone marrow derived stem cells or amniotic derived stem cells. Additional, PRP therapy is included in the treatment at times when necessary.

Along with helping to heal difficult wounds, stem cell therapy is also available for degenerative arthritis, chronic tendonitis, rotator cuff tears, ligament injuries, migraines and much more. Treatments are offered in Orange, Upland and a new La Jolla location by Board Certified doctors with extensive experience.

Most treatments are partially covered by insurance, which helps considerably to keep cost down. Call (888) 828-4575 for more information and scheduling.

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Stem Cell Therapy Now Being Offered for NonHealing Wounds at Telehealth's Three Regenerative Medicine Clinics

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