Cystic Fibrosis Gene Therapy
A short animation to briefly explain the research being conducted at the Gene Therapy Department of the Adelaide Women #39;s and Children #39;s Hospital. Donations can be made at http://www.cure4cf.org/

By: WCH Gene Therapy

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Cystic Fibrosis Gene Therapy - Video

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Walking barefoot on sand "felt like walking on glass" for Keith Wenckowski, who has lived with type-one diabetes for more than two decades.

One of the participants in a new Northwestern Medicine study who suffered from painful diabetic neuropathy (PDN), Wenckowski finally found relief from the constant foot pain that required him to wear shoes at all times, even to the beach.

The study found that those with PDN who received two low dose rounds of a non-viral gene therapy called VM202 had significant improvement of their pain that lasted for months.

"I can now go to a beach and walk on the sand without feeling like I am walking on glass," Wenckowski said.

The results of this phase two, double-blind, placebo-controlled study will be published March 5 in the journal Annals of Clinical and Translation Neurology.

Right now there is no treatment for this disease of the peripheral nerves that affects 20 to 25 percent of diabetics. Patients with the most extreme form of the disease feel intense pain with a slight graze or touch. The pain can interfere with daily activities, sleep, mood and can diminish quality of life.

"Those who received the therapy reported more than a 50 percent reduction in their symptoms and virtually no side effects," said Dr. Jack Kessler, lead author of the study. "Not only did it improve their pain, it also improved their ability to perceive a very, very light touch."

Kessler is the Ken and Ruth Davee Professor of Stem Cell Biology in the department of neurology and a professor in the department of pharmacology at Northwestern University Feinberg School of Medicine. He also is an attending physician at Northwestern Memorial Hospital.

VM202 contains human hepatocyte growth factor (HGF) gene. Growth factor is a naturally occurring protein in the body that acts on cells -- in this case nerve cells -- to keep them alive, healthy and functioning. Future study is needed to investigate if the therapy can actually regenerate damaged nerves, reversing the neuropathy.

Wenckowski had continuous numbness, but now, more than a year since he received the therapy, his symptoms have not returned. "I am hoping the effects I am feeling do not cease," he said.

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Neuropathy: Relief for diabetics with painful condition

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European policies in Personalized Medicine. Isabel de la Mata
Instituto Roche Forum on Personalized Medicine: Challenges for the next decade 25th september 2014, Palacio de Congresos y Exposiciones de Galicia. European policies in Personalized Medicine...

By: institutoroche

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European policies in Personalized Medicine. Isabel de la Mata - Video

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Personalized Medicine MedXPrime DNA testing Safe drugs
Personalized Medicine MedXPrime DNA testing Safe drugs.

By: Jerome Scott

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Personalized Medicine MedXPrime DNA testing Safe drugs - Video

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Q A - Perspectives on Targeting and Implications for Personalized Medicine
CLINAM 7/ 2014, 7th Conference and Exhibition, June 23-25, 2014.

By: TAUVOD

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Q&A - Perspectives on Targeting and Implications for Personalized Medicine - Video

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Aren #39;t Lifestyle Personalized Medicine inspired by Ayurveda?
Aren #39;t Lifestyle Personalized Medicine inspired by Ayurveda?

By: Kerala Ayurveda

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Aren't Lifestyle & Personalized Medicine inspired by Ayurveda? - Video

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LSI Public Talks on Personalized Medicine
UBC Health Information Series and the Life Sciences Institute Present Personalized Medicine: Your Life, Your Genes, Your Health and Happiness. This talk is an informal and open forum that aims...

By: UBC

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LSI Public Talks on Personalized Medicine - Video

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Spinal Cord Injury Spotlight - Dakota W. at Project Walk Houston
Dakota Willman suffered a T10-T11 spinal cord injury as well as a traumatic brain injury during a snowboarding accident on 12/25/2013. She has had a lot of d...

By: Project Walk

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Spinal Cord Injury Spotlight - Dakota W. at Project Walk Houston - Video

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Paraplegic walking with crutches (T12 incomplete spinal cord injury).
This is how I walk with crutches.

By: NYFeetBlog

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Paraplegic walking with crutches (T12 incomplete spinal cord injury). - Video

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Spinal Cord Injury Recovery at NeuroFit360, Pembroke Pines, Florida
NeuroFit360 is a physical therapy gym for individuals with neurological injuries located in Pembroke Pines, Florida. Located new the border of Miami and 30 m...

By: Guy Romain

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Spinal Cord Injury Recovery at NeuroFit360, Pembroke Pines, Florida - Video

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Role of Stem Cells on Cognitive Dysfunction after Cancer Therapy
You #39;d think getting a cancer diagnosis and the subsequent chemo and/or radiation therapy is traumatic enough. But many people receiving cancer therapy also s...

By: California Institute for Regenerative Medicine

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Role of Stem Cells on Cognitive Dysfunction after Cancer Therapy - Video

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REGULAXIS REGENERATIVE MEDICINE
Regulaxis regenerative medicine for osteoarthritis and cartilage recovery after traumatic lesions.

By: Regulaxis Biotech

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REGULAXIS REGENERATIVE MEDICINE - Video

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SciTech - "Regenerative Medicine: Current Concepts and Changing Trends"
The February 2015 edition of our SciTech Lecture Series, featuring: Dr. Anthony Atala, Director, Wake Forest Institute for Regenerative Medicine.

By: Forsyth Tech

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SciTech - "Regenerative Medicine: Current Concepts and Changing Trends" - Video

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US MILITARY INVESTMENT IN REGENERATIVE MEDICINE HD
Moderator - Michael R. Davis, MD, FACS, United States Army Institute of Surgical Research Speakers - Debra Niemeyer, PhD, 59th Medical Wing Joint Base San An...

By: worldstemcell

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US MILITARY INVESTMENT IN REGENERATIVE MEDICINE HD - Video

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Kick starting a process that might repair the damage done in cerebral palsy and multiple sclerosis could begin with disabling a driver that helps block regeneration, said Baylor College of Medicine researchers in a report that appears in the journal Neuron.

When an infant is deprived of oxygen during or shortly after birth, the brain's white matter -- home to the myelin-making oligodendrocytes -- is damaged. Without myelin, the messages between nerve cells are interrupted or slowed. Similarly, the myelin sheath that covers nerves degenerates in multiple sclerosis, again interrupting the message that travels from neuron to neuron.

Cerebral palsy is increasing in recent years, with approximately 12,000 cases diagnosed annually. As more infants' lives are saved at earlier stages in the development, the risk of damage from lack of oxygen to the white matter of the brain increases. That kind of injury is the cause of cerebral palsy.

"Yet, those lesions in the white matter are populated by oligodendrocyte progenitors sitting in suspended animation," said Dr. Benjamin Deneen, associate professor in the Stem Cells and Regenerative Medicine Center at Baylor and the Center for Cell and Gene Therapy at Baylor, Texas Children's Hospital and Houston Methodist Hospital and corresponding author of the report. "The cells that are supposed to be making myelin are not doing it. If you could coax those cells to differentiate, you might have something."

Cells that differentiate are mature and can carry out their prescribed function.

Previously, collaborators at the University of California San Francisco had shown that Wnt signaling pathways are present at high levels in oligodendrocyte precursors, and Wnt blocks the ability of cells to differentiate.

Yet how did the Wnt signaling pathway get involved?

Dr. Hyun Kyoung Lee, a postdoctoral fellow in Deneen's laboratory at Baylor, began to uncover the answer, using chicks and their development as an experimental model.

"We knew a protein called Daam2 is important for Wnt signaling and receptor clustering of the Wnt complex," said Lee. "How does it do that?"

Using a variety of techniques including a hypoxia chamber that caused damage to the white matter, she and her colleagues showed that Daam2 interacts with another protein called PIP5K(inase) to allow the clustering that promotes Wnt signaling and prevents differentiation of the oligodendrocyte precursor.

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From chick to bedside: Removing the Wnt barrier

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Biotechnology human genome sequencing. Javier Garca
Instituto Roche Forum on Personalized Medicine: Challenges for the next decade 25th september 2014, Palacio de Congresos y Exposiciones de Galicia. Session 3...

By: institutoroche

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Biotechnology & human genome sequencing. Javier Garca - Video

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Dr. Oz MedXPrime Personalized Medicine DNA testing

By: Jerome Scott

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Dr. Oz MedXPrime Personalized Medicine DNA testing - Video

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Regulatory Approach to Personalized Medicine
Speaker: Frank F. Weichold CLINAM 7/ 2014, 7th Conference and Exhibition, June 23-25, 2014.

By: TAUVOD

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Regulatory Approach to Personalized Medicine - Video

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Genomics of Personalized Medicine
"Genomics of Personalized Medicine" Joseph Jarvis, PhD, Director of Genomic Risk Reporting at Coriell Institute for Medical Research February 24, 2015.

By: UPENN NBIC

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Genomics of Personalized Medicine - Video

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Personalized Medicine Patent Law Update
Catherine Polizzi, Ph.D., Partner, Morrison Foerster LLP Michael Shuster, Ph.D., Partner, Fenwick West Jose Haresco, Ph.D., Managing Dir. Sr. Equity An...

By: pmwcInt1

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Personalized Medicine Patent Law Update - Video

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Spinal Cord Injury Spotlight - Dan B. at Project Walk Boston
Dan B. suffered a traumatic brain injury as well as a C5 spinal cord injury on April 18, 2014. His will and determination to recover lead him to Project Walk...

By: Project Walk

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Spinal Cord Injury Spotlight - Dan B. at Project Walk Boston - Video

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Spinal cord injury walking
NeuroFit360 is a physical therapy gym for individuals with neurological injuries located in Pembroke Pines, Florida. Located new the border of Miami and 30 m...

By: Guy Romain

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Spinal cord injury walking - Video

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Healing Through Regenerative Medicine - The Balancing Act
It #39;s no surprise that as we age our bodies change. And part of the aging process can involve changes such as Pelvic Organ Prolapse, a medical condition resul...

By: TheBalancingAct

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Healing Through Regenerative Medicine - The Balancing Act - Video

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Regenerative Medicine helps body heal itself denver regenerative medicine
Dr. Joel Cherdack and Denver Regenerative Medicine offer the most cutting edge procedures to help your body chronic injuries. Call them now schedule a consul...

By: Denver Regenerative Medicine

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Regenerative Medicine helps body heal itself denver regenerative medicine - Video

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Aubrey de Grey - Catalyzing Future Day - Progress in Regenerative Medicine - CRISPR
Why Future Day? -How can we use Future Day to raise awareness of and catalyze action in 1) general future thinking and 2) specific projects? Contact media i...

By: Adam Ford

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Aubrey de Grey - Catalyzing Future Day - Progress in Regenerative Medicine - CRISPR - Video

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