Regenerative medicine at CALIBR
Peter G. Schultz , director of the California Institute for Biomedical Research, or Calibr, discusses his institute #39;s research in multiple sclerosis and osteoarthritis. Taken Wednesday, Feb....

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CCHS Regenerative Medicine Introduction
Mrs Williams Regenerative Medicine introduction.

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Launch of Regenerative medicine at KIMS 2015 - Hybiz.tv
Launch of Regenerative medicine at KIMS 2015 - Hybiz.tv.

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[ScienceNews2014]Pluripotent stem cells: Mass production culture technology on the horizon
Interest in regenerative medicine using embryonic stem cells and induced pluripotent stem cells has surged in recent years. Now, in order to realize the potential of these cells for medical...

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Stem Cell Therapy for Bone Fractures - Board-Certified Orhopedic Surgeon, Wade McKenna DO
Dr. McKenna discusses how bone fractures, including non-union fractures can be treated non-surgically with a the patient #39;s own bone marrow stem cells augmented with AlphaGEMS amniotic tissue...

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Glen Wysoki at The STEM CELL ORTHOPEDIC INSTITUTE of Texas
Video Testimonial from Glen Wysoki, treated at The STEM CELL THERAPY INSTITUTE of Texas http://stemcellorthopedicinstituteoftexas.com.

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Procedure Overview - The STEM CELL ORTHOPEDIC INSTITUTE of Texas
Offering new hope for those in pain, Dr. David Hirsch, D.O., and Dr. John Hall, D. O., of The STEM CELL ORTHOPEDIC INSTITUTE of Texas present an overview of ADULT STEM CELL THERAPY from ...

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Stem Cell Therapy for Achilles Tendon Repair - Dr. Wade McKenna
Dr. McKenna discusses non-surgical treatment of acute and chronic tendon problems using bone marrow stem cells augmented with amniotic tissue. He cites an ex...

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Greenbrae, CA, March 03, 2015 --(PR.com)-- Oxyderm Wrinkle Cream by INDERMICA Inc. is an innovative skin care product which is free of artificial preservatives; uses innovative apple, grape and alpine rose stem cells to help reverse the signs of aging, helps filling in fine lines while hydrating and smoothing-out skin texture for a youthful glow.

The Patent Pending formula offers the benefits of: -Fast penetration -Cell cleansing by displacing CO2 from the skin -Forehead globular muscular relaxation -Wrinkle reduction and an overall soft-skin feel. The combination of natural ingredients blended with new-age compounds bridge the gap between science and nature.

About Earth Day 2015 Earth Days 45th anniversary (April 22nd) - could be the most exciting year in environmental history. The year in which economic growth and sustainability join hands. This is the year in which world leaders finally pass a binding climate change treaty.

About Elevate Magazine: Elevate Magazine has been Canada's authority on cosmetic enhancement, wellness and anti-aging for over 13 years. Elevate covers every aspect of cosmetic enhancement, offering readers the latest health and beauty news.

About INDERMICA Inc.

INDERMICA Inc. is a manufacturer and global distributor of comprehensive skin restoration professional treatments and take-home systems. The global presence of INDERMICA labs allows them to provide skin-rebuilding formulations that accommodate all skin types throughout the world; committed to creating products that gently return the skin to a young, healthy glow.

Hydroquinone and paraben free; the INDERMICA innovative skin care and treatment products boast a combination of natural ingredients blended with leading-edge compounds. They use a comprehensive and scientific process of layering molecules to prepare, correct and protect damaged and aging skin.

Contact Information: Media Enquiries: Sandra J. Freer comments@sdapublishing.com 416-239-0781 For product information: http://www.indermica.com

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Come back Frankenstein all is forgiven. Scientists say they are close to manufacturing a baby in a dish from stem cells taken from the skin of two males. Why?

The human race has been producing babies the natural way since the beginning.

Why cant they use their skills to find cures to all the diseases that continue to plague us?

I have every sympathy for those who cant produce children of their own but there are plenty of needy babies awaiting adoption.

The last thing this world needs is more babies.

It is producing far too many already. Over-population will pose a bigger threat to this planet than anything else, unless it is brought under control.

But when I see how impossible it is for nations to agree on other serious issues that affect this world I hold little or no hope for a solution to that problem.

Terry Hillier, Four Crosses

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Letter: Leave babies up to nature

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Contrasto/eyevine

Biologist Graziella Pellegrini has worked on stem-cell therapy at four different Italian institutions, including a hospital run by priests.

Last month saw a major landmark for regenerative medicine: the first time that a stem-cell therapy beside the use of cells extracted from bone marrow or umbilical cord blood had been cleared for sale by any regulatory agency in the world. The European Commission approved Holoclar for use in cases of blindness caused by burning. The achievement is all the more remarkable because Holoclar was developed by a small laboratory in Italy, a country better known for its lack of support for life sciences and for its recent tolerance of an unproven stem-cell concoction, marketed by the Stamina Foundation, that claimed to be a panacea for many diseases. Nature talked to Graziella Pellegrini from the University of Modena about how she and her colleagues overcame the many obstacles to take the therapy from bench to bedside.

The surface of the cornea the transparent tissue that sits in front of the iris is constantly renewed in a healthy eye, to keep it smooth and clear. New corneal cells are generated from a niche of stem cells in the limbus, an area between the cornea and the white of the eye. But if the limbus is destroyed by burning, then the white of the eye grows over the cornea and becomes criss-crossed with blood vessels. This causes chronic pain and inflammation, as well as blindness.

I had seen patients who had starting seeing again after 20 years of blindness: how could I stop?

Holoclar treatment can help to reverse these symptoms by adding new stem cells to seed the regrowth of a transparent cornea. But there must be enough surviving limbus in one eye to allow 1 or 2 square millimetres of tissue to be extracted. This tissue is then cultivated on a support made from modified human fibrin (a biodegradable blood protein) under stringent clinical conditions until at least 3,000 stem cells have been generated. The culture, still on its fibrin scaffold, is transplanted into the injured eye, which has been scraped clear of the invading white, and from there stem cells seed the regrowth of a transparent cornea, free of blood vessels, within a year.

Only around 1,000 people annually in the whole of Europe will be eligible: burns victims who have become blind but whose eyes have not been too extensively destroyed.

It is always very hard to find research money in Italy. We had to uproot many times. I first started working on the concept of the therapy, with my colleague Michele De Luca, in 1990 when we were post-docs at the University of Genova studying the fundamental biology of epithelial cells the cells that form the sheets lining organs, and also the skin. In 1996, we moved to Rome to the Institute Dermopatico Immaculate, a hospital run by priests who were highly committed to research and who offered us wonderful facilities and access to patients. But in the end they did not want to support our eye work through to the clinic. So in 2002, we moved to the Veneto Eye Bank Foundation in Venice, which had an epithelial stem-cell laboratory. Then in 2008 we moved again, to the Centre for Regenerative Medicine Stefano Ferrari, which had been newly created at the University of Modena specifically to incubate such types of advanced therapy.

Italy is not supportive of biomedical research. Things might have been easier if we had not had to struggle so much. But I am Italian, and the best way to stimulate me to find a solution is to tell me I cant do something. And despite the problems, research into advanced therapies does have a history here. One of the worlds first gene-therapy trials on children with an immunodeficiency disorder was carried out in Milan.

We published the results of our first two patients both successes in 19971. That was proof of principle that the therapy could work. Our major clinical paper, on 112 patients, was published in 20102. Around 77% of the transplants were fully successful, and a further 13% partially successful.

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UK Bishops voice opposition to human genetic engineering | Newsbreak 2-26-2015
UK Catholic Bishops voice opposition to House of Lords approval of genetic modification to the Human germ line. -Archdiocese of Detroit #39;s central services are settling into their new space....

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US President Barack Obama is proposing to spend $215 million on a precision medicine initiative, whose centrepiece will be a national study drawing on the health records and DNA of one million volunteers.

The term precision medicine refers to treatments tailored to a persons genetic profile, an idea which is already transforming the way doctors fight cancer and some rare diseases. When treating cancer, for example, doctors can nowadays assess any molecular abnormalities in the cancerous cells so that they can apply the appropriate treatment. Some types of abnormalities may be found in different types of cancer, and patients with these conditions will be given the same treatment. Studying a set of molecular abnormalities in a patient in order to prescribe a unique, personalised treatment for his/her condition appears to be the future of medicine and this means that going forward treatment will be based on peoples individual genetic maps

Barack Obama has recently put forward a funding initiative to support precision medicine with a view to developing technology that has to date been under-exploited. The aim is to change the old one-size-fits-all approach, as Jo Handelsman, associate director for science at the White House Office of Science and Technology Policy, puts it, and to move towards personalised medicine using information from the human genome. Under the Federal funding proposal, $130 million will go to the National Institutes of Health (NIH) for development of a voluntary national research cohort of a million or more volunteers to propel our understanding of health and disease and set the foundation for a new way of doing research through engaged participants and open, responsible data sharing, says the White House factsheet. This will be the largest genome study ever carried out at country level, and should open up amazing opportunities for the advance of science.

In the 1970s, the noted French biologistJacques Monod, regarded as one of the fathers of modern molecular biology, opined that the scale of DNA was too vast for scientists ever to be able to modify the human genome. Just six years later, the first genetic manipulations were being carried out. As recently as 1990, there was general consensus among genetic scientists that human DNA would never be sequenced, yet this feat had been achieved by 2003. Enormous progress has also been made in reducing the cost of human genome sequencing, which has fallen from $3 billion to just $1000 per person! In fact so mainstream has DNA sequencing become that the company ranked by MIT in 2014 as the smartest in the world was Illumina, a San Diego, California-based firm that develops, manufactures and markets integrated systems for the analysis of genetic variation and biological function. Today the main focus of investment in digital health is onBig Data and analytics.

Some companies are now even specialising in combating ageing, including California startupHuman Longevity Inc., a genomics and cell therapy-based diagnostic and therapeutic company whose stated goal is to tackle the diseases associated with age-related human biological decline. The web giants are also muscling into this field. Google is out in front via its R&D biotech firm California Life Company (Calico) on an amazingly ambitious mission to vanquish death, as CEO Larry Page put it. Clearly the White House is aware of the huge opportunities in this sector, hence the Presidents intention to channel Federal dollars into the search for DNA-based treatments.

Jo Handelsman predicts that significant scientific progress will result from studying the genome in a large number of people and merging this information with data from other ongoing studies. In fact she believes it will be a major step forward in how we see medicine. Some $130 million of the budget proposed by Barack Obama will be allocated to the NIH to fund the huge volunteer genome study. Another outcome of the initiative is that patients will be able to obtain lots of genetic information about themselves. We arent just talking about research but also about patients access to their own data, so they can participate fully in decisions about their health that affect them, underlined the director of the White House Office of Science and Technology Policy, John Holdren. The proposal also earmarks $70 million for DNA-driven research on cancer and another $10 million for related certification work by the US Food and Drug Administration.

NIH director Francis Collins underlined that the United States is not looking to create a single bio-bank. Instead, the project will seek to combine data from among over 200 large ongoing American health studies, which jointly together involve at least two million people. The challenge of this initiative is to link those together. Its more a distributed approach than centralised, he explained. Meanwhile, in the search for data, NIH officials have met in recent weeks with administrators from the Veterans Health Administration, whose ongoingMillion Veteran Program has already collected DNA samples from 343,000 former soldiers. Obama also wants to allocate grants to private sector technology firms, and Illumina is likely to be an early beneficiary. As the famous work La mort de la mort (The Demise of Death) by French surgeon DrLaurent Alexandre points out, progress in the field of medicine in the 21st century is in the process of delivering a scientific revolution on an unprecedented scale.

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Genome Studies: Personalised Medicine around the Corner?

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Newswise New research suggests that widely used statin therapy provides the most benefit to patients with the highest genetic risk of heart attack. Using a relatively straightforward genetic analysis, the researchers assessed heart attack risk independently of traditional risk factors such as age, sex, so-called good and bad cholesterol levels, smoking history, family history and whether the patient has diabetes.

Patients in intermediate and low-risk categories still benefit from statin therapy, but that benefit is progressively smaller because theyre starting at lower baseline risk, according to the investigators.

The research, from Washington University School of Medicine in St. Louis, Brigham and Womens Hospital, Massachusetts General Hospital and Harvard Medical School appears March 4 in The Lancet.

For patients at risk of heart disease, doctors routinely prescribe statins, known for their cholesterol-lowering effect. In 2013, the American College of Cardiology and the American Heart Association changed the guidelines for statin therapy, dramatically increasing the number of patients recommended to take it. The move has stirred debate over whether these drugs are overused, especially in light of increasing health-care costs.

There is ongoing debate over which individuals should be allocated statin therapy to prevent a first heart attack, said co-first author Nathan O. Stitziel, MD, a Washington University cardiologist and human geneticist. Some have said we should be treating more people, while others say we need to treat fewer. As an example of precision medicine, another approach is to identify people at high risk and preferentially prescribe statin therapy to those individuals. Genetics appears to be one way to identify high-risk patients.

Stitziel noted that this genetic analysis is not available to patients right now. More research is needed to validate the findings before such a test could be developed for clinical use.

Using statistical methods to combine data on 49,000 people enrolled in five studies, the researchers reported that individuals in the high-risk category have a 70 percent higher risk of heart attacks compared with those at lowest genetic risk. They went on to show that statin therapy results in a 13 percent reduction in risk in the low genetic-risk group, a 29 percent reduction in the intermediate group and a 48 percent reduction in the high-risk group.

Stitziel said the new results differ from past research that consistently has shown statins provide about the same relative risk reduction 30-45 percent depending on dose across all categories of patients.

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Study Shows Who Benefits Most From Statins

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You might resemble or act more like your mother, but a novel research study from UNC School of Medicine researchers reveals that mammals are genetically more like their dads. Specifically, the research shows that although we inherit equal amounts of genetic mutations from our parents the mutations that make us who we are and not some other person we actually use more of the DNA that we inherit from our dads.

The research, published in the journal Nature Genetics, has wide implications for the study of human disease, especially when using mammalian research models. For instance, in many mouse models created for the study of gene expression related to disease, researchers typically dont take into account whether specific genetic expression originates from mothers or fathers. But the UNC research shows that inheriting a mutation has different consequences in mammals, depending on whether the genetic variant is inherited from the mother or father.

This is an exceptional new research finding that opens the door to an entirely new area of exploration in human genetics, said Fernando Pardo-Manuel de Villena, PhD, professor of genetics and senior author of the paper. Weve known that there are 95 genes that are subject to this parent-of-origin effect. Theyre called imprinted genes, and they can play roles in diseases, depending on whether the genetic mutation came from the father or the mother. Now weve found that in addition to them, there are thousands of other genes that have a novel parent-of-origin effect.

These genetic mutations that are handed down from parents show up in many common but complex diseases that involve many genes, such as type-2 diabetes, heart disease, schizophrenia, obesity, and cancers. Studying them in genetically diverse mouse models that take parent-of-origin into account will give scientists more precise insights into the underlying causes of disease and the creation of therapeutics or other interventions.

The key to this research is the Collaborative Cross the most genetically diverse mouse population in the world, which is generated, housed, and distributed from UNC. Traditional lab mice are much more limited in their genetic diversity, and so they have limited use in studies that try to home in on important aspects of diseases in humans. The Collaborative Cross bred together various wild type mice to create wide diversity in the mouse genome. Pardo-Manuel de Villena said that this diversity is comparable to the variation found in the human genome. This helps scientists study diseases that involve various levels of genetic expression across many different genes.

Gene expression connects DNA to proteins, which then carry out various functions inside cells. This process is crucial for proper human health. Mutations that alter gene expression are called regulatory mutations.

This type of genetic variation is probably the most important contributor not to simple Mendelian diseases where theres just one gene mutation [such as cystic fibrosis] but to much more common and complex diseases, such as diabetes, heart disease, neurological conditions, and a host of others, Pardo-Manuel de Villena said. These diseases are driven by gene expression, not of one gene but of hundreds or thousands of genes.

The Collaborative Cross and the expertise we have at UNC allow us to look at different gene expression for every gene in the genome of every kind of tissue, said Pardo-Manuel de Villena, who directs the Collaborative Cross.

Source: sciencedaily.com

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Genetically speaking, mammals are more like dad

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Irvine, CA (PRWEB) March 04, 2015

Proove Biosciences, a commercial and research leader in Personalized Medicine, is excited to announce the launch of their CME-accredited course entitled Incorporating Genetic Testing to Optimize the Management of Pain.

The continuing medical education program will be available at Medscape.com for the next year. The focus of the program is to teach medical professionals how to recognize inadequate pain treatments, integrate appropriate pain management techniques, and incorporate genetic testing into the management plan for treating pain (with a focus on the use and understanding of pharmacogenetics for individual patients).

It is estimated that 116 million American adults suffer from chronic pain, more than those affected by heart disease, cancer, and diabetes combined. Yet despite its prevalence, chronic pain is often under-recognized and under-treated.

"Pain management involves a series of critical considerations to be made by treatment providers: the accurate assessment and diagnosis of pain, the assignment of an appropriate treatment plan, the screening of patients for contraindications, and optimization of the selection, dosage, and frequency of medications. These evaluations are difficult to make accurately due to the large variability and subjectivity innate in such assessments. However, emerging data demonstrates the importance of pharmacogenetics in tailoring clinical decisions and targeting treatment plans towards individual variability, states Svetlana Kantorovich, Ph.D., Director of Clinical & Scientific Affairs at Proove Biosciences. "Despite the fact that pain and addiction have known genetic components, genetic testing is not part of the standard of care."

Proove Biosciences proprietary genetic testing can provide physicians with information to objectively identify responders versus non-responders to specific medications, improve medication efficacy, and avoid adverse drug events. Importantly, the objective screening of patients at risk for opioid abuse and misuse is of paramount importance due to skyrocketing healthcare costs and emergency department visits resulting from nonmedical use of prescription opioids.

About Proove Biosciences Our Mission is to Change the Future of Medicine. Proove is the proof to improve healthcare decisions. We seek to realize a future when clinicians look back and wonder how they couldve ever prescribed medications without knowing how a patient would respond. With offices in Southern California and the Baltimore-Washington metropolitan area, the Company is the research leader investigating and publishing data on the genetics of personalized pain medicine with clinical research sites across the United States. Physicians use Proove Biosciences testing to improve outcomes both safety and efficacy of medical treatment. From a simple cheek swab collected in the office, Proove performs proprietary genetic tests in its CLIA-certified laboratory to identify patients at risk for misuse of prescription pain medications and evaluate their metabolism of medications. For more information, please visit http://www.proove.com or call toll free 855-PROOVE-BIO (855-776-6832).

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Proove Biosciences Launches CME Accredited Program with Medscape

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Newswise (MEMPHIS, Tenn. March 4, 2015) The St. Jude Childrens Research HospitalWashington University Pediatric Cancer Genome Project found that melanoma in some adolescent and adult patients involves many of the same genetic alterations and would likely respond to the same therapy. The research appears in the March issue of the Journal of Investigational Dermatology.

The similarities involved adolescents with conventional melanoma tumors and included the first genetic evidence that sun damage contributes to melanoma in children and adolescents as well as adults. The findings stem from the most comprehensive analysis yet of the genetic alterations responsible for pediatric melanoma, which is the most common skin cancer in children and adolescents.

This study shows that unlike many cancers, conventional melanoma is essentially the same disease in children and adults. That means we need to make it easier for adolescents to access promising therapeutic agents being tried in adults, said co-corresponding author Alberto Pappo, M.D., a member of the St. Jude Department of Oncology. These results also underscore the importance of starting sun protection early and making it a habit for life.

Researchers also identified distinct genetic alterations associated with other pediatric melanoma subtypes, including those associated with large congenital nevi (CNM) and spitzoid tumors. The alterations include a mutation that might help identify spitzoid patients who would benefit from aggressive therapy as well as those who could be cured with less intensive treatment.

Until now the genetic basis of pediatric melanoma has been a bit of a mystery, said co-corresponding author Armita Bahrami, M.D., an assistant member of the St. Jude Department of Pathology. With this study, we have established the molecular signatures of the three subtypes of this cancer, signatures that have implications for diagnosis and treatment.

The National Cancer Institute (NCI) estimates that melanoma is diagnosed in 425 U.S. residents age 19 and younger each year. While the cancer remains rare in young people, the incidence has risen about 2 percent annually in recent decades, primarily in those ages 15 to 19. That age group makes up the majority of current pediatric melanoma patients. For the 75 percent of pediatric patients whose disease has not spread, long-term survival rates now exceed 90 percent.

We were surprised to see that so many of the pediatric melanomas had genetic changes linked to UV damage, said co-author Richard K. Wilson, Ph.D., director of The Genome Institute at Washington University School of Medicine in St. Louis. This in-depth look at the genomics of pediatric melanoma is extraordinarily important for diagnosis and for selecting treatments that give young patients the best chances of a cure.

This study included 23 melanoma patients ranging in age from 9 months to 19 years old. Researchers used whole genome sequencing and other techniques to compare the normal and tumor genomes of patients with three different types of melanoma for clues about the genetic alterations that underlie their disease. The genome is the blueprint for life that is encoded in the DNA found in almost every cell.

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Sun Damage Causes Genetic Changes That Predispose Children and Adolescents to Melanoma

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Mutants Genetics Gladiators Campaas Supra Campos Gamma
Gracias Por Dia A Dia Seguirme Los Quiero Mucho.

By: Nosferatus Gamexx

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Flat Bench Workout for Strength Gains - Simple Exercise
Product Links Perfect 10 Fat Burner Click Link: http://www.amazon.com/Natural-Genetics-Promotes-Metabolism-Supplements/dp/B00T3JRJY4/ref=sr_1_1?s=hpc ie=UTF8 qid=1425444813 sr=1-1 ...

By: Natural Genetics

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The Sims 3 - Perfect Genetics Challenge - Pt5 - Possible New House
If you like this video please leave a thumbs up, it really helps Open fully for *NEW SCHEDULE* info and social media links Weekly Schedule (Subject t...

By: xSimSugar

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Let #39;s Play The Sims 3 - Perfect Genetics Challenge - Episode 58
Make sure to leave baby names in the comments!. #VampireClan #VampireClan4Life.

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Genetics! coupling (cis) vs Repulsion (trans)

By: thomas underhill

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Karma genetics
Getting ready to go into one gallon pots.

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Karma genetics - Video

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Ask Al #50 - Genetics, HIIT vs. Steady State Cardio, and Combining Lifting With Calisthenics
Blog - http://www.AlKavadlo.com Facebook - https://www.facebook.com/pages/Al-Kavadlo/205151489148 Twitter - https://twitter.com/AlKavadlo Google+ ...

By: Al Kavadlo

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Molecular Genetics of Pocket Mice
Recorded with ScreenCastify (http://www.screencastify.com), the screen video recorder for Chrome.

By: John Vieira

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