Imperial genetics
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Genetics plays The Musical Box (Genesis)
September 21, 2013, Teatro Coliseo, Buenos Aires, Argentina http://www.genetics.com.ar Official Facebook page https://www.facebook.com/geneticsband.

By: Genetics

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Genetics plays The Musical Box (Genesis) - Video

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MPG Primer: Population Genetics
MPG Primer: Population Genetics Stephen Schaffner - Sr Computational Biologist The Primer on Medical and Population Genetics is a series of informal weekly d...

By: broadinstitute

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MPG Primer: Population Genetics - Video

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Ocean Grown Genetics - AlienAbduction Cannabis Grow - The Drop presented by TheSocialGrow.com
Ocean Grown Genetics Alien Abduction Social Grow! TheSocialGrow.com was lucky enough to get our hands on the Alien Abduction. This is Alien Dawg x Alien OG a...

By: Green Clouds

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UNL - Plant Breeding Genetics Online Certificate Program
University of Nebraska-Lincoln professor and Nebraska Wheat Growers Presidential Chair, Dr. Baezinger explains the benefits of the Plant Breeding Genetics Online Certificate Program.

By: Plant Genetics University of Nebraska-Lincoln

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UNL - Plant Breeding & Genetics Online Certificate Program - Video

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Developing the Next Generation of Genetics
Select Sires is a global supplier of semen, but what we market isn #39;t just tiny, frozen, plastic straws, of, well you know what #39;s in there, it #39;s genetics.

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Developing the Next Generation of Genetics - Video

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Genetics Selection Tools in Beef Cattle EPDs and Antagonisms
UNL Extension Beef Genetics Specialist Matt Spangler discusses understanding and using EPDs in cattle selection.

By: Rick Rasby

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Genetics Selection Tools in Beef Cattle EPDs and Antagonisms - Video

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TjrA + Imperial Genetics - Growers Love Giveaway Video
Shout out to TjrA homemadegrowbox and Beneath Manners for their collab giveaway. Growers love BU.

By: Badass Unicorn

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One clinical study, which was released 2 weeks before Christmas holidays captured my attention (but not attention of mass media). One of the most scandalous Indian stem cell tourism clinic Nutech Mediworld published(!) results of the study, which evaluates embryonic stem cell transplantation in children with cerebral palsy. Yes, youre reading it correctly embryonic stem cells in children! Now, I have no idea how this study was approved by Independent Ethics Committee (as stated in the paper) and how this manuscript passed peer review of Journal of Translational Medicine, but here is the fact study is done and results are published. I think, we should at least read it, try to analyze it (its not easy!) and maybe discuss it. Before we dive into the study, Id like to give you a little bit of background.

Geeta Shroff a director of Nutech Mediworld is a highly controversial and highly criticized by westerners figure in stem cell tourism. She is a retired obstetrician and self-taught embryonic stem cell practitioner, who used to be skeptical about sharing data with peers:

Dr. Shroff does not share data, has not submitted to peer review (shes said she has no peers) and has performed no controlled clinical trials. While patients call her a saviour, other researchers call her a quack, a fraud or names even less flattering.

Well, seem like she changed her mind lately. I remember, that many critics refused to believe that actual embryonic stem cells (ESC) were used by Nutech. They thought that Nutech used term embryonic for fetal cells, derived from aborted material. But, according the paper its real single ESC line, derived from preimplantation embryo post IVF.

Lets move to the study. As I mentioned above, study protocol was approved by Ethics Committee. Also, it was reported to National Apex Body (I dont know what is it, but sounds like something on government level). Yet another interesting fact the last author of the paper is a government worker (Ministry of Home Affairs, Government of India). Id like to remind you that this is not the first embryonic stem cell study from India. So, I think, one thing we have to realize is that if these kind of studies could be shocking and hard to imagine in US or Europe, it could be normal and totally acceptable for India or some other countries. Also, we have to realize that reporting of some particular number of patients (cherry picking?), treated in one particular stem cell clinic is very different from well designed clinical study or trial. We have no way to check how information, presented in the paper is accurate, since its not a registered trial and there is no (as far as I understand) oversight from any agency.

Next, Id like to touch ESC product composition, which was used in kids with cerebral palsy. The authors did not bother much with differentiation of ESC into mature cells. In fact, transplanted ESC were Oct4+, SSEA3+, Nanog+, Sox+, betaHCG+, CD34+, Nestin+, GAF+ and NeuN+. So, it was a great mix of undifferentiated ESC and neurally induced progenitors. There is a reference to Shroffs patent in the paper. If we look at this patent (which btw covers everything all types of ESC derivatives and all kind of diseases), we can see that ESC product contains at least 40% of undifferentiated cells:

in one embodiment, the portion of undifferentiated stem cells will be no more than about 80% of the total population of cells. In another embodiment, the portion of undifferentiated stem cells will be no more than about 40% of the total population of cells.

ESC progeny in the product are not characterized and could be hematopoietic, neural, mesenchymal, hepatic Cells were infused and injected multiple times via all possible routes: intramuscular, intravenously, intra-caudal, as eye drops, as nasal spray, retro-bulbar, as oral or ear drops. Since, there was no immunosuppression, researchers check hypersensitivity to ESC product via skin probe before starting a treatment. One more interesting thing the cells were cryo-stored in pre-filled syringes at -20C. There is no viability data in the paper.

91 children were included in the study with age from 1 month to 18 years with different degree and course of disease. The authors noticed functional improvement in all ages and starting scores of disease, based on functional scales (GMFCS-E & R). Also, they indicate improvement in cognition. Of course, we cannot make solid conclusions about efficacy, since it was not randomized and controlled trial. About 10% of patients had adverse events, such as swelling, itching, fever, chest congestion and others. However, there is no information about long-term safety and, especially, about such important potential complication as ESC-related excessive tissue growth. According the paper, about half of patients were not followed more than 3-6 months after the first treatment (did not return for 2nd and 3rd phases of treatment).

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Cell Trials

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Personalized Medicine: Do You Want to Know?
If you had a genetic mutation that made you 15 times more likely to develop Alzheimer #39;s disease, would you want to know? How would you react to such knowledg...

By: World Science Festival

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Rehabilitation in Spinal Cord Injury
Follow the link to find out the various rehabilitation options available for individuals with spinal cord injuries. http://oatleyvigmond.blogspot.ca/2014/10/...

By: Oatley Vigmond Personal Injury Lawyers LLP

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International Center for Spinal Cord Injury- Benefits of Adaptive Sports
The International Center for Spinal Cord Injury (ICSCI) at Kennedy Krieger Institute was founded on the philosophy that individuals with paralysis can always...

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Kim Solez Intro to AI: Stem Cells Regenerative Medicine Pathology-2015 and Aibos
Dr. Kim Solez gives the introduction to the first artificial intelligence lecture, with discussion of student participation in the Pathology-2015 meeting in New Orleans, stem cell and regenerative...

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Kim Solez Intro to AI: Stem Cells Regenerative Medicine Pathology-2015 and Aibos - Video

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In the contemporary world, Medical Ethics is associated with professional standards of conduct and dilemmas that arise with medical practice. Medical Ethics is the application of ethical reasoning to medical practice. As medical practice today is delivered increasingly in a multidisciplinary working environment, where the emphasis is placed strongly on team work and partnership, medical ethics is a subset of the wider 'Healthcare Ethics'.

The turning point in medical ethics has occurred since the Second World War. This is a result of change in social attitudes, increasing plurality of cultural and religious norms and the development of a system of internationally recognised Human Rights. Hence, medical ethics had to develop towards a more analytical approach. Today there is a clear shift in the practice of medicine from the previous reliance on medical paternalism ( Doctor knows best) to a Doctor Patient (Participation) approach.

Two concepts of medical ethics are now acknowledged.

*Traditional medical ethics - seen as the professional norms and standards of medical practice

* Analytical medical ethics - seen as the critical process through which substantive ethical claims are justified or criticised in the light of argument and counter argument.

The latter is influenced by our multicultural society and various academic disciplines like Philosophy, Law, Social Sciences, History and Theology. Thus medical ethics has ceased to be the sole domain of doctors and has become a 'part of the general moral and ethical order by which we live.' Increasingly in practice , it is tested against the ethical principles of society.

Medical advances and ethics

Advances in medicine itself ie wider variety of more powerful technologies, the capacity to prolong life, alter psychological states, impede and enhance reproductive capacity and more recently the ability to alter genetic structure, have all influenced the adoption of this analytical approach.

Reproductive Medicine

There are many areas in modern Reproductive Medicine which pose ethical challenges. To document a few , they are, Assisted Reproduction, abortion on demand, surrogacy, selection of sex of child for termination, assisted conception for same sex couples, selective reduction of foetuses in multiple pregnancies and Genetic engineering.

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Technological Advances and Medical Ethics

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Do Genetics Play a Role in Natural Bodybuilding ?
Some say genetics is not an important factor when it comes to building muscle naturally. Some claim, that you can achieve everything by only hardwork. But is...

By: Rico van Huizen

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Do Genetics Play a Role in Natural Bodybuilding ? - Video

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Introduction to Human Genetics- for medical students
This video lecture includes the definition of human genetics, its different branches, history, common terminologies, principle of human genetics, definition of Mendelian inheritance and classificat...

By: Janak Lecture Series

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Introduction to Human Genetics- for medical students - Video

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Superior Genetics - BODYBUILDING MOTIVATION [GetBigNow]
HD Bodybuilding Motivation #39;SUPERIOR GENETICS #39; by GetBigNow visit http://www.beastmotivation.com OUR FACEBOOK: http://www.facebook.com/GetBigNowOFFICIAL SUBSCRIBE our ...

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lily and america gene therapy

By: America Evans

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lily and america gene therapy - Video

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Parkinson #39;s Disease: Mr Garnet #39;s experience 6 months after stem cell therapy by Harry Adelson, N.D.
At Docere Clinics, our clinical focus is on the treatment of musculoskeletal pain disorders. On rare occasions, we have patients, usually relatives of satisf...

By: Harry Adelson, N.D.

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Parkinson's Disease: Mr Garnet's experience 6 months after stem cell therapy by Harry Adelson, N.D. - Video

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Indian discovery gives boost to hopes for Malaria vaccine
A stunning new discovery in India could in future lead to the development of a new vaccine against malaria. A team of scientists at the Jawaharlal Nehru University (JNU) and the International...

By: NDTV

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January 24, 2015

(GMO growing facility. Credit: Thinkstock)

Chuck Bednar for redOrbit.com Your Universe Online

Two teams of US scientists are currently working on a way to produce safer genetically modified organisms (GMOs) that would be unable to spread in the wild, finding a potential solution to a primary concern to critics of genetic engineering research.

According to BBC News, the researchers have altered the genetic code of bacteria so that they can only use synthetic chemicals to grow. If they escaped into nature, they would simply die out, ideally alleviating some of the fears over GMOs and opening the door for their increased use in the fields of agriculture, medicine, and environmental clean-up.

As explained in the journal Nature, the bacteria relies upon an amino acid (one of the building blocks of protein) that does not occur in nature. While the microbes can thrive in the lab as long as they have access to the unnatural amino acid, none survived an experiment in which the artificial supplement was withheld.

Genetically engineered micro-organisms are currently used in the US, Europe, and China in order to produce drugs or fuels under contained industrial conditions, the BBC said. However, scientists are looking to develop internal fail-safe measures to help keep them from spreading if used in real-world conditions.

Re-writing the genetic code

What weve done is engineered organisms so that they require synthetic amino acids for survival or for life, Yale University professor Farren J. Isaacs, who led one of the two studies, told BBC News. What were seeing here is an important proof of concept that re-coding genomes and engineering dependence on synthetic amino acids is technically feasible in not just E coli but other micro-organisms and multicellular organisms such as plants.

Our strains, to the extent that we can test them, wont escape, added Daniel J. Mandell, a synthetic biologist at Harvard. The new bacteria is also unable to exchange their DNA with the natural versions of the same bacteria, since they no longer speak each others genetic language.

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Safer GMOs possible with spread-resistant bacteria

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100% NATURAL - INSANE GENETICS ATHLETICISM - Rich Piana
http://www.5percentnutrition.com/ ^^SUPPLEMENT LINE^^ http://www.1dayumay.com/ ^^CLOTHING^^ SUBSCRIBE: http://www.youtube.com/subscription_center?add_user=1DAYUMAY.

By: Rich Piana

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100% NATURAL - INSANE GENETICS & ATHLETICISM - Rich Piana - Video

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Kylie Jenner no make up selfie! Flawless Kardashian genetics! Girlfriend to wack rapper Tyga!
Kylie Jenner no make up selfie! Flawless Kardashian genetics! Girlfriend to rapper Tyga and leader of the free world! http://meetmagazine.blogspot.com/2015/01/kylie-jenner-no-make-up-selfie-flawl...

By: MEET Magazine

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Kylie Jenner no make up selfie! Flawless Kardashian genetics! Girlfriend to wack rapper Tyga! - Video

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Gene therapy trial for thalassemia at Royal Prince Alfred Hospital
A world first gene therapy trial is currently underway at Royal Prince Alfred Hospital with the potential to cure patients living with thalassemia. Patient Stacey Wong has required long frequent...

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Flagship Journal Current Gene Therapy
A short promotional video of Bentham Science High Impact Journal Current Gene Therapy.

By: Bentham Science Publishers

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Flagship Journal Current Gene Therapy - Video

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