SOS 11/4/14 P.1 Dr.A Singh on Modi #39;s Claim:Ancient India Had Genetics, Cloning, Plastic Surgery
Dr. Amarjit Singh on Modi #39;s Claim : Ancient India Had Genetics, Cloning, Plastic Surgery, Airplanes.

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Dr. Matt Spangler UNL Extension Beef Genetics Specialist
Dr. Matt Spangler- University of Nebraska-Lincoln, Beef Genetics Specialist was one of the featured presenters at the State of Beef Conference held November 4-5, 2014 in North Platte, NE. ...

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When Glenn ONeill and his wife, Cara, learned about a gene therapy treatment that could save their daughters life, they started a foundation and set off to raise the $2.3 million it would take to fund the manufacturing and clinical trial costs for the drug.

Today, thanks to about 26,000 donors from 70 different countries, theyre just $530,000 away from their goal.

Their daughter, 4-year-old Eliza ONeill, suffers from Sanfilippo Syndrome-Type A, a disease that causes children to lack an enzyme necessary for normal cellular function. The disease eventually causes a lethal buildup of a toxic material called heparin sulfate, leading to learning disabilities and behavioral problems. The disease is seen in 1 in 70,000 births, and most children born with with Sanfillipo Syndrome-Type A die by the time they are teenagers.

While there is currently no cure or treatment for the disease, researchers at Nationwide Childrens Hospital in Columbus, Ohio have found a potential gene therapy that, in a study, successfully rid mice of heparin sulfate buildup.

When Cara spoke to lead researcher Dr. Haiyan Fu, principal investigator at the Center for Gene Therapy at Nationwide, and learned about the potential treatment, the family began raising money to fund it.

That was the first glimmer of hope that I got in all of this, Cara ONeill told FoxNews.com.

A couple of months after the diagnosis in July 2013, they began a slew of traditional fundraising efforts, from bake sales and 5Ks, to parties and a golf tournament. At the end of 2013, they started the Cure Sanfilippo Foundation and have launched SavingEliza.com through the fundraising site GoFundMe.com. In April 2014, a videographer made a free video for the family that went viral, and the family started a social media campaign called Sing Two Lines, similar to the ALS Ice Bucket Challenge, where people would challenge others to sing two lines of their favorite song. Actress Andie MacDowell and members of the band Gloriana participated.

The ONeills have raised $1.7 million since December and have been able to fund the manufacturing costs of the drug as well as some of the preclinical work. Their goal is to meet the $2.3 million mark by Elizas fifth birthday, Nov. 16.

Weve made it a point not to ask previous donors to donate again, Glenn ONeill told FoxNews.com, but at some point we knew it was going to come to crunch time. At this point, with [Elizas] birthday coming up, we really need to spend more time with Eliza, and focusing on her and keeping her learning at the top of the game.

Researchers at Nationwide have proposed what they feel is a sufficient toxicology plan to move forward with the clinical trial, and they are currently waiting for the Food and Drug Administrations (FDA) comments.

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Saving Eliza: Family raising money for Sanfilippo Syndrome drug $530K away from goal

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Developing Tools for Discovery Implementation in Personalized Medicine - Dan Roden, M.D.
Dr. Roden received his medical degree and training in internal medicine from McGill University in Montreal and trained in clinical pharmacology and cardiology at Vanderbilt University, where...

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Jablonski Leads Hockey #39;s Biggest Stick Tap at Wild Game
Former Minnesota prep hockey player Jack Jablonski took to the ice at Saturday #39;s Wild-Stars game to help raise awareness of spinal cord injury research.

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Tony Stewart Darrell Gwynn Safe Driving PSA 2014
This Public Service Announcement is provided by the Darrell Gwynn Foundation as part of Spinal Cord Injury Awareness Week in Florida, November 11-16, 2014. #SCIAW.

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Teen with spinal cord injury golfs in special chair
A spinal cord injury won #39;t hold Walid back, as he is given the trip of a lifetime to golf in a specialized chair. (Video: Jen Zielinski)

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AREA 4. BIOMATERIALS, TISSUE ENGINEERING AND REGENERATIVE MEDICINE Medicine
Leader: Prof. Po Gonzlez-Fernndez Applied Physicist. Lines of research: Scaffolds and biocoatings. Bioinspired ceramic scaffolds. New biocompatible coatings. Nanomedicine....

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Regenerative Medicine - Professor Siddarthan Chandran
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Epigenetics Stem Cells in Development Regenerative Medicine - Michael Boland, Scripps Institute
Speaker: Michael Boland, Ph.D., Research Associate, The Scripps Research Institute.

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Epigenetics Stem Cells in Development Regenerative Medicine - Allyson Moutri, UC San Diego
Speaker: Alysson Muotri, Ph.D., Assistant Professor, Department of Pediatrics/Cellular Molecular Medicine, UC San Diego.

By: Alliance for Regenerative Medicine

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QUT Grand Challenge Lecture Series - Biofabrication: The Future of Regenerative Medicine?
Discover how you can be a part of this research: http://ow.ly/DHC7H Presented by Associate Professor Mia Woodruff (QUT). 3D printing is currently taking the world by storm with the ability...

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David C P. Chen, MD., MHP - Stem Cell Therapy Q A1
David C P. Chen, MD., MHP - Stem Cell Therapy Q A1.

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David C P. Chen, MD., MHP - Stem Cell Therapy Q A2

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Enliven: Journal of Anesthesiology and Critical Care Medicine ISSN : 2374 - 4448 I e001
Left Ventricular Assist Device and Resident Cardiac Stem Cells in Heart Failure: Human Heart #39;s Potential Matter.

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An eight-year-old girl whose hunt for a bone marrow donor inspired hundreds to take selfies with their pants on their heads has died.

Hollie Clarks family broke the news on the Facebook page that they used to raise awareness of her battle with the bone marrow disorder MDS, Wales Online reports.

Her dad Stephen of Penylan, Cardiff, wrote: Sad news today Im afraid.

"After a seven month battle with MDS Hollie past away peacefully in her parents arms. It is utterly heartbreaking and makes no sense.

We have a million memories and take huge comfort in the number of Anthony Nolan registrations that the campaign made.

We are sure that someday soon one of you will be asked to donate stem cells and give someone like Hollie a chance.

Thank you all for your support. We would appreciate some time and space to try and pick ourselves up. Love from Hollies Dad. The proudest Dad in the world.

The family also used the @HelpHollie Twitter account to tell all those who had supported their campaign the news.

They wrote: Very sadly today our brave little angel passed away. Hollie was the happiest child ever and we are blessed that she was part of our family.

RIP Hollie. We tried our best. You were the best daughter any mum and dad could wish for. Thank you.

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As 'good' cholesterol goes up, odds of heart disease, stroke go down

WebMD News from HealthDay

By Amy Norton

HealthDay Reporter

THURSDAY, Nov. 6, 2014 (HealthDay News) -- Even among people who live well into their 90s, those with a particular gene variant may survive the longest, a new study finds.

The variant is in a gene known as CETP, and researchers have known for more than a decade that people who carry it have a better shot at an exceptionally long life -- past 95 or even 100.

CETP is involved in cholesterol metabolism, and the longevity-linked variant raises blood levels of HDL cholesterol (the "good" kind) and promotes larger-than-normal HDL particles, researchers say.

The new findings show that even when you look at people who've already lived beyond age 95, those with the "favorable" CETP variant survive longer, said Dr. Sofiya Milman, an assistant professor at the Albert Einstein College of Medicine in New York City.

Milman was scheduled to present the findings Thursday at the annual meeting of the Gerontological Society of America in Washington, D.C. Data and conclusions presented at meetings are usually considered preliminary until published in a peer-reviewed medical journal.

The results build on work that began at Einstein in the late 1990s. Researchers there have been studying centenarians in and around New York City, all of Ashkenazi Jewish descent. They've found that people in this long-lived group often carry the CETP variant, and have very high HDL levels.

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6- Mutation Genetic Engineering

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6- Mutation & Genetic Engineering - Video

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Newswise Angelina Jolies decision to undergo a double mastectomy inspired many other women to seek genetic counseling, too. But for women in rural areas, getting a genetic test can impose its own set of barriers, like multiple long trips for counseling, testing and follow-up. New research by Anita Kinney, PhD, RN, offers some hope. The research showed that telephone counseling was just as effective as in-person counseling in many respects. Dr. Kinney, now at the University of New Mexico Cancer Center, and her colleagues published the work in the Journal of the National Cancer Institute.

The research team identified the 988 women in the study as being at-risk for hereditary breast or ovarian cancer or both. They gave each a personalized brochure and other materials about genetic testing. A board-certified genetic counselor reviewed the materials with each woman. The research team assigned about half of the women to meet with the genetic counselor in person; they assigned the other half to talk with the counselor over the phone. They surveyed the women one week after initial counseling.

If a woman chose to have genetic testing after talking with the counselor, the researchers gave or mailed her a genetic testing kit. Each kit contained instructions explaining how to take a cheek-swab DNA sample and mail it for testing. Women who were tested also discussed their results with the genetic counselor and were surveyed one week after their test result counseling session. The researchers surveyed all the women again after six months.

More of the women who talked with a genetic counselor in person chose to get a genetic test than women who talked with a counselor over the phone. But the research team found no difference between the groups in measures of anxiety, distress, quality of life and knowledge gained. They also found no difference in how the women felt about the counseling sessions.

The researchers suggest that more women who received in-person counseling chose to undergo genetic testing because they could give their DNA sample and send it for testing immediately. Women counseled on the phone may have changed their minds because they had to wait for the testing kit to arrive in the mail and then had to drive to a mailing location to send the kit. The researchers suggest further study to understand how women make these decisions.

But the study showed that genetic counseling over the phone was just as helpful as in-person counseling. Over-the-phone counseling gave women the information they needed to make a decision about genetic testing. And it explained the results of the genetic testing for urban and rural women.

This research shows that using the telephone is a viable alternative to in-person genetic counseling, Dr. Kinney says. Using the phone, we can effectively increase womens access to genetic counseling services. And that can help them make informed and life-saving decisions for their health no matter where they live.

About Anita Kinney PhD, RN Anita Kinney, PhD, RN, is a Professor in the Department of Internal Medicine, Division of Epidemiology, at the UNM School of Medicine and is The Carolyn R. Surface Endowed Chair in Cancer Control and Population Sciences. Dr. Kinney serves as Associate Director for Population Sciences and as Cancer Control Research Program Co-Leader at the UNM Cancer Center. She trained at the University of Pennsylvania, UT-Houston School of Public Health, the University of North Carolina-Chapel Hill, and the National Cancer Institute. Dr. Kinney is an internationally recognized and highly acclaimed expert in cancer prevention and public health. Her research focuses on understanding variations in cancer risk and outcomes, in diverse populations and communities and developing effective strategies to prevention and control cancer.

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Phones Bring Genetic Counseling to Rural Women

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Health Longevity: Genetics is not an Excuse | Dr. Weston
The debate continues to rage on whether health and longevity is affected more by genetics or lifestyle choices. Dr. Weston tells us that while we can #39;t do an...

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Document Genetics
http://www.document-genetics.co.uk/document-management-software Nucleus Research, an independent research firm specialising in measuring the Return on Investment (ROI) of IT investments, ...

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SOUTH West Genetics' annual Mortlake on-property sale sold 22 of 44 rams offered to $800.

Selling agent Garry Whitehead, Landmark attracted Mortlake said while the Texel rams subdued interest, the 121 quality one year-old Coopworth- cross ewes drew strong competition and sold for $152.

"Crossbreed Texels are doing well but there is further positive publicity needed to boost interest in the breed," Mr Whitehead said.

"The Texel rams displayed the major performance data required in the (prime lamb) industry and have always been a high indexing breed but it wasn't reflected in the sale which was disappointing because the quality was there.

"The strong interest in the Coopworth cross ewes was terrific and reflected the growing attraction to maternal type sheep within the industry."

Several rams sold to the top price of $800, with Tony Dupleix, Leslie Manor being a volume buyer at the sale purchasing five rams to av $680.

"Texel's are performing well for tenderness (shear force) and lean meat yield, generally having a positive correlation whereas the general rule is a negative correlation," South West Genetics principal Steve Parker said."

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PUBLIC RELEASE DATE:

6-Nov-2014

Contact: Yixian Zheng zheng@ciwemb.edu 410-246-3032 Carnegie Institution @carnegiescience

Baltimore, MD--As animals age, their immune systems gradually deteriorate, a process called immunosenescence. It is associated with systemic inflammation and chronic inflammatory disorders, as well as with many cancers. The causes underlying this age-associated inflammation, and how it leads to diseases, are poorly understood. New work in Carnegie's Yixian Zheng's lab sheds light on one protein's involvement in suppressing immune responses in aging fruit flies. It is published in Cell.

Insects have an immune organ called the fat body, which is roughly equivalent to the mammalian fat and liver. It is responsible for many immune functions. Zheng and her team--Carnegie's Haiyang Chen and Xiaobin Zheng--found that the fruit fly fat body experiences a great deal of inflammation in aged flies.

These inflamed fly fat bodies then secrete proteins that lead to a reduction in immune response of the gut. This reduction of the gut immune response causes the gut's stem cells to undergo excessive division and inappropriate differentiation, creating a condition called hyperplasia that shares features with the precancerous polyps found in human guts.

Zheng and her team found that the gradual reduction of a protein called lamin-B in the fat bodies of aging flies is the culprit behind fat body inflammation and the resulting hyperplastic gut, all of which falls under the umbrella of immunosenescence.

Lamin-B is part of the lamin family of proteins, which form the major structural component of the material that lines the inside of a cell's nucleus. Lamins have diverse functions, including suppressing gene expression, and they are found in an array of tissues and organs. In humans, diseases caused by mutations in lamins are called laminopathies and include premature aging.

B-type lamins have long been suspected to play a role in gene suppression by binding to segments of DNA. The team's work revealed that when the fruit fly fat body was depleted of lamin-B, the normal suppression of genes involved in the immune response is reversed, just as it would be in response to bacterial infection or injury, but in this case there is no apparent infection or injury. The un-suppressed immune response initiates the inflammation and resulting gut hyperplasia.

"Our findings have implications for mammals as well as for insects, as immune response genes in mammals also are known to have lamins present on them," Zheng explained. "We think that lamin-B might play an evolutionarily conserved role in suppressing inflammatory genes in immune organs in the absence of infection or injury and our work could provide insight into immunosenescence in humans."

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A cause of age-related inflammation found

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New research from McLean Hospital and the Harvard Stem Cell Institute has shown that stem cell therapy reduces seizures in mice.

Researchers used an animal model to transplant seizure-inhibiting, human embryonic stem cell-derived neurons into the brains of mice that had a common form of epilepsy. Half of the mice that received the transplanted neurons no longer had seizures, while the other half experienced a significant drop in seizure frequency.

The transplanted neurons integrated into the mouse brains and began to receive neuronal activity. The neurons then released GABA, an inhibitory response that reversed the electrical hyperactivity that causes seizure.

Previous studies showed increasing inhibition in the epileptic brain can help control the seizure and also a lot of anti-epilepsy drugs are mimicking this GABA, so many of them worked by binding to the GABA receptors, researcher Sangmi Chung, assistant professor of psychiatry at Harvard, told FoxNews.com.

Researchers initially set out to test the functionality of human neurons, but later decided to test their effect on epilepsy because it is such a devastating disease. About 30 percent of people do not respond to seizure drugs and one out of 26 people will be affected by seizures in their lifetime, Chung said.

Over 65 million people worldwide are affected by epileptic seizures, which can cause convulsions, loss of consciousness and other neurological symptoms. Patients are treated with anti-seizure drugs, and may choose to have a portion of their brain removed.

Because mouse cells mature more quickly than human cells within weeks instead of years it was unclear how long a stem cell transplant in a human would take before becoming effective, Chung noted.

If we compare it with the mouse [model], we believe it will be years, not weeks, she said.

However, the study found that, even without full maturation, the cells integrated into the epileptic mouse brains, receive signals and release GABA, therefore preventing seizures.

I think its really good news in terms of transplantation even maturing, not fully mature [cells] still work, Chung said.

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Newswise Hematopoietic stem cells (HSCs) give rise to all blood and immune cells throughout the life of vertebrate organisms, from zebrafish to humans. But details of their genesis remain elusive, hindering efforts to develop induced pluripotent stem cell (iPSC) replacements that might address a host of blood disorders.

In a paper published Nov. 20 in the journal Cell, researchers at the University of California, San Diego School of Medicine describe the surprising and crucial involvement of a pro-inflammatory signaling protein in the creation of HSCs during embryonic development, a finding that could help scientists to finally reproduce HSCs for therapeutic use.

The recent breakthrough of induced pluripotency has made the concept of patient-specific regenerative medicine a reality, said principal investigator David Traver, PhD, professor in the Department of Cellular and Molecular Medicine. The development of some mature cell lineages from iPSCs, such as cardiac and neural, has been reasonably straightforward, but not with HSCs. This is likely due, at least in part, to not fully understanding all of the factors used by the embryo to generate HSCs. We believe the discovery that pro-inflammatory cues are important in vivo will help us recapitulate instruction of HSC fate in vitro from iPSCs.

Traver and colleagues specifically looked at the role of a cytokine (a type of cell signaling protein) called tumor necrosis factor alpha or TNFa, which plays a pivotal role in regulating systemic inflammation and immunity. The work extended previous research by Spanish biologist Victoriano Mulero, who had reported that TNFa was important in the function of the embryonic vascular system and that in animal models where TNF function was absent, blood defects resulted.

The Cell papers first author Raquel Espin-Palazon, a postdoctoral researcher in Travers lab and a former colleague of Muleros, determined that TNFa was required for the emergence of hematopoietic stem cells during embryogenesis in zebrafish a common animal model.

Traver said the finding was completely unexpected because HSCs emerge relatively early in embryonic formation when the developing organism is considered to be largely sterile and devoid of infection.

Thus, there was no expectation that pro-inflammatory signaling would be active at this time or in the blood-forming regions, Traver said. Equally surprising, we found that a population of embryonic myeloid cells, which are transient cells produced before HSCs arise, are the producers of the TNFa needed to establish HSC fate. So it turns out that a small subset of myeloid cells that persist for only a few days in development are necessary to help generate the lineal precursors of the entire adult blood-forming system.

The newly discovered role of TNFa in HSC development mirrors a parallel discovery regarding interferon gamma (INFg), another cytokine and major mediator of pro-inflammatory signaling, highlighting multiple inputs for inflammatory signaling in HSC emergence. Traver said the crucial roles of TNFa and INFg in HSC emergence are likely similar in humans because of the highly conserved nature of HSC development across vertebrate evolution.

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Before There Will Be Blood

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