The Mizzou Advantage - Genetics Role in Obesity Epidemic
Society puts a lot of focus on individual efforts, but University of Missouri researcher Dr. Elizabeth Parks says body weight is 60-80% genetics, not lifestyle. Overweight people are often...

By: TheMizzouTube

Read the original post:
The Mizzou Advantage - Genetics Role in Obesity Epidemic - Video

Recommendation and review posted by Bethany Smith

Genetics Lesson Two Apple Version

By: TheGamingTeacher

See original here:
Genetics Lesson Two Apple Version - Video

Recommendation and review posted by Bethany Smith

Living with Sanfilippo Syndrome: Reagan #39;s Story
Learn more about Gene Therapy: http://bit.ly/1vAhRiI Learn more about our clinical studies: http://bit.ly/1vAhOn7 Learn more about Dr. McCarty: http://bit.ly/1vAhODE Learn more about Dr. Flanigan:...

By: NationwideChildrens

View original post here:
Living with Sanfilippo Syndrome: Reagan's Story - Video

Recommendation and review posted by Bethany Smith

Mining Gene Expression Data Focusing Cancer Therapeutics
An understanding towards genetics and epigenetics is essential to cope up with the paradigm shift which is underway. Personalized medicine and gene therapy will confluence the days to come....

By: KAASHIV INFOTECH

Here is the original post:
Mining Gene Expression Data Focusing Cancer Therapeutics - Video

Recommendation and review posted by Bethany Smith

MEDS-380
Stem cells have captured the imaginations of scientists, physicians, and the general public for their ability to revolutionize not only how we treat diseases but the foundations of life itself....

By: Erin Yamauchi

Link:
MEDS-380 - Video

Recommendation and review posted by sam

Response Genetics RGDX Stock Pumps
The latest news on Response Genetics RGDX Stock Probability software for Penny stocks: http://hotstocked.com/hotstockedprecision-free3/v52.

By: Hotstocked Videos

Continued here:
Response Genetics RGDX Stock Pumps - Video

Recommendation and review posted by Bethany Smith

Puffy Eye Bags are Mostly Caused by Genetics and Can Appear While Still Young with No Health Issues
A 33-year-old man has under eye bags that make him look tired. Creams and other things didn #39;t work for him. He wants to know the best way to get rid of the b...

By: Amiya Prasad, M.D.

See the original post:
Puffy Eye Bags are Mostly Caused by Genetics and Can Appear While Still Young with No Health Issues - Video

Recommendation and review posted by Bethany Smith

Attack of the B Team - Episode 21: Starting to play with Genetics!
Today we take our first few steps in the world of Genetics! Welcome to Attack of the B-Team, this is a Modpack of Minecraft, it is actually the first Modpack that was based around a Fundraiser,...

By: Christian Pelchat | Gaming

See the article here:
Attack of the B Team - Episode 21: Starting to play with Genetics! - Video

Recommendation and review posted by Bethany Smith

Malice Map d11 The Genetics Lab
Walkthrough of The Genetics Lab Secret Level (Map d11) from Malice Quake 1 mission pack. This follows on from map d10 The Hospital. Played using DarkPlaces engine in Kubuntu 14.04.

By: quidsup

Read the original:
Malice Map d11 The Genetics Lab - Video

Recommendation and review posted by Bethany Smith

When Meg DeBoe decided to tap her Christmas fund to order a $99 consumer DNA test from 23andMe last year, she was disappointed: it arrived with no information on what her genes said about her chance of developing Alzheimers and heart disease. The report only delved into her genetic genealogy, possible relatives, and ethnic roots.

Thats because just a month earlier, in November 2013, the Food and Drug Administration had cracked down on 23andMe. The direct-to-consumer gene testing companys popular DNA health reports and slick TV ads were illegal, it said, since theyd never been cleared by the agency.

But DeBoe, a mommy blogger and author of childrens books, found a way to get the health information she wanted anyway. Using a low-budget Web service called Promethease, she paid $5 to upload her raw 23andMe data. Within a few minutes she was looking into a report with entries dividing her genes into Bad news and Good news.

As tens of thousands of others seek similar information about their genetic disposition, they are loading their DNA data into several little-known websites like Promethease that have become, by default, the largest purveyors of consumer genetic health services in the United Statesand the next possible targets for nervous regulators.

After the FDA crackdown, consumers are trading information on where to learn about their genes. Dont let the man stop you, said one.

Promethease was created by a tiny, two-man company run as a side project by Greg Lennon, a geneticist based in Maryland, and Mike Cariaso, a computer programmer. It works by comparing a persons DNA data with entries in SNPedia, a sprawling public wiki on human genetics that the pair created eight years ago and run with the help of a few dozen volunteer editors. Lennon says Promethease is being used to build as many as 500 gene reports a day.

Many people are arriving from directly from 23andMe. After its health reports were blocked, consumers complained angrily about the FDA on the companys Facebook page, where they also uploaded links to the Promethease website, calling it a workaround, a way to get exhaustive medical info in reports that are similar, but not as pretty. The mood was one of civil disobedience. Dont let the man stop you from getting genotyped, wrote one.

The FDA is being cautious with personal genomics because although DNA data is easy to gather, its medical meaning is less certain.

Consumer DNA tests determine which common versions of the 23,000 human genes make up your individual genotype. As science links these variants to disease risk, the idea has been that genotypes could predict your chance of getting cancer or heart disease, or losing your eyesight. But predicting risk is tricky. Most genes dont say anything decisive about you. And if they do, you might well wish for a doctor at your side when you find out. I dont believe that this kind of risk assessment is mature enough to be a consumer product yet, says David Mittelman, chief scientific officer of Gene by Gene, a genetic laboratory that performs tests.

In barring 23andMes health reports, the FDA also cited the danger that erroneous interpretations of gene data could lead someone to seek out unnecessary surgery or take a drug overdose. Critics of the decision said it had more to do with questions about whether consumers should have the right to get genetic facts without going through a doctor. Its an almost philosophical issue about how medicine is going to be delivered, says Stuart Kim, a professor at Stanford University who helped developed a DNA interpretation site called Interpretome as part of a class he teaches on genetics. Is it going to be concentrated by medical associations, or out there on the Internet so people can interact?

Read the original post:
How a Wiki Is Keeping Direct-to-Consumer Genetics Alive

Recommendation and review posted by Bethany Smith

Knee arthritis 7 months after bone marrow stem cell therapy by Harry Adelson, N.D.
Carolyn describes her outcome seven months after bone marrow stem cell therapy for her arthritic knee pain http://www.docereclinics.com.

By: Harry Adelson, N.D.

Go here to see the original:
Knee arthritis 7 months after bone marrow stem cell therapy by Harry Adelson, N.D. - Video

Recommendation and review posted by Bethany Smith

Dr Charles Krome Stem Cell Therapy
This video is about Dr Charles Krome Stem Cell Therapy.

By: John lore

Read the original post:
Dr Charles Krome Stem Cell Therapy - Video

Recommendation and review posted by Bethany Smith

A new kind of genetic test that analyzes all of a persons genes can provide a diagnosis about a quarter of the time for patients whose conditions have baffled doctors, scientists reported Saturday. And for young children with mysterious developmental delays, the test gives a diagnosis more than 40 percent of the time.

The test is called whole-exome sequencing, and it looks at all 20,000 or so genes in the human body. Its not a whole genome sequence because it leaves out DNA thats not classified as a gene. But such tests provide a good map of the so-called protein coding sequences.

It was a relief for Audrey Lapidus of Los Angeles, whose baby son Calvin seemed just fine at first. But at 6 months, an osteopath suggested genetic testing. She said he had some very interesting facial features, Lapidus told NBC News. Other pediatricians rejected the notion.

But then he just wasnt hitting the milestones, she said. He wasnt sitting up or rolling over.

Deep down, I knew something was wrong."

Still, pediatricians and friends alike reassured her. A basic genetic panel came back clear.

Everyone wants to tell you about their nephew who didnt walk until he was 2 and he graduated from Harvard, Lapidus said. I was holding on to those stories.

At the same time, she continued to visit geneticists and neurologists. Deep down, I knew something was wrong, she said.

Calvin became the first child at UCLA to get a whole-exome genetic test at UCLA, in 2012. When it came back, it showed Calvin had Pitt-Hopkins Syndrome, a rare genetic disorder affecting only 250 children worldwide.

Its caused by a single mutation on one gene found on chromosome 18. It causes developmental delays, seizures and, as Calvins osteopath suspected, distinctive facial features, such as thin eyebrows and sunken eyes. Children often never learn to speak or walk without help.

Excerpt from:
New Clues: Whole-Gene Scan Analyzes Mystery Illnesses

Recommendation and review posted by Bethany Smith

PUBLIC RELEASE DATE:

18-Oct-2014

Contact: Glenna Picton picton@bcm.edu 713-798-4710 Baylor College of Medicine @bcmhouston

HOUSTON -- (Oct. 18, 2014) Approximately one-fourth of the 3,386 patients whose DNA was submitted for clinical whole exome testing received a diagnosis related to a known genetic disease, often ending a long search for answers for them and their parents, said researchers from the Baylor College of Medicine departments of molecular and human genetics and pediatrics and the Baylor Human Genome Sequencing Center and the University of Texas Health Science Center at Houston.

In an online report in the Journal of the American Medical Association, the scientists led by Drs. Yaping Yang, laboratory director of the Whole Genome Laboratory at Baylor, and Christine Eng, professor of molecular and human genetics at Baylor and senior director of Baylor's Medical Genetics Laboratories, found a molecular diagnosis (meaning a genetic mutation or variation linked to a disease) in 25 percent of the large group of cases confirming in this much larger group of patients the diagnostic yield from their initial report on the first 250 cases that appeared in the New England Journal of Medicine a little more than a year ago.

Eng will also present results of the study on Oct. 21 during the American Society of Human Genetics Annual Meeting in San Diego, Calif.

"The findings in this report, I believe, will forever change the future practice of pediatrics and medicine as a whole," said Dr. James R. Lupski, professor of molecular and human genetics and pediatrics at Baylor and a coauthor of the report. "It is just a matter of time before genomics moves up on the physician's list of things to do and is ordered before formulating a differential diagnosis. It will be the new 'family history' that, better yet, gets you both the important variants inherited from each parent and the new mutations that contribute to disease susceptibility."

In fact, a large percentage of the diagnoses made were patients who inherited a new mutation (in the egg or sperm) that was not previously seen in their parents.

"The routine application of new genome methods in the clinic is not only benefitting patients but changing the way we think about research," said Dr. Richard Gibbs, director of the Baylor College of Medicine Human Genome Sequencing Center and an author of the report.

"It has been wonderful to watch this very large team of colleagues bridging from the patient in clinic to the very most cutting edge genomic technology to give families answers where previously there were none," said Dr. Arthur Beaudet, professor of molecular and human genetics who was chair of the department when the Whole Gene Laboratory was begun and who began the Baylor College of Medicine Medical Genetics Laboratories.

See the original post here:
Whole exome sequencing closer to becoming 'new family history'

Recommendation and review posted by Bethany Smith

Contact Information

Available for logged-in reporters only

Newswise Audrey Lapidus adored her babys sunny smile and irresistible dimples, but grew worried when Calvin did not roll over or crawl by 10 months and suffered chronic digestive problems. Four neurologists dismissed his symptoms and a battery of tests proved inconclusive. Desperate for answers, Audrey and her husband agreed to have their son become UCLAs first patient to undergo a powerful new test called exome sequencing.

Using DNA collected from Calvins and his parents blood, a sophisticated sequencing machine rapidly scanned the boys genome, compared it to his parents and flagged a variant on his 18th chromosome. Calvin was diagnosed with Pitt-Hopkins Syndrome, a rare genetic disorder affecting only 250 children worldwide. At last Audrey and her husband had a concrete diagnosis and clear direction for seeking the best treatment for their son.

Now a landmark UCLA study makes a persuasive argument for the routine clinical use of exome sequencing as a valuable tool for diagnosing children like Calvin with rare genetic disorders. Published in the Oct. 18 online edition of the Journal of the American Medical Association, the findings show that exome sequencing produced a definitive diagnosis in 40 percent of UCLAs most complex cases a quantum leap from the fields 5-percent success rate two decades ago.

Our study is the first to show that sequencing a childs genome together with his or her parents dramatically improves geneticists ability to reach a firm diagnosis in rare disorders, said corresponding author Dr. Stan Nelson, vice chair of human genetics and a professor of pathology and laboratory medicine at David Geffen School of Medicine at UCLA. We discovered a genetic cause for the conditions affecting 40 percent of the hundreds of young children who come to UCLA for exome sequencing due to developmental delays or intellectual disabilities.

The UCLA Clinical Genomics Center was established in 2011 as one of three facilities in the world (including Baylor and Harvard) to put DNA sequencing to clinical use. Unlike earlier diagnostics that study one gene at a time, this test rapidly sifts through all of the 37-million base pairs in a persons 20,000 genes to tease out the single DNA change causing a rare genetic disorder. It focuses on the exome, the protein-coding portions of genes that account for only 1 percent of DNA but nearly 85 percent of the glitches known to cause human diseases.

In this two-year study, Nelson worked with first author Hane Lee, an assistant adjunct professor of pathology, to sequence and analyze the exomes of 814 children whose symptoms had baffled previous clinicians despite exhaustive genetic, biochemical and imaging tests.

Heres how it worked. The UCLA center funneled the raw data from sequencing the genomes of each child and their parents through its informatics pipeline to identify variants from the standard human genome. The average persons exome contains more than 20,000 variants, nearly all benign.

Next the team applied a series of filters to the data based on the patients family history and other relevant aspects of his or her condition. The researchers hunted for all genes and mutations linked by medical literature to the patients symptoms. Finally UCLAs Genomics Data Board, a multidisciplinary team of experts, reviewed the findings to reach a diagnosis.

Continued here:
New Test Scans All Genes Simultaneously to Identify Single Mutation Causing Child's Rare Genetic Disease

Recommendation and review posted by Bethany Smith

PUBLIC RELEASE DATE:

17-Oct-2014

Contact: Robert Redmond rredmond@cshl.edu 516-422-4101 Cold Spring Harbor Laboratory @CSHLnews

Since the appearance of modern humans in Africa around 200,000 years ago, we have migrated around the globe and accumulated genetic variations that affect various traits, including our appearance, skin color, food tolerance, and susceptibility to different diseases. Large-scale DNA sequencing is now allowing us to map the patterns of human genetic variation more accurately than ever before, trace our ancestries, and develop personalized therapies for particular diseases. It is also reinforcing the idea that human populations are far from homogeneous, are highly intermixed, and do not fall into distinct races or castes that can be defined genetically.

Human Variation from Cold Spring Harbor Laboratory Press provides a state-of-the-art view of human genetic variation and what we can infer from it, surveying the genetic diversity seen in Africa, Europe, the Americas, and India. The contributors discuss what this can tell us about human history and how it can be used to improve human health. They also caution against assumptions that differences between individuals always stem from our DNA, stressing the importance of nongenetic forces and pointing out the limits of our knowledge. The book is thus essential reading for all human geneticists and anyone interested in how we differ and what this means.

###

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Link:
New book from CSHL Press with focus on genetics, personalized medicine and human diversity

Recommendation and review posted by Bethany Smith

What Is The Definition Of Hemostasis, genetics of - Medical Dictionary Free Online Terms
Visit our website for text version of this Definition and app download. http://www.medicaldictionaryapps.com Subjects: medical terminology, medical dictionary, medical dictionary free download,...

By: Medical Dictionary Online

Read more:
What Is The Definition Of Hemostasis, genetics of - Medical Dictionary Free Online Terms - Video

Recommendation and review posted by Bethany Smith

[Modded Minecraft] "Attack Of The B-Team" SMP | "Advanced Genetics"
[Modded Minecraft] "Attack Of The B-Team" SMP | "Advanced Genetics" Attack Of The B-Team link: http://full.sc/1d2YmVZ Series Playlist: http://full.sc/XxyD2E ...

By: BIGCountrysTV

View original post here:
[Modded Minecraft] "Attack Of The B-Team" SMP | "Advanced Genetics" - Video

Recommendation and review posted by Bethany Smith

Webinar- Genetics of PXE
Genetics can be confusing - come read the code! Presenter Tim Hefferon will discuss the basics of genetics and DNA and specific issues around PXE, how PXE is inherited, and whether a genetic...

By: PXEInter

Link:
Webinar- Genetics of PXE - Video

Recommendation and review posted by Bethany Smith

My Genetics Project
Parasite: Balamuthia Mandrillaris By: Noor Naeem Citation: http://en.wikipedia.org/wiki/Balamuthia_mandrillaris http://www.cdc.gov/parasites/balamuthia/ http://dermnetnz.org/arthropods/balamuthia.h...

By: Noor Horan

Read more:
My Genetics Project - Video

Recommendation and review posted by Bethany Smith

Gene Therapy Animation Video

By: HotHoneyLips04

Read more:
Gene Therapy Animation Video - Video

Recommendation and review posted by Bethany Smith

Eugene Kolker (Seattle Children #39;s Hospital) Interview -- Strata + Hadoop 2014
From the 2014 Strata Conference + Hadoop World in New York City, an interview with Seattle Children #39;s Chief Data Officer on predictive analytics in healthcare, using data to make actionable...

By: O #39;Reilly

Continue reading here:
Eugene Kolker (Seattle Children's Hospital) Interview -- Strata + Hadoop 2014 - Video

Recommendation and review posted by sam

Dr. O #39;s Pit Bull Therapy with Change Your Range
Erika McElwey gives a video consultation recheck for Gambatte O #39;Sullivan. Gambatte is a 6 year old Pit Bull who is currently using a wheel chair custom made for him by Eddie #39;s wheels after...

By: Caroline O #39;Sullivan

More here:
Dr. O's Pit Bull Therapy with Change Your Range - Video

Recommendation and review posted by sam

The Big Idea: Epidural Stimulation Research for SCI
The Big Idea aims to transform what it means to live with a spinal cord injury through vital research. Donate now join the movement!

By: ReeveFoundation

Link:
The Big Idea: Epidural Stimulation Research for SCI - Video

Recommendation and review posted by sam

Overview of Regenerative Medicine Partnering Merger Acquisition Market
The report provides a detailed understanding and analysis of how and why companies enter regenerative medicine and stem cells partnering deals. The majority ...

By: John Brown

Here is the original post:
Overview of Regenerative Medicine Partnering Merger & Acquisition Market - Video

Recommendation and review posted by sam