Supplementing the diet with omega-6 polyunsaturated fatty acids has beneficial effects on heart health by lowering "bad" LDL cholesterol and raising "good" HDL cholesterol, but the underlying mechanisms involved are poorly understood. Now research based on the genetic information from over 100,000 individuals of European ancestry has uncovered a gene that affects blood cholesterol levels through the generation of a compound from omega-6 polyunsaturated fatty acids, called lipoxins. The study, publishing online October 16 in the Cell Press journal Cell Metabolism, also provides additional evidence that aspirin assists in preventing heart attacks by promoting lipoxin production. These insights could change the way doctors care for patients at increased risk for heart disease.

"Our findings could help pave the way for novel therapeutic approaches to prevent cardiovascular disease and its associated clinical sequelae, including heart attacks and stroke," says senior author Dr. Ivan Tancevski, of the Innsbruck Medical University, in Austria.

In assessing the genetic information from the study participants of European descent, Dr. Tancevski and his colleagues identified one gene, called Alox5, that codes for an enzyme that generates lipoxins from omega-6 polyunsaturated fatty acids to help the body get rid of bad cholesterol. Lipoxins have anti-inflammatory properties.

The team found that aspirin, which is widely used to prevent heart attacks and stroke, also acts on this pathway. In experiments conducted in mice, aspirin stimulated production of lipoxins that then promoted the transport of excess cholesterol to the liver, where it is excreted through bile. Treating mice that had atherosclerotic plaques in their blood vessels with aspirin even caused the plaques to regress. "Aspirin is known to prevent cardiovascular disease due to its antithrombotic and anti-inflammatory effects. We now identified a third mechanism by which aspirin may confer protection," says Dr. Tancevski.

The researchers went a step further in generating and testing chemically modified lipoxins mimetics that were even more effective at lowering LDL cholesterol, suggesting that new lipoxin-based specific drugs could provide greater benefits for patients.

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The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.

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Human genetic research uncovers how omega-6 fatty acids lower bad cholesterol

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The notion of the jumping gene that hops from one species to another has been known since the 1950, causing for example antibiotic resistance that helps superbugs like MRSA to survive. File photograph taken from the Dublin City of Science 2012 initiative.

It was a seriously tough neighbourhood back when the earth was young. It was a smash and grab world where if one species didnt have the genes it needed to survive it just stole them from a neighbour, according to new research.

The findings are going to force a rewrite of how evolution works, says NUI Maynooths Prof James McInerney who was part of the team along with scientists from Germany and New Zealand.

It completely changes the textbook standard models for evolution, he says. Evolution does occur but we have now discovered it is much more fantastic than before, it is awesome.

The standard model says that most new traits emerged in early microorganisms primarily through mutation, spontaneous changes that either helped survival or caused death.

Not so the researchers found. Genetic changes in these primitive organisms called the archaea and the eubacteria were more likely to occur by stealing genes from one another. This horizontal gene transfer in turn caused evolution to occur by sudden large leaps and bounds and not just by mutation of a single gene, they write this afternoon in the journal Nature.

There were significant flows of genes from one species to another. There was a constant borrowing and stealing of genes between species, Prof McInerney says.

The notion of the jumping gene that hops from one species to another has been known since the 1950, causing for example antibiotic resistance that helps superbugs like MRSA to survive, he said. This is completely different however.

The scientists used powerful computers to search back through the genetic changes that took place in these early organisms. This showed when genes suddenly arrived to deliver new traits.

Most of the theft was perpetrated by the archaea, with this group of microorganisms five to 10 times more likely to take genes than the hapless eubacteria, but it was a two way flow cutting both ways.

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Gene stealing was the way to go for life on early earth

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Tyranny Totalitarianism Past, Present Future: The Future
What is the likely shape of tyranny in the future? Will it resemble the soft-despotism of Tocqueville? Will it be Orwellian political thought-control? Or the...

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Genetic Engineering DNA Extraction Part 1 Anytime Education
Mr James Dundon explains DNA extraction/isolation. DNA is extracted from human cells for a variety of reasons. With a pure sample of DNA you can test a newborn for a genetic disease, analyze...

By: James Dundon

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PUBLIC RELEASE DATE:

16-Oct-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

New Rochelle, NY, October 15, 2014Palliative care provided in the hospital offers known clinical benefits, and a new study shows that inpatient palliative care can also significantly lower the cost of hospitalization and the rate of readmissions. Further, the study shows the hospital can get the expertise it needs through a collaborative relationship with a community hospice. The results of a comparative study are published in Journal of Palliative Medicine, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Palliative Medicine website until November 15, 2014.

In the article "A Hospice-Hospital Partnership: Reducing Hospitalization Costs and 30-Day Readmissions among Seriously Ill Adults (http://online.liebertpub.com/doi/full/10.1089/jpm.2013.0612)," John Tangeman, MD, Christopher Kerr, MD, PhD, and Pei Grant, PhD, Center for Hospice and Palliative Care (Cheektowaga, NY), and Carole Rudra, PhD, MPH, Rudra Research (Buffalo, NY), compared cost per hospital admission and readmission rates among patients who received inpatient palliative care to those who did not at two hospitals in western New York.

"Palliative care has been proven to deliver on the value equation," says Charles F. von Gunten, MD, PhD, Editor-in-Chief of Journal of Palliative Medicine and Clinical Professor of Medicine, Ohio University. "To be successful, every health system will want to maximize its investment in palliative care to deliver the highest quality of care at the lowest cost."

###

Journal of Palliative Medicine is the official journal of the Center to Advance Palliative Care (CAPC) and an official journal of the Hospice and Palliative Nurses Association

About the Journal

Journal of Palliative Medicine, published monthly in print and online, is an interdisciplinary journal that reports on the clinical, educational, legal, and ethical aspects of care for seriously ill and dying patients. The Journal includes coverage of the latest developments in drug and non-drug treatments for patients with life-threatening diseases including cancer, AIDS, cardiac disease, pulmonary, neurological, and respiratory conditions, and other diseases. The Journal reports on the development of palliative care programs around the United States and the world and on innovations in palliative care education. Tables of content and a sample issue can be viewed on the Journal of Palliative Medicine website.

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16-Oct-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

New Rochelle, NY, October 16, 2014To treat the debilitating anemia associated with reduced erythropoietin (EPO) production by the kidneys in chronic renal disease, patients are often given recombinant human EPO to increase hemoglobin levels. But that treatment has risks. A new approach that uses a small interfering RNA (siRNA) drug to stimulate natural EPO production by the liver has shown promising results in nonhuman primates, as reported in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers. The article is available free on the Nucleic Acid Therapeutics website until November 16, 2014.

Marc T. Abrams and colleagues, Merck Research Laboratories (West Point, PA and Boston, MA), designed a siRNA drug that targets and inhibits expression of the EGLN1 gene, thereby blocking production of a protein called prolyl-4-hydrolase 2 (PHD2). The liver normally makes only small amounts of EPO in adult primates and humans, but one dose of the siRNA drug led to increased levels of EPO and hemoglobin in the blood of the primates. The siRNA effect was dose-dependent and was sustained for at least two months, report the authors in the article "A Single Dose of EGLN1 siRNA Yields Increased Erythropoiesis in Nonhuman Primates."

"The translational relevance of this paper is that it successfully advances the in vivo therapeutic investigation of PHD inhibitors from previous mouse-based work to achieve increased serum EPO and hemoglobin in a primate model, " says Executive Editor Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit, MI.

###

About the Journal

Nucleic Acid Therapeutics is an authoritative, peer-reviewed journal published bimonthly in print and online that focuses on cutting-edge basic research, therapeutic applications, and drug development using nucleic acids or related compounds to alter gene expression. The Journal is under the editorial leadership of Co-Editors-in-Chief Bruce A. Sullenger, PhD, Duke Translational Research Institute, Duke University Medical Center, Durham, NC, and C.A. Stein, MD, PhD, City of Hope National Medical Center, Duarte, CA; and Executive Editor Graham C. Parker, PhD. Nucleic Acid Therapeutics is the official journal of the Oligonucleotide Therapeutics Society. Complete tables of content and a sample issue may be viewed on the Nucleic Acid Therapeutics website.

About the Society

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Actress Angelina Jolies decision to have a preventative double mastectomy after learning she carried the faulty gene BRCA1 has heighted awareness for genetic testing. The Angelina Jolie Effect has lead to an increase in testing for the BRCA1/2 mutations among North American women, according to a recent Canadian study. But, is genetic testing for everyone? And, what questions should women consider?

Gail Vance, MD, FCAP, a pathologist and a clinical geneticist specializing in cancer genetics for inherited diseases at the Indiana University School of Medicine, is available for interviews for breast cancer awareness stories on what women need to know when considering genetic testing for the breast cancer. She is available to answer such questions as:

In lieu of all the recent advancements in genetic testing, what questions should patients be asking their doctors? Why is it important for a pathologist to be involved? How affordable are these tests? Are these tests covered by health care providers?

Dr. Vance also can offer tips for patients who are weighing this important decision, including: Talk with your physician about which genetic testing is appropriate for you Discuss the risks and benefits of genetic testing Learn which treatment is right for you. If you have diagnosed with cancer, an evaluation of your tumor will assist your oncologist in determining the appropriate treatment

Pathologists are the physicians who use laboratory medicine to examine cells, tissues, and body fluids to identify and diagnose disease, including breast cancer. They are involved in every aspect of health care. Pathologists provide the medical interpretation of genetic testing, which is critical to help patients make informed decisions about their health.

About Dr. Gail Vance: Gail H. Vance, MD, FCAP, is the Sutphin professor of Cancer Genetics and interim chairperson of the Department of Medical and Molecular Genetics at the Indiana University School of Medicine. She also is director of the Division of Diagnostic Genomics and the Indiana Familial Cancer Program, which provides genetic counseling, risk assessment, and genetic testing to individuals with an elevated risk for developing cancer.

About the College of American Pathologists As the leading organization with more than 18,000 board-certified pathologists, the College of American Pathologists (CAP) serves patients, pathologists, and the public by fostering and advocating excellence in the practice of pathology and laboratory medicine worldwide. The CAPs Laboratory Improvement Programs, initiated 65 years ago, currently has customers in more than 100 countries, accrediting 7,600 laboratories and providing proficiency testing to 20,000 laboratories worldwide. Find more information about the CAP at cap.org. Follow CAP on Twitter: @pathologists.

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Pathologist and Genetic Counselor Available for Interviews on the "Angelina Jolie Effect" and What Patients Need to Know

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15-Oct-2014

Contact: Duska Anastasijevic newsbureau@mayo.edu 507-284-5005 Mayo Clinic @MayoClinic

Rochester, Minn. The American Academy of Neurology (AAN) and the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) offer a new guideline on how to determine what genetic tests may best diagnose a person's subtype of limb-girdle or distal muscular dystrophy. The guideline is published in the October 14, 2014, print issue of Neurology, the medical journal of the AAN.

Researchers reviewed all of the available studies on the muscular dystrophy, a group of genetic diseases in which muscle fibers are unusually susceptible to damage, as part of the process in developing the new guideline.

Doctors should conduct a thorough evaluation of symptoms, family history, ethnicity, and results of physical exam and certain lab tests to determine what genetic tests may be more appropriate to order.

"The guideline should help physicians arrive at the right diagnosis quicker so patients will not need to take unnecessary test", says Mayo Clinic neurologist Duygu Selcen, M.D., who was part of the multi-center research team led by Julie Bolen, PhD, MPH, from the National Center on Birth Defects and Developmental Disabilities, at the Centers for Disease Control and Prevention (CDC). "This is particularly important because the muscle diseases are often hard to diagnose", adds Dr. Selcen.

There are several known subtypes of limbgirdle muscular dystrophy and distal muscular dystrophy. Experts continue to discover new subtypes and the guidance should help shorten the time to the right treatment.

While there is no cure for these disorders, complications can be managed. The guideline makes recommendations about treating and managing complications, which may include muscle symptoms, heart problems and breathing problems.

The guideline recommends that care for people with these disorders should be coordinated through treatment centers specializing in muscular dystrophy. People with these disorders should tell their doctors about any symptoms such as the heart beating too fast or skipping beats, shortness of breath and pain or difficulty in swallowing, as treatments may be available. People should also talk to their doctors about exercises that are safe.

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New guideline in genetic testing for certain types of muscular dystrophy

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Newswise (NEW YORK - Oct. 15) A team led by researchers at The Rockefeller University and the Icahn School of Medicine at Mount Sinai has explained the function of key immune protein and solved an international medical mystery, according to a letter published this week in the journal Nature.

In previous work, the research team lead had linked small changes in a key gene with a reduced ability to fight off a set of rare bacterial infections. Shortly afterward, a team of Chinese scientists reached out to say they had found three Chinese children with mutated versions of the same gene. Strangely, the Chinese children had no history of the severe bacterial infections, but instead had seizures and unusual calcium deposits in their brains.

The disconnect led to the discovery of an immune protein with two seemingly opposing roles: amplifying and tamping down aspects of an immune system response, according the study, published on Sunday, Oct. 12. The roles explained how the protein, or lack of it, could weaken response to an infectious disease in one instance, but contribute to the attack by the immune system on a persons own tissues (autoimmune disease) in another.

It has turned out that mutations in a single gene eliminates the immune protein ISG15, giving rise to two different problems: an inability to resolve harmful inflammation, which can lead to autoimmune disease, and susceptibility to infections caused by the tuberculosis bacterium and its cousins, said Jean-Laurent Casanova of the St. Giles Laboratory of Human Genetics of Infectious Diseases at Rockefeller. By identifying the source of this genetic disorder, we have taken a first step toward finding treatments for those facing the autoimmune disease and severe TB-related infections it may produce.

When under attack, the immune system releases signaling proteins known as interferons, which further activate the bodys defenses. In previous research, Dusan Bogunovic, PhD, Assistant Professor at the Department of Microbiology at Icahn School of Medicine at Mount Sinai and study author, had linked a lack of ISG15 to an unusual vulnerability to infections by mycobacteria, a group of common bacteria that include the tuberculosis bug.

He and colleagues had previously found children, one from Turkey, two from Iran, who became severely ill after receiving the anti-tuberculosis BCG vaccine. Normally, ISG15 protects against infection by mycobacteria by prompting the release of type 2 interferon, but all three children had two copies of a defective form of the ISG15 gene, and became infected by a TB-related component of the vaccine.

When Bogunovic and his colleagues reported this link publically, scientists in China reached out saying they had also seen loss-of-function mutations in three patients, all from a single Chinese family. But none of these three had had unexplained mycobacterial infections, such as those caused by the vaccine.

We asked why these children were patients; our Chinese colleagues said these kids had seizures, said Dr. Bogunovic. When we looked into their BCG vaccination history, we found these children, who were born at home in a remote village, never received their shots, so they never became sick.

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Muscular Dystrophy (MD) is well-known as a disease that progressively weakens muscles, leading to muscle spasms, difficulty walking, and eventually difficulty breathing. What many people dont know is that MD is actually a group of diseases, each of which can have different effects on the human body. Doctors are still discovering and classifying new forms of MD.

This week the American Academy of Neurology (AAN) and the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) issued guidelines meant to differentiate between MD disease types in preparation for genetic testing. The guidelines, published in this weeks Neurology, use symptoms, physical exams, lab tests, family history, and ethnicity to determine which genetic tests doctors should perform.

According to the guidelines lead author, Dr. Pushpa Narayanaswami, MD can often be difficult to diagnose. The guidelines should help doctors determine MD subtypes, leading to better treatments and avoiding unnecessary tests.

Looking at a range of clinical signs and symptoms such as which muscles are weak and if there is muscle wasting or enlargement, winging out of the shoulder blades, early signs of contracted limbs, rigidity of the neck or back, or heart or lung involvement can help doctors determine which genetic test to order, said Dr. Anthony Amato, senior author of the guidelines and a neurologist at Brigham and Womens Hospital. This in turn can shorten the time to diagnosis and start of treatment while helping avoid more extensive and expensive testing.

According to the guidelines MD treatment should take place at facilities that specialize in the disease. No cure for MD yet exists, so the guidelines also suggest that MD patients inform their doctors of treatable symptoms such as shortness of breath or irregular heartbeat and that they seek out safe exercises.

Before this publication, there were no care guidelines that covered both limb-girdle muscular dystrophy and distal MD and were based on the evidence, said Julie Bolen, team lead on the guidelines and a member of the National Center on Birth Defects and Developmental Disabilities at the U.S. Centers for Disease Control and Prevention (CDC). We hope that this guideline will fill that gap for both the people who live with these rare disorders and the health care professionals who treat them.

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Genetic Testing Guidelines Issued For Muscular Dystrophy

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PUBLIC RELEASE DATE:

16-Oct-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

New Rochelle, NY, October 16, 2014Delivering traditional emergency medical care at ground zero of natural disasters and military conflicts is challenging. First responders trained in simple integrative medicine approaches such as acupuncture, hypnosis, or biofeedback can provide adjunctive treatment to help relieve patients' pain and stress. How to teach and utilize modified techniques and their potential benefit are described in a Review article in Medical Acupuncture, a peer-reviewed journal from by Mary Ann Liebert, Inc., publishers. The article is available free on the Medical Acupuncture website at http://online.liebertpub.com/doi/full/10.1089/acu.2014.1063 until November 16, 2014.

In the article "The Roles of Acupuncture and Other Components of Integrative Medicine in Cataclysmic Natural Disasters and Military Conflicts" Richard Niemtzow, MD, PhD, MPH, Editor-in-Chief of Medical Acupuncture, a retired Air Force Colonel, and current Director of the USAF Acupuncture Center, Joint Base Andrews, Maryland; Wayne Jonas, MD, President and Chief Executive Officer of the Samueli Institute (Alexandria, VA); and coauthors from InsideSurgery, LLC (Wayne, PA) and Samueli Institute present integrative health care approaches suitable for use by emergency responders and rescuers that do not require extensive equipment, facilities, or supplies.

"These approaches are usually inexpensive and nontoxic, are inherently low-risk, do not require complicated delivery methods, and can be pushed far forward in disaster relief effort even when other resources cannot be delivered," state the authors. "Such approaches may provide significant and rapid relief for victims of disasters and wars, as well as for their caregivers."

The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the United States Air Force Medical Corps, the Air Force at large, or the Department of Defense.

###

About the Journal

Medical Acupuncture, the Official Journal of the American Academy of Medical Acupuncture, is an authoritative peer-reviewed journal published bimonthly in print and online. The Journal presents evidence-based clinical articles, case reports, and research findings that integrate concepts from traditional and modern forms of acupuncture with allopathic medicine. Tables of content and a sample issue may be viewed on the Medical Acupuncture website at http://www.liebertpub.com/acu.

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Should first responders use acupuncture & integrative medicine in natural disasters & battle zones?

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9th Grade Biology: Genetics - Heredity
An introduction to the concept of genetic inheritance including alleles, dominant and recessive traits, Punnet squares, Gregor Mendel his peas.

By: Michael Cook

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9th Grade Biology: Genetics - Heredity - Video

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TRANSHUMANISM GMO GENETICS AND NOAH,S FIRE
Non profit,freely give as I give unto you,,I dint own images or music.

By: CAMILIA KEEN

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TRANSHUMANISM GMO GENETICS AND NOAH,S FIRE - Video

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Create A Sim (Perfect Genetics Challenge) Ariana Spenman
Simmoa #39;s info* facebook: http://www.facebook.com/simmoasimmer Twitter: @SimmoaSimmer Tumblr:@SimmoaSimmer Sims 3 Accounts: ByeBye Stupid IKR LOL Follow, Like, Comment ...

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Gene Therapy - AAV Virus
Explore Research at the University of Florida: A common virus known as AAV, or Adeno-Associated Virus, has been described as boring because while it affect...

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Epidural Stimulation Research for Spinal Cord Injury Recovery
April 2014. Features the amazing, groundbreaking results achieved by Dr. Susan Harkema and her team at the University of Louisville Spinal Cord Injury Resear...

By: BEL13VERS

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Los Angeles Brain Spinal Injury Attorney- Law Offices Of Gerald L. Marcus- Call (800) 905-8777
http://www.geraldmarcuslaw.com/ Los Angeles Brain and Spinal Injury Attorney Brain and spinal injuries are among the most devastating injuries an individual can sustain. The damages involved...

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Dr. Deepak Srivastava, a leading biomedical research policy expert, will discuss "Stem Cells, Regenerative Medicine and Policy Impediments to the New Future" at Rice University's Baker Institute for Public Policy Oct. 21. The event is free and open to the public, but registration is required.

Who: Dr. Deepak Srivastava, the Baker Institute's nonresident scholar for biomedical research policy and the Younger Family Director and senior investigator at the Gladstone Institute of Cardiovascular Disease.

Neal Lane, the Malcolm Gillis University Professor, senior fellow in science and technology policy at Rice's Baker Institute for Public Policy and a professor of physics and astronomy, will give introductory remarks.

Stem cells and regenerative medicine are exciting and emerging fields of biomedical research, according to event organizers. Proposed applications include treating conditions such as blindness, diabetes and heart disease. Regenerative medicine could also help heal failing organ systems and replace damaged tissue. While these fields hold great promise for medicine, external factors limit and, in some cases, stall research, organizers said. Ethical controversies surrounding human embryonic stem cells, policy issues affecting federal and state funding and regulation, and economic pressures all play a role in determining the future of research.

In his presentation, Srivastava will explore the current and future potential of stem cells and regenerative medicine. Following the presentation, he will discuss policy challenges and opportunities with Lane.

The event is sponsored by the Baker Institute's Science and Technology Policy Program and the Health Policy Forum.

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Stem cell, regenerative medicine policies to be discussed at Rice's Baker Institute

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Knee arthritis 2.5 years after stem cell therapy by Harry Adelson, N.D.
Janet discusses her outcome three and a half years after bone marrow stem cell therapy by Dr Harry Adelson for her arthritic knees http://www.docereclinics.com.

By: Harry Adelson, N.D.

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Interview: Christopher Reeve #39;s Son Talks Advancements In Spinal Cord Injury Treatment
It has been 10 years since the death of actor Christopher Reeve. Since his spinal cord injury, the Christopher and Dana Reeve Foundation has worked tirelessly to make advancements in the way...

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"In Transit" by D #39;Quan Brown
In 2012, 10 yr old D #39;Quan Brown was diagnosed with leukemia and admitted for immediate care at a South Florida children #39;s hospital. 6 days later, he suffered a spinal hematoma that subsequently...

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Spinal Cord Injury | Stem Cell + Epidural Stimulation Treatment Testimonial
Get the treatment: http://www.stemcelltreatmentnow.com/spinal-cord-injury/ The future of SCI treatment may already be here. Follow Narine #39;s progress: http://...

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Carson Tueller: Music nourishes the soul after spinal cord injury
Carson Tueller is a pianist, a flutist, and a private music teacher. After serving a full-time LDS mission in Chile, Concepcion he attended Weber State Unive...

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Mr. Seelan on FAMI Fat Grafting at Empire Regen CEntre
The FAMI Facial Fat Graft Volume Enhancement is done utilizing the world renowed FAMI technique. Dr Callanta is well versed with this technique after having done hundreds of cases over...

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Ronnie Henares on FAMI Fat Grafting at Empire Regen Centre
The FAMI Facial Fat Graft Volume Enhancement is done utilizing the world renowed FAMI technique. Dr Callanta is well versed with this technique after having done hundreds of cases over...

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