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New Jersey, USA,"Global Breast Cancer Predictive Genetic Testing Market Analysis to 2028" is a professional and in-depth industry study with a particular focus on analyzing global market trends. The report aims to provide an overview of the next-generation clinical sequencing market with detailed market segmentation by type, application, and region. The report provides key statistics on the market status of key Breast Cancer Predictive Genetic Testing market players and provides key trends and opportunities in the market.

In addition, the global Breast Cancer Predictive Genetic Testing Market is expected to grow at a CAGR of about XX % over the next five years, will reach XX Billion US $in 2020, XX Billion US $in 2028

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Competitor Analysis

The competitive landscape is an important aspect that every key player should be familiar with. The report throws light on the competitive scenario of the global Breast Cancer Predictive Genetic Testing market to know the competition at both domestic and global levels. Market experts also provide an overview of all the leading players of the global Breast Cancer Predictive Genetic Testing market, considering key aspects such as local operations, production, and product portfolio. In addition, the company's report is based on research key factors such as the company's size, market share, market growth, income, output, and profit.

The research focuses on the current market size of the Breast Cancer Predictive Genetic Testing market and its growth rates based on records with the company outlines of key players/manufacturers:

The major players covered in Breast Cancer Predictive Genetic Testing Markets:

Market segmentation of Breast Cancer Predictive Genetic Testing market:

Breast Cancer Predictive Genetic Testing market is divided by type and application. For the period 2021-2028, cross-segment growth provides accurate calculations and forecasts of sales by Type and Application in terms of volume and value. This analysis can help you grow your business by targeting qualified niche markets.

Breast Cancer Predictive Genetic Testing Market breakdown by Type:

Breast Cancer Predictive Genetic Testing Market breakdown by application:

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Breast Cancer Predictive Genetic Testing Market Report Scope

Regional market analysis Breast Cancer Predictive Genetic Testing can be represented as follows:

Each regional Breast Cancer Predictive Genetic Testing sectors is carefully studied to understand its current and future growth scenarios. This helps players to strengthen their position. Use market research to get a better perspective and understanding of the market and target audience and ensure you stay ahead of the competition.

The base of geography, the world market of Breast Cancer Predictive Genetic Testing has segmented as follows:

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The study explores in depth the profiles of the main market players and their main financial aspects. This comprehensive business analyst report is useful for all existing and new entrants as they design their business strategies. This report covers production, revenue, market share and growth rate of the Breast Cancer Predictive Genetic Testing market for each key company, and covers breakdown data (production, consumption, revenue and market share) by regions, type and applications. Breast Cancer Predictive Genetic Testing historical breakdown data from 2016 to 2020 and forecast to 2021-2029.

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Breast Cancer Predictive Genetic Testing Market To Observe Exponential Growth By 2021-2028 | Roche, Thermo Fisher Scientific, PerkinElmer, Quest...

Recommendation and review posted by Bethany Smith

A Wadsworth woman was reunited with a son she put up for adoption33 years ago.

Beacon Journal partner News 5 Cleveland reports that the woman found her son through 23andMe, a DNA genetic testing service.

Melanie Pressley told News 5 that she was 18 when she was pregnant with her first son. She knew she couldn't take care of him financially, and she wanted him to have a mom and dad, so she put him up for adoption through an agency in Akron.

She gave birth to him in 1988, which was the last time she saw her son.

News 5 reports that her son, Greg Vossler, was adopted by a family in Stow. At age 7, he and his family moved to Winchester, Virginia.

Pressley had gone on to become happily married and had more children, but she always wondered about her son, she told News 5. Eventually, Vossler also wanted to know more about his biological parents.

He took a 23andMe test in 2019. She took one in May 2021, and the tests matched them together.

Instantly sent a message, and my first message wasI believe we're related, said Pressley. The next message wasI believe I am your birth mother. And from there it just blew up.

One of the very first questions I asked him, which was big for me, was, Are you happy? And he came back that he was oh, my gosh that he's married, he has two boys. I mean, it was just like spilling everything, Pressley said.

In June, the two met in Wadsworth and saw each other for the first time in 33 years.

Vossler told News 5 thathe and Pressley talked for four hours straight that first day. He also met 17 members of his new extended family.

Everyone's emotional, everyone's shaking hands or hugging. And, you know, Hey, I'm your half-brother, your half-sister. And her oldest sister, who was instrumental in allowing Melanie to have that first picture, came up and grabbed my face. The first time in 33 years that she's seen me, Vossler said.

It's an amazing feeling. And it just goes to show that there's always room for families to grow and always room for more love within each other, Vossler said.

The two are continuing to nurture their new relationship, News 5 said, with Pressley planning to visit Vossler in Virginia soon.

Read more about the story from News 5 Cleveland here.

Read the original:
Wadsworth woman reunited with son she put up for adoption after 33 years - Akron Beacon Journal

Recommendation and review posted by Bethany Smith

WADSWORTH, Ohio For years, a Medina County woman has wondered about the son she gave up for adoption more than three decades ago.

What does he look like? What does he do for a living? Was he happy?

Well, thanks to the popular DNA genetic testing service 23andMe, she now has those answers and more.

Melanie Pressley was just 18 when she got pregnant with her first child a boy. Her boyfriend at the time wasnt supportive and wanted her to get an abortion. Pressley refused and continued on with the pregnancy.

But eventually, she knew she couldnt keep him.

I just knew, financially, I wouldn't be able to do it. And the other thingI wanted him to have a mother and father, so I decided at that point it was best to put him up for adoption, said Pressley.

With the support of her family, she went through the adoption process with an agency based in Akron.

On June 17, 1988, she gave birth to her son at the then-Timken Mercy Hospital in Canton. She didnt name him because she wanted his adoptive parents to have that honor.

She said that day, she wasnt allowed to hold him, but the next day, her sister asked a nurse if they could hold the baby.

She said, I will take you into a private room so that she can hold him, and she said, Take all the time you need. And at that point, when I was holding him, my sister took a picture and that was the only picture that I had of him for thirty three years. That was the only picture that I had of him, said Pressley.

Pressley has had three more kids since then and is happily married, but she said every day, and especially every time June 17 rolled around, she thought about the son she gave up for adoption.

There was still always a little bit of that sadness in me on that day. And that's basically the easiest way to describe it, said Pressley.

In Winchester, Virginia, 307 miles away from her Wadsworth home, it turns out Pressleys son was thinking of her too.

He was adopted by the Vossler family and named Greg. They lived in Stow for about seven years after he was adopted, and then moved to Winchester.

Maybe nine or 10 or somewhere around that age range, they shared with me the story that I was adopted and that the woman who gave me up for adoption thought I could have a better life elsewhere, said Vossler, who still lives in Winchester.

Vossler said his curiosity wasnt immediate.

Some years later, he found descriptions of his birth parents that were provided from accounts from the hospital, but there werent any names, birth dates, or ages.

Never was really curious. I'd always joke saying, you know, I don't see a celebrity that looks like me, or, No one who's a king or queen in some faraway land resembles me. And I always said that was just my joke. You know, whenever somebody asked, it was just my way of having that quick response in my back pocket, I'd never really given it some serious thought, said Vossler.

But he said it was always in the back of his mind through college, getting married, and raising two sons.

The reason I named my first son Gregory was because he was my first blood relative that I knew. So I wanted to have that bond, said Vossler.

Then, in 2019, he decided he wanted to know more.

My wife and I were sitting and talking one night, and I'm like, I don't know any of my medical history, genetics, you know, where I'm from. And there was a 23andMe promotion or something going on. And so I took the test, said Vossler.

That same year, Melanies mom died, which pushed her to do what shes always wanted to.

It was always my wish that I wanted him to meet my mother, but she passed away. And the night that she passed away, we were all around the table, my nieces, nephews, my sisters and everybody. And we were going around just kind of saying things and it got to me and I had just started crying and I said, I need to find my son, said Pressley.

But that moment didnt come until May 2021, when one of Melanie's daughters bought her a 23andMe test as a birthday gift.

The results came back in just days and with them a match to a potential son named Greg Vossler.

Instantly sent a message, and my first message was, I believe we're related, said Pressley. The next message was, I believe I am your birth mother. And from there it just blew up.

One of the very first questions I asked him, which was big for me, was, Are you happy? And he came back that he wasoh my goshthat he's married, he has two boys. I mean, it was just like spilling everything, said Pressley.

Messages on 23andMe turned into emails and finally texts.

Vossler said they vetted each other thoroughly to make sure the connection was real.

We were very investigative with each other, you know, the hospital where I was born changed the name. So I said, Well, do you remember the hospital where I was born? And she said the name that it was back in 1988. And I was like, OK, alright we got there, and there were a few additional things that I had asked and she answered, she passed the test, said Vossler.

You're just sitting there and it's not something that you can ever prepare for mentally, and the way I would constantly describe it was just a surreal moment, said Vossler.

But when Vossley asked if he could call Pressley, she told him she didnt want to hear his voice until she could see him in person.

So in June, Vossler, his wife Chelsea, and their sons drove to Wadsworth for a weekend.

Both Vossler and Pressley were worried that the connection wouldnt happen, and that it was somehow all a farce, but they were happily mistaken.

Vosslers wife took a photo of when the two saw each other for the first time.

I am so thankful for her for doing that because It was the very first time and it was awesome, said Pressley.

Vossler said he and Pressley talked for four hours straight that first day. He also met 17 members of his new extended family, including two of his siblings, his aunts, and grandfather.

Everyone's emotional, everyone's shaking hands or hugging. And, you know, Hey, I'm your half brother, your half sister. And her oldest sister, who was instrumental in allowing Melanie to have that first picture, came up and grabbed my face. The first time in 33 years that she's seen me, said Vossler.

It's an amazing feeling. And it just goes to show that there's always room for families to grow and always room for more love within each other, said Vossler.

Pressley and Vossler are continuing to nurture their newfound bond. Pressley and her husband, Tim, plan to travel to Virginia this weekend to meet the Vossler family.

Vossler and his family have also been invited to his half-sisters wedding this fall and plans to attend.

I am just excited with the ball moving and I am just going to soak up every moment and just enjoy it. Enjoy the little ones also with every opportunity that we get to see them, said Pressley.

Now, the picture that Pressleys sister took of them 33 years ago in the hospital isnt the only one this mother and son have together.

Life has a funny way of giving you what you need, not what you want. And I guess life just realized that we needed this connection and our families needed each other, said Vossler.

Jade Jarvis is a reporter at News 5 Cleveland. Follow her on Facebook, Twitter, and Instagram.

Download the News 5 Cleveland app now for more stories from us, plus alerts on major news, the latest weather forecast, traffic information and much more. Download now on your Apple device here, and your Android device here.

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Wadsworth woman finds son she put up for adoption 33 years ago through 23andMe - News 5 Cleveland

Recommendation and review posted by Bethany Smith

BALTIMORE & HOUSTON--(BUSINESS WIRE)--Tesis Labs, a leader in targeted genetic sequencing, and Personal Genome Diagnostics Inc. (PGDx), a leader in cancer genomics, today announced a new collaboration to maximize the power of genetic sequencing and bioinformatics. Through this collaboration, the companies intend to combine resources and expertise to create new genomics solutions that could combat cancer and improve outcomes for patients, and advance market access initiatives to accelerate adoption in the market.

The National Institutes of Health estimates that by 2040, there will be 29.5 million new cancer cases and nearly 16.4 million deaths worldwide per year. This new strategic collaboration brings together highly specialized clinical laboratory and biotechnology teams, enabling their expertise, creativity, and passion for delivering the latest genetic and bioinformatic insights to advance cancer predisposition, profiling, and treatment.

We are excited to partner with PGDx and leverage our aligned vision and collective expertise to enable new and creative clinical opportunities, stated Ron King, Tesis Labs CEO. Genetic sequencing and genetic biomarkers are revealing new opportunities for medicine. Our clinical expertise and approaches to unlocking the power of genetic sequencing are bringing new insights to cancer research, profiling and treatment.

We are thrilled to partner with Tesis Labs, a company that shares our passion for expanding the reach of genetic sequencing through decentralized testing, said Megan Bailey, Chief Executive Officer of PGDx. We look forward to working with Tesis Labs to further progress advancements in genomic insights and patient-centered oncology care.

Tesis uses a genetically integrated medical platform for targeted genetic sequencing and comprehensive genetic data collection to support many medical specialties. The companys existing labs are in Denver, Lafayette, Colo., and Houston.

PGDx currently offers three pan-cancer NGS kitted solutions elio tissue complete, an FDA cleared kit, elio plasma complete, a comprehensive liquid biopsy solution, and elio plasma resolve, which has received FDA breakthrough device designation that provide researchers and clinicians with the ability to identify biomarkers and profile tumors through advanced genomic sequencing within their own hospital systems and laboratories.

About Tesis Labs

Tesis Labs' genetically integrated medical platform has revolutionized targeted genetic sequencing. Our mission is to change medicine by providing physicians, hospitals, and researchers with the tools to help patients treat and overcome major chronic conditions such as heart disease, lung disease, cancer, and diabetes through advanced genetic testing. Tesis offers healthcare providers and physicians access to our unique genetic testing and precision medicine, enabling them to create personalized care plans for treating chronic diseases individually and across generations. We also enable medical device companies and pharmaceuticals to bring new products to market and create a robust repository of genetic data and research. Visit http://www.tesislabs.com to learn more.

About Personal Genome Diagnostics

Personal Genome Diagnostics (PGDx) empowers the fight against cancer by unlocking actionable information from the genome. We are committed to improving clinical insight, speed of results, and healthcare economics by delivering a portfolio of regulated tissue-based and liquid biopsy genomic products for health systems worldwide. PGDx was established by researchers from Johns Hopkins University who are pioneers in cancer genome sequencing and liquid biopsy technologies. PGDxs elio Platform has enabled the development of standardized tissue-based and liquid biopsy next-generation sequencing (NGS) kits for laboratories worldwide, featuring automated bioinformatics that ensures consistent results and quality of testing. By automating the data analysis process, PGDx is enabling the scalability of precision medicine with a fast, reliable, and accurate diagnostics platform. For additional information, visit http://www.pgdx.com.

Read more here:
Tesis Labs and Personal Genome Diagnostics Announce Collaboration to Advance Cancer Profiling and Treatment - Business Wire

Recommendation and review posted by Bethany Smith

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DELRAY BEACH, Fla.--(BUSINESS WIRE)--Genetics Institute of America announced today that it has undergone an Accreditation Inspection by the College of American Pathologists (CAP) and passed with no deficiencies.

A team from the College of American Pathologists performed a general laboratory and molecular pathology accreditation inspection on Tuesday, August 10th. The purpose of this inspection is to help laboratories maintain accuracy of test results and ensure accurate patient diagnosis. CAP inspections are a part of the accreditation and inspection cycle.

This successful CAP inspection validates our quality assurance and management practices and ensures that we are providing the best in physician and patient-centered genetic testing services, said Dr. Ana Perez-Miranda, Laboratory Manager for Genetics Institute of America.

Our mission at Genetics Institute of America is to save lives, change lives and give back, said Holly Magliochetti, CEO and Founder. Our Team knows that the work we do has a multi-generational impact, and this CAP accreditation is a very important step to continue to uphold the most stringent clinical laboratory testing standards in molecular and Next Generation Sequencing.

The U.S. federal government recognizes the CAP Laboratory Accreditation Program, begun in the early 1960s, as being equal-to or more-stringent-than the governments own inspection program. According to the CAP, they accredit the entire spectrum of laboratory test disciplines using the most scientifically rigorous customized checklist requirements. These checklists are developed from rigorous accreditation standards that are more stringent than or equal to the requirements of the Clinical Laboratory Improvement Program (CLIA). They are designed to cover regulatory compliance requirements and assist laboratories in achieving the highest standards of excellence for positively impacting patient care.

About the College of American Pathologists (CAP)

As the worlds largest organization of board-certified pathologists and leading provider of laboratory accreditation and proficiency testing programs, the College of American Pathologists (CAP) serves patients, pathologists, and the public by fostering and advocating excellence in the practice of pathology and laboratory medicine worldwide. Built on more than a half-century of experience, the CAPs Laboratory Accreditation Program has been the champion of laboratory excellence. We are recognized as the global leader in improving the quality of services using established performance standards. For more information, READ THE CAP ANNUAL REPORT at http://www.cap.org.

About Genetics Institute of America

Genetics Institute of America is a national laboratory dedicated to heightening the awareness of early intervention and genetic screening to promote longevity and quality of life outcomes by focusing on DNA, RNA and Proteins. Our modern CLIA certified, CAP accredited laboratory facility in Delray Beach, FL specializes in high complexity molecular testing and contains the most current technology, allowing us to provide leadership in both research and clinical laboratory testing. For more information, please visit http://GenlabUS.com.

View source version on businesswire.com: https://www.businesswire.com/news/home/20210812005857/en/

Holly Magliochettimedia@GenLabUS.com

Source: Genetics Institute of America

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Genetics Institute of America Receives Accreditation from the College of American Pathologists - StreetInsider.com

Recommendation and review posted by Bethany Smith

Zolgensma is a novel drug that was approved by the US Food and Drug Administration (FDA) in May 2019 as an one-time gene therapy for children with spinal muscular atrophy (SMA), said the National University Hospital in an e-mail reply to The New Paper yesterday.

Valued at US$2.125 million (S$2.9 million)for each patient, it is said to be the most expensive drug in the world.

SMA is diagnosed through genetic testing. Besides treatment, patients are usually supported symptomatically, with physiotherapy to manage muscle weakness and prevent complications like contractures.

They are also supported by medical means such as appropriate seating and mobility devices, respiratory support, as well as regular therapy.

"Aside from Zolgensma, other options of treatment for SMA include the use of other drugs and supportive treatment.

"These alternative options for SMA include Spinraza, a recurring therapy given intrathecally every four months, and Risdiplam, an oral medication administered daily," said NUH.

Zolgensma is administered intravenously as a single dose over 60 minutes.

While it has a hefty price tag, the other treatments are also expensive. The Spinraza costs more than $1 million for the five or six injections required in the first year of treatment, and an annual amount of a little over $500,000 for three injections each year subsequently. The Risdiplam oral treatment costs around $460,000 a year.

Zolgensma manufacturer, US-based biopharmaceutical company Novartis Gene Therapies, has stated that the drug is designed to target the genetic root cause of SMA by replacing the function of the missing or non-working survival of motor neuron 1 (SMN1) gene with a new, working copy of a human SMN gene.

Child neurologist Wendy Liew of Dr Wendy Liew Paediatric and Child Neurology Centre said while none of the three FDA-approved treatments for SMA are available in Singapore, they can be imported under the Health Sciences Authority's (HSA) Special Access Route.

On HSA's website, it is stated that the named-patient application allows a licensed hospital or clinic to import and supply an unregistered therapeutic product that presents a life-saving treatment option to the patient whose condition would be clinically compromised without the requested therapy, and that there is no effective alternative therapy registered in Singapore.

TNP understands the approval of such applications usually takes 14 working days and needs to be done before buying the treatment for import.

When asked if any treatment is superior to the others, Dr Liew said: "There are many considerations (when selecting a treatment), such as the age of the patient, the route of administration, the expected benefit, the anticipated adverse effects and the cost of each treatment.

"At the moment, all three treatments have been proven to work, so it is hard to say that one is definitely better than the others."

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Hefty price tag for treatment of spinal muscular atrophy - The New Paper

Recommendation and review posted by Bethany Smith

China in vitro diagnostics(IVD) market is anticipated to grow over US$ 11 Billion by 2025 with an impressive double-digit growth rate in the forecast period 2018 2025.

The market is driven by number of factors such as rising incidences of chronic lifestyle diseases, public health awareness, demand of tests in rural areas stimulated by the healthcare reform plan, increasing demand from the middle class for highend products and an increase in the number of private hospitals and independent testing laboratories.

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China In Vitro Diagnostics (IVD) Market Analysis 2012 2017 and Forecast 2018 2025: Clinical Chemistry,Immunoassay,Molecular Testing,SMBG,Point of Care Testing (POCT), Hematology, Coagulation, Microbiology, Genetic Testing, Infectious Diagnostics, Histology and Cytology presents an in-depth assessment of the in vitro diagnostics(IVD) market dynamics, opportunities, future roadmap, competitive landscape and discusses major trends. The report offers the most up-to-date industry data on the actual market situation and future outlook for in vitro diagnostics(IVD) in China. The research includes historic data from 2012 to 2017 and forecasts until 2025.

The report contains a granular analysis of the China in vitro diagnostics market segmentation by 11 applications and illustrative forecast to 2025.A comprehensive analysis has been done on market share of China in vitro diagnostics by application, end-user and company share by revenue.

The report also includes assessment of in vitro diagnostics regulation in China.Key trends in terms of partnerships and recent developments are analyzed with details. The report also explores detailed description of growth drivers,restraints, trends and opportunities of the China in vitro diagnostics market.

Market Segmentation by Application and Analysis (2012 2025)

Clinical Chemistry Immunoassay Molecular Testing SelfMonitoring of Blood Glucose (SMBG) Point of Care Testing (POCT) Hematology Coagulation Microbiology Genetic Testing Infectious Diagnostics Histology and Cytology

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The Major Companies Dominating this Market for its Products, Services and Continuous Product Developments are:

Roche Diagnostics Abbott Laboratories Siemens Healthineers Sysmex Corporation Mindray Medical International Limited Beckman Coulter Inc Shanghai Fosun Pharmaceutical Group Thermo Fisher Scientific Inc Hologic Inc Qiagen Cepheid Bio-Rad Laboratories Inc Da An Gene Co. Ltd Shanghai Kehua BioEngineering Co. Ltd.

The Latest Industry Data Included in this Report:

China In Vitro Diagnostics Market Revenue & Forecast (2012 2025) China In Vitro Diagnostics Market Dynamics China In Vitro Diagnostics Market Segmentation by Application (2012 2025) China In Vitro Diagnostics Market Revenue Share by Application (2012 2025) China In Vitro Diagnostics Market, Company Share by Revenue, 2017 China In Vitro Diagnostics Market Share by End-User (Hospitals, Homecare, Research Institutes, Independent laboratories),2017 Assessmentof In Vitro Diagnostics Regulation in China Major Partnership Deals in China In Vitro Diagnostics Market Recent Developments in China In Vitro Diagnostics Market Overview of Key Companies in China In Vitro Diagnostics Market

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China In Vitro Diagnostics (IVD) Market growth graph to witness upward trajectory during 2021-2026 - The Market Writeuo - The Market Writeuo

Recommendation and review posted by Bethany Smith

New Jersey, United States,-Verified Market Research recently released a new report titled Cannabis Testing MarketSize Report, Growth and Forecast 2021-2028, Breakdown Data by Company, Key Regions, Types and Applications. The report has been compiled using primary and secondary research methodology that will provide a precise and precise understanding of the Cannabis Testing market. Analysts used a top-down and bottom-up approach to assess the segments and properly assess their impact on the Cannabis Testing market. The report offers a market overview which briefly describes the market situation and major segments. It also mentions the best players represented in the Cannabis Testing market.

The 2021 report offers an in-depth analysis of each sector of this Cannabis Testing industry. Fill in historical Cannabis Testing data according to customer requirements. It offers Cannabis Testing market research globally and locally. The detailed segment and manufacturer information of Cannabis Testing helps guide future benefits and make important decisions for the growth of Cannabis Testing.

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The report covers extensive analysis of the key market players in the market, along with their business overview, expansion plans, and strategies. The key players studied in the report include:

Shimadzu Corporation, Millipore Sigma, Restek Corporation, SC Laboratories Agilent Technologies Inc., Waters Corporation, PerkinElmer Inc., AB SCIEX LLC, CannaSafe Analytics and Steep Hill Labs.

Cannabis Testing Market Segmentation

Cannabis Testing Market, By Product And Software

Products Software (Cannabis LIMS)

Cannabis Testing Market, By Service

Potency Testing Pesticide Screening Heavy Metal Testing Genetic Testing Others

Cannabis Testing Market, By End-User

Laboratories Drug Manufacturers

In the next chapters, the research report reveals the development of the Cannabis Testing market segments. Analysts have segmented the market on the basis of product, application, end-users, and geography. Each segment of the Cannabis Testing market has been studied with in-depth insight. Analysts have evaluated the changing nature of the market segments, growing investments in manufacturing activities, and product innovation that are likely to impact them. In terms of geography, the report studies the changing political environment, social upliftment, and other government initiatives that are expected to contribute to the regional markets.

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Cannabis Testing Market Report Scope

Geographic Segment Covered in the Report:

North America (USA and Canada) Europe (UK, Germany, France and the rest of Europe) Asia Pacific (China, Japan, India, and the rest of the Asia Pacific region) Latin America (Brazil, Mexico, and the rest of Latin America) Middle East and Africa (GCC and rest of the Middle East and Africa)

Key questions answered in the report:

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Verified Market Research is a leading Global Research and Consulting firm that has been providing advanced analytical research solutions, custom consulting and in-depth data analysis for 10+ years to individuals and companies alike that are looking for accurate, reliable and up to date research data and technical consulting. We offer insights into strategic and growth analyses, Data necessary to achieve corporate goals and help make critical revenue decisions.

Our research studies help our clients make superior data-driven decisions, understand market forecast, capitalize on future opportunities and optimize efficiency by working as their partner to deliver accurate and valuable information. The industries we cover span over a large spectrum including Technology, Chemicals, Manufacturing, Energy, Food and Beverages, Automotive, Robotics, Packaging, Construction, Mining & Gas. Etc.

We, at Verified Market Research, assist in understanding holistic market indicating factors and most current and future market trends. Our analysts, with their high expertise in data gathering and governance, utilize industry techniques to collate and examine data at all stages. They are trained to combine modern data collection techniques, superior research methodology, subject expertise and years of collective experience to produce informative and accurate research.

Having serviced over 5000+ clients, we have provided reliable market research services to more than 100 Global Fortune 500 companies such as Amazon, Dell, IBM, Shell, Exxon Mobil, General Electric, Siemens, Microsoft, Sony and Hitachi. We have co-consulted with some of the worlds leading consulting firms like McKinsey & Company, Boston Consulting Group, Bain and Company for custom research and consulting projects for businesses worldwide.

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Cannabis Testing Market Size, Analysis, Competitive Strategies and Forecasts to 2028 - The Market Writeuo - The Market Writeuo

Recommendation and review posted by Bethany Smith

Abstract

Male breast cancer is a rather uncommon and understudied disease. It accounts for less than 1% of all breast cancers, but in recent decades its frequency has been on the rise. Clinical trials of breast cancer have traditionally excluded men. Due to the lack of large-scale prospective studies, most published data come from single-institution, small-cohort studies, and treatment recommendations are based on the extrapolation of data from clinical trials enrolling only women. Although to some extent etiology, diagnosis, and treatment characteristics can be similar, male breast cancer exhibits some distinct features. Men tend to be diagnosed with breast cancer at an older age and at a more advanced stage. A better understanding of the biologic features, clinically relevant differences, effective treatments, and outcomes of male breast cancer is crucial to appropriately manage these patients. We present a male breast cancer case with a germline BRCA2 mutation and discuss the epidemiologic, pathologic, and clinical characteristics along with treatment and follow-up recommendations in view of our recent understanding of this disease.

Male breast cancer is a rare disease accounting for less than 1% of all breast cancers, and less than 1% of all cancers in men. Worldwide estimated incidence of male breast cancer has been reported to be 1 per 100,000 men per year, with a mean age at diagnosis of 60 to 70 years.1,2 The average age at diagnosis is approximately 5 years older than it is for women (67 years vs 62 years, respectively).3 Based on data from the Surveillance, Epidemiology, and End Results (SEER) program, the age-adjusted incidence rate has increased from 0.85 cases per 100,000 in 1975 to 1.43 cases per 100,000 in 2011. Black men appear to be at greater risk than non-Hispanic White men.4,5

Male breast cancer seems to be an estrogen-driven disease; it has been likened to late-onset, postmenopausal, estrogen receptor/progesterone receptorpositive (ER+/PR+) female breast cancer.6 Male breast cancer tends to occur at a later age and to present at a more advanced stage, with more hormone receptor positivity.7 However, there are differences, resulting in an ongoing debate regarding the level of similarity.

Male breast cancer may be a unique tumor type with biological and clinicopathological features distinct from female breast cancer. However, similar to female breast cancer, family history has been shown to be an important risk factor.8,9 The risk of breast cancer doubles for men who have a first-degree relative with the disease.10 Population-based studies indicate that mutations in the 2 major high-penetrance breast cancer genes, BRCA1 and BRCA2, account for approximately 10% of male breast cancers11; 0% to 4% of men with breast cancer have BRCA1 mutations and 4% to 16% have BRCA2 mutations.8,9,12,13 The lifetime risk of developing male breast cancer has been estimated to be in the range of 1% to 5% for BRCA1 and 5% to 10 % for BRCA2 mutation carriers, compared with a risk of 0.1% in the general population.14-17

Genes other than BRCA1/2 may also be involved. A truncating mutation (CHEK2*1100delC) has been shown to increase the risk of male breast cancer by a factor of 10, compared with the risk among men who do not have the mutation.13,18 Also reported have been mutations in other genes, including the PTEN tumor suppressor gene and the androgen receptor gene, as well as TP53 mutations (Li-Fraumeni syndrome), PALB2 mutations, and mismatch repair mutations associated with hereditary nonpolyposis colorectal cancer (Lynch syndrome).13,19-21 Other risk factors for male breast cancer are hormonal imbalances (caused by liver disease, Klinefelter syndrome, or obesity) and environmental factors (eg, chronic exposure to heat or radiation).22-26

A White man, aged 64 years, presented with complaints of a palpable lump on the upper outer quadrant of his left breast along with some pain for the past several months. On physical exam, he was noted to have a 2.5-cm left breast mass along with retraction of the retroareolar and nipple region without discharge (Figure 1). A left breast mammogram showed scattered areas of fibroglandular density throughout the breast. Ultrasound (US) confirmed a 1.9 cm 1.7 cm irregular hypoechoic mass with no identifiable axillary nodes. US-guided biopsy reported an invasive ductal carcinoma grade 3, ER+ (85%), PR negative (<1%), HER2 negative, and Ki-67 (30%). MRI of the bilateral breasts confirmed a retroareolar mass on the left consistent with known malignancy, with no chest wall or axillary involvement, and normal appearance of the right breast (Figure 2).

The patient was treated with left mastectomy and axillary sentinel lymph node (LN) sampling. Pathology revealed a 2.1-cm invasive ductal carcinoma, grade 3, with no ductal carcinoma in situ (DCIS) (Figure 3). One of the 3 sentinel nodes showed isolated tumor cells. Pathologic stage was pT2, pN0(i+). Tumor Oncotype-Dx Breast Recurrence Score (BRS) was 42. Pretest cancer genetic counseling followed by germline targeted multigene mutation analysis revealed a pathogenic mutation, c.1147delA in the BRCA2 gene, consistent with hereditary breast and ovarian cancer (HBOC) syndrome. Family pedigree is shown in Figure 4.

The most common clinical presentation in men with breast cancer is a painless, retroareolar mass. Nipple retraction, bleeding from the nipple, skin ulceration, and palpable axillary adenopathy are among other reported signs and symptoms.27 To differentiate from gynecomastia, a highly prevalent condition, breast imaging should be considered. The American College of Radiology recommends initial US for men aged younger than 25 years with an indeterminate palpable mass. For men 25 years or older or those with questionable findings on physical examination, mammography is recommended as the initial diagnostic test followed by US if the mammographic findings are inconclusive or suggestive of cancer.28 On mammograms, male breast cancers appear as eccentric, retroareolar masses with irregular, spiculated edges.29,30 Due to low public awareness and the lack of screening mammograms for men, male breast cancers are more frequently diagnosed as larger tumors with regional nodal metastases.31 Staging for breast cancer in men is the same as for women with no gender-specific recommendations.

Men with abnormal imaging findings suggestive of malignancy should undergo core biopsy to confirm the diagnosis. Approximately 10% of men with breast cancer present with DCIS compared with 20% to 25% of women. Lobular carcinoma in situ in men is very rare due to anatomical absence of terminal lobules in the male breast. Most male breast cancer cases are invasive ductal carcinomas, but rarely papillary cancers (in 2% to 3% of cases) and mucinous cancers (in 1% to 2% of cases) can be seen.3,32,33 Invasive lobular carcinoma is much less prevalent among men, accounting for only 1% to 2% of cases.3,34 In the largest series of male patients with breast cancer analysis, tumor samples from 1483 men showed 99% ER+, 97% androgen receptor positive, 87% PR+, and 9% HER2+. Less than 1% of male breast cancer specimens were triple negative.34

In a genomic profiling study of 59 male patients with breast cancer, 29% of samples were classified as luminal Alike and 71% as luminal Blike, with a heterogeneous repertoire of somatic genetic alterations. PIK3CA and TP53 mutations, and losses of 16q, which are typically seen in ER+/HER2-negative female breast cancers, were less frequent in male breast cancer samples. Mutations affecting DNA repairrelated genes were more frequent.35 Using unsupervised clustering approach, a gene-expression analysis study identified 2 unique and stable subgroups of male breast cancer with differences in tumor biological features and outcome: luminal M1 tumors with low expression of ER signaling genes, aggressive clinical behavior, and worse prognosis; and luminal M2 tumors with activated ER signaling genes, upregulated immune response genes, and favorable clinical behavior. Both subgroups differed from the established 4 intrinsic subgroups of female breast cancer.36

Evidence from observational studies shows that breast-conserving therapy in men is associated with similar survival rates as mastectomy.37-40 Interestingly, however, men with breast cancer, even in early-stage disease, are being treated with mastectomy and either with axillary LN dissection or sentinel node biopsy despite the absence of any medical contraindication for breast conservation. Based on a SEER registry data analysis, only 18% of men with T1N0 tumors underwent breast-conserving surgery.38 Sentinel node biopsy, the standard approach for women with a clinically negative axilla, has been shown to be feasible and effective in men with breast cancer.41,42

Due to the rarity of male breast cancer and lack of randomized trials, the role of radiotherapy after mastectomy in node-positive male breast cancer has not been well studied. Hypofractionated radiotherapy regimens have not been tested in male breast cancer, as men were excluded from the UK START trials as well as the Canadian trial(NCT00156052.)43-44As adjuvant radiotherapy has been shown to decrease the rate of relapse, adjuvant radiotherapy should be offered to men who have undergone breast-conserving surgery, based on the same guidelines developed for women with breast cancer.2 Indeed, population-based observational studies suggest a benefit in this setting.45-47

In real-world practice, however, radiotherapy seems to be underutilized in men with breast cancer. Also, patient compliance rates with adjuvant radiation therapy seem to be generally low. Based on the SEER data, only 42% of men with stage I breast cancer received radiotherapy after breast-conserving surgery.38,48 Recently published National Cancer Data Base study data are somewhat encouraging and show that adjuvant radiotherapy was given to 70% of patients undergoing breast-conserving surgery in stage I to III male breast cancer.49 Worldwide data involving 1483 male patients with breast cancer treated between 1990 and 2010, examined in a retrospective study in collaboration with the European Organization for Research and Treatment of Cancer, the Translational Breast Cancer Research Consortium, the North American Breast Cancer Group, and the Breast International Group period, showed that about one-half of men who were treated with breast-conserving surgery did not receive radiotherapy.34

Due to exclusion of male patients with breast cancer from clinical trials involving female breast cancer, there are no randomized studies of adjuvant or neoadjuvant chemotherapy or of HER2-targeted therapy in this population. There has been 1 reported prospective National Cancer Institute study evaluating adjuvant chemotherapy in 31 men who had stage II breast cancer with LN involvement. Patients were treated with mastectomy and 12 cycles of cyclophosphamide, methotrexate, and fluorouracil between 1974 and 1988. This cohort was followed for more than 20 years; survival was 80% at 5 years, 65% at 10 years, and 42% at 20 years, comparing favorably with historical rates.50 In a more recent study of 32 men with breast cancer treated with systemic adjuvant/neoadjuvant chemotherapy, the 5-year and 10-year overall survival rates were 86% and 75%, respectively, for men with LN-negative disease, and 70% and 43%, respectively, for men with LN+ disease. For men with LN+ disease, adjuvant chemotherapy was associated with a lower risk of death (HR, 0.78).51 Additional observational cohort studies in men have suggested improved survival with the use of adjuvant chemotherapy.52-55

Since the majority of male breast cancers are HR+, endocrine therapy plays an important role in both in the adjuvant and metastatic settings. Observational studies of adjuvant treatment with tamoxifen suggest a survival benefit. Male patients with breast cancer were shown to benefit more from endocrine therapy with tamoxifen than from aromatase inhibitors (AIs) in a cohort of 257 patients.56,57 Population-based series have shown inferior survival rates when men were treated with adjuvant AIs as compared with tamoxifen. The lack of complete estradiol suppression due to feedback loops in the hypothalamus and pituitary glands has been shown to be the reason for the lower efficacy of AIs in men.58,59 For men who are not good candidates for tamoxifen, a GnRH analogue with or without an AI can be used to overcome this.60

Gene expression profiling assays have been widely used to quantify the risk of recurrence as well as to guide systemic therapy in early-stage breast cancer in women. The 21-gene BRS and 70-gene MammaPrint assay tests provide individualized estimates of distant recurrence risk and help predict benefit from adjuvant chemotherapy in women with ER+ breast cancer.61 Data on the utility of these assays in male patients with breast cancer are limited. Crozier et al reported that while similar MammaPrint index distributions between male and female breast cancer tumors existed, there were distinct biological pathways between male and female breast cancernotably, upregulation of estrogen response and MTORC1 signaling in male compared with female breast cancer specimens.62 Similarly, Oncotype DX results have shown comparable mean BRS in men and women, but mean quantitative gene expression for genes related to ER, proliferation, and invasion were higher in men compared with women.63-65

Germline mutations in BRCA1/2 are inherited in an autosomal dominant manner with the majority of individuals having inherited it from a parent (de novo rate 5%).66 The parent with the mutation may or may not have had a cancer diagnosis for several reasons, including penetrance of the mutation, gender and age of the parent, cancer risk reduction due to screening/prophylactic surgeries, or early death.67 It is appropriate to offer germline testing to both parents of an individual with a BRCA1/2 mutation to determine which side of the family is at risk; however, the parent with the family history of BRCA1/2-related cancers can be tested first. Being a carrier of a BRCA1/2 mutation also comes with reproductive risks. For example, in cases where both partners carry a BRCA2 mutation, there may be a high risk for the offspring to develop Fanconi anemia, a rare autosomal recessive condition.68 Additionally, a case has been found in which biallelic BRCA1 mutations caused a Fanconi anemialike disorder.69 The current estimates of the frequency of BRCA1 and BRCA2 gene mutations in the population is approximately 1 in 500 individuals.70

Male carriers of BRCA1/2 mutations are at increased risk for development of several types of cancers, including breast (BRCA1, 1.2% lifetime; BRCA2, 7% to 8% lifetime), prostate (BRCA1, exact risk unknown; BRCA2, 20% to 30% lifetime), pancreas (BRCA1, 2% to 3% lifetime; BRCA2, 3% to 5% lifetime), and melanoma (BRCA2, 3% to 5% lifetime).14,16,71-73 The National Comprehensive Cancer Network (v1.2021) recommends breast self-exam training and education starting at age 35 years, a clinical breast exam every 12 months starting at age 35 years, and consideration of annual mammogram screening in men with gynecomastia starting at age 50 years or 10 years before the earliest known male breast cancer in the family (whichever comes first).74

While tamoxifen can be used as a chemopreventive agent for female breast cancer, there are no data for men in this setting. Similarly, prophylactic mastectomy has not been offered due to lack of data to support this type of risk reduction. However, Jemal et al.75 reported an increase in contralateral mastectomy in men diagnosed with a unilateral breast cancer. The procedure was more common in younger, White, and privately insured patients. For male patients harboring BRCA2 mutations,prostate cancer surveillance with annual prostate-specific antigen and digital rectal examination beginning at age 40 years is recommended, and these should be considered for male BRCA1 carriers as well. Pancreatic cancer screening with contrast-enhanced MRI/ magnetic resonance cholangiopancreatography and/or endoscopic US is recommended for BRCA1/2 carriers at age 50 years (or 10 years younger than the earliest pancreatic cancer in the family, whichever comes first who have 1 or more first- or second-degree relatives with pancreatic cancer. No BRCA1/2-specific screening guidelines exist for melanoma, but general melanoma management, with annual full-body skin examination and minimizing ultraviolet exposure, is a sensible option.74

Here, we discuss a male patient with breast cancer presenting with a palpable mass; surgical treatment and staging led to a diagnosis of pT2, pN0(i+) invasive ductal carcinoma of the breast with a Oncotype Dx BRS of 42. Pretest cancer genetic counseling followed by germline targeted multigene mutation analysis revealed a pathogenic mutation, c.1147delA in the BRCA2 gene, consistent with HBOC syndrome.

Although breast cancer in men and in women is similar in some ways, thereremain gaps in our understanding of breast cancer in men. Examination of the biology of the disease would help identify the differences and determine whether identified differences have therapeutic implications. Further work that focuses on appropriate treatment of men with breast cancer is needed.

Following surgical treatment, the patient was treated with adjuvant chemotherapy (docetaxel/ cyclophosphamide) for 4 cycles; postmastectomy radiation; and adjuvant tamoxifen therapy to be given for 5 years. Currently he does not have any evidence of disease.

Financial Disclosure: The authors have no significant financial interest in or other relationship with the manufacturer of any product or provider of any service mentioned in this article.

References

View post:
A 64-Year-Old Man With Germline BRCA2-Mutated Breast Cancer: Known and Unknown Aspects of Male Breast Cancer - Cancer Network

Recommendation and review posted by Bethany Smith

One-third of the members of the editorial board of a leading American medical journal has resigned in protest against the publication of several research papers that could help the Chinese regime in its persecution of minorities. According to a report by The Intercept, after a slew of research papers that can help racial profiling of minorities in China were published by the journal named Molecular Genetics & Genomic Medicine, eight of the 25 editorial board members resigned in protest. The members protested after the management of the journal failed to take any action on the papers despite repeated complaints.

According to The Intercept, emails accessed by it shows that the editor-in-chief of the journal was slow in responding to several controversial papers related to Tibetans, Uyghurs and other ethnic groups in China. Molecular Genetics & Genomic Medicine is published by Wiley, a New Jersey based company, and the company also took a long time to respond to concerns about the papers published by the journal.

The papers under question were first flagged by Yves Moreau, a Professor of Engineering and a bioinformatician at the University of Leuven in Belgium, and according to The Intercept, he has been fighting a tireless campaign to get journals to retract troubling or unethical papers. He has been successful in getting an order of Kuwait govt overturned, which had called for compulsory DNA collection from all citizens.

He was studying the DNA profiling of the minorities done by the Chinese authorities. During such searches, he found 18 papers published by Molecular Genetics & Genomic Medicine, which dealt with various genetic topics related to the people in China. Some analysed the genetic differences between ethnic groups, including the genetic gaps between the majority Han community and minorities like Tibetans and Hui Muslims, and some had relied on samples that Moreau suspects were collected without proper consent.

Many of the papers were related to forensic genetics, a problematic subject in the entire scientific community. It refers to the collection of DNA for forensic databases, which is used by the police in criminal investigations. But although in theory it should be used only to find suspect criminals, it has the potential to conduct racial profiling, a highly problematic area. Moreover, scientists also worry about collection of DNA sample from ethnic minorities without their consent, which is happening in China.

The Chinese government is already DNA from its male citizens to build a massive a national forensic DNA database. Reportedly, the Communist government aims to collect and store genetic profiles of around 70 million people, around 10% of the countrys male population. Apart from that, Chinese police also forcibly collecting DNA samples from ordinary citizens, including migrant workers, dissidents, and minority Uyghur Muslims.

Although the Chinese govt says it is being done to fight crimes, researchers dont believe that, they say it is a part of the government efforts to deepen social control. Although most western countries collect DNA sample of convicts, the collection of such samples from ordinary citizens have been described as unprecedented. Human Rights Activists say the only purpose of this genetic profiling is the oppression of ethnic minorities by the Chinese govt.

This concern is being raised because of the kind of data collected by the Chinese govt. They are cataloguing markers known as short tandem repeats (STRs), which are repeating regions of DNA that are specific to the Y chromosome found in men. These STRs are extremely similar between men in the same male lineage, which means, when the authorities nab a dissident man, they can track all his male relatives using the database, even if they are not identified as relatives in official documents.

Since 2019, Molecular Genetics & Genomic Medicine has published several papers authored by Chinese authors on the topic of forensic genetics, which means they used samples collected by the police, many of which could be done without consent. Many of the papers listed institutions as co-authors which work closely with the police or receive funding from the police. One paper even lists the Public Security Bureau in Tibet as the co-author, which is the police agency in the region.

All these show that the research papers published by the American journal were effectively authored or sponsored by the Chinese govt.

After discovering the papers, Yves Moreau had written in March this year to Suzanne Hart, the journals editor-in-chief and deputy director at the medical genetics and genomic medicine training program with the U.S. National Institutes of Healths National Human Genome Research Institute. He noted that before 2019, the journal had published only two papers on forensic genetic studies from outside China, which shows that the Chinese govt has specifically identified the journal where the papers on forensic genetic studies of vulnerable Tibetan and Muslim minorities can be published.

However, although Suzanne Hart acknowledged the mail and promised to look into the matter, he received no update for months after that. As a result, he wrote to the entire Editorial Board in June, describing the concerns with the papers published by them. Many of the board members agreed with him for a probe in the matter, and many said that they were not even aware of the papers.

When the board members wrote to Hart, she said she will get back with further information on how the management intends to address this issue. But when no communication came from her for several weeks, the board members started to resign in protest. Ophir Klein, a board member and a pediatric medical geneticist at the University of California San Francisco said that he left the board as he was really concerned about the lack of communication.

However, not all editorial board members who question the paper have resigned, some have decided to stay on to push for scrutiny of the papers, including Joris Veltman, the dean of the Biosciences Institute at Newcastle University Medical School in UK. After he wrote to the management escalating the issue, they responded that Wiley would begin an investigation immediately.

After that, the company released a statement saying that the Integrity in Publishing Group of the company was overseeing the matter. However, they informed that they are only contacting with the authors and the institutional review boards associated with the published papers to clarify the consent procedures undertaken for collecting the DNA samples.

Although the consent was a major issue, it was not the only one. The company kept silence on the much larger issue of use of scientific instruments in racial profiling and discrimination by authoritarian governments. Moreau said the focus on consent is too narrow, and the larger question is whether the journal should be publishing research on vulnerable minorities, some of which directly involves the authorities persecuting them.

The board members are saying that if the papers are determined to be unethical, at least they should be retracted.

This is not the first time that Wileyhas been accused of allying with China. In September 2000, the editor of another journal published by the company had resigned over the issue of freedom of speech. Prof David Curtis, from University College Londons Genetics Institute, had resigned as the editor-in-chief of the Annals of Human Genetics, after he was prevented from publishing an article which said that academic journals should boycott papers from China protesting against Chinas human rights violations in Xinjiang.

Wiley, and Lancet which also refused to published the article, had said that publication of the article could pose difficulties for their offices in China. Yves Moreau was one of the co-authors of the article.

Read more:
One-third of editorial board members of American medical journal resign over papers that could help China persecute its minorities: Details - OpIndia

Recommendation and review posted by Bethany Smith

Ungulate keepers and scientists at the Smithsonian Conservation Biology Institute (SCBI) in Front Royal, Virginia, are celebrating the birth of two scimitar-horned oryx calves born via non-surgical artificial insemination. A male calf was born July 9 to 6-year-old female Esmerelda, and a female calf was born July 10 to 5-year-old female, Leanne. Both mothers and calves are doing well and bonding. As the calves grow, their vocalizations and play behavior with each other and interactions with the rest of the herd will increase.

Assisted reproduction for rare and endangered species is constantly evolving, said Budhan Pukazhenthi, reproductive physiologist at SCBI. Scimitar-horned oryx have similar estrous cycles to those of cattle, so we tried a protocol developed for the artificial insemination of livestock called CO-Synch. Narrowing the insemination window helped increase the chance of conception. These births are proof positive we can apply this protocol with increased success in scimitar-horned oryx population management in zoos and for animals being prepared for reintroduction to the wild.

Though once distributed across most of North Africa, scimitar-horned oryx are currently considered extinct in the wild due to a combination of widespread over-hunting, habitat loss and persistent drought.A reintroduction project led by the Environmental AgencyAbu Dhabi and including the Sahara Conservation Fund, the Zoological Society of London and SCBI is working collaboratively with the government of Chad and the international zoo community to return oryx to their native habitat. The first release, consisting of 23 individuals bred in human care, began in 2016. Smithsonian scientists monitor the release of every animal via satellite tracking collars. The tracking collars provide data on oryx movements and survival, as well as a means for tracking and monitoring individuals on the ground through radio telemetry.

Artificial insemination helps zoos and conservation breeding facilities with limited space maximize genetic diversity and minimize the number of animals needing to be transported, which can be costly and potentially stressful for the animal. In 2017, SCBI scientists developed an alternate protocol for inseminating scimitar-horned oryx where animal handling takes place in a hydraulic restraint device without the need for anesthesia. In June 2018, there was a successful birth using this modified approach.

The revised CO-Synch protocol included three hormone injections over nine days leading up to the non-surgical artificial inseminations in November 2020. Esmerelda and Leanne were artificially inseminated using frozen-thawed semen collected from two different male oryx ranked in the top 45 of male oryx in the Association of Zoos and Aquariums Species Survival Plan. The samples were originally collected 20 and 13 years ago.

SCBI plays a leading role in the Smithsonians global efforts to save wildlife species from extinction and train future generations of conservationists. SCBI spearheads research programs at its headquarters in Front Royal, Virginia, the Smithsonians National Zoo in Washington, D.C., and at field research stations and training sites worldwide. SCBI scientists tackle some of todays most complex conservation challenges by applying and sharing what they learn about animal behavior and reproduction, ecology, genetics, migration and conservation sustainability.

# # #

See the article here:
Two Scimitar-Horned Oryx Calves Born as Result of Artificial Insemination at Smithsonian Conservation Biology Institute - Smithsonian's National Zoo...

Recommendation and review posted by Bethany Smith

Queen of Dancehall Spice had a stellar opening week for her new album 10 to say the least. With rave reviews from various outlets (including ours) plus billboards in Times Square, Spice has been over the moon about the response and the only place left for her to go wasup.

The acrobatic deejay takes on an intergalactic space mission to find the perfect male specimen in her latest video, Send It Up. Hilarious antics ensue (with cameos from comedians World Dawg and Slick Whiteline) but Spice didnt come to play, as the old, young and well-endowed see how they measure up with the waistline warrior Queen.

Many have lauded the transportive quality of Spices debut LP: a nostalgic medley of booming 90s dancehall with EDM, R&B and Afropop nudges and an overall inventive cadence. For her fourth music video from the suite, the Inches singer took fans light-years away with a cinematic concept on the sexually charged track. With only ten men left in the universe, Spice must find the chosen one to repopulate the planet Zariah.

Mi cyaan live without man so me ah go find him, Spice says upon receiving her mission and spends the clip fashionably fulfilling her duty.

In the Jay Will directed visuals, Spice reaffirms yet another of 10s track titles: Size Matters. The QOD and her team of experts aboard Starship Spice busily test genetics, waistlines and fitness as Spice lays down the credentials.

One f mi gi yuh, we nuh haffi romantic/ Me ah gyal weh like when di sittn gigantic, Spice declares in the first verse, a lyric that was also quoted by rap queen Nicki Minaj, when she hailed Send It Up as her favorite track on the album.

Even amongst stars and planets, Spice brings her dancehall A game with a Magnum Tonic Wine to power through the mission. After all the raunchy dance moves and lab work, however, the cinematic clip ends in suspense and we never get to see Spices cosmic Prince Charming.

She does leave us a clue though, as an unseen character in a spacesuit makes his way towards the lab and it seems we might be in for a follow-up soon.

10 is clearly the Genie deejays magic number nearly 200K viewers have sent the mini-movie to Top 10 Youtube trending in mere hours. Most weighed in on its cinematic style, while others praised the QOD for taking traditional dancehall to a new frontier.

All hail the Queen SPICEthis video is out of this world. . literally. Absolutely love it, you are blessed beyond measure. Nuff Love and Respect, one fan wrote while another praised the blue haired divas golden touch, Queen, you delivered once again, you have the midas touch, anything you touch is just golden. Once again well done.

Press play on the Send It Up visuals above.

Read more:
Spice Goes On Intergalactic Mission In Cinematic Visuals For Send It Up: Watch - DancehallMag

Recommendation and review posted by Bethany Smith

About 30,000 years ago, when enormous mammoths and woolly rhinos roamed the Northern Hemisphere, a tiny cave lion cub with golden-brown fur took her final stroll through the Siberian tundra.

Disaster struck suddenly perhaps a mudslide, or a crack splitting open the permafrost underfoot and the cub fell. Buried in ice, she was quickly mummified; today, her fur, skin, organs and teeth remain almost exactly as they appeared on the day of her death, thousands of years ago.

Scientists named this ill-fated cub Sparta, after mammoth tusk hunters discovered her fossilized remains poking out of the melting permafrost of Yakutia, Siberia, in 2017. Along with Boris a male cave lion cub discovered just 50 feet (15 meters) away in 2018 Sparta is the subject of an extensive new study published Aug. 4 in the journal Quaternary, in which scientists examined the anatomy of the extinct cats in unprecedented detail.

"Sparta is probably the best-preserved ice age animal ever found, and is more or less undamaged apart from the fur being a bit ruffled," study co-author Love Daln, a genetics professor at the Centre for Palaeogenetics in Stockholm, Sweden, told CNN.com. "She even had the whiskers preserved."

Cave lions (Panthera spelaea) are close relatives of modern African lions. They lived widely across the Northern Hemisphere during the last ice age (the chilly epoch that spanned from approximately 2.1 million to 11,600 years ago). Unlike their modern cousins, these large cats adapted to extremely harsh conditions, including freezing winds and long, cold winters marked by continuous nights.

According to the new study, Boris and Sparta didn't get much of a chance to test their mettle against the perils of the ice age. Through a variety of methods including radiocarbon dating, X-ray imaging and partial DNA sequencing, the researchers learned that the two cubs were approximately 1 to 2 months old when they died, with their sharp frontal teeth just beginning to emerge.

Although the cubs' remains were discovered a stone's throw away from each other, their deaths were separated by tens of thousands of years. A radiocarbon analysis of the cubs' skin, hair and muscle showed that Sparta died approximately 28,000 years ago, while Boris met his end more than 43,000 years ago. This finding suggests that the area was probably "attractive to cave lions for making dens, but it was probably also susceptible to them collapsing," the researchers wrote in the study.

X-ray scans of the cubs' bones seem to support a collapse scenario. Both cubs showed skull damage, dislocated ribs and other small "distortions" in their skeletons that could have been caused by "the earth's mass pressure," the researchers wrote. Further distortions likely occurred after the cubs were already buried, as the surrounding permafrost turned their bodies into furry mummies.

For all their injuries, the cubs didn't show any markings indicative of a predator attack, the team added.

At the moment, there's little more that can be learned about how the cubs died but further research could help reveal how they lived. In future studies, the researchers hope to completely sequence Boris and Sparta's DNA, which could put the evolutionary history of cave lions in a broader context and reveal some of their unique genetic features.

Originally published on Live Science.

Read the original post:
Frozen mummy of extinct cave lion is 'best-preserved ice age animal ever found,' researchers say - Livescience.com

Recommendation and review posted by Bethany Smith

He said he had been consuming the blackpill overdose, referring to a fatalistic sector of the incel community who describe themselves as blackpilled and believe there is no hope of life getting any better for them because their genetics rule out any woman ever being attracted to them.

Most incels start by, as they call it, taking the red pill, a metaphor borrowed from The Matrix science-fiction films, in which swallowing a coloured capsule allows the protagonist to see the world as it really is. They claim to have discovered that the whole world is a feminist gynocracy ruled by women, where men are helpless victims.

Some believe it is possible to improve their relationship prospects through strategies like gymmaxxing (working out), but those describing themselves as blackpilled have a nihilistic worldview and tend to see violence against women as a better solution than self-improvement.

Online incel forums are steeped in extremist misogyny, with members regularly suggesting women should be raped and murdered. They encourage each other to rise up in a day of retribution or incel rebellion, when they will punish society, and women in particular, for their suffering, by murdering as many normies (non-incels) as possible.

I know this because I spent two years undercover in incel forums to research these communities and the threat they pose, for my book Men Who Hate Women.

It started when I realised some of the boys I work with on gender inequality and sexual consent in UK schools were parroting extremist beliefs and fake statistics (didnt you know 87 per cent of women lie about rape, one of them said). I soon realised that these teenagers had been radicalised online. But it wasnt a kind of radicalisation anyone was talking about.

So I posed online as Alex, a disillusioned young white man who was tired of being called privileged when he felt deeply unsatisfied with life.

I had to pass tests to be allowed access to certain forums, explaining in detail what kind of incel I was so I began the painstaking process of learning incel terminology and the bizarre pseudoscientific theories incels use to justify their worldview.

Read the original here:
I went undercover in the incel community to try to understand men like Jake Davison - Telegraph.co.uk

Recommendation and review posted by Bethany Smith

Alopecia is an autoimmune disorder that usually results in unpredictable, patchy hair loss. Read to know everything about this hair condition.

Written by Arushi Bidhuri | Updated : August 9, 2021 2:07 PM IST

The first Saturday of August each year is observed as International Alopecia Day to raise awareness about Alopecia, which is an autoimmune disorder that usually results in unpredictable, patchy hair loss. A disease known as androgenetic alopecia is the most prevalent kind of hair loss. Both men and women are susceptible to this form of hair loss. "Male pattern balding" and "female pattern hair loss" are two more names for androgenetic alopecia. But who is more likely to suffer from alopecia men or women? We asked some experts in the industry to help you understand all about alopecia and who is more likely to develop the problem.

Dr Viral Desai says, "Alopecia or androgenetic alopecia is also known as patterned baldness, which may occur in men or women due to several factors such as ageing, genetics, lifestyle disorder, nutritional deficiencies and stress." According to the expert, male-pattern baldness is a well-defined pattern, beginning from the hairline and progressing backwards in a central zone up to the crown region (top part of the head), often progressing to partial or complete baldness. He further states, "In female pattern hair loss, the hair thinning is present all over the head, and the hairline does not recede. Androgenetic alopecia in women rarely progresses to complete baldness."

While alopecia can affect both men and women, studies suggest that men are more likely to suffer from the condition. Dr Desai gave us some statistics, explaining, "a recent study found that alopecia is known to occur in 50 per cent of men above the age of 50 and 30 per cent under the age of 50. In women, the onset of alopecia commonly occurs around menopause. From the above statistics, it is clear that alopecia affects men, both young and old, more than women."

If you are wondering why alopecia affects more men, Mr Vikas Chawla, Founder and Director, Vedas Cure explains how it affects males and why is it more common in men. He says, "Alopecia is much more prevalent in men and occurs especially due to a male sex hormone known as dihydrotestosterone (DHT) leading to male pattern baldness the most common symptom. DHT is thought to cause hair follicles to miniaturize; it inhibits the nutrients to reach the follicles leading to hair loss. This may differ in the pattern as hair starts to recede at the temples and on the crown slowly thin and eventually disappear. Alopecia also occurs due to usage of salty water and begins in men from age 27-35."

The situation today is such that men are presenting with hair loss much earlier than ever before, says Dr Rinky Kapoor, Director - The Esthetic Clinics India, and Inventor of the QR 678 therapy for hair loss treatment. "Earlier, the problem affected men in their thirties and forties, now we see teens and men in their early twenties suffering from hair fall. This leads to physical, social, emotional and psychological stress in the group." Highlighting that women causes of hair fall are also increasing in women, Dr Kapoor says, "There are more and more women suffering from hormonal issues due to stress of modern life, poor lifestyle habits, polycystic ovarian disease and environmental factors. As high as 60% men over the age of 30 and 45% women over the age of 30 seem to be facing some sort of hair fall issue and are increasingly seeking treatment for retaining their hair, and thus, their confidence."

Talking about the treatment for the same, Dr Kapoor says, "The revolutionary QR 678 therapy works really well for both male and female hair loss and also for COVID related hair fall and is a major part of our arsenal now for our young patients, as it is plant based and has zero side effects."

Some of the common cures for this disorder can be keeping a good diet full of nutrients. Vedas Cure has prepared a herbal composition comprising of 30 herbs that contribute to hair growth, prevent hair loss, and facilitate nutrients to the hair. Along with the products a diet plan is also recommended. Hair is made of a tough protein called keratin. It needs proteins for good growth. If the Alopecia symptoms are genetic, then the precautions must be taken from the age of 15-16 years.

Some of the herbs which treat the dehydrated as well as damaged hair and help in gaining hair naturally are Bringraj, Punarnava, Amla, Brahmi etc.

Once alopecia is diagnosed by the doctor, it is vital to find the cause and treat it. Thankfully, there are some non-surgical and surgical treatments available when making lifestyle changes that don't work. Here are the treatments as explained by Dr Viral Desai.

Note: If you are suffering from alopecia or massive hair fall, do consult a dermatologist to get a proper diagnosis.

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International Alopecia Day: Is This Serious Hair Condition Reversible? Here's What You Need To Know - TheHealthSite

Recommendation and review posted by Bethany Smith

It was in 1968 when archaeologists discovered a weapon grave at Suontaka Vesitorninmki in Finland. Ever since then, the remains found in the grave have been at the centre of a major debate over the gender of its occupant. Initial interpretations of the remains suggested that the grave contained a woman but, the interpretations have always been debated.

Now, DNA analysis of the grave, including an examination of its content, soil sample and microremains, have once again challenged long-held beliefs. The analysis suggests that the 1000-year-old grave could be of a non-binary person.

The new findings not only challenge pre-held notions, but also raise the possibility that non-binary people were accepted as well as respected among their peers in ancient times. The findings of the DNA analysis, which were published in the European Journal of Archaeology, state that the occupant of the grave was a respected person whose gender identity may have been non-binary.

The early medieval grave, likely dated 10501300 AD, had a person buried with two swords -- a hiltless sword placed on the persons left side and another buried above the original grave. The interpretation of the occupant being a woman was made based on dress accessories and jewellery, which suggested that the individual was dressed in feminine clothes.

"For decades, the grave has been a popular example of powerful women in Late Iron Age and early medieval societies. The grave was used as evidence of female leaders in the past. The decorated bronze-hilted sword allegedly found in the Suontaka burial is presented as a female warrior's weapon," the researchers behind the latest findings said in their paper.

A plan of the Suontaka burial. Tckdike marks the water pipe trench which led to the discovery of the grave. (Photo: Finnish Heritage Agency)

Ulla Moilanen, an archaeologist from the University of Turku said that the buried individual seems to have been a highly respected member of their community.

Researchers conducted a study of microscopic animal hair and fibre remains from soil retrieved from the grave and studied ancient DNA (aDNA) from the skeletal remains to infer the chromosomal sex of the individual. It is to be noted that historically, the gender identity of buried individuals is inferred based on the remains of objects or items found alongside. However, with the advancement of technology and modern genetics, new methods have been developed to determine gender of remains.

DNA analysis of the 1000-year-old grave in Finland showed that the occupant of the grave had Klinefelter syndrome -- a condition where boys are born with an extra X chromosome. Normally, a female has two X chromosomes (XX) and a male has one X and one Y (XY). According to UK's National Health Service (NHS), the X chromosome is not a "female" chromosome and is present in everyone. The presence of a Y chromosome denotes male sex.

People with Klinefelter syndrome (XXY) don't exhibit any specific symptoms during childhood. They are usually marked with shyness and low self-confidence. During the teenage years, the syndrome leads to broader hips, poor muscle tone, and reduced facial and body hair that starts growing later than usual. In adulthood, the syndrome could lead to inability to have children naturally and a low sex drive.

The objects found in the Suontaka grave. A: bronze-hilted sword; B: hiltless sword with silver inlays (inset); C: two oval brooches with textile fragments; D: twin-spiral chain-bearer ; E: sheathed knife ; F: penannular brooch ; G: sickle. (Photo: Finnish Heritage Agency)

The researchers believe that the body in the Finnish grave had XXY chromosomes and that the person was non-binary. "It is rare in a Nordic context to find a sword in a grave with several artefacts with feminine gender association," the researchers said in the paper.

Non-binary people are those who do not identify themselves with a particular gender. According to the National Centre for Transgender Equality, people whose gender is not male or female use many different terms to describe themselves, with non-binary being one of the most common. Other terms include genderqueer, agender, and bigender among others.

None of these terms mean exactly the same thing -- but all speak to an experience of gender that is not simply male or female.

"The complexity of gender is evident in the problem of determining the sex or gender of individuals based on the artefacts recovered from their graves. It is unclear how well the grave goods represent the gender roles and identities of the past, and whether these roles should be interpreted from a binary perspective," the paper said.

Non-binary identities have been recognised by cultures and societies around the world.

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Man or woman? 1000-year-old grave in Finland likely of a non-binary human being - India Today

Recommendation and review posted by Bethany Smith

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Over the years, many physical traits have been touted as correlated with male success. Tall guys make more money. Attractive men have a better chance of getting hired. Obese fellows suffer in job interviews.

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That height/income correlation is pretty well documented. University of Florida researcher Timothy Judge and colleagues analyzed data from 8,500 American and British subjects and worked out that someone who is six feet tall earns, on average $166,000 more in a 30-year career than someone who is 5 feet 5 inches. This was true for both genders, though shorter men are slightly more likely to encounter height bias in the workplace than are shorter women.

Likewise, the attractiveness bias, sometimes called lookism, is well established. A 2019 article in the Harvard Business Review noted that it starts early. Attractive applicants score higher in college admissions interviews and earn higher grades when they get to class. The author, business psychology professor Tomas Chamorro-Premuzic, cites the very well-established halo effect whereby attractive people are generally perceived as being more sociable, healthy, successful, honest, and talented.

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He also makes an interesting suggestion for tackling this type of bias artificial intelligence. If programmed correctly, he writes, AI could become an objective way to measure what we dont always see ourselves. The key phrase there is if programmed correctly. So far, many artificial intelligence models simply automate the biases of their creators.

Testosterone certainly appears to predict some kinds of business success. Researchers led by Sean Harrison of the University of Bristol note that among male executives, circulating testosterone has been linked with a number of subordinates and among male financial traders, with daily profits.

It has been suggested that this happens because higher testosterone levels tend to increase a mans tolerance for risk. This, in turn, leads many guys with high testosterone to choose the path of entrepreneurship, with the attendant risks and rewards. Even for those in standard employment situations, a higher testosterone level may affect willingness to engage in assertive wage bargaining.

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Harrison and colleagues dove into a huge biomedical database, the U.K. Biobank, and studied the records of 306,248 men and women. They were seeking to establish a causal relationship between testosterone levels and what they called socioeconomic position (SEP).

One concern here is the direction of causation. Perhaps having a lower SEP causes lower testosterone levels in men. This would make sense because being poor is stressful and, as they note, psychosocial stress associated with socioeconomic adversity could influence testosterone alongside other aspects of health.

One unique contribution of this study is the fact that it used a technique called Mendelian Randomization. Made possible by advances in genetics, this method analyzes single nucleotide polymorphisms (SNPs) which are determined at conception and related to a single factor, in this case, testosterone production. This allows the researchers to rule out reverse causation and other confounding effects.

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At the end of the day, they concluded that We found little evidence that testosterone affected socioeconomic position, health, or risk-taking. Were previous studies wrong? Not necessarily, but they may have been clouded by reverse causation or other factors.

Another study, also from the U.K., compared men who grew up in the relatively healthy and wealthy environment of London with those raised in Sylhet, Bangladesh. As the authors note, Men in wealthier countries tend to have higher levels of testosterone than men in poorer countries or places with high rates of infectious disease.

What wasnt clear is when this effect took place. Was it in infancy? Childhood? After puberty? New research by Kesson Magid of Durham University studied men who moved to London at various life stages. The researchers looked at factors like height, age of puberty, and testosterone levels as adults.

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Migration before puberty predicted higher testosterone and an earlier recalled pubertal age compared with Bangladeshi sedentees or adult migrants, with more pronounced differences in men who arrived before the age of eight.

They have an interesting explanation for their results, which is based on the energy cost of various activities. Boys in Bangladesh, where sanitation is poor, spend a lot of their biological resources developing immunity. This comes at the expense of building a strong reproductive function.

As the authors write, We found that the longer a man lived in Bangladesh as a child, the shorter he was as an adult. This suggests that boys growing up in Bangladesh had to trade off growing taller for something else, such as immunity.

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Theres not much you can do about your height or attractiveness unless you are ready for serious plastic surgery. As for tweaking your testosterone levels, experts like urologist Dr. Puneet Masson of the University of Pennsylvania urge caution. He treats men with low testosterone levels who are trying to become fathers. Many times Im taking these guys off of supplements or medications and putting them on something to get their body to make its own testosterone, he notes. The Penn Medicine site also cautions that taking exogenous or external testosterone shuts off other hormones essential for sperm development.

Its worth a mention that these testosterone studies were published both in academic journals and, in a more approachable format, on a free website called theconversation.com/ca. Spending some time reading articles there might have an even stronger correlation with your career success than your height, looks, or testosterone levels.

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Keenan: Is your success tied to your testosterone? - Calgary Herald

Recommendation and review posted by Bethany Smith

As well as the objects we find in graves, were able to extract ever more information from the bones themselves. For me, as a biological anthropologist, its been astonishing how the science around this has developed over the past 20 to 30 years.

If Im presented with a skeleton, I can tell quite a lot just by looking at the bones with the naked eye. I have a background as a medical doctor and before I started learning the business of osteoarchaeology, I would have thought: Its just a skeleton. How much can you really tell? You cant ask it about symptoms, you cant do blood tests. But I was astonished at how much you could work out. First, bone responds to disease. Some infections, such as syphilis and tuberculosis, affect bone in very distinctive ways. Osteoarthritis is also easy to identify from tiny holes on the surface of a joint.

Next you can look at teeth. People suffered from dental disease in the past, just as we do today, but most prehistoric people actually had much better teeth than ours because they didnt have such a starchy, sugary diet. They didnt brush their teeth as fastidiously as we do, but their teeth are nevertheless usually in surprisingly good condition.

Employing radiography techniques, such as using X-rays, allows us to uncover more clues hidden features of the bones. And with a micro CT [computed tomography] scanner were able to slice up the bones virtually, allowing us to analyse them without incurring any damage.

Then there are chemical techniques that allow us to analyse the ratios of different elements in bones and teeth. Our bodies are built from what we consume, so we are essentially made out of our surroundings. That means that the signatures of the landscapes in which we grew up are written into our bodies particularly into teeth, because tooth enamel is laid down in childhood.

For instance, your body is constantly incorporating different stable isotopes of oxygen and strontium in various ratios. We can analyse isotopes in ancient human remains, and see how these elemental ratios match those found in the geology of places in Britain or farther afield. This can be really useful for telling where somebody grew up, for instance, or where they spent the last decade of their life.

Finally, we can extract DNA from ancient bones and sequence it. That technology has come on in leaps and bounds in recent years.

Alice Roberts is the author of Ancestors: A Prehistory of Britain in Seven Burials (Simon & Schuster, 2021)

The human genome was fully sequenced in 2003. Since then weve developed the ability to extract DNA from very ancient bones, and to work out how to combine separate fragments of DNA into a complete genome. By doing that, were able to look for rare variants that might give us clues indicating when particular groups of people moved in or out of Britain. Sometimes were able to reconstruct more detailed information about individuals, too. One of the prehistoric skeletons I discuss in the book is known as Cheddar Man, who was discovered in Somerset in 1903, and lived around 10,000 years ago. By analysing his genome, geneticists have revealed that he probably had an unusual combination of dark skin and bright blue eyes. Being able to work that out from just a skeleton is utterly extraordinary.

DNA can also reveal information about kinship and relationships between individuals. Thats been quite profound when it comes to looking at the communal burials found inside Neolithic chamber tombs, for instance. One theory about these chamber tombs is that they were intended to anonymise the dead, and therefore contain people from across the whole community. Another theory is that they effectively acted as family vaults and some recent genetic analyses provide hints that this may indeed have been the case. For example, its been revealed that two bodies buried together in a Neolithic monument at Primrose Grange in County Sligo, Ireland are those of a father and his daughter.

Elsewhere in Ireland, DNA analysis of a man buried at Newgrange Stone Age tomb in the Boyne valley has revealed that he was the son of an incestuous union between either a parent and a child or two siblings. So were finding out some quite extraordinary details, some of which may not even have been public knowledge at the time of those peoples deaths.

Genetic science is not a panacea. Its not as though DNA technology somehow supersedes archaeology in fact, it could actually leave us with more questions than answers. But it does provide important strands of new evidence with the potential to answer some big questions, especially about mobility and migration. We should view it more as a tool for archaeologists to use one that will hopefully help us see the picture more clearly.

Genetics can certainly be disruptive. In fact, its probably as disruptive as radiocarbon dating was when that emerged, from the late 1940s suddenly, archaeologists were able to pin absolute dates on organic material. I think you can see a similar effect playing out with DNA analysis at the moment.

There have been some instances of geneticists treading on archaeologists toes. Theres been a perception by some archaeologists that geneticists have waded into long-standing archaeological debates and simply said: Youve been arguing about this for ages. Well, now weve got the answer. Not surprisingly, archaeologists have responded: Hang on a minute first you need to learn a bit about archaeology and the kinds of questions were asking.

But weve got to capitalise on the power of genetics to help us solve archaeological conundrums. In the book, I talk about a cutting-edge new project called 1,000 Ancient British Genomes, led by Swedish geneticist Pontus Skoglund of the Francis Crick Institute. This is a brilliant example of the power of collaboration between geneticists and archaeologists. Skoglund is engaging with archaeologists up and down the UK, asking them to identify questions that genetics might be able to help solve.

One of the people I became quite obsessed with is Augustus Pitt-Rivers (18271900). Hes best known as a collector, but he also came up with some really interesting ideas about how cultures change and evolve over time, and how these transitions happened. Pitt-Rivers was very influenced by 19th-century evolutionary theory and biology, and wondered how these ideas could apply to culture. He also started to think about whether the origins of new cultures might be linked to the movement of people.

For instance, Bronze Age people in Britain obviously had a different culture from the Neolithic people who preceded them. But where did they pick up this culture from? Pitt-Rivers suggested that there had effectively been a population replacement that Bronze Age culture was actually brought in by a whole load of new people. He tried to back up this theory by measuring skulls, arguing that there were detectable differences between the shapes of Neolithic and Bronze Age skulls. He was trying to use the study of skulls in a similar way to how we would now use DNA studies.

Whats astonishing is that DNA evidence now emerging suggests that Pitt-Rivers may have been right that a lot of people may have arrived in Britain during the Bronze Age, largely replacing Neolithic populations. Those earlier people didnt completely disappear, but there was a really profound turnover of population. Its really interesting to think about the contact between these two groups, and about the ways in which their different cultures may have merged.

Archaeology is a very introspective, self-aware discipline, which I think is extremely useful. Weve long been aware that every archaeologist always has ideas from their own time in the back of their mind whenever they approach a set of observations.

That can impact ideas about gender, for example. Take Iron Age chariot burials: not all of them contain men we know that some, such as the site at Wetwang in East Yorkshire, definitely contain women. I think that in the past antiquarians would have very quickly jumped to a conclusion that the body was male, based on the style of the burial or perhaps artefacts that were buried with the body. This is similar to what Reverend William Buckland (17841856) did when he discovered the oldest skeleton yet found in Britain, on the Gower peninsula in south Wales, which he called the Red Lady of Paviland. The remains are clearly male, but Buckland didnt think it could possibly be a man because the individual was buried with what looked to him like ivory jewellery. As a 19th-century antiquarian, he couldnt stomach the idea that a man might be buried with jewellery.

And these ideas still persist. When we find an Iron Age burial with a sword, theres often an assumption that its a man. Or if a mirror is excavated from a burial, theres an assumption that the remains are that of a woman. In the book, I talk about the need to avoid seeing discoveries through our own current cultural lens to accept that there may have been many more diverse identities in the past than perhaps we understand today, for example. We think that our society and culture is normal in the way that it defines two genders, but perhaps in the past there was a much more diverse approach to identity. Certainly, if you find an Iron Age burial with both a sword and a mirror (and one such site has been excavated), that might be telling us something quite interesting about ancient identities.

I think that new scientific technologies encourage us to move away from our current preconceptions to look at the evidence in isolation to begin with and then to build up a bigger picture.

Its a stunning discovery the most richly furnished Copper Age burial yet found in Britain. This man was buried with almost 100 objects in his timber-lined grave, so he was certainly high status or special in some way. All sorts of things were buried with him: lots of flints and arrowheads, and stone items that we presume are wrist guards for archery hence his name as well as copper knives and five bell-shaped beakers. There were also gold ornaments, thought to be hair wraps or possibly earrings the oldest gold found in Britain.

Because the Amesbury Archer was found only about three miles from Stonehenge, some have suggested that he may have had a link with that site. That may be true, but well never be able to prove it. You can also speculate about who he was his position in that society: are we looking at some kind of Bronze Age shaman or magician? And, connected with that idea, what did people think of those who first developed the ability to extract metal out of stone? It must have been amazing to see a completely new material being produced.

What I find particularly interesting about the Amesbury Archer is that analysis of the stable isotopes in his remains shows that he wasnt a local in fact, he grew up in or near the Alps. Graves such as his show just how far these connections stretched, and the distances that people were travelling. Theres this popular idea that in the ancient past people never travelled farther than the next village, but now we have evidence of some, such as the Amesbury Archer, travelling hundreds of miles in a lifetime.

That burial, found in 2017, is absolutely spectacular. I was lucky enough to visit it with the team that discovered it. We dont see many Iron Age burials across most of Britain, but in Yorkshire several very characteristic chariot burials have been found. These belonged to the Arras culture, which had connections to the near continent and possibly brought this very distinctive funerary style with them.

That Pocklington grave contains the body of a man buried within a chariot. In other similar burials, the chariots tend to have been dismantled before being put in the grave flatpacked, essentially. This one, though, was standing up and intact, with the man placed inside in a crouching position.

Along with the grave, theres evidence of a funeral feast. You get the impression that this funeral was a great spectacle, intended to show off the status of the deceased individual but also that of the surviving family. There are animal bones in the grave, including a rack of ribs, so it looks as if dishes from the feast were being shared with the deceased individual.

The other utterly extraordinary thing is that two pony skeletons were found standing up in the grave. That was just unbelievable. We spent quite a long time scratching our heads, wondering how on earth they got those ponies in there upright. Did they winch dead animals into the grave and then somehow support them, maybe piling up the soil underneath to hold them in a standing position? Or were the ponies led into the grave and then killed? I dont know if well ever quite get to the bottom of how it was achieved, but obviously it was extremely important to the design of the grave to have the chariot looking as though it was ready to depart, taking the dead man off, possibly to the afterlife. That is, of course, if they believed in the afterlife we dont know!

I think that exploring prehistory shows us just how multicultural Britain has always been. What weve seen is that many different groups of people have crossed the North Sea and the Channel in both directions over time, and that those cultures all enriched the others.

Although I write a lot about the power of genetics, I dont think we should be trying to trace direct genetic links between us and people in the ancient past because, once you get back into prehistory, these connections arent terribly meaningful. You dont need to have a direct genetic link with the Red Lady of Paviland or the Amesbury Archer to think about what the lives of these individuals might have been like. Im aiming for an egalitarian approach to ancestry in the landscape. The ancestors I look at in the book belong to everybody.

Alice Roberts is the author of Ancestors: A Prehistory of Britain in Seven Burials (Simon & Schuster, 2021). Buy it now on Amazon, Waterstones or Bookshop.org

This article was first published in the July 2021 issue of BBC History Magazine

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Prehistoric Graves: Why They Are Time Capsules Of Early Britain - BBC History Magazine

Recommendation and review posted by Bethany Smith

Everyone wants their skin to be flawless and younger-looking. Unfortunately, our skin becomes dull and flaky because of regular contact with dust, residue, pollution, and the suns harmful rays. Hyperpigmentation is the umbrella term for these often undesirable skin alterations.

UV light, which encourages the production of melanin, is one of the most common hyperpigmentation culprits. Every dermatologist we spoke with emphasized the necessity of using sunscreen to protect the skin from UV rays, whether you are treating existing spots or attempting to avoid developing new ones.

If you are struggling with skin issues, this article is for you, as it is about the best skin lightening creams for scars and hyperpigmentation. All you have to do now is find the best option for you. So, let us get started.

Before starting with the guide, we will first talk about what this is. Hyperpigmentation is a condition in which an area of skin becomes darker than the surrounding skin. Our bodies produce melanin, a pigment molecule that gives our skin its black color. The organelle that secretes this chemical is the cells melanosomes. It occurs when your melanocytes secrete too much melanin, resulting in a tan or skin discoloration.

Melasma and sunspots, for example, are more prone to affect parts of the skin that are exposed to the sun, such as the face, arms, and legs. Cuts, burns, acne, and lupus are examples of hyperpigmentation that occurs after an injury or with skin inflammation. These can show up anywhere on the body.

Skin problems like scars and pigmentations can be treated with a variety of therapy regimens. Let us take a look at each one individually:

Avoiding sun exposure, which is one of the most common causes of hyperpigmentation, is the simplest option. If you must go out in the sun, an SPF 30+ cream should be used.

You can always go to a cosmetologist or dermatologist for clinically approved therapies including laser treatment, strong pulsed light therapy, chemical peels, and other procedures.

This is the type of product we will be discussing in this article. These lotions are safe, have no negative effects, and are simple to obtain. Hyperpigmentation creams are the greatest option if you do not mind waiting a little longer for results.

Collagen is a natural protein that gives your body its structure. It appears to be effective because it is already present in the human body. It provides us with advantages such as youthful and healthy skin. Unfortunately, the amount of collagen in our skin decreases as we get older.

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Zeta White is a three-step skin lightening treatment that consists of a face wash, moisturizer, and sleep cream. All three are suitable for all types of skin. The Zeta White skin whitening technique is marketed as a safe alternative to harsh bleaching treatments.

The lotion contains anti-inflammatory characteristics that brighten skin without causing damage and addresses uneven skin or dark spots. It may also lighten your general appearance.

It is made entirely of safe and natural materials, 95% of which are organic. It is free of the harsh chemicals and poisons found in most bleaching creams. It brightens the skin and provides a calming and anti-inflammatory effect.

It can also treat uneven skin tone caused by acne, aging, freckles, melasma, scars, and sun damage with excellent results. Any part of your body that you desire to lighten can be treated with Zeta White products.

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Zeta White is a product of the United Kingdom, made by a reputable producer. In terms of safety and purity, its component list is encouraging. It is entirely organic and manufactured from natural extracts and mineral oils.

If you are looking for the greatest face wash, moisturizer, or night cream to brighten your skin and stimulate skin regeneration, you will have to pay a lot of money and receive no results. However, Zeta White offers you all three for the price of one, as well as a bonus with your order.

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Melanin is a pigment found naturally in the skin that gives it color. Melanin pigment is produced in melanosomes, which are specialized cytoplasmic organelles. Melanosomes in the darker parts of the skin are more active than those found elsewhere on the body. Overactive melanosomes can also lead to apparent skin hyperpigmentation, such as aging, melasma, and other skin color disorders.

Meladerm works by combining the well-documented qualities of the most efficient skin whitening substances to diminish the appearance of hyperpigmentation. Many of the formulas active constituents are taken from natural extracts like Mulberry, Licorice, and Bearberry. Civant Skin Care prioritizes your safety beyond all else. Their products are free of hydroquinone, mercury, steroid hormones, and other bleaching agents.

Meladerm, when used with exfoliation agents, can typically show results in as little as two to four weeks. On average, the full results take about two to three months and depend on the type of skin of the person. In addition, a 30-day money-back guarantee is offered to new customers with their first purchase.

Meladerm may be worth a try if you are having trouble getting rid of dark patches on your skin. It is one of the most natural skincare options available, and many Meladerm reviews back up its efficacy claims.

The product is extremely popular and is the number one skin-lightening formula on the market. Skincare professionals have used and have been recommending it all over the world for more than a decade.

Visit the Official Website of Meladerm for the Best Discount

Illuminatural is a topical serum that must be administered to the skin to eliminate all dark spots and wrinkles. It is part of the Skinception skin care line, which is made in the United States by Leading Edge Health. They focus on the development and marketing of beauty-related items, particularly for women.

It is one of the few skin lighteners on the market today that does not include any dangerous ingredients. The product works by blocking the tyrosinase enzyme, which causes skin cells to create melanin when stimulated. It also exfoliates pigmented dead skin cells, promoting the growth of new skin cells. It is a much safer and more convenient alternative to using a peeler to exfoliate the skin.

The products main goal is to eliminate these skin issues, and users of the topical serum do not experience any skin irritation, which is frequent with similar skincare products. The manufacturers also claim that in as little as four weeks, the solution may lighten the skin and may improve the appearance of unattractive dark areas.

Customer reaction has been overwhelmingly positive thus far for this product. Many people have turned to natural skin whitening methods, mostly because they are 100% safe and have no known adverse effects. Our research, as well as information from other Illuminatural 6i reviews, reveals this product makes a difference, particularly with little dark spots.

It is a highly effective, natural skin-lightening product and is one of the most well-known and widely used whitening products on the market. It is made by a renowned brand, and it also comes with a guarantee.

Visit the Official Website of Illuminatural 6i for the Best Discount

Amaira Natural Lightening Serum is one of Amaira Skincares many plant-based products. The brand promotes skin care regimes that are as natural as possible. Amaira dermatologists use herbal elements to create safe and helpful skincare solutions. The same ingredients are used in Amaira Natural Lightening Serum to whiten skin in delicate regions.

It claims to reduce the appearance of unpleasant dark patches, birthmarks, and freckles. It is suitable for all skin types and contains no hazardous chemicals, parabens, fragrances, or colorants. Natural components in Amaira provide a safe and quick way to lighter skin.

Six weeks of treatment is usually suggested; however, some people get effects in as little as two weeks.

The formula for Amaira Natural Lightening Serum is FDA certified and can be used by men and women of all skin types. This lightening cream is gentle enough to use on both the face and the body, giving you even-toned, young skin from head to toe.

This is a popular, well-designed product that claims to minimize the appearance of dark spots and discoloration by working with the skins natural renewal cycles. It appears to provide satisfactory outcomes, although not every user is totally happy with this product.

Customers have given the product a thumbs up in product reliability. A vast number of users around the world have given positive feedback. One point of worry is the packaging, as there have been several instances of the pump assembly on the bottle breaking relatively quickly, making use of the product more difficult.

Overall, we found Amaira Natural Lightening Serum to be a reasonable product. The result matters most, and the vast majority of users are able to attain their desired outcomes in the end.

Visit the Official Website of Amaira Natural Serum for the Best Discount

Hyperpigmentation might affect any region of your body. However, those that damage the face, chest, or limbs require rapid attention. Melasma, sunspots, and post-inflammatory hyperpigmentation are the most prevalent.

Melasma is mostly caused by hormonal changes and is most commonly seen in pregnant women. Hyperpigmentation can affect any part of the body, however, it most typically affects the stomach and face.

Sunspots, also known as liver spots or solar lentigines, are a common occurrence. However, if you are routinely exposed to the sun, it will only happen over time.

This is caused by a skin injury or inflammation. Post-inflammatory hyperpigmentation includes acne, pimples, and scar discoloration.

When opposed to ordinary whitening face creams, these ones offer a wide range of benefits. The following are some highlights:

Because all of the items mentioned above are 100% natural, safe, and organic, there are no long-term side effects. The following are some of the possible adverse effects which you may face:

If you are on a budget and want to save money on hyperpigmentation treatments, the best option is to use a lightening cream. Treatments like intense pulsed light therapy, laser peel, chemical peels, etc. come with adverse effects and are very expensive too.

As a consumer, you are looking for therapy that gives the best possible answer to your problem at the lowest possible cost. So, a lightening cream is the greatest option for this.

Hydroquinone is a natural pigment lightening and skin brightening combination derived from African potato and tara tree. It also boosts collagen and infuses your skin with beneficial antioxidants. Your dark spots will lighten as a result, and your complexion will become more even. In addition, the solution protects your skin, slowing the formation of new hyperpigmentation.

Gigawhite is a skin lightener and brightener that helps to reduce the appearance of age spots and melanin concentrations in the skin. This substance has anti-inflammatory and antioxidant properties that help to soothe your skin and even out skin tone and dark spots.

Licorice Root works as a natural skin lightening agent by inhibiting the enzymes that cause melanin formation. It helps to prevent future hyperpigmentation while also reducing the appearance of existing dark spots on your skin. Licorice Root is also an anti-inflammatory, so it will benefit your skin by lowering swelling and redness, as well as assisting in skin regeneration for a more balanced complexion.

We have already discussed the mechanism of hyperpigmentation. A variety of factors can cause this phenomenon, including sun exposure and possibly an underlying ailment. Some of the most common causes are:

Melasma can be passed down across generations. According to studies, over half of all women with melasma have a family member who is also affected. As a result, if you are a woman and your mother has melasma, you are more likely to get it as well.

Melasma can be caused by a variety of factors, including your gender. Melasma affects more women than it does men. While female-to-male ratios vary by the group due to factors including skin type and sun exposure, studies have reported female-to-male ratios ranging from 6:1 to 39:1. Melasma is typically provoked by sun exposure in men with this skin disorder.

One of the most common things that causes Melasma is exposure to the sun. To protect the skin from prolonged sun exposure, the body creates more melanin. This might cause age spots or sunspots, which are dark spots or patches on the skin. In addition to sun exposure, extremely bright artificial light can exacerbate melasma. Melasma might be difficult to cure for people who work in these types of environments. Heat, which is scientifically known as infrared radiation, can also aggravate melasma.

Antimalarial medicines and tricyclic antidepressants, for example, can produce hyperpigmentation. One of the most researched causes of melasma is inflammation caused by skin irritants.

Certain scents, soaps, and cosmetics can irritate the skin. The usage of these products can create inflammation in people who have melasma due to their genetics, gender, or skin type, which can lead to a melasma flare.

Although it may seem self-evident, popping pimples causes hyperpigmentation. This is one of those skin-care guidelines that has not changed in a long time. When you get a pimple, your body interprets it as an injury and rushes to the scene to fix it. However, instead of letting your body cure itself, many people pick at their spots.

When you pop a pimple, it causes further irritation. Inflammation then triggers melanin production. As a result, long after the inflammation has faded, you may get acne scars.

It should go without saying that touching or plucking your skin regularly can aggravate hyperpigmentation. Exfoliating too much might cause inflammation and compromise the skins moisture barrier, which is the first line of protection against bacteria and other contaminants. Your moisture barrier can no longer fully protect you if it becomes damaged.

As a result, acne and hyperpigmentation may become more prevalent. If you give in to the temptation to use severe pressure or too abrasive materials on your skin, you may wind up doing more harm than good.

We do not always consider it, but eating a 15-minute lunch outside in direct sunlight can exacerbate hyperpigmentation. You have probably heard it before, but skincare protection is critical for preventing hyperpigmentation.

Inflammation is exacerbated by prolonged sun exposure. As a result, the formation of acne scars is aided. Applying sunscreen and going about your day is not enough. You should reapply throughout the day.

As the name implies, these are creams that whiten the current layer of skin to improve skin tone. Depending on the cream, the process used to accomplish this may differ.

Plant extracts are used in the normal whitening or lightening creams mentioned above to suppress the production of the tyrosinase enzyme, which catalyzes melanin synthesis.

A bleaching cream, on the other hand, would diminish the number of melanocytes in skin cells, lowering melanin secretion. Other creams act by exfoliating the outer or pigmented skin to promote the growth of new skin cells.

Yes, you can apply makeup over these items. However, allow enough time for the lightening cream to seep into your skin. These items might be sticky and can cause problems with makeup.

However, once the cream has thoroughly diffused into the skin, no sign of it remains. Some brands also exfoliate the dead skin as a bonus, resulting in greater highlights on the fresh skin.

Breastfeeding women are permitted to use skin-lightening cosmetics discreetly. These are all-natural items that are free of dangerous chemicals.

However, it is preferable to avoid using this product on feeding days because it may be absorbed into the bloodstream. The study is still underway, and convincing proof of the safety of this cream during pregnancy or feeding days has yet to be established.

As a result, if you require expert advice before using these items, you should consult your doctor.

In the beginning, mens skincare products were quite rare. However, many products in the womens market are now available for males as well.

Nowadays, most items are designed to be unisex; so, people of any gender may use them, and their gender has no bearing on how well they operate.

All of the products described above are safe for both men and women to use. The creams are based on a universal molecular phenomenon that whitens the skin and is found in everyone.

As a result, males can use the skin whitening cream without fear.

However, because of differences in skin texture and roughness, certain product categories, such as moisturizers, may act differently on men and women.

Benefits may be visible in a few days. Depending on the product, the complete result, i.e., the improvement in uneven skin tone, may take up to eight weeks.

These products must first diffuse into the skin before being able to control melanin synthesis. You must wait until new cells proliferate before doing anything with the already created pigments.

After that, the hyperpigmentation begins to recede, and after long-term use, it may totally vanish.

No, you do not have to see a doctor to utilize these lotions. However, it is a good idea to schedule a simple consultation.

To begin with, these skin-lightening creams are produced with natural components that are safe to use on the skin.

Second, before being formed into a product, they are thoroughly researched in the lab and clinically evaluated. So, you do not need to see a doctor unless you have a skin issue that is being treated or has been treated previously.

We all have a highly hectic routine in our daily lives and are often outside in the sun. In the process, we overlook the factors that affect our skin, such as dust, sunshine, or anything else that causes hyperpigmentation.

Hyperpigmentation is a challenging skin condition to treat; but, with the provided knowledge in this article, you can easily overcome that obstacle. When looking for the best lightening cream for hyperpigmentation, keep in mind that each persons hyperpigmentation responds to treatment differently.

We trust that we have provided you with sufficient information to protect you against its negative consequences. You may see the effects soon if you use the lightning cream correctly and follow the instructions.

More here:
5 Best Skin Lightening Creams for Hyperpigmentation in 2021 - The Island Now

Recommendation and review posted by Bethany Smith

SCOTTS VALLEY, Calif.--(BUSINESS WIRE)--Dovetail Genomics, the world-leader in high-quality de novo genome assembly, and Revive & Restore, the leading wildlife conservation organization promoting the incorporation of biotechnologies into standard conservation practice, announced today a new partnership that will accelerate the use of de novo genome assembly in the conservation efforts of threatened and endangered species.

Through its Wild Genomes program, Revive & Restore is funding high-quality, de novo genome assembly for select species in which an immediate, practical application of genomic data can inform and improve conservation efforts. Dovetail Genomics will be the preferred de novo genome assembly provider for this effort, building on the companys near decade-long success in delivering over 1600 high-quality plant and animal assemblies to hundreds of researchers across the globe.

We are honored that Revive & Restore has selected Dovetail to be their preferred genome assembly partner, said Todd Dickinson, CEO of Dovetail Genomics. Applying high-quality reference genomes more broadly to biodiversity efforts will advance conservation efforts globally as it quickly becomes a standard tool for the conservation biologist.

Global biodiversity is being lost at an alarming rate due to climate change and other human-based pressures. Perhaps one of mankinds most important responsibilities is the preservation and even enhancement of biodiversity, for this generation and those to come. A high-quality reference genome assembly is required to fully understand the biology of any organism and is a critical tool for species preservation.

Genomic insights are foundational to genetic rescue. The information that is held within a species DNA can help conservationists discover the genetic basis of adaptability and resilience, reveal breeding structures, the genetics of stress and immune responses or local adaptations. This information can help us predict a species responses to climate change, and allow people to make better wildlife management decisions, said Revive & Restores Wild Genomes program manager Bridget Baumgartner.

Revive & Restore will initially leverage Dovetail Genomics experience and sample-to-assembly workflow to build reference genomes for 15 endangered species in the Revive & Restore Wild Genomes program. One of these species, the Banggai cardinalfish, will be funded using a unique crowd-sourcing arrangement. Dovetail Genomics will donate $500 on behalf of every Dovetail services customer starting August 9, 2021, until enough funds are raised to sequence and assemble the cardinalfish genome. The genome assembly will be available as an open resource to the scientific community.

Learn more about this program: https://dovetailgenomics.com/a-genome-for-basuki/. To view, use this password: Basuki

The male Banggai cardinalfish specimen that will be sequenced has been nicknamed Basuki, which means to prosper or flourish. The goal of this program is to help restore the Banggai cardinalfish population back to historical numbers. Banggai cardinalfish went from discovery to near extinction in a matter of a few years due to high demand in the aquarium trade; their current status is endangered and their population is in severe decline. The Banggai cardinalfish distribution range is extremely small a 23 km2 region of the Banggai Archipelago in Indonesia. Several local populations are now either extinct or vanishing. Unlike most other coral reef fishes, Banggai cardinalfish lack a pelagic larval phase that portion of their life where dispersal occurs. Instead, they exhibit mouthbrooding and direct development, where juveniles remain close to their parents. This unique life history results in genetically distinct local populations that are ecologically and evolutionarily significant, but also extremely vulnerable.

We are thrilled to finally have the opportunity to utilize a genome assembly for this critically endangered fish, stated Giacomo Bernardi, Ph.D., Professor of Ecology and Evolutionary Biology at UC Santa Cruz. The genome assembly will be an important tool that we will put to use immediately to measure population diversity, heterozygosity and other metrics that will help us in our quest to save this species.

About Revive & Restore

Revive & Restore is the leading wildlife conservation organization promoting the incorporation of biotechnologies into standard conservation practice. The Sausalito, California non-profit was formed in 2012 with the idea that 21st century biotechnology can and should be used to enhance genetic diversity, build disease resistance, facilitate adaptation and more. Its mission is to enhance biodiversity through the genetic rescue of endangered and extinct species.

Wild Genomes is part of Revive & Restores Catalyst Science Fund, which supports proof-of-concept science to advance the development of new biotechnology tools for conservation. Launched in 2018, the Catalyst Science Fund is designed to hasten impactful innovations in conservation. A key barrier to the adoption of genomic solutions by the conservation community has been the lack of success stories. To that end, the Catalyst Science Fund supports early-stage, transformative bio-science research, and proof-of-concept projects.

For more information visit https://www.reviverestore.org/wild-genomes and follow Revive & Restore on Twitter @Revive_Restore.

About Dovetail

Dovetail Genomics LLC is transforming genomics by making long-range information readily accessible to all. The company enables researchers and clinicians to solve complex problems involving de novo assembly, structural variation, microbiome analysis, cancer research, phasing analysis and more by providing them a more comprehensive view of the genome. With 68 pending applications and 14 issued patents, its proprietary in vitro proximity ligation approach and assembly algorithms simplify genomic discovery by integrating the highest quality long-range genomic information with next-gen sequencing output. Dovetail is based in Scotts Valley, California. For more information on Dovetail, its technology, and service offerings, visit https://dovetailgenomics.com/omni-c/. Follow Dovetail on Twitter @DTGenomics.

See original here:
Dovetail Genomics and Revive & Restore Form Partnership to Sequence and Assemble Genomes of 15 Endangered Species - Business Wire

Recommendation and review posted by Bethany Smith

On the great philosophical question of why bad things (i.e. injuries) happen to good people (i.e. runners who obey the ten percent rule), the sages are divided. Some say its because we havent yet figured out precisely which form flaw, muscle imbalance, or training error triggers a given injury. Others say that the problem runs deeperthat we need a comprehensive causal framework that links together training and life stresses, the resulting biomechanical loads applied to different parts of the body, and the ever-changing capacity of each joint and tissue to absorb those loads.

In a new (and free to read) opinion piece in the International Journal of Sports Physical Therapy, running injury experts Chris Napier of the University of British Columbia and Rich Willy of the University of Montana advance that latter perspective. For example, they point out, simple rules about training load are doomed to failure because increasing the stress on a tissue like a tendon by just ten percent will cause it to fail 50 percent earlier. Thats one reason that the addition of speedwork so often triggers problems even if youre not running any farther than usual. You cant prevent an injury unless you understand the sequence of events thats likely to cause it.

But drawing that web of causal arrows remains a tall ordera point illustrated nicely by another new study, this one on Western States ultramarathoners. A team led by Emily Kraus, a sports medicine doctor and researcher at Stanford University, studied 123 runners (83 men, 40 women) who ran the 100-mile race in 2018 and 2019, publishing the results in the Clinical Journal of Sports Medicine. Their goal: to explore the components of the female and male athlete triads, including the risk of stress fractures and other bone stress injuries, in ultramarathoners.

In women, the athlete triad refers to the combination of low energy availability, menstrual irregularities, and low bone mineral density (BMD). In men, low levels of sex hormones such as testosterone substitute for menstrual irregularities. Its a subset of the broader condition known as relative energy deficiency in sport (RED-S).

In theory, the causal arrow here is pretty straightforward. If you dont eat enough, either overall or during the periods of the day when you need it most to support your training, youll end up with lower levels of sex hormones. Thats what triggers the warning sign of irregular or absent periods. And over time, it can lead to lower bone mineral density, which in turn leaves you vulnerable to stress fractures, even at training loads you might previously have been able to handle. Theres good evidence for every step of this chain.

Based on a self-reported questionnaire (sample question: Are you trying to change your body weight or body composition to improve your performance?), lots of the Western States runners appeared to be at risk of disordered eating: 62.5 percent of the women and 44.5 percent of the men. Quite a few (16.7 and 30.1 percent, respectively) had low bone density, defined as a Z-score less than -1. Many (37.5 and 20.5 percent) had a history of stress fractures, which matches data from other studies of hardcore runners. Add in a few other variables like low body mass and irregular periods, and you can calculate a cumulative triad risk score, which identified 61.1 percent of women and 29.2 percent of men as being at moderate risk for bone stress injuries and 5.6 percent of each as high risk.

In a sense, this is a nice illustration of Napier and Willys point. If you zero in on a single risk factor like bone mineral density, youre not going to get a very useful gauge of injury risk. Relatively few of the women had low BMD, but lots had stress fractures; for men, it was the opposite. Hormone levels, measured using InsideTrackers blood testing battery, were similarly ambiguous. In women, there did seem to be a link between low levels of testosterone and estradiol and low bone mineral density. The same pattern didnt show up in men, though.

If you broaden the causal diagram, as with the cumulative triad risk score, you get a more meaningful assessment of injury risk. In one of Krauss previous studies, for example, every one-point increase in the cumulative risk score for male athletes (which doesnt even include any direct assessment of hormones, since theres no simple proxy like menstrual dysfunction for men) produced a 57 percent increase in the risk of a subsequent stress fracture. For women, its even more pronounced: a diagnosis of moderate risk doubles your chances of a stress fracture, and high risk quadruples it.

Thats still just one part of Napier and Willys grand plan, though. Napier co-authored another recent paper (with Karrie Hamstra-Wright of the University of Illinois at Chicago and Kellie Huxel Bliven of A.T. Still University) that describes a holistic approach to bone stress injuries, suggesting that athletes have their own cumulative risk profile that influences their capacity to withstand specific training loads. Here theyre no longer talking only about triad risk factors: instead theyre summing up a vast web of non-modifiable (sex, race, age, genetics, alignment, prior injury) and modifiable (strength, fatigue, flexibility, biomechanics, stress, recovery, nutrition) intrinsic factors, as well as extrinsic factors like footwear, training surface, and training load.

Theres no equation for this hypothetical super-calculation of injury riskyet. In a sense, this is simply an attempt to mathematically describe what already goes on inside the head of a good clinician when he or she is assessing an athlete. The big question is whether the equationor, more likely, a future machine-learning algorithmwill ever be able to combine all those inputs and produce injury advice thats meaningfully better than, say, the ten percent rule plus occasional reminders not to do anything stupid. Only time, and a lot of painstaking research, will tell.

For more Sweat Science, join me on Twitter and Facebook, sign up for the email newsletter, and check out my book Endure: Mind, Body, and the Curiously Elastic Limits of Human Performance.

Read more here:
Seeking a Grand Theory of Injury Prevention - Outside Magazine

Recommendation and review posted by Bethany Smith

This article was originally published here

Rev Endocr Metab Disord. 2021 Aug 13. doi: 10.1007/s11154-021-09672-y. Online ahead of print.

ABSTRACT

Besides the pulmonary manifestations caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), an emerging endocrine phenotype, which can heavily impact on the severity of the syndrome, has been recently associated with coronavirus disease 2019 (COVID-19). Patients with pituitary diseases or the pituitary gland itself may also be involved in COVID-19 clinical presentation and/or severity, causing pituitary apoplexy.Moreover, hypopituitarism is frequently burdened by several metabolic complications, including arterial hypertension, hyperglycemia, obesity and vertebral fractures, which have all been associated with poor outcomes and increased mortality in patients infected by SARS-CoV-2.This review will discuss hypopituitarism as a condition that might have a bidirectional relationship with COVID-19 due to the frequent presence of metabolic comorbidities, to the direct or indirect pituitary damage or being per se a potential risk factor for COVID-19. Finally, we will address the current recommendations for the clinical management of vaccines in patients with hypopituitarism and adrenal insufficiency.

PMID:34387832 | DOI:10.1007/s11154-021-09672-y

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COVID-19 and hypopituitarism - DocWire News

Recommendation and review posted by Bethany Smith

On last nights episode of Beauty & The Geek,they went on a makeover frenzy, giving four geeks incredible glow ups. But did you know there was another geek who is just as hot, yet he never had a makeover?

Yes, Jackson Palmer, is an undercover hottie who could honestly be a Calvin Klein model. The geek has been posting some fire pics on his Insta post-show and OOFT.

Palmers beauty on the show was Jessica Antoniou, who made a TikTok about how she actuallyhad the hot geek this season.

Remember this guy?

Well this is what he actually looks like.

The TikTok has over 1.5 million views and isnt even the first time the Beauty & The Geek star has gone viral. Antoniou has made a number of TikToks about her BATG journey, including ones made within the mansion (or apartment) they were staying in.

Just kidding already knew jackson was a qt #beautyandthegeek#batg#jessickbish#foryoupage#makeover

Know Yourself Drake

Many of the comments asked if the pair were still together. However, Antoniou hasnt been able to reveal anything and thats likely because Beauty & The Geek is still airing and shes under a contract.

But *fingers crossed* they still are, because they are cute AF.

Theyre not the only couple either where real love looks like a possibility. George and Josie (who are still on the show) seem to really be obsessed with each other and I am so here for it.

Kiran and Bryanna are my other favourite couple, who also genuinely seem smitten with one another. They also played coy when asked about their relationship, which only makes it seem more likely that they are together IRL.

No comment, both Bryanna and Kiran told PEDESTRIAN.TV when asked if they were still together last week.

Inject Beauty & The Geek into my veins. I am truly obsessed.

Originally posted here:
One Of The Geeks From BATG Had A Post Show Glow Up & Damn, I Could Cut Steak With That Jaw - Pedestrian TV

Recommendation and review posted by Bethany Smith

Matt Damon is copping mass backlash for revealing in an interview that fa**ot (a homophobic slur) was part of his vocabulary up until months ago when his daughter pointed out that its a fucked-up thing to say.

Speaking to The Sunday Times, he recounted dropping the word in conversation while at the table with his family.

The word that my daughter calls the f-slur for a homosexual was commonly used when I was a kid, with a different application, he toldThe Times.

I made a joke, months ago, and got a treatise from my daughter. She left the table. I said, Come on, thats a joke! I say it in the movieStuck on You!, Matt Damon added, referencing the 2003 film in which he plays a conjoined twin with Greg Kinnear.

She went to her room and wrote a very long, beautiful treatise on how that word is dangerous. I said, I retire the f-slur! I understood.

After the interview did the rounds online, folks on Twitter began calling him out for thinking it was okay to use it as of 2021. Come on, man..

Matt Damon actor has three daughters Isabella, 15, Gia, 12, and Stella, 10, with his wife of 16 years, Luciana Barroso.

It comes shortly after rapper DaBaby was called out for going on a gross homophobic rant at a recent performance.

According to avideo posted by TMZ, DaBaby encouraged the audience to hold up their phones, but only if they didnt show up today with HIV/AIDS or any of them deadly sexually transmitted diseases that will make you die in two to three weeks, among other derogatory remarks about HIV/AIDS and LGBTQ+ people.

Following the backlash, DaBaby tried to defend the comments he made at the show via Instagram Live, but he dug himself an even deeper hole by making further offensive statements.

He denied that the rant was homophobic, but rather a call to action. He also said that his gay fans dont got fucking AIDS because they arent nasty or junkies.

Several stars have slammed his actions, including Dua Lipa and Madonna, and he has been subsequently dropped from Lollapalooza, Apple Music and Boohoo (to name a few).

Wonder if Matt Damon will cop similar repercussions

See original here:
Matt Damon Is Copping A Pasting After Revealing He Used The Homophobic F Word Until Recently - Pedestrian TV

Recommendation and review posted by Bethany Smith

Testosterone is an essential hormone for male growth and masculine characteristics. In males, testosterone is primarily produced in testicles, and in females, it is produced in ovaries and adrenaline glands. In women, testosterone is produced in a very small amount. At adolescence, testosterone level may increase up to 30 times and after adulthood, the level decreases by a certain amount each year. In this article, we will discuss how testosterone therapy can help you by increasing your testosterone levels.

Healthy Heart and Blood Circulation

Low testosterone levels are associated with many cardiovascular risks. Testosterone helps in producing red blood cells from bone marrow. It also helps in keeping your heart healthy, ensuring a healthy blood flow to all organs and muscles of the body helping to keep the body at its peak level. A 2000s study report says that men having heart diseases after undergoing hormone therapy showed improvements in their heath. According to the U.S. Department of Veterans Affairs,in 2015 more than 83K men who underwent hormone therapy, showed a significantly lower risk of heart attack and stroke compared to untreated men.

Reduces Fat

Testosterone helps in reducing body fat and increasing muscle mass. A proper muscle mass helps in controlling the weight and increases the energy production inside the body. After getting testosterone therapy, men who had low testosterone levels previously reported a significant change in body mass and increase in strength. For better results, one must try strength enhancement exercise after therapy.

For testosterone therapy and hormone replacementvisit NovaGenix.

Strengthens Your Bones

Strong bones play an important role in supporting your bodys muscles and organs. As age increases, testosterone decreases as a result of which bone density also decreases significantly. Weak bones and osteoporosis are some common problems that men develop with age. High doses increase bone density but there is no medical evidence yet to show that an increase in testosterone levels can reduce the risks of bone fractures.

Improves Verbal Memory and Reasoning Ability

There is a strong connection between testosterone levels and thinking and verbal ability. Testosterone therapy in men of age group between 34 and 70 years showed a significant improvement in spatial memory. Men with increased testosterone levels also have a lower risk of having Alzheimers disease.

Improves Libido

Testosterone level rises naturally in response to sexual activity and arousal. Men with improved testosterone levels have higher sexual activity. It should also be noted that erectile dysfunctions are not always related to low testosterone levels, it may happen due to other conditions also.

Better Mood

Low testosterone level is often responsible for the low quality of life. Low testosterone levels cause depression, irritability, fatigue, etc. These symptoms are more common in men suffering from hypogonadism. But for men whose testosterone level decreases normally with age do not show all such mood-related symptoms.

These are the 6 benefits you can have by increasing testosterone level with testosterone therapy. Besides all these benefits, there are also some risks that you should not ignore, like increased urination, low sperm count, decrease in size of testicles, increased aggressiveness, etc.

Read the original here:
Top 6 Benefits of Testosterone Therapy Times Square Chronicles - Times Square Chronicles

Recommendation and review posted by Bethany Smith