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Michigan bone marrow recipient meets her donor

MONROE, Mich. (AP) - Jessie Kelly wanted to honor the woman who gave her life. On Sept. 20, she hosted a celebration for Nariana Petty, a 26-year-old woman originally from Phoenix whose stem cells saved her. Family and friends gathered to thank Petty and her husband, Chris, for saving Kellys life. The celebration took place at Oakridge Estates Community Center. The Pettys were given baskets filled with items from Michigan, including wine, maple syrup and more.

But the day was about more than just food and fun. It was the first time the women met face to face.

In 2008, Kelly was diagnosed with non-Hodgkin lymphoma. When chemotherapy did not work, she was given a bone marrow transplant - using her own bone marrow - at Karmanos Cancer Institute in Detroit.

But after 90 days, she received demoralizing news.

It failed. The transplant didnt take, the 57-year-old Monroe resident said. It was emotionally devastating.

Kellys five siblings were tested, and no one was a match, the Monroe News (http://bit.ly/1sl9S8C ) reported.

I was devastated, she said. I thought for sure one of them would be a match, but that wasnt the case.

Her transplant nurse told her about the National Bone Marrow Registry. Within two weeks, Kelly received a call saying they had found a match.

Kelly and Petty didnt meet when the stem cells were harvested two years ago. For confidentiality reasons, they had to wait a year before they learned about each other.

When she got the call, Petty, 26, was living out West and flew to Detroit for the stem cell harvest. For a few days, she was given shots, and, on Sept. 14, 2012, the bone marrow was extracted from her neck.

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Stem cell therapies making slow but promising progress

Edgar Irastorza was just 31 when his heart stopped beating in October 2008.

A Miami property manager, break-dancer and former high school wrestler, Irastorza had recently gained weight as his wifes third pregnancy progressed. I kind of got pregnant, too, he said.

During a workout one day, he felt short of breath and insisted that friends rush him to the hospital. Minutes later, his pulse flat-lined.

He survived the heart attack, but the scar tissue that resulted cut his hearts pumping ability by a third. He couldnt pick up his children. He couldnt dance. He fell asleep every night wondering if he would wake up in the morning.

Desperation motivated Irastorza to volunteer for a highly unusual medical research trial: getting stem cells injected directly into his heart.

I just trusted my doctors and the science behind it, and said, This is my only chance, he said recently.

Over the last five years, by studying stem cells in lab dishes, test animals and intrepid patients like Irastorza, researchers have brought the vague, grandiose promises of stem cell therapies closer to reality.

Stem cells broke into the public consciousness in the early 1990s, alluring for their potential to help the body beat back diseases of degeneration like Alzheimers, and to grow new parts to treat conditions like spinal cord injuries.

Progress has been slow. The Michael J. Fox Foundation for Parkinsons Research, an early supporter of stem cell research, pulled its financial backing two years ago, saying that it preferred to invest in research that was closer to providing immediate help for Parkinsons disease patients.

But researchers have been slowly learning how to best use stem cells, what types to use and how to deliver them to the body findings that arent singularly transformational, but progressive and pragmatic.

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Stem cell therapies making slow but promising progress

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How stem cells help cure diseases

MANILA -- The use of stem cell therapy has become an option in treating different medical conditions.

Stem cells are the body's natural healing cells. They are used by human tissues to repair and regenerate damaged cells. In the right environment, stem cells can change into bone, cartilage, muscle, fat, collagen, neural tissue, blood vessels, and even some organs.

There are two kinds of stem cells: adult or embryonic. Adult stem cells appear to be particularly effective against painful joints, repairing cartilage and ligaments, and even painful conditions along the spine.

Adult stem cells are usually harvested from fat tissues. By using technology, the collagen that binds the fat and the stem cells are broken down, separating a solution rich in the patient's own stem cells, which will then be used for treatment.

Stem cells may be effective in the treatment of macular degeneration, Crohns disease and numerous pulmonary conditions such as chronic obstructive pulmonary disease (COPD), asthma, and fibrosis. Stem cells are also being used for patients suffering from kidney failure and ailments of the bone, cartilage and joints.

However, stem cell therapy is not recommended for patients with active infections or cancer.

In the Philippines, fat-derived stem cell therapy is available through StemCare Institute. At present, the clinic employs an orthopedic team of doctors and surgeons with international qualifications.

StemCare, with the advancement of stem cell technology and the refinement its of clinical protocols through international experts, now offers more accessible treatment options for patients suffering from these degenerative orthopedic conditions.

Kim Atienza and Inno Sotto. Composite Image

Among the personalities who have used stem cell therapy in the country are Inno Sotto, a fashion designer who is suffering from a tear in his right elbow, and Kim Atineza, who is using fat stem cell injections to help strengthen and repair his knee joints after suffering from Guillain-Barre disease.

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Pfizers Lung Cancer Drug Helps Patients With Gene Defect

Pfizer Inc. (PFE)s Xalkori for advanced lung cancer shrunk tumors in those with a rare genetic mutation, according to a study that may provide the first targeted treatment for these patients.

Xalkori reduced the size of tumors in 36 of 50 patients in the study while halting tumor growth in another nine, according to company-funded research released today at the European Society for Medical Oncology meeting in Madrid and online in the New England Journal of Medicine.

About 15,000 people, or 1 percent of the estimated 1.5 million annual new cases of non-small-cell lung cancer, have an abnormality to the ROS1 gene, according to New York-based Pfizer. Todays findings also showed that Xalkori was effective for about 18 months in patients, longer than the average eight to 12 months seen for some other targeted treatments, said Alice Shaw, a lead study author.

Were seeing much longer durations of remissions, Shaw, an associate professor of medicine at Harvard Medical School and Massachusetts General Hospital in Boston, said in a telephone interview. This points to being a very good target in lung cancer and this drug being a very effective targeted therapy for these patients.

Xalkori helps shut off the ROS1 gene that is causing cancer tumors to grow, she said. It was approved in 2011 to treat non-small-cell lung cancers in patients with mutations to the ALK gene, which has structural similarities to the ROS1 gene. The National Comprehensive Cancer Network, an alliance of 25 cancer centers, already recommends that doctors use Xalkori in patients who have this gene defect.

Pfizer continues to support clinical research of Xalkori in patients with ROS1 rearrangements to better understand the compounds activity in this population, Sally Beatty, a company spokeswoman, said in an e-mail.

The cancer drug generated $282 million in 2013 sales, according to data compiled by Bloomberg. The drug may produce revenue of more than $812 million in 2017, according to the average of five analysts estimates.

Patients with a mutation to the ROS1 gene are often younger and usually arent smokers, Shaw said.

Todays study is an expansion of the original Phase 1 clinical trial of Xalkori in patients with the ALK gene mutation. Researchers enrolled 50 patients who were ROS1 positive starting in late 2010 through August 2013. Those in the study received Xalkori two times daily.

By the end of the trial, half of the patients were still getting Xalkori and had no signs of their tumors growing, the authors said.

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