"By directly reprogramming cells we've managed to produce an artificial cell type that, when transplanted, can form a fully organised and functional organ. This is an important first step towards the goal of generating a clinically useful artificial thymus in the lab."

The thymus is the central hub of the immune system sending out infection fighting T-cells.

People with a defective thymus lack functioning T-cells and are highly vulnerable to infections. This is especially hazardous for bone marrow transplant patients, who need a working thymus to rebuild their immune systems after surgery.

Around one in 4,000 babies born each year in the UK have a malfunctioning or completely absent thymus, due to rare conditions such as DiGeorge syndrome.

Thymus disorders can be treated with infusions of extra immune cells or transplantation of a new organ soon after birth. However, such approaches are severely limited by a lack of donors and tissue rejection.

The new research, published in the journal Nature Cell Biology, raises the possibility of creating a whole new functioning thymus using cells manufactured in the laboratory.

While fragments of organs, including hearts, livers and even brains, have been grown from stem cells, no one before has succeeded in producing a fully intact organ from cells created outside the body.

Dr Rob Buckle, head of regenerative medicine at the MRC, said: "Growing 'replacement parts' for damaged tissue could remove the need to transplant whole organs from one person to another, which has many drawbacks not least a critical lack of donors.

"This research is an exciting early step towards that goal, and a convincing demonstration of the potential power of direct reprogramming technology, by which once cell type is converted to another. However, much more work will be needed before this process can be reproduced in the lab environment, and in a safe and tightly controlled way suitable for use in humans."

Chris Mason, Professor of Regenerative Medicine at University College London, said: "Using living cells as therapies has the big advantage in that the functionality of cells is many orders of magnitude greater than that of conventional drugs. Nowhere is this level of functionality more needed than in curing disorders of the immune system.

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British scientists create first complete working organ from cells

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LUMINESCE Stem cell Therapy Dr Nathan Newman
LUMINESCE Stem Cell Technology by JEUNESSE created from Telomere Research. Order Now: http://www.evenyounger.jeunesseglobal.com/PersonalCare.aspx?id=1.

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Aug. 24, 2014, 2:09 a.m.

An Australian-based biomedical company has been given approval from AFL to use stem-cell therapy on players recovering from injury.

An Australian-based biomedical company has been given approval from the AFL to use stem-cell therapy on players recovering from injury.

Sydney-based Regeneus has revealed it was recently given permission for its HiQCell treatment on players suffering from such issues as osteoarthritis and tendinopathy.

The treatment is banned by the World Anti-Doping Agency if it is performance-enhancing but allowed if it is solely to treat injuries.

Regeneus commercial development director Steven Barberasaid the regenerative medicine company had sought approval from the AFL for what the company says is "innovative but not experimental" treatment.

"In 2013, Regeneus sought and received clearance from ASADA [Australian Sports Anti-Doping Authority] for its proprietary HiQCell therapy for use with athletes who participate in sporting competitions subject to the WADA Anti-Doping Code. The AFL is one of many professional sports bodies which applies the WADA Anti-Doping Code within its regulations for players," he said.

"In March this year, the AFL introduced a Prohibited Treatments List as an additional level of scrutiny over and above the WADA code for player treatments. In light of this, Regeneus made a submission to the AFL to confirm that our specific treatment is not prohibited under that list. Subsequently, the chief medical officer of the AFL has recently communicated with our primary Melbourne-based HiQCell medical practitioner that the treatment is not prohibited and can be administered on a case-by-case basis to players.

"We anticipate documented confirmation of this outcome in the near future from the AFL.

"To our knowledge, the permission is specific to HiQCell and not necessarily to cell-based therapies in general."

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AFL approves stem-cell therapy

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An Australian-based biomedical company has been given approval from the AFL to use stem-cell therapy on players recovering from injury.

Sydney-based Regeneus has revealed it was recently given permission for its HiQCell treatment on players suffering from such issues as osteoarthritis and tendinopathy.

The treatment is banned by the World Anti-Doping Agency if it is performance-enhancing but allowed if it is solely to treat injuries.

Regeneus commercial development director Steven Barberasaid the regenerative medicine company had sought approval from the AFL for what the company says is "innovative but not experimental" treatment.

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"In 2013, Regeneus sought and received clearance from ASADA [Australian Sports Anti-Doping Authority] for its proprietary HiQCell therapy for use with athletes who participate in sporting competitions subject to the WADA Anti-Doping Code. The AFL is one of many professional sports bodies which applies the WADA Anti-Doping Code within its regulations for players," he said.

"In March this year, the AFL introduced a Prohibited Treatments List as an additional level of scrutiny over and above the WADA code for player treatments. In light of this, Regeneus made a submission to the AFL to confirm that our specific treatment is not prohibited under that list. Subsequently, the chief medical officer of the AFL has recently communicated with our primary Melbourne-based HiQCell medical practitioner that the treatment is not prohibited and can be administered on a case-by-case basis to players.

"We anticipate documented confirmation of this outcome in the near future from the AFL.

"To our knowledge, the permission is specific to HiQCell and not necessarily to cell-based therapies in general."

The AFL confirmed it had given approval on a "case-by-case" basis.

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AFL approves stem-cell therapy treatment

Recommendation and review posted by Bethany Smith

An Australian-based biomedical company has been given approval from the AFL to use stem-cell therapy on players recovering from injury.

Sydney-based Regeneus has revealed it was recently given permission for its HiQCell treatment on players suffering from such issues as osteoarthritis and tendinopathy.

The treatment is banned by the World Anti-Doping Agency if it is performance-enhancing but allowed if it is solely to treat injuries.

Regeneus commercial development director Steven Barberasaid the regenerative medicine company had sought approval from the AFL for what the company says is "innovative but not experimental" treatment.

Advertisement

"In 2013, Regeneus sought and received clearance from ASADA [Australian Sports Anti-Doping Authority] for its proprietary HiQCell therapy for use with athletes who participate in sporting competitions subject to the WADA Anti-Doping Code. The AFL is one of many professional sports bodies which applies the WADA Anti-Doping Code within its regulations for players," he said.

"In March this year, the AFL introduced a Prohibited Treatments List as an additional level of scrutiny over and above the WADA code for player treatments. In light of this, Regeneus made a submission to the AFL to confirm that our specific treatment is not prohibited under that list. Subsequently, the chief medical officer of the AFL has recently communicated with our primary Melbourne-based HiQCell medical practitioner that the treatment is not prohibited and can be administered on a case-by-case basis to players.

"We anticipate documented confirmation of this outcome in the near future from the AFL.

"To our knowledge, the permission is specific to HiQCell and not necessarily to cell-based therapies in general."

The AFL confirmed it had given approval on a "case-by-case" basis.

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AFL approves stem-cell treatment

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King's College researchers have joined experts from around the world If they find the biology behind the disease they can better treat sufferers The research has been called 'invaluable' as it will take away the stigma

By Emily Kent Smith for The Mail on Sunday

Published: 18:58 EST, 23 August 2014 | Updated: 18:58 EST, 23 August 2014

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British scientists are calling for anorexia sufferers to join a ground-breaking study to find the genes that may cause the condition.

Researchers from Kings College London have joined forces with experts from around the world in an effort to prove that victims are born with the illness.

Anorexia affects about 1.6million people in Britain alone.

Charlotte Bevan, who died in January, and her daughter Georgie who was diagnosed with anorexia aged 12

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UK scientists launch hunt for 'anorexia gene: Plea for 1,000 volunteers to help prove health victims are born with ...

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The Sims 3 | Perfect Genetics Challenge Part 20: Birthday Bash
In this part, Cassandra, Hunter Skyla age up and we try for another baby! *fingers crossed that it has the perfect genetics next* Links! *: My Website: http://simplyapril.blogspot.com...

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The Sims 3: Perfect Genetics Challenge- {Part 22} FINALLY!
Read Me. I finally get to upload and in this part something exciting happens! 😀 ...

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Corey Rayner Advanced Genetics Sponsored Athlete
Training some back August 23rd.

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Hannes Smarason: 4 Factors for Improving Genomic Data for Personalized Medicine
Four factors are helping to advance the use of genomic data to provide faster, more accurate, more in-depth information for personalized patient care.

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Hannes Smarason: Personalized Medicine: The Future is Almost Here
In the decade since the human genome was first sequenced, we have been on a journey of applying this new discovery to create personalized medicine.

By: Hannes Smarason

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VOL 3 JOHOR 06 MR RAY KEE PURTIER CURE Spinal cord injury , physical sensitive issues
purtieronline.com.

By: Riway Purtier

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VOL 3 JOHOR 06 MR RAY KEE PURTIER CURE Spinal cord injury , physical sensitive issues - Video

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HOWARD, Wis. -- A northeastern Wisconsin girl, who would have died without a bone marrow transplant, has finally met the man whose donation saved her life.

About three years ago, Mira Erdmann was diagnosed with an auto-immune disease that affects about one in a million people. Doctors said a bone marrow transplant was the Howard girl's only chance of survival.

Christian Werth of Germany found out he was Mira's match just three months after he became a donor, WBAY-TV reported.

"That brought me tears. I sat at home. I called my wife. She was at work, and I told her, I said 'It was for a little girl,' " Werth said.

His stem cells were harvested and sent to Mira's doctors in the U.S. Mira received the transplant and pulled through despite several complications and a tentative outcome.

"My part was the smallest one, but it's cool to see that she's now so happy and healthy after all that," Werth said.

The Werths and the Erdmanns initially communicated through letters because registry rules require anonymity for two years.

"When we received letters, there was something blacked out or it was something made to where we couldn't read it," Werth said. "We took a flashlight behind to find some information!"

Werth and his wife flew to Wisconsin to meet with the Erdmanns this week.

"It was almost surreal, because we had been chatting with him on Skype since December, so to see him in person, I thought I would never let him go," Mira's mother, Tania Erdmann, said. "We cried and we hugged, and it was just really emotional."

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Wisconsin girl meets marrow donor who saved her life

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13 hours ago

Anyone who has suffered an injury can probably remember the after-effects, including pain, swelling or redness. These are signs that the body is fighting back against the injury. When tissue in the body is damaged, biological programs are activated to aid in tissue regeneration. An inflammatory response acts as a protective mechanism to enable repair and regeneration, helping the body to heal after injuries such as wounds and burns. However, the same mechanism may interfere with healing in situations in which foreign material is introduced, for example when synthetics are grafted to skin for dermal repair. In such cases, the inflammation may lead to tissue fibrosis, which creates an obstacle to proper physiological function.

The research group of Arun Sharma, PhD has been working on innovative approaches to tissue regeneration in order to improve the lives of patients with urinary bladder dysfunction. Among their breakthroughs was a medical model for regenerating bladders using stem cells harvested from a donor's own bone marrow, reported in the Proceedings of the National Academy of Sciences in 2013.

More recently, the team has developed a system that may protect against the inflammatory reaction that can negatively impact tissue growth, development and function. Self-assembling peptide amphiphiles (PAs) are biocompatible and biodegradable nanomaterials that have demonstrated utility in a wide range of settings and applications. Using an established urinary bladder augmentation model, the Sharma Group treated a highly pro-inflammatory biologic scaffold used in a wide array of settings with anti-inflammatory peptide amphiphiles (AIF-PAs). When compared with control PAs, the treated scaffold showed regenerative capacity while modulating the innate inflammatory response, resulting in superior bladder function.

This work is published in the journal Biomaterials. Says Sharma, "Our findings are very relevant not just for bladder regeneration but for other types of tissue regeneration where foreign materials are utilized for structural support. I also envision the potential utility of these nanomolecules for the treatment of a wide range of dysfunctional inflammatory based conditions."

Explore further: Taking tissue regeneration beyond state-of-the-art

More information: Bury MI, Fuller NJ, Meisner JW, Hofer MD, Webber MJ, Chow LW, Prasad S, Thaker H, Yue X, Menon VS, Diaz EC, Stupp SI, Cheng EY, Sharma AK. The promotion of functional urinary bladder regeneration using anti-inflammatory nanofibers. Biomaterials. Available online 18 August 2014. http://www.sciencedirect.com/science/ ii/S0142961214008667

Journal reference: Proceedings of the National Academy of Sciences Biomaterials

Provided by Children's Memorial Hospital

A new approach to bladder regeneration is capitalizing on the potential of two distinct cell populations harvested from a patient's healthy bone marrow, a new study reports.

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Tissue regeneration using anti-inflammatory nanomolecules

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STEM CELL THERAPY CONCERTO
HEALING is the inevitable objective of stem cell rejuvenation, which is just beautiful integrative with time proven treatments such as acupuncture and entrenched with social science for the...

By: Leong Lau

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STEM CELL THERAPY CONCERTO - Video

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Whats the difference between adult stem cell taken from body fat and from bone marrow
Whats the difference between adult stem cell taken from body fat and from bone marrow? In conversation with Dr Alok Sharma (MS, MCh.) Professor of Neurosurgery Head of Department, LTMG Hospital...

By: Neurogen Brain and Spine Institute

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Whats the difference between adult stem cell taken from body fat and from bone marrow - Video

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(PRWEB UK) 21 August 2014

The success of stem cell medicine does not depend on funding alone

Funding is of the upmost importance but access to the right material is vital.

Stem Cell Banking of a childs own stem cells for potentially a lifetime of use, is a way of storing their health for their future. So it is vital that the right stem cells are available for treatment when they are needed at any time in their life.

Tony Veverka, Group CEO of specialist stem cell bank BioEden says, "Funding is of the upmost importance so that research can continue, but access to the right material is vital."

Gaining access to the right material for stem cell therapy has dramatically simplified since BioEden pioneered an entirely non-invasive method of taking stem cells from children's baby teeth. No longer is there just the option of stem cells from embryos, bone marrow or cord blood, but the option of taking quality cells from the baby tooth after it has fallen out naturally.

BioEden believes it can cut NHS funding dramatically by individuals banking their own stem cells, and they continue to call for clarity and transparency so that a prolonged and healthier life is accessible to all. http://www.thetimes.co.uk/tto/business/industries/health/article4181168.ece

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The Times Have Published Only Half the Story, Says Specialist Stem Cell Bank BioEden

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ICGEB Neurobiology Lab takes up the Ice Bucket Challenge for a world without ALS
http://www.alsa.org/fight-als/ice-bucket-challenge.html.

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ICGEB Neurobiology Lab takes up the Ice Bucket Challenge for a world without ALS - Video

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18 hours ago

It is possible to apply genetic modification to the crop crambe so it meets market demands and takes into account what modern society wants. These are the results of research for which Weicong Qi will receive his PhD on 27 August at Wageningen University, part of Wageningen UR.

Qi has developed a technique to genetically modify crambe without marker genes appearing in the crop. Using this technique he was able to steer the manufacture of metabolic substances in a direction that would make the crop more attractive to the processing industry.

Crambe (Crambe abyssinica), a bio-based economy crop, is a source of renewable raw materials that will allow industry to become less dependent on petroleum, thus leading to a more sustainable economy.

Biobased Economy

At the moment, however, the quantities of oil this crop produces are too small to meet the needs of industry, which has a particular interest in erucic acid. That is why crambe has been bred for a number of decades. It seems that when Crambe is crossbred, it can produce, at most, 65% erucic acid: too little to make the crop economically viable. That is why the Chinese PhD student Weicong Qi investigated the possibility of enhancing erucic acid production in crambe by applying genetic modification.

Genetically modifying crambe

Qi has developed a workable system for genetically modifying crambe, and one that does not lead to marker genes in the crop. He used the technique to transfer a gene to crambe which meant the plant could build oil molecules with not two, but three erucic acid molecules on the three available positions on each oil molecule (glycerol). In this way Qi managed to increase the erucic acid levels to more than 75%. According to his co-supervisor, Frans Krens, this is an important step forward. "It's not the whole story, but Qi has shown that this approach can work. A start has been made"

Explore further: Research uses camelina to build better biofuel

A Kansas State University biochemist is improving biofuels with a promising crop: Camelina sativa. The research may help boost rural economies and provide farmers with a value-added product.

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Crambe could be an even better oil crop thanks to gene technology

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Lecture 8: Plant Genetics
I would like to welcome you to Lecture 8 of the subject Future Farming Technologies. This subject is a component of the BACHELOR OF AGRICULTURE AND TECHNOLOGY offered at both NMIT ...

By: Nicky Cooley

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Lecture 8: Plant Genetics - Video

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BroadE: Statistical Genetics - Meta-analysis
Copyright Broad Institute, 2013. All rights reserved. BroadE: Statistical Genetics - Meta-analysis - Daniel Howrigan These presentations were filmed during the September 2013 Statistical...

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Genetics - An Overview (Part I)
Introduction to the Levels of Genetics.

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Genetics - An Overview (Part I) - Video

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Perfect Genetics Part 7 Preggers Again
Please like and subscribe. Comment below to give me some feedback please and thank you! Sims 3 Profile: http://mypage.thesims3.com/mypage/Courtneydhooks.

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Genetics - An Overview (Part II)
The two types of traits, risk, and benefits of knowing risks.

By: Chemtano

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Genetics and You! #TheFutureIsHere
The filed of genetic science is fast approaching into our everyday lives. Xcode Life Sciences is at the leading edge of providing evidence based tools for the fitness and beauty industry. By...

By: Xcode Life Sciences Australia

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