Stem cell therapy | stem cells laboratory chip osteoarthritis
http://www.arthritistreatmentcenter.com A 3 D lab chip for osteoarthritis... learn more next... Living human cartilage grown on lab chip In Business Standard, scientists have created the...

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It's possible to alter genetic material of stem cells to provide HIV resistance A DNA sequence can be removed from the cells and replaced with another The replacements can be taken from people with natural HIV resistance These altered stem cells can then be used to create HIV-resistant white blood cells

By Emma Innes

Published: 07:57 EST, 11 June 2014 | Updated: 12:03 EST, 11 June 2014

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HIV could be cured by genetically editing stem cells, researchers believe.

U.S. scientists say they have already demonstrated that it is possible to alter the genetic material of some stem cells.

This in turn provides HIV resistance, they report.

A new 'genome editing' technique could be the key to curing HIV. Image shows HIV in human tissue

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Could 'editing' genes be the key to curing HIV? Giving patients altered blood cells could make them resistant to the ...

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Stemologica
Researchers have verified that when included in our skin creams, the Uttwiler Sptlauber Swiss apple stem cells will communicate with you have skin #39;s stem ce...

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Stemologica - Video

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Obesity Weight (Stem Cell Therapy)
The subject matter of this video Obesity Weight.

By: Mohammad Sadique

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Obesity & Weight (Stem Cell Therapy) - Video

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PARIS, June 17, 2014 (AFP) - Women with a specific gene mutation have a higher risk of dying from a type of breast cancer, said a study Tuesday that raised prospects of targeted drugs.

Previous research had shown that the chances of surviving breast cancer after treatment were partly inherited. It was suspected that genes in the body's immune system were involved, but it was unclear which ones.

Now scientists link a variant in CCL20 -- a gene involved in immune response -- to a higher risk of death for women who have undergone chemotherapy for so-called oestrogen receptor negative (ER-) cancer.

The discovery "can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities," said the results published in the journal Nature Communications.

The team used data from numerous studies involving more than 2,600 women in different countries.

They looked at protein-coding changes in genes among women who had received chemotherapy for ER- cancer, a category that affects a minority of patients and is harder to treat than ER+ cancer.

The team adjusted the results for possibly confounding traits like a patient's age at diagnosis and tumour size.

The discovery explained only a small fraction of the variation associated with breast cancer survival, and more mutations must be uncovered to fully understand the genetic basis of ER- prognosis, wrote the researchers.

In a separate breast cancer study published online by the British Medical Journal (BMJ), researchers from Norway and the United States found that mammograms carried out once every two years may reduce death risk by about 28 percent.

About 27 deaths from breast cancer can be avoided for every 10,000 women who did mammography screening -- or about one in 368, said the team after analysing data from all women in Norway aged 50 to 79 between 1986 and 2009.

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Gene mutation affects breast cancer survival chance: study

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Jun 16, 2014 by Lisa Zyga (a) In the absence of artificial cells (circles), E. coli (oblong) cannot sense theophylline. (b) Artificial cells can be engineered to detect theophylline and in response release IPTG, a chemical signal that induces a response in E. coli. Credit: (c) 2014 Nature

(Phys.org) Genetic engineering is one of the great achievements of modern science, allowing for the insertion or deletion of genes in order to control an organism's characteristics and behaviors. However, genetic engineering has its drawbacks, including the difficulties involved in engineering living systems and the potential long-term consequences of altering ecosystems with engineered organisms.

But a new study has shown that controlling organisms on the cellular level does not necessarily require genetic modification. Writing in Nature Communications, Roberta Lentini, et al., have demonstrated that Escherichia coli (E. coli) behavior can be controlled by constructing artificial cells that first sense molecules that E. coli alone cannot sense, and then release different molecules that E. coli can sense. In a way, the artificial cells act as translators by converting unrecognized signals into a chemical language that organisms can understand. The translated signal can then potentially trigger a controllable response in the organism.

"In my opinion, the greatest significance of our work is that it shows that there's more than one way to do synthetic biology," coauthor Sheref Mansy, an assistant professor of biochemistry at the University of Trento in Italy, told Phys.org. "Too often everyone gets excited about one technology or one approach, which sometimes means that solutions to problems get missed because these potential solutions don't depend on prevalent methods. What we've shown is that artificial cells could be used to get around a few of the aspects of living technologies that make people uncomfortable."

In their experiments, the researchers constructed artificial cells that contain a special vesicle which in turn contains several biological components, including a chemical that E. coli can sense (isopropyl b-D-1 thiogalactopyranoside, or IPTG) and DNA that encodes for a riboswitch that responds to an external stimulus. In this case, the external stimulus is the molecule theophylline, commonly found in cocoa beans.

When the artificial cell's riboswitch detects the presence of theophylline, it activates the translation process: a small pore opens in the cell, resulting in the release of IPTG. The E. coli responds to IPTG by exhibiting a green fluorescence, enabling the researchers to easily observe that the new strategy works successfully.

Although E. coli does not respond to theophylline on its own, the artificial cells effectively "expand the senses" of the bacteria by allowing it to indirectly respond to theophylline by translating the chemical message. In this way, E. coli's cellular behavior can be controlled without the need for genetic engineering. The new strategy can potentially overcome the disadvantages of genetic engineering, including the technical difficulties and unintended side effects.

The researchers highlight several examples of how artificial cells may play a role in controlling cellular behavior. One application is using bacteria to search for and clean up environmental contaminants. Instead of genetically engineering bacteria to do this, artificial cells could be constructed to sense the contaminant molecules and release chemoattractants that lure natural bacteria capable of feeding on the contaminants to the site.

Artificial cells could also be used for medical applications, such as to destroy tumors and bacterial infections. For example, rather than spraying engineered bacteria into the lungs of cystic fibrosis patients, artificial cells could be built to detect the presence of specific biofilms, and then release small molecules to disperse the biofilms and thus clear the infection. Similar strategies could also be used to replace engineered probiotics in food and supplements with artificial cells that communicate with gut microbiota to prevent disease.

Before these applications can be realized, however, artificial cells will need several improvements. One of the most important limitations is the batch-to-batch variability of the artificial cells, which results in varying degrees of activity. More work also needs to be done to protect against degradation of the artificial cells' membranes, which would result in the release of the encapsulated molecules even in the absence of the environmental molecules. Future work may also include merging non-genetically modified and genetically modified components to tailor specific cellular features.

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Introducing synthetic features to living organisms without genetic modification

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A new genetic 'barcode' for malaria parasites has been found which could be used to track and contain the spread of the disease, according to new research led by the London School of Hygiene & Tropical Medicine.

Malaria kills around 600,000 people per year, and increased population mobility through international air travel carries further risks of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic marker that quickly and accurately identifies the geographic origin of infections would be a valuable tool for locating the source of outbreaks, and spotting the spread of drug-resistant parasites from Asia to Africa.

New research published in Nature Communications has found a highly predictive barcode in the genetic sequence of the malaria parasite Plasmodium falciparum which can be used to identify the geographic origin of a parasite from a blood sample and monitor its spread.

The researchers from the London School of Hygiene & Tropical Medicine analysed the DNA of over 700 P. falciparum malaria parasites taken from patients in 14 countries in West Africa, East Africa, South East Asia, Oceania and South America. They found several short genetic sequences which were distinct in the DNA of parasites from certain geographic regions, which allowed them to design a genetic 'barcode' to be used in identifying the source of new infections.

Lead author Dr Taane Clark, Reader in Genetic Epidemiology and Statistics at the London School of Hygiene & Tropical Medicine, said: "Being able to determine the geographic origin of malaria parasites has enormous potential in containing drug-resistance and eliminating malaria. Our work represents a breakthrough in the genetic barcoding of P. falciparum, as it reveals very specific and accurate sequences for different geographic settings. We are currently extending the barcode to include other populations, such as India, Central America, southern Africa and the Caribbean, and plan to include genetic markers for other types malaria, such as P. vivax."

Genetic markers have proved extremely valuable in tracking and eradicating diseases, such as polio. However, previous candidates for malaria genetic barcodes have relied on identifying DNA markers found in the parasite's cell nucleus, which shows too much genetic variation between individual parasites to be used accurately.

Now for the first time, the researchers studied the DNA found in two parts of the parasite's cells outside of the nucleus. The mitochondria (the 'power houses' of the cell) and the apicolasts (used in the cell's metabolism) are only inherited through maternal lines and so their genes remain much more stable over generations, and have therefore often been used as tools to explore the origins of humans.

By identifying short sequences in the DNA of the parasite's mitochondria and apicoplasts which were found to be specific for different geographic locations, the team were able to design a highly accurate genetic barcode (92% predictive) which is stable and geographically informative over time.

Study co-author Dr Cally Roper, Senior Lecturer in Malaria Genetics from the London School of Hygiene & Tropical Medicine, said: "By taking finger-prick bloodspots from malaria patients and using rapid gene sequencing technologies on small amounts of parasite material, local agencies could use this new barcode to quickly and accurately identify where a form of the parasite may have come from, and help in programmes of malaria elimination and resistance containment."

The authors say this barcode is limited as the current study lacks representation of the Indian sub-continent, Central America, southern Africa and the Caribbean, owing to the scarcity of sequence data from these regions. In addition, there is a need to study more samples from East Africa, a region of high genetic diversity, high migration and poor predictive ability.

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Genetic 'barcode' for malaria could help contain outbreaks

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Irvine, CA and Annapolis Junction, MD (PRWEB) June 16, 2014

Proove Biosciences, a commercial and research leader in personalized medicine, presented the PILL 2 study at last weeks I nternational Conference on Opioids. The conference was presented by the Journal of Opioid Management and hosted by Harvard Medical School.

The PILL 2 study examined the prevalence of genetic variations in a population of chronic pain patients who were taking prescription opioids. Proove researchers found that there is in fact a greater prevalence of these genetic variations in the study group vs. the control population.

We believe the PILL 2 study shows how genetics can play an important role in personalizing treatment for chronic pain, stated Brian Meshkin, President of Proove Biosciences. When physicians are armed with knowledge about their patients genetic profile, they are better able to assess how that patient will respond to certain medications and treatments.

This study was only a baseline metric providing a benchmark to direct our future research efforts. We are analyzing co-occurring disorders, evaluating additional SNPs, haplotypes and continuously developing new IRB approved prospective studies.

The International Conference on Opioids explores emerging opioid research and initiatives aimed at improving patient care and reducing harm. This years conference assembled experts on opioid analgesics who shared real world knowledge on therapies, as well as insight and perspective on the future of opioids in medicine.

Proove Biosciences was honored to be among the worlds brightest minds in opioid therapy, research, and policy, Meshkin said. We believe genetic testing will dramatically improve patient care and cost efficiency within the market.

About Proove Biosciences

Our mission is to change the future of medicine by providing proof to improve healthcare decisions. We envision a future when clinicians will know how patients are likely to respond to medications before writing a prescription. We believe such knowledge can be provided by genetic testing: Using a simple cheek swab, Proove performs proprietary genetic tests in its CLIA-certified laboratory. Healthcare providers use the results to evaluate how their patients will metabolize medications, and to screen for the likelihood of medication misuse.

Founded in 2009 with offices in Southern California and the Baltimore-Washington metropolitan area, Proove Biosciences is the leader in genetics-related personalized pain medicine research with hundreds of clinical research sites across the U.S. For more information, please visit http://www.proovebio.com or call toll free 855-PROOVE-BIO (855-776-6832).

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Proove Biosciences Presents P.I.L.L. 2 Study at International Conference on Opioids

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Let #39;s Play The Sims 3 - Perfect Genetics - Episode 41
My Sims 3 Page: http://mypage.thesims3.com/mypage/Llandros2012 My Blog: http://Llandros09.blogspot.com My Facebook: https://www.facebook.com/Llandros09?

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Let's Play The Sims 3 - Perfect Genetics - Episode 41 - Video

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Let #39;s Play The Sims 3 - Perfect Genetics Challenge: Cowgirl and Horse Edition Episode 3
Come join me on my latest journey into the complex world of sims 3 genetics, as I try to get perfect foals and perfect children. Will I succeed in getting perfect genetics in both? Can I keep...

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Gene Therapy for Beta Thalassemia

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How To Do Rear Deltoid Exercise using Theraband
Shannon Minnick has a spinal cord injury (tetraplegia, level of injury C6-C7). Here she shows some tips and techniques on how to do rear deltoid exercise using theraband.

By: HealthyTomorrow

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How To Do Rows Exercise using Theraband
Shannon Minnick has a spinal cord injury (tetraplegia, level of injury C6-C7). Here she shows some tips and techniques on how to do rows exercise using theraband.

By: HealthyTomorrow

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How To Do Rows Exercise using Theraband - Video

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Jazzmin walking at Project Walk Atlanta
C5 SCI, gait training on treadmill at Project Walk Atlanta spinal cord injury recovery.

By: Tony Davenport

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Jazzmin walking at Project Walk Atlanta - Video

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Mark Pollock: What a difference 4 years makes
In 2010 blind adventurer Mark Pollock fell out a window and broke his back rendering him paralysed from the waist down. Now, in 2014, Mark devotes his time to finding a cure for spinal cord...

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Mark Pollock: What a difference 4 years makes - Video

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Introduction to the McGowan Institute (2013)

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Introduction to the McGowan Institute (2013) - Video

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By Ian Dipple Wednesday 18 June 2014 Updated: 18/06 11:28

REDDITCH residents have been urged to join the bone marrow register to help the fight against blood cancer.

Anthony Nolan and Redditch MP Karen Lumley have joined forces for the appeal. For the first time the charity has mapped the bone marrow register across the UK by local area.

In Redditch there are more than 562 people willing to donate their stem cells or bone marrow to save the life of a stranger.

However it is well below the average of 796 per Parliamentary constituency and is ranked 467th out of 650.

Two thirds of UK patients in need of a transplant will not find a matching donor from their family. Anthony Nolan helps them find an unrelated donor but can currently only match half of all requests.

Mrs Lumley said: "I want to see many more of my constituents join this fight. Im hunting for more crusaders to sign up today, so we can fight blood cancer together. It is something truly heroic to give a stranger a second chance at life. This is why Im proud to champion this cause to my constituents."

Ann OLeary, head of register development at Anthony Nolan, added: "Donating is an incredibly selfless thing to do and will give someone with blood cancer their best chance at survival."

Anyone aged 16 to 30 and in good health can join the bone marrow register. It involves filling out a simple online form and spitting into a tube.

Visit http://www.anthonynolan.org/superhero for more information.

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MP calls for bone marrow champions

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A.P.REYES, MD ~U.S.SENATOR, LEGALIZING STEM CELL THERAPY IN U.S.A.
I created this video with the YouTube Slideshow Creator (http://www.youtube.com/upload)

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A.P.REYES, MD ~U.S.SENATOR, LEGALIZING STEM CELL THERAPY IN U.S.A. - Video

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New jab would act like a one-off 'vaccination' against heart attack It works by 'knocking out' gene which raises levels of cholesterol in blood Scientists say it could cut the risk of heart attack by 90 per cent Still in development, but after tests it could be available in a decade

By Richard Spillett

Published: 01:06 EST, 11 June 2014 | Updated: 02:58 EST, 11 June 2014

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A single injection that slashes the risk of heart attack by up to 90% could be available within 10 years, scientists say.

The jab uses DNA-editing technology to 'knock out' a liver gene believed to raise levels of cholesterol in the bloodstream.

The one-off treatment has already been tested successfully on mice, reducing the blood concentrations of cholesterol in the animals by 35 to 40 per cent within days.

A new injection which cuts the risk of heart attack could be used as 'a vaccination' within 10 years

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Genetics and Kidney Disease And Soutions Part 2
Kidney problems are common. And the number of people with serious kidney problems, such as kidney disease and kidney cancer, is increasing.The kidneys are tw...

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Genetics and Kidney Disease And Soutions Part 2 - Video

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Genetics and Society - Gregory Cochran
If you have seen this video multiple times, it #39;s because you haven #39;t subscribed yet! Click subscribe to get the latest content of HCEO #39;s research networks delivered to you. The Human Capital...

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BRS 2014 - Population Genetics of the Short-tailed Babbler in Singapore - Prof Rheindt and Ms Keren
Habitat Fragmentation, Local Extinction and the Loss of Population BRS 2014, 24/05/2014, Function Hall, Speaker 2, Professor Frank Rheindt and Ms Keren Sadanandan.

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British Heart Foundation #39;Genetics #39;
A hard hitting DRTV charity ad featuring live action filming and dramatic 4D graphic footage of a baby in a mother #39;s womb.

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British Heart Foundation 'Genetics' - Video

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Loreweaver - Rogue Legacy Part 2: Fun With Genetics
Will learns some things about Mendel plots. Will #39;s Twitch: http://twitch.tv/loreweaver15 Our Facebook: http://facebook.com/worldsfinestgaming Our Tumblr: http://worldsfinestgaming.tumblr.com.

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Loreweaver - Rogue Legacy Part 2: Fun With Genetics - Video

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New Gene Therapy Rapidly Helps Patients With Rare Blood Disorder
Two patients who were given Bluebird Bio #39;s experimental gene therapy for the rare blood disorder beta-thalassemia were able to stop receiving blood transfusi...

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New Gene Therapy Rapidly Helps Patients With Rare Blood Disorder - Video

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