Beverly Hills, CA (PRWEB) June 16, 2014

The top stem cell doctors at Beverly Hills Orthopedic Institute are now offering regenerative medicine procedures for Achilles tendonitis and tears. The procedures include options for several types of stem cell procedures that can provide pain relief and help patients avoid surgery. Call (310) 438-5343 for more information and scheduling.

Achilles tendonitis or tears may bother patients for many months and not respond well to traditional treatments. This may include NSAIDS, bracing and steroid injections. While surgery for these conditions may be extremely successful, there is often a considerable rehabilitation and potential surgery complications.

Stem cell injections for Achilles tears or tendonitis have been a revolutionary treatment. This may include bone marrow derived injections, or amniotic derived stem cell procedures. Both offer exceptional concentrations of stem cells, growth factors and additional reparative materials.

The procedures are performed as an outpatient, with the amniotic derived material coming from consenting donors after scheduled c-sections. There is no fetal material used, negating any ethical concerns.

Dr. Raj at Beverly Hills Orthopedic Institute is a Double Board Certified orthopedic doctor. He treats patients from weekend warriors to amateur and professional athletes, along with celebrities, executives, manual laborers and grandparents.

For more information and scheduling, call (310) 438-5343.

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Stem Cell Doctor at Beverly Hills Orthopedic Institute Now Offering Regenerative Procedures for Achilles Tendonitis ...

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Innovation HealthJam - Personalized Medicine/Genomics Highlights
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Prof Jrgen Pannek I Introducing his work with spinal cord injury urinary tract infection.
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Tour the Center for Regenerative Medicine Biotrust at #MayoClinicMN
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THURSDAY, June 12, 2014 (HealthDay News) -- There is vast genetic diversity among Mexicans, and some groups of people in the country are as different from one another as Europeans are from East Asians, a new study shows.

The findings call into question the current practice of grouping all Mexicans or Hispanics together as a single group for genetic, clinical or population studies, the team of international investigators said.

"Mexico harbors one of the largest amounts of pre-Columbian genetic diversity in the Americas," study co-author Dr. Andres Moreno-Estrada, a life sciences research associate at Stanford University, said in a university news release. "For the first time, we've mapped this diversity to a very fine geographic scale."

The researchers conducted genetic analyses of 511 people representing 20 indigenous populations from across Mexico, 500 people of mixed Mexican, European and African heritage from 10 Mexican states, a region of Guadalajara and Los Angeles, as well as people from 16 European populations and the Yoruba people of West Africa.

"We're moving beyond blanket definitions like Mexican or Latino," Moreno-Estrada said. "Now we're putting finer details on that map. Those broad terms imply common ground among populations, but we're finding that it's much more like a mosaic."

The results could help influence health care and public health policies, the team added.

"Understanding the genetic structure of a population is important for understanding its population history, as well as designing studies of complex biomedical traits, including disease susceptibility," explained study co-senior author Carlos Bustamante, a professor of genetics at Stanford.

"As we deploy genomics technology in previously understudied populations like those of Latin America, we discover remarkable richness in the genetic diversity of these important groups and why it matters for health and disease," he added.

One particularly notable finding of the study is that genetic variations in Native American ancestry among Mexicans and Mexican Americans have a major effect on biomedical traits, such as lung function.

The study appears in the June 13 issue of the journal Science.

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Gene 'Map' of Mexicans Reveals Great Diversity

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EDUC514 Final Video Genetic Engineering Hodge 2014
Class Video on Genetic Engineering GMOs.

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EDUC514 Final Video Genetic Engineering Hodge 2014 - Video

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16.06.2014 - (idw) Universitt Basel

T cells use a novel mechanism to fight leukemia. They may recognize unique lipids produced by cancer cells and kill tumor cells expressing these lipid molecules. A study conducted by researchers at the University of Basel shows that a tumor-associated lipid stimulates specific T cells, which efficiently kill leukemia cells both in vitro and in animal models. The results have been published in the Journal of Experimental Medicine. Leukemias are cancer diseases affecting blood cells . Acute leukemias prevent development of normal bold cells and thereby are severe life-threatening diseases. Current therapy for acute leukemias is based on chemotherapy that eradicates tumor cells followed by bone-marrow stem cell transplantation that reconstitutes the patient with healthy blood cells. In some cases, leukemia cells survive this treatment and start to re-grow. A major aim of many studies is finding novel and efficient ways to detect and eradicate leukemia cells before a second outbreak of the disease.

More punch against tumor cells

T lymphocytes are major contributors to fight against leukemias. T cells may recognize and become activated by tumor-specific protein antigens in some instances produced in large amounts only by tumor cells. These protein antigens are also called tumor-associated antigens (TAA) and stimulate specific T cells, which in turn kill leukemia cells. However, protein TAA accumulation can be drastically reduced by variant leukemia cells and some TAA may change their structure, thus preventing recognition by T cells and facilitating tumor immune evasion.

Prof. Gennaro De Libero and his team from the Department of Biomedicine at the University of Basel has identified a new approach that might help to make the immune system more efficient in recognizing leukemia cells. His research team is studying T cells that specifically recognize lipid antigens since several years. Together with colleagues in Italy, China and Singapore, the Swiss team has identified a new lipid that accumulates in leukemia cells and that stimulates specific T cell responses. The new lipid methyl-lysophosphatidic acid (mLPA) is very abundant in several forms of human leukemias and is the first example of a lipid TAA.

The published study also shows that it is possible to isolate human T cells that specifically recognize and kill mLPA-expressing leukemia cells in in vitro tests. When these T cells were transplanted into mice, they also displayed great in vivo therapeutic efficacy against leukemia cells.

An important feature of mLPA is that differently from protein TAA, it does not change its structure, and remains abundant in leukemia cells. The Swiss team is now investigating, whether mLPA can be used to target leukemia cells in addition to protein TAA. This type of immunotherapy may be extremely beneficial in preventing relapses of the disease after chemotherapy and bone marrow transplantation. It opens new avenues to novel non-invasive cancer immunotherapies.

Original source Marco Lepore, Claudia de Lalla, S. Ramanjaneyulu Gundimeda, Heiko Gsellinger, Michela Consonni, Claudio Garavaglia, Sebastiano Sansano, Francesco Piccolo, Andrea Scelfo, Daniel Hussinger, Daniela Montagna, Franco Locatelli, Chiara Bonini, Attilio Bondanza, Alessandra Forcina, Zhiyuan Li, Guanghui Ni, Fabio Ciceri, Paul Jen, Chengfeng Xia, Lucia Mori, Paolo Dellabona, Giulia Casorati, and Gennaro De Libero

Further information Prof. Gennaro De Libero, University of Basel, Department of Biomedicine, phone: +41 61 265 23 65, email: gennaro.delibero@unibas.ch Dr. Lucia Mori, University of Basel, Department of Biomedicine, phone: +41 61 265 23 27, email: lucia.mori@unibas.ch Weitere Informationen:http://www.jem.org/cgi/doi/10.1084/jem.20140410 - Abstract

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Lipids Help to Fight Leukemia

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BOSTON (CBS) Behaylu Barry is on the mend at home in Stratham, New Hampshire, after 34 days at Boston Childrens Hospital.

Behaylu, 13, received a bone marrow transplant in an effort to rebuild his immune system, compromised by a rare blood disorder.

I didnt feel like I had anything at all until I started doing something, said Behaylu of his aplastic anemia, diagnosed in February.

The star athlete scored seven goals in a January soccer game but a week later, felt exhausted and out of breath. Nose bleeds and infected cuts led his parents to believe something was seriously wrong. When doctors told Midori and Aidan Barry that Behaylu would need a bone marrow transplant, it was terrifying to hear.

The reality is we havent had time to think about it. Youre a parent. You go into campaign mode, said Aidan. That campaign lead the Barrys back to a village in Ethiopia where they first met Behaylu in 2007. Then 6-years-old, his biological parents couldnt afford to care for Behaylu so they put him up for adoption. Though the Barrys had three grown children of their own, they brought Behaylu home and eventually began assisting his other siblings still in Africa.

We thought we were helping them. We never thought theyd help us, said Aidan of the familys quick response to the Barrys request for cheek swabs, in an attempt to find a bone marrow donor for Behaylu. Two of his five siblings were perfect matches. Rediat, 16, and Eden, 10, quickly came to the United States.

The trio had two weeks to reconnect, even attending a New England Revolution game when the team was gracious enough to donate box seats. Behaylus compromised immune system makes it dangerous for him to be exposed to crowds.

During the visit, doctors decided Rediat should be the bone marrow donor. The two brothers underwent the painful procedure in May. Behaylu also received chemotherapy. Now his body is building a new immune system with the help of stem cells from Rediat.

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NH Teen In Recovery After International Search For Bone Marrow Donor

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LOS ANGELES (KABC) --

Amanda Canale doesn't take time with her daughter and niece for granted. She's just happy to feel good.

"I've been in the hospital, and I've been sick my whole life," Amanda said.

Amanda was born with a rare blood disorder that required daily shots.

"Basically, I have no white blood cells," Amanda said. "I have no immune system at all."

At 23, she developed leukemia and was given two weeks to live. She desperately needed a bone marrow transplant, but family members weren't matches. Her doctor suggested an umbilical cord blood transplant.

"The cord was a perfect match and it was available, so it was the right solution for her," Edward Agura, MD, Medical Director of Bone Marrow Transplantation, Baylor University Medical Center, Dallas, said.

Cord blood contains stem cells that regenerate. Mothers of newborns can save their child's own blood or donate it. More than 30,000 transplants have been performed worldwide. However, because the blood comes from a tiny newborn, there's not much of it.

"The cord blood is rare, precious and few, and yet is more potent in its ability to grow," Dr. Agura said.

Now, doctors at Baylor are treating patients by combining cord blood from multiple donors. They've found this increases the number of stem cells and provides faster recovery. Amanda's transfusion was from a baby whose mother donated six years earlier. The procedure completely cured her cancer and blood disorder.

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Cord blood infusion saves woman's life

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H-E-B's private label skin care line is the retailers Beauty Pick of the Month.

The formula for EverVescence by H-E-B includes Uttwiler Spatlauber Swiss Apples, which contain stem cells that help reduce the appearance of fine lines, wrinkles and tired skin.

The line includes: Redefining Eye Cream, Redefining Face Serum and Facial Moisturizer with SPF 15.

As the beauty pick of the month, the line is promoted on heb.com and social media.

The Beauty Pick of the Month is also reviewed by members of H-E-B's beauty panel, which includes H-E-B's employees as well as beauty bloggers.

Among the reviews:

"The eye cream is like a spa treatment with a cooling effect that sinks in and feels fabulous, wrote "Cheryl," online editor for heb.com. Now I can pick up my skincare products at my HEB.

Meanwhile, Liz, H-E-Bs digital marketing manager, said she would recommend all three items to others:

"I used all three as directed and found my skin was softer, she said. The smell was light and not unpleasant like other products I have tried. The products did not irritate my sensitive skin.

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H-E-B promotes store brand skin care line

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Writers, artists and historians have long pondered what it means to be Mexican. Now science has offered its answer, and it could change how medicine uses racial and ethnic categories to assess disease risk, testing and treatment.

The broadest analysis of the Mexican genome ever undertaken reveals a nation of staggering genetic diversity, where European conquest only thinly masks the ancestral DNA of Native Americans, and where some populations remain as distinct from one another as Europeans are from Chinese, according to findings published Thursday in the journal Science.

Forty researchers, who share Latino heritage as well as professional qualms over the significance of ethnic and racial categories, teamed up across borders to analyze more than 1 million variations in the building blocks of DNA. They examined more than 500 samples collected in Mexicos remote Indian villages and polyglot cities, and from Mexican Americans in California.

Because these populations are so rich, so genetically differentiated, you cant just lump them all in, said lead investigator Carlos Bustamante, a population geneticist and co-director of Stanford Universitys Center for Computational, Evolutionary and Human Genomics. You really have to embrace that diversity and think about doing medical genetic studies on a very large scale.

To illustrate their point, the researchers compared their new genetic data with the results of lung function tests for children in Mexico City and Latinos in the San Francisco Bay Area. They discovered that pulmonary function varied in ways that were mirrored in DNA. It was as if someone with a fraction of Maya ancestry had lungs that were 10 years older than someone with a bit of northern indigenous heritage.

Those results could affect how doctors define normal ranges on such tests, and thus diagnoses and treatment for common conditions such as asthma and pulmonary obstruction, said Dr. Esteban Gonzalez Burchard, a UC San Francisco asthma researcher and one of the studys coauthors.

Were pushing the ball down the field toward precision medicine, he said. We actually just care about what your ancestry is at a particular gene.

Indeed, it turns out that the genetic meaning of Mexican is quite complicated. The variation among indigenous populations, for instance, gets sharper by distance a gradient that runs roughly parallel to Mexicos northwest-to-southeast mountain ranges. So a Seri from the Gulf of California area varies as much from a Lacandon Maya near Guatemala as a white person does from an Asian, researchers found.

But Mexico is a land of mixture, captured in the term mestizo that describes someone of European and Native American heritage. The researchers wondered whether the genetic signature of the Aztec, Maya and other cultures had been overwhelmed by the genes of the Spanish conquistadors over the course of the last half millennium.

They were shocked to find that the indigenous component of mestizo samples replicated the same geographic differences found in the indigenous samples. Conquest had not swamped the genetic signal of ancient Mexico.

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Mexico boasts a staggering genetic diversity, study shows

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In personalized medicine, gene detection technologies and bioinformatics are playing an important role in providing the most appropriate medical care to respective patients. They do this by analyzing detected gene information to help determine individual conditions such as clinical progress and responsiveness to drug therapies.

Toppan Printing, the Institute of Physical and Chemical Research (RIKEN) and RIKEN Venture Capital Co., Ltd., jointly established RIKEN GENESIS in 2007 to accelerate their practical application in real medical settings and widely promote RIKEN's leading-edge research achievements in the field of personalized medicine.

RIKEN GENESIS, which provides lab-assay services as well as products for genetic testing based on cutting-edge gene analysis technologies and bioinformatics, is one of the few Japanese companies that have technologies for and the experience/ know-how in the field of personalized medicine.

Positioning RIKEN GENESIS at the core of its life science business, Toppan Printing has been proactively working on research and development in the domain of genetic testing for personalized medicine. An example of their efforts involved jointly developing a genetic analysis system that enables quick and easy detection of cancer driving somatic gene mutations.

Sysmex has been enhancing its approach to expand their technological portfolio of in-vitro diagnostics for the realization of personalized medicine through the 2013 acquisition of Inostics GmbH, which possesses digital PCR technology2, open innovation with research institutes, universities and medical institutions for biomarker acquisition, and other activities.

Toppan Printing, Sysmex and Riken Genesis have found a common direction in personalized medicine by genetic testing technologies through anticipated technological synergies.

Through this alliance, the companies will aim at expanding platforms for genetic testing technologies and, on a short term basis, global distribution of the Japan-oriented companion diagnostics. This will be achieved by utilizing the pipeline of companion diagnostics projects with pharmaceutical companies in both RIKEN GENESIS and Sysmex.

From the mid-to-long term perspective, the companies will accelerate their approach to personalized medicine by providing high-value biomarkers as new clinical tests to practical medicine through the flexibly to respond to various needs for genetic testing at each stage and supporting a seamless connection between them.

The companies are aiming to establish a place in the global market for Japan-oriented genetic testing technologies by bringing out their comprehensive capabilities in genetic testing as well as driving research and development and business operations.

Company Profile|Print|Alerts

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Recent Sysmex News

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Scientists from The University of Manchester have identified an important trigger that dictates how cells change their identity and gain specialized functions.

And the research, published in Cell Reports, has brought them a step closer to being able to decode the genome.

The scientists have found out how embryonic stem cell fate is controlled which will lead to future research into how cells can be artificially manipulated.

Lead author Andrew Sharrocks, Professor in Molecular Biology at The University of Manchester, said: "Understanding how to manipulate cells is crucial in the field of regenerative medicine which aims to repair or replace damaged or diseased human cells or tissues to restore normal function."

During the research the team focused on the part of the cellular genome that gives a gene its expression known as the 'enhancer'. This controls the conversion of DNA from genes into useful information that provides the building blocks that determine the structure and function of our cells.

Different enhancers are active in different cell types, allowing the production of distinct gene products and hence a range of alternative cell types. In the current study, the team have determined how these enhancers become active.

Professor Sharrocks said: "All of us develop into complex human beings containing millions of cells from a single cell created by fertilization of an egg. To transit from this single cell state, cells must divide and eventually change their identity and gain specialised functions. For example we need specific types of cells to populate our brains, and our recent work has uncovered the early steps in the creation of these types of cells.

"One of the most exciting areas of regenerative medicine is the newly acquired ability to be able to manipulate cell fate and derive new cells to replace those which might be damaged or lost, either through old age or injury. To do this, we need to use molecular techniques to manipulate stem cells which have the potential to turn into any cell in our bodies."

But one of the current drawbacks in the field of regenerative medicine is that the approaches are relatively inefficient, partly because scientists do not fully understand the basic principles which control cell fate determination.

"We believe that our research will help to make regenerative medicine more effective and reliable because we'll be able to gain control and manipulate cells -- thus our understanding of the regulatory events within a cell shed light on how to decode the genome," concluded Professor Sharrocks.

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Scientists find trigger to decode the genome

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Institute for Stem Cell and Regenerative Medicine at the University of Washington
Meet the folks behind the impressive discoveries and science occurring at UW Medicine #39;s South Lake Union Research complex. http://depts.washington.edu/iscrm/...

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In January, Jordan passed a law to control research and therapy using human stem cells derived from embryos the first such regulation in the Arab and Islamic region. I was part of the group headed by Abdalla Awidi Abbadi, director of the Cell Therapy Center at the University of Jordan in Amman, that initiated the call for the law and later drafted it. Stem-cell research is a hot topic for Jordan because of the kingdoms status as a health-care hub that draws patients from abroad. It is already one of few countries in the Middle East with regulations for protecting people who participate in clinical trials. This latest law should serve as an example to other countries in the region.

The new rules ban private companies from using human embryonic stem (ES) cells in research or therapies. Such work will be allowed only in government organizations or publicly funded academic institutions in Jordan, which have higher levels of transparency than private firms and are supervised by the health ministry and a specialized committee. The law also bans payment for donations of stem cells and eggs, and says that modified and manipulated cells are not to be used for human reproduction. There is no current research on human ES cells in Jordan; this is a pre-emptive step.

Much of the controversy and disagreement over work on stem cells worldwide arises from the different views of the major religions on the earliest stages of life. Although the use of human ES cells is opposed by the Roman Catholic Church and some Protestant denominations, it is generally supported by the Jewish community and accepted in many Muslim countries. There is no consensus on when human embryonic life begins, but the majority of Muslim scholars consider it to start 40120 days after conception and therefore hold the view that a fertilized egg up to 5days old has no soul it is not human life but biological life. So for many, there is no ethical problem in the Islamic faith with using an early embryo to produce stem cells.

All our discussions in Jordan have concluded that stem-cell research is permissible in Islam.

Such conclusions are not easy to reach. Many Muslim countries consider legislation and bioethics principles to be based on three pillars of Islamic law. The first is the Quran. The second is Sunnah, or the legislative decisions of the Prophet Muhammad. The third is ijmaa the consensus of Muslim scholars and ijtihad, the concept that every adequately qualified scholar has the right to independently solve problems. On the basis of these pillars, Iran, Saudi Arabia and Tunisia have drawn up guidelines on stem-cell research, but they are not legally binding.

Jordans stem-cell law is the product of years of discussions by committees comprising scientists, physicians, Arabic-language experts, lawyers and Muslim and Christian theologians. The issues that arose confusion between stem cells and embryonic stem cells, for instance were discussed and resolved. We consulted with both the National Committee for Science and Technology Ethics and the education ministry. The final law was approved by the council of Muslim scholars, the Majlis Al-Iftaa.

The council agreed with a 2003 decision (fatwa) by Muslim scholars that allows the use of human ES cells from permissible sources including legally produced excess fertilized eggs from invitro fertilization. The decision to ban private companies from using these cells was driven by concerns that the work would encourage termination of pregnancies, which is illegal in Jordan unless the mothers life or health is at risk. The council was clear that the new law must forbid human reproductive cloning and should not allow embryos to be created from the sperm and eggs of unmarried couples.

The distinction drawn between the various sources of stem cells earlier in the discussion process allowed the Majlis Al-Iftaa to take a more permissive approach to techniques using stem cells that are not derived from human embryos. For example, somatic-cell nuclear transfer (in which a patients DNA is transplanted into an unfertilized human egg that has no nucleus) and induced pluripotent stem cells, which are made from adult cells, can be worked on by the private sector under the new rules.

The therapeutic use of bone-marrow transplantation including transplants of blood-forming stem cells is well established in Jordan. Such procedures are already regulated by existing laws on medical practice, so the new law makes a clear distinction between these techniques and human ES-cell therapy.

The legislation not only covers all current aspects of stem-cell research and use, but also leaves room for later modification. It mandates the creation of a national committee that, among other things, will take responsibility for laying out specific regulations for stem-cell banking in accordance with international standards.

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Jordans stem-cell law can guide the Middle East

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An experimental gene-based diet helped a group of slimming volunteers increase their weight loss by a third, research has shown.

Tailoring nutrition to individual genetic profiles could revolutionise dieting and improve people's health, say the scientists who carried out the study.

Personalised diets were prepared for 87 obese individuals based on an analysis of 19 genes known to affect metabolism and taste.

The diets were tweaked to take account of individual genetic make-ups. For example, people whose profile showed a less efficient ability to process fats were given less fat, while the number of calories remained unchanged.

After two years the volunteers had lost 33 per cent more weight than a matched group of 104 participants whose diets were not adjusted to suit their genes.

Lead researcher Dr Nicola Pirastu, from the University of Trieste in Italy, said: 'Although there were no significant differences in age, sex and BMI (Body Mass Index) between the two groups at the beginning of the trial, we found that people in the group who had followed the gene-based diet lost 33 per cent more weight than the controls over two years, and the percentage of lean body mass also increased more in this group.

'By uncovering the genetic bases of taste and food preferences, we will be able to increase not only the effectiveness of nutritional interventions, but also compliance with them.'

Another study conducted by Dr Pirastu involved an analysis of DNA samples from 4,000 European and Asian volunteers which uncovered 17 genes associated with liking certain foods.

The range of foods was wide, including bacon, coffee, chicory, dark chocolate, blue cheese, ice cream, liver, butter, orange juice, yoghurt, white wine and mushrooms.

Surprisingly, none of the genes played an active role in taste or smell perception.

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Study reveals gene diet aids weight loss

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Albany, New York (PRWEB) June 14, 2014

Gene expression is a process that results in the synthesis of a functional gene product with the help of the information coded on genes. These products usually are proteins with respect to coding genes but in case of non-coding genes such as tRNA (transfer RNA), or RNA (ribosomal RNA), the functional product is a functional RNA. The process of gene expression is significant in both prokaryotes (bacteria) and eukaryotes (multicellular organisms) in order to ensure the generation of macromoleular machinery for their life. Gene expression comprises transcription and translation processes. Transcription (DNA to RNA) refers to production of RNA copies of DNA with the help of the enzyme RNA polymerase. While translation (RNA to protein) is a process that results in the synthesis of proteins based on the information on the coding genes (messenger RNA). There is a possibility of the alteration of several steps in gene expression process such as in RNA splicing, post-translational modification of proteins and others. Gene regulation is the basis for morphogenesis, cellular differentiation and versatility and renders cell control over structure and function of the genes.

Browse the Gene Expression Reagents Market Report: http://www.transparencymarketresearch.com/gene-expression-reagents.html.

Gene expression profiling refers to the process of measuring the activity (expression) of several genes at once in to understand the cellular functions. This analysis can facilitate scientists to identify the molecular basis of phenotypic differences and also enables selection of gene expression targets for the future research studies. The various analysis techniques employed for gene expression are SAGE (serial analysis of gene expression), Real Time PCR-based gene expression profiling, microarray analysis, transcriptome sequencing and others. Gene expression reagents are the chemicals used in gene expression studies performed to determine the gene expression patterns. Sample preparation and isolation kits, sample labeling and amplification kits, TaqMan Gene Expression assay kits, gene expression hybridization kits and others are some of the examples of the commercially available gene expression reagents kits. Confirmation of appropriate gene expression is essential in order to ensure normal functioning of genes and any deviation from the normal expression pattern might result in the development of some disorder either genetic or acquired. Also, regulation of faulty gene expression inhibits the production of faulty functional products. For example, in case of cancer patients, RNA silencing is employed that includes the silencing of the cancerous gene expression.

The market for gene expression reagents can be analyzed on the basis of the reagents used in gene expression profiling along with application areas and geography. The reagents can be further segmented into the reagents used in PCR, Microarray, SAGE and others. The application areas that can be covered are drug discovery and research, biomarkers identification, clinical diagnostics and others. Geographically the market can be analyzed on the basis of four major regions namely North America, Asia-Pacific, Europe and RoW.

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The major factors favoring the growth of the market are consistent technological advances, increased intensity of research and development activities and development of gene expression databases across the globe. In addition, increased investments and funding by the government for genetic research along with elevated awareness levels further propel the market growth. On the other hand, high instrumentation costs along with lack of technical expertise in this field would impede the growth of the market. Owing to several advantages and increasing preference for personalized medicine, the scope for growth and uptake of gene expression studies will also increase and in turn increase uptake of gene expression reagents. Affymetrix, Inc., Illumina, Inc., Qiagen N.V., Thermo Fisher Scientific (Life Technologies Corporation), Bio-Rad Laboratories, Inc. and Agilent Technologies are some of the companies competing in gene expression reagents market.

This research report analyzes this market depending on its market segments, major geographies, and current market trends. Geographies analyzed under this research report include:

Browse the Gene Expression Reagents Market Report: http://www.transparencymarketresearch.com/gene-expression-reagents.html.

This report provides comprehensive analysis of:

Original post:
Gene Expression Reagents Market: Global Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019

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Joe Dangor (@joedangor) published a blog post June 10th, 2014

Longer Telomeres, Considered Sign of Good Health, Linked to Brain Cancer Risk

Research conducted by Mayo Clinic investigators has found that two common gene variants that lead to longer telomeres the caps on chromosome ends thought by many scientists to confer health by protecting cells from aging also significantly increase the risk of developing gliomas, a deadly form of brain cancer.

The genetic variants, in two telomere-related genes known as TERT and TERC, are respectively carried by 51 percent and 72 percent of the general population. Because it is somewhat unusual for such risk-conferring variants to be carried by a majority of people, the researchers propose that, in these carriers, the overall cellular robustness afforded by longer telomeres trumps the increased risk of high-grade gliomas, which are invariably fatal but relatively rare.

The research was published online in the journal Nature Genetics. There are clearly high barriers to developing gliomas, perhaps because the brain is specially protected, says Robert Jenkins, M.D., Ph.D., a pathologist at Mayo Clinic. Its not uncommon for people diagnosed with glioma to comment, Ive never been sick in my life.

In the first phase of the new study, researchers at Mayo Clinic and the University of California San Francisco analyzed genome-wide data from 1,644 glioma patients and 7,736 healthy control individuals, including some who took part in The Cancer Genome Atlas project sponsored by the National Cancer Institute and National Human Genome Research Institute. This work confirmed a link between TERT and gliomas that had been made previously; they also identified TERC as a glioma risk factor for the first time.

Since both genes have known roles in regulating the action of telomerase, the enzyme that maintains telomere length, the research team combed a massive genomic analysis of telomere length in nearly 40,000 individuals conducted at the University of Leicester in the United Kingdom and found that the same TERT and TERC variants associated with glioma risk were also associated with greater telomere length.

So, though longer telomeres may be good for your whole person by reducing many health risks and slowing aging, they might also cause some cells to live longer than theyre supposed to, which may predispose someone to cancer, Dr. Jenkins says.

Dr. Jenkins says the relevance of the new research should extend beyond gliomas, since similar TERT variants have also been implicated in lung, prostate, testicular and breast cancers, and TERC variantsin leukemia, colon cancer and multiple myeloma.

In addition to Mayo Clinic, research for this study was conducted at the University of California San Francisco, the University of Leicester in the United Kingdom and the University Medical Center Groningen in the Netherlands.

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Longer Telomeres, Considered Sign of Good Health, Linked to Brain Cancer Risk

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