A closer look at Amy Van Dyken #39;s spinal cord injury
Dr. Vikas Patel a spine surgeon from the University of Colorado Hospital discusses her spinal cord injury.

By: Nancy Melear

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A closer look at Amy Van Dyken's spinal cord injury - Video

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Persons with Spinal Cord Injury playing soccer while wearing Berkeley Exoskeleton
Two young men, one with paraplegia (spinal cord injury) and the other with spinal cord damage play soccer wearing the Berkeley exoskeleton modules in Berkeley, California. The Berkeley exoskeleton...

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Amy Van Dyken-Rouen Shares First Photo Since Spinal Cord Injury: Says She #39;s "Doing Great Today"

By: MissPiggyLuver3

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A deep dive analysis of erythropoietin market
Erythropoietin is a glycoprotein hormone produced in the kidney that stimulates the production of red blood cells by bone marrow stem cells. http://www.bigma...

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Cambridge News Follow us on

Thursday 12 Jun 2014 11:35 AM

Written byJORDAN DAY

Leukaemia survivor, Bill Evans, pictured with his family.

2 Images

A grandfather whose life was saved by an anonymous bone marrow donor is urging others to consider donating theirs.

It was in January 2008 that Bill Evans was diagnosed with Leukaemia, aged 62, at Addenbrookes Hospital.

But thanks to the blood cancer charity, Anthony Nolan, and a generous man who still to this day Bill does not know, the father-of-two and grandfather-of-four was able to fight the cancer.

Bill, now aged 69 and who lives in Ely, said: Last weekend I celebrated my five years post transplant. There are no words to express my gratitude.

Because of Anthony Nolan and the wonderful man who donated his stem cells to me, Ive been able to see my four lovely grandchildren growing up, my wife and I have celebrated our Ruby wedding anniversary and next year I will be 70.

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NBC News -- Researchers have grown part of an eye in a lab dish, using a type of stem cell made from a piece of skin.

They said the little retina started growing and developing on its own an important step towards creating custom-tailored organs in the lab.

We have basically created a miniature human retina in a dish that not only has the architectural organization of the retina but also has the ability to sense light," said M. Valeria Canto-Soler, an assistant professor of ophthalmology at the Johns Hopkins University School of Medicine.

The team used cells called induced pluripotent stem cells, or iPS cells, which are immature stem cells whose powers resemble those of embryonic stem cells they can morph into any cell type in the body.

Theyre made by tricking an ordinary cell, like a skin cell, into reverting back into embryonic mode. Then the researchers activate genes to get the cell to redirect itself into forming the desired cells in this case cells of the retina.

To the surprise of the researchers, the cells started developing as if they were in a growing human embryo.

"We knew that a 3-D cellular structure was necessary if we wanted to reproduce functional characteristics of the retina, but when we began this work, we didn't think stem cells would be able to build up a retina almost on their own. In our system, somehow the cells knew what to do, Canto-Soler said in a statement.

The experiment may ultimately lead to technologies that restore vision in people with retinal diseases, she added.

Tests showed the cells responded to light, the team reported in the journal Nature Communications. "Is our lab retina capable of producing a visual signal that the brain can interpret into an image? Probably not, but this is a good start," Canto-Soler said.

Other teams have used iPS cells to make a piece of human liver and are using them to study a range of human diseases.

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Eye in a Dish: Researchers Make Retina From Stem Cells

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An Okotoks boy may not understand his community is helping to give him a better life this weekend, but there is a good chance he will be smiling anyway.

At four years old, Ryker Menzies communicates through a series of sounds, suffers from frequent muscle spasms, is in a wheelchair because hes unable to walk or sit on his own and is constantly on painkillers.

This has been Rykers reality since infancy due to a severe case of cerebral palsy, and his parents Tiffany Boyd and Jamie Menzies are hopeful stem cell therapy treatment in Panama City will improve his muscle movement, vision and speech.

Unfortunately, they havent been able to afford the procedure living on one income while Boyd cares for Ryker.

To help pay for the $15,600 treatment, the couple is organizing a mini-market at the Foothills Centennial Centre on June 14 from 11 a.m. to 4 p.m. and inviting the community to check out an abundance of second-hand items and products from home-based and privately-owned businesses for an entry fee of $2.

Money will also be raised through a food vendor, numerous raffle tickets for prizes including vacations and toys, and items donated by residents. Okotoks singer Emily Gryba will perform at the event.

Ive been getting a lot of calls from people donating stuff to the market to sell there, as well as a few online donations, said Boyd. We will just set up about five tables and have family run them. The proceeds will go to Ryker.

Boyd said she is ecstatic at the amount of community support for Rykers stem cell treatment. An online fund she established called Raise for Rykstar collected $1,300, with another $2,000 donated by family, friends and community members.

The feedback has been fantastic, she said. Were already at $3,500.

As the family gets closer to reaching their financial goal, Boyd is eager to book an appointment to give Ryker the best life possible. She said she was told they will have an appointment within a month or two of making the call.

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Boy getting a chance for a better life

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Hope for Autism, Genetics or Environment.
With rates of Autism now affecting 1/50 children and the CDC admitting that 1/5 US children will be diagnosed with a mental illness, it is time we stop this epidemic. Researchers are now saying...

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Hope for Autism, Genetics or Environment. - Video

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AAP Biology Gene Therapy Overview

By: Everett Davis

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Attack of the B - Team EP8 - Drowning for Science!
Attack of the B-Team Modded Minecraft on the Seed Team server with JSeed47 and friends. A little gene therapy and testing death for science... Modpack: http://www.technicpack.net/attack-of-the-bt...

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More people in the capital have signed up to donate their stem cells than residents in any other part of Britain - d espite Londoners having an unfriendly reputation .

Blood cancer charity Anthony Nolan has mapped its bone marrow register for the first time, showing the proportion of people in each region who are signed up to the bone marrow register.

The charity said that more than 80,000 people in the capital are now signed up to the register - 0.97% of London's population.

A spokeswoman said that other "selfless hotspots" are the East Midlands, where 0.91% of the population has signed up, Scotland where 0.89% of people are on the register and in the south east where 0.87% of people have pledged to donate their stem cells.

Places with the lowest rates of sign-ups are the West Midlands and the south west, where just 0.66% and 0.65% of people, respectively, have signed up to the register.

The register was set up 40 years ago to help find lifesaving matches for people with blood cancer who desperately need a stem cell, or bone marrow, transplant.

Ann O'Leary, head of register development at Anthony Nolan, said: "Donating stem cells to save the life of a stranger is a remarkably selfless act so it's great to see so many Londoners challenging the city's stereotype and signing up to our register.

"Two thirds of patients will not find a matching donor from within their families; instead they turn to Anthony Nolan to find them an unrelated donor.

"Even though London has the highest proportion of donors of any region, it's still less than one per cent of the overall population of London, which shows us that we urgently need to recruit donors from all over the UK so we can give people with blood cancer the best possible hope of a cure."

Ms O'Leary added: "Mapping the register in this way will help us to target our efforts in order to grow the register and save more lives.

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UK & World

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By altering how a liver gene works, scientists say theyve developed a way to cut cholesterol permanently with a single injection, eliminating the need for daily pills to reduce the risk of heart attack.

In a test in mice, scientists at the Harvard Stem Cell Institute and the University of Pennsylvania disrupted the activity of a gene, called PCSK9, that regulates cholesterol, the fatty material that builds up in veins, hindering blood flow. The process permanently dropped levels of the lipid by 35 to 40 percent, said Kiran Musunuru, the lead researcher.

Thats the same amount of cholesterol youll get with a cholesterol drug, said Musunuru, who is a cardiologist and assistant professor at Harvard. The kicker is we were able to do that with a single injection, permanently changing the genome. Once that changes, its there forever.

Pfizer Inc. (PFE)s Lipitor and AstraZeneca Plc (AZN)s Crestor, both of which target so-called bad cholesterol, are pills that are designed to be taken daily. The prospect of replacing them with the newly tested procedure may be 5 to 10 years away, Musunuru said in a telephone interview.

The PCSK9 gene is the same one now being targeted by Amgen Inc., Sanofi (SAN) and Regeneron Pharmaceuticals Inc. (REGN) with experimental compounds designed to suppress the protein the gene produces. Certain rare PCSK9 mutations are found to cause high cholesterol and heart attacks. Good mutations also exist, and people with them have a heart attack risk that ranges from 47 to 88 percent below average, the researchers said.

Its not too much of a leap to think that if it works as well in mice, it will work as well in humans, said Musunuru, who works in the Cambridge, Massachusetts schools Department of Stem Cell and Regenerative Biology. With one shot, a patient would be like those people born with the good mutations.

The research is published today in Circulation Research, a journal of the American Heart Association.

The approach used a two-part genome-engineering technique that first targets the DNA sequence where the gene sits, and then creates a break in the system. The therapy was carried to the liver using an injected adenovirus.

The genome-editing technique used in the experiment has only been around for about a year and a half, Musunuru said.

The next step is to see how effective the therapy is in human cells, by using mice whose liver cells are replaced with human-derived liver cells, he said. Assessing safety will be the primary concern.

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Cholesterol Controlled for Good by Gene Therapy in Mice

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Why You Should Support Team Walk #39;n #39;Rollers
Sonja Gaudet explains why YOU should support Team Walk #39;n #39;Rollers in the Scotiabank Charity Challenge on June 22nd To Learn More or Donate visit: http://sci-b...

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Burin Terzioglu- Spinal Cord Injury Association Show
Burin Terzioglu Arabs Fan Club http://murat-burcin-arab.forum-log.com/ https://twitter.com/MuratBurcinArab https://www.facebook.com/BurcinTerziogluFans.

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Tweet your regenerative medicine questions to Prof Sara Rankin
Professor of Regenerative Pharmacology, Sara Rankin, will be taking part in a live Twitter Q A on Monday 9 June from 13:45 until 14:30. Tweet your questions ...

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Regenerative Medicine Solutions
Get more information and the product brochure here: http://www.comecer.com/isolation/isolator-glove-boxes/regenerative-medicine/ Isolation Technology Solutions for Tissue Engineering and Regenerat...

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Regenerative Medicine Solutions - Video

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The company which has an annual turnover of 4m, pulls in 32pc of its revenue from the domestic market, 30pc from southern Europe, 28pc from the Middle East and Gulf and 10pc from Hong Kong.

As most NHS hospitals will not allow midwives to collect cord blood on the request of the parents, Smart Cells sends a phlebotomist to the labour ward to drain tissue after the baby is born, as the placenta comes away, and a courier then transports it back to the Smart Cells laboratory, via a temperature-controlled kit, where it is then frozen for up to 25 years. The process costs 2,500 per child.

When we first started there was a lot of controversy surrounding stem cell storage people felt it was a waste of time and we were scaremongering but 30,000 transplants have now been completed worldwide, he says.

Stored stem cells have been used in transplants to treat more than 70 different diseases including lymphoma, sickle-cell disease, and some metabolic disorders. Unlike marrow, which is obtained through a painful medical procedure and replenished by the body, this method of collection is simple and not directly from the child.

But access to this service can come down to one individual despite the mothers wishes. Most of the reasons why we are not allowed to collect full stop is based on the views of the head of department. For example at Princess Alexandra the head of midwifery was against cord blood collectiond via a private company, she moved to Queens Hospital in Romford and changed their policy too.

In certain hospitals, there is a stem cell collection procedure and public bank for ill children but this doesnt give the parents the choice to store for their own family.

In many cases such as leukaemia the stem cells of one healthy child can help save the life of his or her sibling. The health alert last week over babies who were poisoned in neonatal care units via nutritional drips, used to feed premature newborns, could also trigger a concern around external services and procurement. The contaminated batch killed one baby in Londons St Thomass.

In this case there was no liability on the part of the hospital and such a situation could have regretfully also occurred with something like outside catering, said Ahmed. But given the way the NHS do behave and at times get into panic, it may have a further impact on other companies being allowed in.

Smart Cells, which once stored blood for Darcey Bussell, the ballerina and Strictly Come Dancing judge, encountererd its fair share of setbacks with the global economic downturn.The science was popular in southern Europe until the eurozone crisis put in a dent in demand for its service.

The rise of the internet also bred more competition, with a series of digital-only services springing up. A handful of cowboy outfits sprang up but have fallen by the wayside, said Ahmed. And of course reputable organisations have set up in competition as well, such as Virgins Health Bank.

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A baby's gift that keeps giving

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Ryan White, CTV Calgary Published Saturday, June 7, 2014 4:38PM MDT Last Updated Saturday, June 7, 2014 6:30PM MDT

Dozens of men stepped forward to offer their cheek cells for testing in the hope of assisting patients in need of stem cell or bone marrow transplants.

On Saturday, the Village Brewery offered beer tastings and tours to those who took part in the swab-a-thon.

The event was created by Steve Carpenter, the operator of a local micro-brewery, whose brother Al was diagnosed with a rare form of leukemia in November. Al, married and the father of two, was in desperate need of stem cell treatment and Canadian Blood Services was unable to locate a suitable match through its stem cell and bone marrow donor program.

Steve and his friends organized a swab-a-thon in the hopes of locating a suitable donor, and Jim Button, a childhood friend of Als and the owner of Village Brewery, offered the use of his brewery.

Miraculously, in the days before the swab-a-thon was to be held, a suitable stem cell match was located for Al and he underwent treatment in an Ottawa hospital. Doctors say Al is responding well to the treatment.

Despite the fact a donor had been located for his brother, Steve made the decision to continue with his plans for Saturdays event.

We are here to tell people it is a very easy program, said Steve. We really appreciate anybody coming out to sign up on registry, be it for my brother or any other people in need.

Mike Carron was the first volunteer to step up to register and offer up a saliva sample. He says he wanted to help the cause after stem cell treatment extended the life of a close family member.

I thought it would be good to pay it forward, explains Carron. I had an uncle who needed stem cell treatment three years ago and it gave him an extra three years.

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It takes a Village; local brewery hosts swab-a-thon

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New genomic research led by UC San Francisco scientists reveals that two common gene variants that lead to longer telomeres, the caps on chromosome ends thought by many scientists to confer health by protecting cells from aging, also significantly increase the risk of developing the deadly brain cancers known as gliomas.

The genetic variants, in two telomere-related genes known as TERT and TERC, are respectively carried by 51 percent and 72 percent of the general population. Because it is somewhat unusual for such risk-conferring variants to be carried by a majority of people, the researchers propose that in these carriers the overall cellular robustness afforded by longer telomeres trumps the increased risk of high-grade gliomas, which are invariably fatal but relatively rare cancers.

The research was published online in Nature Genetics on June 8, 2014.

There are clearly high barriers to developing gliomas, perhaps because the brain has special protection, said Margaret Wrensch, MPH, Ph.D., the Stanley D. Lewis and Virginia S. Lewis Endowed Chair in Brain Tumor Research at UCSF and senior author of the new study. Its not uncommon for people diagnosed with glioma to comment, Ive never been sick in my life.

In a possible example of this genetic balancing act between risks and benefits of telomere length, in one dataset employed in the current study a massive genomic analysis of telomere length in nearly 40,000 individuals conducted at the University of Leicester in the United Kingdom shorter telomeres were associated with a significantly increased risk of cardiovascular disease.

Though longer telomeres might be good for you as a whole person, reducing many health risks and slowing aging, they might also cause some cells to live longer than theyre supposed to, which is one of the hallmarks of cancer, said lead author Kyle M. Walsh, Ph.D., assistant professor of neurological surgery and a member of the Program in Cancer Genetics at UCSFs Helen Diller Family Comprehensive Cancer Center.

In the first phase of the new study, researchers at UCSF and the Mayo Clinic College of Medicine analyzed genome-wide data from 1,644 glioma patients and 7,736 healthy control individuals, including some who took part in The Cancer Genome Atlas project sponsored by the National Cancer Institute and National Human Genome Research Institute. This work confirmed a link between TERT and gliomas that had been made in previous UCSF research, and also identified TERC as a glioma risk factor for the first time.

Since both genes have known roles in regulating the action of telomerase, the enzyme that maintains telomere length, the research team combed the University of Leicester data, and they found that the same TERT and TERC variants associated with glioma risk were also associated with greater telomere length.

UCSFs Elizabeth Blackburn, Ph.D., shared the 2009 Nobel Prize in Physiology or Medicine for her pioneering work on telomeres and telomerase, an area of research she began in the mid-1970s. In the ensuing decades, untangling the relationships between telomere length and disease has proved to be complex.

In much research, longer telomeres have been considered a sign of health for example, Blackburn and others have shown that individuals exposed to chronic stressful experiences have shortened telomeres. But because cancer cells promote their own longevity by maintaining telomere length, drug companies have searched for drugs to specifically target and block telomerase in tumors in the hopes that cancer cells will accumulate genetic damage and die.

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Longer telomeres linked to brain cancer risk

Recommendation and review posted by Bethany Smith

New genomic research led by UC San Francisco scientists reveals that two common gene variants that lead to longer telomeres, the caps on chromosome ends thought by many scientists to confer health by protecting cells from aging, also significantly increase the risk of developing the deadly brain cancers known as gliomas.

The genetic variants, in two telomere-related genes known as TERT and TERC, are respectively carried by 51 percent and 72 percent of the general population. Because it is somewhat unusual for such risk-conferring variants to be carried by a majority of people, the researchers propose that in these carriers the overall cellular robustness afforded by longer telomeres trumps the increased risk of high-grade gliomas, which are invariably fatal but relatively rare cancers.

The research was published online in Nature Genetics on June 8, 2014.

There are clearly high barriers to developing gliomas, perhaps because the brain has special protection, said Margaret Wrensch, MPH, PhD, the Stanley D. Lewis and Virginia S. Lewis Endowed Chair in Brain Tumor Research at UCSF and senior author of the new study. Its not uncommon for people diagnosed with glioma to comment, Ive never been sick in my life.

In a possible example of this genetic balancing act between risks and benefits of telomere length, in one dataset employed in the current studya massive genomic analysis of telomere length in nearly 40,000 individuals conducted at the University of Leicester in the United Kingdomshorter telomeres were associated with a significantly increased risk of cardiovascular disease.

Though longer telomeres might be good for you as a whole person, reducing many health risks and slowing aging, they might also cause some cells to live longer than theyre supposed to, which is one of the hallmarks of cancer, said lead author Kyle M. Walsh, PhD, assistant professor of neurological surgery and a member of the Program in Cancer Genetics at UCSFs Helen Diller Family Comprehensive Cancer Center.

In the first phase of the new study, researchers at UCSF and The Mayo Clinic College of Medicine analyzed genome-wide data from 1,644 glioma patients and 7,736 healthy control individuals, including some who took part in The Cancer Genome Atlas project sponsored by the National Cancer Institute and National Human Genome Research Institute. This work confirmed a link between TERT and gliomas that had been made in previous UCSF research, and also identified TERC as a glioma risk factor for the first time.

Since both genes have known roles in regulating the action of telomerase, the enzyme that maintains telomere length, the research team combed the University of Leicester data, and they found that the same TERT and TERC variants associated with glioma risk were also associated with greater telomere length.

UCSFs Elizabeth Blackburn, PhD, shared the 2009 Nobel Prize in Physiology or Medicine for her pioneering work on telomeres and telomerase, an area of research she began in the mid-1970s. In the ensuing decades, untangling the relationships between telomere length and disease has proved to be complex.

In much research, longer telomeres have been considered a sign of healthfor example, Blackburn and others have shown that individuals exposed to chronic stressful experiences have shortened telomeres. But because cancer cells promote their own longevity by maintaining telomere length, drug companies have searched for drugs to specifically target and block telomerase in tumors in the hopes that cancer cells will accumulate genetic damage and die.

Original post:
Longer Telomeres Linked to Risk of Brain Cancer

Recommendation and review posted by Bethany Smith

Teen with rare disease fighting for help on birthday

A Gold Coast teenager with a rare genetic disorder is not only fighting for her life, she's battling the government to subsidise the only drug that can treat her condition.

Bianca Scott turned 18 today and she says all she wants is a chance at a normal life.

But instead of planning a party, this 18-year-old is doing media interviews trying to raise funds for a life saving treatment.

Bianca suffers from aHUS - a rare genetic blood disorder.

"I want to have a place in this world and I don't think I'll be able to without this medicine," she told 7News.

"It's so rare they actually label it as an ultra rare disease.

"Ten per cent sadly die within the first year of their attack and the other 90 per cent die within 5 years."

Their birthday wish is for a drug called Soliris to be subsidised by the Government. It's the only medicine that can treat aHus.

"It stops aHus from coming back again, that's a proven fact, Biancas mother said.

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Teen with rare disease fighting for help on birthday

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Cathy and Charles Fitch of Mount Pleasant are enjoying life as he is in remission from leukemia. Doctors have based treatments based on Charles' genome since his diagnosis in June 2011. David Quick/Staff

Genomic sequencing 101

Nearly every cell in the human body, from the ones in the fingernails to the ones deep inside the brain, contains a complete set of DNA, the operating instructions that influence everything from a person's hair color to susceptibility to disease.

For years, doctors have been able to test specific genes to detect the presence of mutations associated with disorders such as cystic fibrosis and sickle cell disease.

But only recently have scientists been able to map out a person's entire genetic code, or genome, by sequencing all 25,000 or so genes in one fell swoop.

How many have the potential to cause cancer? Dr. Stephen Ethier, chairman of breast cancer research at the Medical University of South Carolina says, "We're still searching for the final answer, but it's probably a few hundred genes. Some we know well. Most we still don't."

To sequence a person's genome, doctors need to collect less than a teaspoon of blood or saliva. Then chemicals are used from this sample to break open the cell membranes and gather the DNA that had been housed inside them. Enzymes strip away surrounding proteins to isolate a clump of tiny, whitish strands of DNA. That genetic material is placed in sophisticated machines that "read" each of the 3 billion base pairs that make up a person's genetic code.

Sequencing a genome used to take a year. Now, it can be done in a day.

Air Force veteran Charles Fitch is alive today, most likely because of "personalized" cancer treatment that used to be the stuff of science fiction, all thanks to cancer research and treatment based on genomics.

Genes vs. genome

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MUSC using genetic mapping for research and personalized treatment of cancer

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The Sims 3 | Perfect Genetics Challenge Part 8: School ew
In this part, Ashley meets a new friend and we teach Riley how to walk talk! Backstory: "Once upon a time, the Mighty Player sent a Sim to live in the world where all its creations were...

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The Sims 3 | Perfect Genetics Challenge Part 8: School ew - Video

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5 Genomics and Personalized Medicine October 20, 2009

By: tawkaw OpenCourseWare

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5 Genomics and Personalized Medicine October 20, 2009 - Video

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4 - Emerging World of Personalized Medicine @ Gibbs Cancer Center CASIS Annual Conference
Panel Discussion: "Emerging World of Personalized Medicine" Gena Cook Jeff Pollard, M.D. Lincoln Nadauld, M.D., Ph.D. Mark Watson, M.D., Ph.D.

By: ISSCASIS

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4 - Emerging World of Personalized Medicine @ Gibbs Cancer Center & CASIS Annual Conference - Video

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