Joel Dudley : Assistant Professor of Genetics Genomics

By: Stanford Medicine

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Joel Dudley : Assistant Professor of Genetics & Genomics - Video

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Minecraft: ADVANCED GENETICS MOD! Attack Of The B-Team Minecraft Mod Survival (40)
Thanks for Subscribing! 🙂 http://bit.ly/SubLog JOIN MY SERVER! play.thehelmmc.net Let #39;s hit 1000 Likes! Thanks for your support! Attack of the B-Team modpack is a brand new Modded...

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The Sims 3: Perfect Genetics Challenge - Ep. 3

By: simsiguess

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The Sims 3: Perfect Genetics Challenge - Ep. 3 - Video

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Combine some microbiologists with some mechanical engineers and you never know what might happen.

A recent collaboration of those two fields of scientists at Brigham Young University produced a machine so small it takes a microscope to see it.

It's not just for fun, however. It could pave the way for research into diseases including Alzheimer's, cancer and diabetes.

For decades scientists have conducted gene research by transferring genetic material into a new cell by a process called microinjection. It was just considered an unfortunate by-product of the process to have 40 percent of the cells die.

Enter BYU and a different process called nanoinjection, which occurs by transferring material including DNA into cells.

"Because DNA is naturally negatively charged, it is attracted to the outside of the lance using positive voltage," said Brian Jensen, a BYU professor of mechanical engineering, in a release. "Once we insert the lance into a cell, we simply reverse the polarity of the electrical force and the lance releases the DNA."

The lance being used is 10 times smaller than what was used previously. In the past, researchers used a hollow needle to pump a DNA-filled liquid into an egg cell nucleus, but the extra fluid caused many of the cells to swell and die.

With the new method, the team found that nearly 80 percent of the cells proceeded to the next stage of development, a significant increase from the previous 60 percent success rate.

No extra fluid is used and the cells undergo less stress and have a higher survival rate.

"It is really great engineering stuff," said Sandra Burnett, associate professor of microbiology at BYU.

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Smaller is better: BYU creates new gene therapy technology

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by Jason Whitely / WFAA.com

WFAA.com

Posted on May 24, 2014 at 10:38 AM

Updated yesterday at 10:38 AM

DALLAS Hispanics, African Americans and Asians have a more difficult time of getting a bone marrow transplant because the national database of potential donors doesnt include many minorities.

But, an effort is underway over the Memorial Day weekend to increase the number of minority donors.

Jose Barrera is among the thousands suffering from a blood cancer specifically Chronic Myeloid Leukemia but he never showed a symptom of it.

"Your body flushes out the white blood cells in your body," Barrera explained. "But with me, the dead ones were just staying in my blood stream and they were overcrowding and that's when you develop cancerous cells."

Barrera, 22, works weekends at Sherlock's Baker Street Pub on Park Lane and studies accounting at the University of North Texas.

Doctors discovered his CML during a routine eye exam at Wal-Mart last September. Fortunately, he said, its the most curable.

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Critical need for Hispanic, minority bone marrow donors

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Towards the democratization of cell therapy

By: Roberto Hernan

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Towards the democratization of cell therapy - Video

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Genetic Engineering...allowed to what extent?
To what extent the Genetic Engineering is allowed? #39; #39; #39; #39;

By: Waqf Nau Canada

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Scotch Moses: Genetic Engineering
For more from Scotch Moses, subscribe to their channel: http://www.youtube.com/subscription_center?add_user=scotchmosesofficial A pregnant couple decides just how much to mess with mother...

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AOTBT #21- Advanced Genetics Mod!
Hello Everybody! theperson here, and this is today #39;s video: Me and my bro Goldenguy33 play Minecraft with the Attack of the B-Team modpack! Twitter: http://www.twit...

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The Sims 3 Perfect Genetics Challenge (Part 4) Baby Tucker!
OPEN FOR IMPORTANT LINKS AND INFO Like/Follow me on: ONLINE STORE: http://jessamica92.spreadshirt.com/ SECOND CHANNEL: http://www.youtube.com/user/JessaG...

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The world has great expectations that stem cell research one day will revolutionize medicine. But in order to exploit the potential of stem cells, we need to understand how their development is regulated. Now researchers from University of Southern Denmark offer new insight.

Stem cells are cells that are able to develop into different specialized cell types with specific functions in the body. In adult humans these cells play an important role in tissue regeneration. The potential to act as repair cells can be exploited for disease control of e.g. Parkinson's or diabetes, which are diseases caused by the death of specialized cells. By manipulating the stem cells, they can be directed to develop into various specialized cell types. This however, requires knowledge of the processes that regulate their development.

Now Danish researchers from University of Southern Denmark report a new discovery that provides valuable insight into basic mechanisms of stem cell differentiation. The discovery could lead to new ways of making stem cells develop into exactly the type of cells that a physician may need for treating a disease.

"We have discovered that proteins called transcription factors work together in a new and complex way to reprogram the DNA strand when a stem cell develops into a specific cell type. Until now we thought that only a few transcription factors were responsible for this reprogramming, but that is not the case," explain postdoc Rasmus Siersbaek, Professor Susanne Mandrup and ph.d. Atefeh Rabiee from Department of Biochemistry and Molecular Biology at the University of Southern Denmark.

"An incredibly complex and previously unknown interplay between transcription factors takes place at specific locations in the cell's DNA, which we call 'hotspots'. This interplay at 'hotspots' appears to be of great importance for the development of stem cells. In the future it will therefore be very important to explore these 'hotspots' and the interplay between transcription factors in these regions in order to better understand the mechanisms that control the development of stem cells," explains Rasmus Siersbaek.

"When we understand these mechanisms, we have much better tools to make a stem cell develop in the direction we wish," he says.

Siersbaek, Mandrup and their colleagues made the discovery while studying how stem cells develop into fat cells. The Mandrup research group is interested in this differentiation process, because fundamental understanding of this will allow researchers to manipulate fat cell formation.

"We know that there are two types of fat cells; brown and white. The white fat cells store fat, while brown fat cells actually increase combustion of fat. Brown fat cells are found in especially infants, but adults also have varying amounts of these cells.

"If we manage to find ways to make stem cells develop into brown rather than white fat cells, it may be possible to reduce the development of obesity. Our findings open new possibilities to do this by focusing on the specific sites on the DNA where proteins work together," the researchers explain.

Details of the study

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Stem cell development: Experts offer insight into basic mechanisms of stem cell differentiation

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Arthritic knee 10 weeks after stem cell therapy by Dr Harry Adelson
Frank describes his results for his stem cell therapy injection by Dr Harry Adelson for his arthritic knee http://www.docereclinics.com.

By: Harry Adelson, N.D.

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Arthritic knee 10 weeks after stem cell therapy by Dr Harry Adelson - Video

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4 Michael Jewett, MD Research Priorities, Survivorship, Genetics, Quality and Personalized Medicine
2014 Patient Conference.

By: KidneyCancerCanada

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4 Michael Jewett, MD Research Priorities, Survivorship, Genetics, Quality and Personalized Medicine - Video

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Spinal cord research helps paralysed hand to move again
For the first time, scientists in Newcastle University #39;s Institute of Neuroscience have been able to restore the ability to grasp with a paralysed hand using...

By: Newcastle University

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Achondroplasia Gene Research
#39;Achondroplasia, a medical disorder of bone growth that is the most common form of short-limb dwarfism. The research project carried by USM researcher, Lee L...

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Achondroplasia Gene Research - Video

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May 23, 2014

Image Caption: Microscopic image of human cells (stained purple), showing the primary cilium (green). A new study shows how FTO, a gene commonly associated with obesity, contributes to weight gain. Changes in this gene indirectly affect the function of the cilium -- a hair-like appendage found on brain and other cells. Irregularities in the cilium, in turn, can affect receptors for leptin, which suppresses appetite. Credit: Lab of Rudolph L. Leibel, M.D.

Columbia University Medical Center

Researchers have discovered how a gene commonly linked to obesityFTOcontributes to weight gain. The study shows that variations in FTO indirectly affect the function of the primary cilium, a little-understood hair-like appendage on brain and other cells. Specific abnormalities of cilium molecules, in turn, increase body weight, in some instances, by affecting the function of receptors for leptin, a hormone that suppresses appetite. The findings, made in mice, suggest that it might be possible to modify obesity through interventions that alter the function of the cilium, according to scientists at Columbia University Medical Center (CUMC).

If our findings are confirmed, they could explain how common genetic variants in the gene FTO affect human body weight and lead to obesity, said study leader Rudolph L. Leibel, MD, the Christopher J. Murphy Memorial Professor of Diabetes Research, professor of pediatrics and medicine, and co-director of the Naomi Berrie Diabetes Center at CUMC. The better we can understand the molecular machinery of obesity, the better we will be able to manipulate these mechanisms and help people lose weight.

The study was published on May 6 in the online edition of Cell Metabolism.

Since 2007, researchers have known that common variants in the fat mass and obesity-associated protein gene, also known as FTO, are strongly associated with increased body weight in adults. But it was not understood how alterations in FTO might contribute to obesity. Studies have shown that knocking out FTO in mice doesnt necessarily lead to obesity, and not all humans with FTO variants are obese, said Dr. Leibel. Something else is going on at this location that we were missing.

In experiments with mice, the CUMC team observed that as FTO expression increased or decreased, so did the expression of a nearby gene, RPGRIP1L. RPGRIP1L is known to play a role in regulating the primary cilium. Aberrations in the cilium have been implicated in rare forms of obesity, said Dr. Leibel. But it wasnt clear how this structure might be involved in garden-variety obesity.

Dr. Leibel and his colleague, George Stratigopoulos, PhD, associate research scientist, hypothesized that common FTO variations in noncoding regions of the gene do not change its primary function, which is to produce an enzyme that modifies DNA and RNA. Instead, they suspected that FTO variations indirectly affect the expression of RPGRIP1L. When Dr. Stratigopoulos analyzed the sequence of FTOs intronits noncoding, or nonprotein-producing, portionwe found that it serves as a binding site for a protein called CUX1, said Dr. Leibel. CUX1 is a transcription factor that modifies the expression of RPGRIP1L.

Next, Dr. Stratigopoulos set out to determine whether RPGRIP1L plays a role in obesity. He created mice lacking one of their two RPGRIP1L genes, in effect, reducing but not eliminating the genes function. (Mice that lack both copies of the gene have several serious defects that would obscure the effects on food intake.) Mice with one copy of RPGRIP1L had a higher food intake, gained significantly more weight, and had a higher percentage of body fat than controls.

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How Does Common Obesity Gene Contribute To Weight Gain?

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A Shot in the Arm for Evolutionary Genetics Research | Pew
http://www.pewscholars.org 2012 Pew biomedical scholar Nels Elde studies the evolution of conflict -- how the process of infection can drive some of the most dramatic adaptations seen in nature....

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Vision for Personalized Medicine: Princess Margaret 2014 Conference
On Feb. 10-11, 2014, the Princess Margaret Cancer Centre - the largest comprehensive cancer centre in Canada and one of the world #39;s top five - hosted its inaugural conference, "Beyond the Genetic...

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Vision for Personalized Medicine: Princess Margaret 2014 Conference - Video

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Rick Hansen Difference Makers (2014)
Share your difference making story and help create a barrier-free world. This video was created to support Rick Hansen Foundation #39;s campaign to promote the power of difference making and connect...

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May 22, 2014

The world has great expectations that stem cell research one day will revolutionize medicine. But in order to exploit the potential of stem cells, we need to understand how their development is regulated. Now researchers from University of Southern Denmark offer new insight.

Stem cells are cells that are able to develop into different specialized cell types with specific functions in the body. In adult humans these cells play an important role in tissue regeneration. The potential to act as repair cells can be exploited for disease control of e.g. Parkinson's or diabetes, which are diseases caused by the death of specialized cells. By manipulating the stem cells, they can be directed to develop into various specialized cell types. This however, requires knowledge of the processes that regulate their development.

Now Danish researchers from University of Southern Denmark report a new discovery that provides valuable insight into basic mechanisms of stem cell differentiation. The discovery could lead to new ways of making stem cells develop into exactly the type of cells that a physician may need for treating a disease.

"We have discovered that proteins called transcription factors work together in a new and complex way to reprogram the DNA strand when a stem cell develops into a specific cell type. Until now we thought that only a few transcription factors were responsible for this reprogramming, but that is not the case", explain postdoc Rasmus Siersbaek, Professor Susanne Mandrup and ph.d. Atefeh Rabiee from Department of Biochemistry and Molecular Biology at the University of Southern Denmark.

"An incredibly complex and previously unknown interplay between transcription factors takes place at specific locations in the cell's DNA, which we call 'hotspots'. This interplay at 'hotspots' appears to be of great importance for the development of stem cells. In the future it will therefore be very important to explore these 'hotspots' and the interplay between transcription factors in these regions in order to better understand the mechanisms that control the development of stem cells", explains Rasmus Siersbaek.

"When we understand these mechanisms, we have much better tools to make a stem cell develop in the direction we wish", he says.

Siersbaek, Mandrup and their colleagues made the discovery while studying how stem cells develop into fat cells. The Mandrup research group is interested in this differentiation process, because fundamental understanding of this will allow researchers to manipulate fat cell formation.

"We know that there are two types of fat cells; brown and white. The white fat cells store fat, while brown fat cells actually increase combustion of fat. Brown fat cells are found in especially infants, but adults also have varying amounts of these cells.

"If we manage to find ways to make stem cells develop into brown rather than white fat cells, it may be possible to reduce the development of obesity. Our findings open new possibilities to do this by focusing on the specific sites on the DNA where proteins work together", the researchers explain.

Read this article:
New insight into stem cell development

Recommendation and review posted by simmons

Whiplash headaches 11 months after stem cell therapy by Dr Harry Adelson
Neil discusses his outcome 11 months after his stem cell therapy by Dr Harry Adelson for the treatment of his post-whiplash headache syndrome http://www.docereclinics.com.

By: Harry Adelson, N.D.

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Whiplash headaches 11 months after stem cell therapy by Dr Harry Adelson - Video

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Mike Brandon was given just 60 days to find a bone marrow transplant. If he didn't, his leukaemia - cancer of white blood cells - was going to overwhelm his body.

Most people faced with such odds may have given up, but Brandon's fiance, Kate Robertson launched a desperate bid to find a matching donor for her husband-to-be.

The odds paid off: less than a month after Miss Robertson's campaign was launched, a donor has been found.

Anthony Nolan said that her efforts has led to a 650% increase in people joining the bone marrow register. The blood cancer charity said that there was a particular surge among potential donors in the couple's home city of Bristol.

Miss Robertson, 31, said the response has been "astounding".

"It's been an incredibly difficult time so the relief we're feeling is overwhelming," she said.

"A matching donor means that we can go ahead with Mike's bone marrow transplant. We know we have a rocky road ahead as a transplant is a serious procedure, but knowing there is a good match for Mike is a fantastic boost that we desperately needed.

"We are hugely grateful to the selfless person who has stepped forward to help Mike, and to everyone who has pledged to do the same for someone else, by joining the Anthony Nolan register."

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Bride Saves The Life Of Her Fianc Who Had Only 60 Days To Live By Finding A Stem Cell Donor

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The seemingly miraculous recovery of little Hannah Day who rebounded earlier this month after a rare bone marrow transplant cancer free for 60 days has suffered a major setback.

Mother Brooke Ervin said her stem cells, which were transplanted into her daughter on March 19, are attacking her four-year-old daughters body from the inside out, manifesting in a rash and third-degree-like burns.

She has burns to 90 per cent of her body and is now admitted back to [B.C. Childrens] hospital in hopes they can stop it.

Hannah is in immeasurable pain as her family watches, terrified and helpless, Ervin said Wednesday.

Hannah is not responding to oral antibiotics, and steroids being pumped into her body to stop the burning are suppressing her immune system, which is needed to fight off the cancer.

This is such a horrible life she got, a distraught Ervin said.

She has spent most of her life suffering just to stay alive. No one should have to fight so hard, especially an innocent child.

She wants to live so bad and she shows us every day with her fight and will to live, Ervin said. She wont give up and we cant either. We have to hold strong in the hopes one day this will end.

On May 6, Hannah was discharged from hospital in Vancouver after receiving stem cells from her mother in a haploidentical transplant.

Although only a half match, doctors hope Hannahs cells will recognize her moms cells which once protected her in the womb and allow them to kill off cancer cells in Hannahs body.

Excerpt from:
After cancer rebound, Victoria's little Hannah Day back into life of pain as transplanted stem cells attack her body

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Its an image Angie Lawn said shed never forget.

It was May of 2013, and she was at her 19-year-old sons funeral. PJ had just died after complications related to leukemia. The day was a blur, and she was distraught as she walked out of the service and into the parking lot.

On the periphery of the crowd at the edge of the parking lot was this long line of La Salle boys all standing with their jackets, very respectfully, with their hands folded, she recalled. They were some of the last to leave.

A year later, Angie and her family, who live in Wyndmoor, near La Salle College High Schools campus, are organizing a bone marrow donor drive at Springfield Township High School May 31 in honor of PJ.

Angie described her son as a brainiac who loved writing and computer science. He found pleasure in comic books, movies, TV shows, games like Monopoly and a good cheesesteak, she said. He played guitar and piano, and he was skilled at doing imitations and making people laugh.

He took very little for granted, partly because of the cancer, but partly because thats just who he was, she said.

PJ was 12 years old when he was first diagnosed with leukemia, a cancer of the blood cells.

Angie remembered they were going to get ice cream, and PJ didnt want any because he said his chin was bothering him. To be cautious, they went to the doctor, and a blood test determined it was acute lymphoblastic leukemia.

At that point, PJ was just about to head to St. Genevieves for the seventh grade, but instead he was tutored at CHOP as an inpatient that year. The doctors decided to try a bone marrow transplant, but neither Angie nor her husband, Patrick, were a match for PJ. Siblings have a slightly better chance at being a match, so the Lawns other children were tested: Shannon, a senior now at Springfield Township High School; Sean, a sophomore at the high school; and Owen, a seventh-grader at St. Genevieves currently.

Shannon was 10 years old when she was determined to be a match for her older brother. Continued...

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Wyndmoor family remembers son with bone marrow drive at Springfield Township High School

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San Francisco, California (PRWEB) May 22, 2014

The global market for stem cells is expected to reach USD 170.15 billion by 2020, according to a new study by Grand View Research, Inc. Growing prevalence of chronic diseases such as cardiovascular and liver disease, diabetes and cancer coupled with the presence of high unmet medical needs in these disease segments is expected to drive market growth during the forecast period. Moreover, increasing government support pertaining to funding R&D initiatives and the growing demand for medical tourism and stem cell banking services is expected to boost the demand for stem cells over the next six years. The future of this market is expected to be driven by opportunities such as the growing global prevalence of neurodegenerative diseases, increasing demand for contract research outsourcing services and the substitution of animal tissues by stem cells in the

The stem cells technology market was valued at USD 12.88 billion in 2013 and is expected to grow at a CAGR of over 12.0% during the forecast period. This market was dominated by the cell acquisitions technology segment in terms of share in 2013 owing to the fact that this technology serves as the foremost step to process involving stem cells culture. The global stem cell acquisition technology market is expected to reach USD 10.88 billion by 2020, growing at a CAGR of over 14.0% over the next six years.

The report Stem Cells Market Analysis By Product (Adult Stem Cells, Human Embryonic Cells, Pluripotent Stem Cells), By Application (Regenerative Medicine, Drug Discovery and Development) And Segment Forecasts To 2020, is available now to Grand View Research customers at http://www.grandviewresearch.com/industry-analysis/stem-cells-market

Request Free Sample of this Report @ http://www.grandviewresearch.com/industry-analysis/stem-cells-market/request

Further key findings from the study suggest:

Browse All Biotechnology Market Reports @ http://www.grandviewresearch.com/industry/biotechnology

For the purpose of this study, Grand View Research has segmented the global stem cells market on the basis of product, application, technology and region:

Latest Reports Published By Grand View Research:

Global Polymethyl Methacrylate (PMMA) Market Expected to Reach USD 10.87 Billion by 2020 (https://www.grandviewresearch.com/industry-analysis/polymethyl-methacrylate-pmma-industry)

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Stem Cells Market By Application (Regenerative Medicine), By Technology (Acquisition, Sub-Culture), By Product (Adult ...

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