Revision: Genetics
Download the Show Notes: http://learn.mindset.co.za/learn/sites/files/LXL2014/LXL_Gr12LifeSciences_12_Revision_Genetics_30Apr2014.pdf In this Gr 12 Life Sciences show we take another look...

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Revision: Genetics - Video

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Gene Therapy using SMaRT

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Gene Therapy using SMaRT - Video

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SCID gene therapy class

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SCID gene therapy class - Video

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Washington, DC (PRWEB) May 05, 2014

There will be a Media Event in Washington, DC, on Wednesday, May 21, 2014, from 10:45 am 12:15 pm in Wilson A of the Marriott Wardman Park Hotel, which is sponsored by the American Society of Gene & Cell Therapy (ASGCT).

The event will profile exciting clinical trial results in patients suffering from serious and often fatal diseases such as human immunodeficiency virus (HIV), Inherited Immunodeficiencies, Hemophilia B, and complications from Thrombosis. All registered media will have the opportunity for personal, one-on-one questions with academic and industry leaders in the field, including:

Dr. Bruce L. Levine of the University of Pennsylvania is developing a gene and cell therapy strategy to achieve a functional cure for HIV infection by genome editing of cells, and results from the first-in-human trial of this novel treatment strategy will be presented.

Professor Adrian Thrasher of the University College of Londons Institute of Child Health will discuss the impressive results of recent advances in gene therapy technology to treat inherited immunodeficiencies in patients, many of whom are children.

Researchers at St. Jude Children's Research Hospital have successfully treated Hemophilia patients with gene therapy that led to their disease-free living for several years. Dr. Andrew Davidoff will provide the latest update on these exciting clinical results.

Thrombosis, or the formation of blood clots inside a blood vessel, remains the major cause of death and disability in the western world. Dr. Bruce Sullenger of Duke University Medical Center will describe the recent development of gene and cell therapy strategies to control thrombosis that is currently in a Phase 3 clinical trial.

The media event will take place in Wilson A in the Marriott Wardman Park Hotel.

Members of the media are welcome to conduct individual interviews with each speaker following the presentation, and will receive complimentary full-access registration to the ASGCT 17th Annual Meeting. Representatives who wish to attend may contact ASGCT directly at 414.278.1341 or mdean(at)asgct(dot)org.

The American Society of Gene & Cell Therapy (ASGCT) is a professional nonprofit medical and scientific organization dedicated to the understanding, development and application of genetic and cellular therapies and the promotion of professional and public education in the field. For more information on ASGCT, visit its website, http://www.asgct.org.

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Gene and Cell Therapy for Thrombosis, AIDS and Inherited Disorders

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Newswise Orlando, Fla. In two separate studies, vision scientists have developed healthy genes to prevent blinding diseases that stem from genetic defects. The research is being presented at the 2014 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) this week in Orlando, Fla.

In a clinical trial to treat choroideremia, a rare disease that causes progressive and irreversible blindness, scientists developed a virus that can replace the missing gene (that causes the disease) in the cells at the back of the eye. Six months after the virus was injected into patients, findings showed that some patients experienced improved vision.

Abstract Title: Improved visual function in patients with choroideremia undergoing subretinal gene therapy Presentation Start/End Time: Sunday, May 4, 3:15 3:30pm Location: S 320AB Session Number: 147

In a separate study, researchers developed a gene therapy to stop the progression of a form of retinitis pigmentosa, an inherited disease transmitted from mothers to sons. Two years after the therapy was used to treat dogs at an early stage of the disease, the treatment remained effective. Further use of the technique in dogs with mid and late stages of the disease also resulted in a positive response to the intervention.

Abstract Title: RPGR gene augmentation delivered at early, mid and late stage disease in a canine model of XLRP rescues photoreceptor structure and function Presentation Start/End Time: Tuesday, May 6, 11am 12:45pm Location: Exhibit/Poster Hall SA Session Number: 342 # # #

The Association for Research in Vision and Ophthalmology (ARVO) is the largest eye and vision research organization in the world. Members include some 11,500 eye and vision researchers from over 70 countries. ARVO encourages and assists research, training, publication and knowledge-sharing in vision and ophthalmology.

All abstracts accepted for presentation at the ARVO Annual Meeting represent previously unpublished data and conclusions. This research may be proprietary or may have been submitted for journal publication.

Embargo policy: Journalists must seek approval from the presenter(s) before reporting data from paper or poster presentations. Press releases or stories on information presented at the ARVO Annual Meeting may not be released or published until the conclusion of the presentation.

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Gene Therapy Used to Preserve Sight in Patients

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Developing and testing a new anti-cancer drug can cost billions of dollars and take many years of research. Finding an effective anti-cancer medication from the pool of drugs already approved for the treatment of other medical conditions could cut a considerable amount of time and money from the process.

Now, using a novel bioinformatics approach, a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has found that the approved antimicrobial drug pentamidine may help in the treatment of patients with advanced kidney cancer. Described online in the journal Molecular Cancer Therapeutics, the discovery reveals how linking cancer gene expression patterns with drug activity might help advance cancer care.

"The strategy of repurposing drugs that are currently being used for other indications is of significant interest to the medical community as well as the pharmaceutical and biotech industries," says senior author Towia Libermann, PhD, Director of the Genomics, Proteomics, Bioinformatics and Systems Biology Center at BIDMC and Associate Professor of Medicine at Harvard Medical School. "Our results demonstrate that bioinformatics approaches involving the analysis and matching of cancer and drug gene signatures can indeed help us identify new candidate cancer therapeutics."

Renal cell cancer consists of multiple subtypes that are likely caused by different genetic mutations. Over the years, Libermann has been working to identify new disease markers and therapeutic targets through gene expression signatures of renal cell cancer that distinguish these different cancer subtypes from each other, as well as from healthy individuals. In this new paper, he and his colleagues were looking for drugs that might be effective against clear cell renal cancer, the most common and highly malignant subtype of kidney cancer. Although patients with early stage disease can often be successfully treated through surgery, up to 30 percent of patients with renal cell cancer present with advanced stages of disease at the time of their diagnosis.

To pursue this search, they made use of the Connectivity Map (C-MAP) database (http://www.broadinstitute.org/cmap), a collection of gene expression data from human cancer cells treated with hundreds of small molecule drugs.

"C-MAP uses pattern-matching algorithms to enable investigators to make connections between drugs, genes and diseases through common, but inverse, changes in gene expression," says Libermann. "It provided us with an exciting opportunity to use our renal cell cancer gene signatures and a new bioinformatics strategy to match kidney cancer gene expression profiles from individual patients with gene expression changes inducted by various commonly used drugs."

After identifying drugs that may reverse the gene expression changes associated with renal cell cancer, the investigators used assays to measure the effect of the selected drugs on cells. This led to the identification of a small number of FDA-approved drugs that induced cell death in multiple kidney cancer cell lines. The investigators then tested three of these drugs in an animal model of renal cell cancer and demonstrated that the antimicrobial agent pentamidine (primarily used for the treatment of pneumonia) reduced tumor growth and enhanced survival. Gene expression experiments using microarrays also identified the genes in renal cell cancer that were counteracted by pentamidine.

"One of the main challenges in treating cancer is the identification of the right drug for the right individual," explains first author Luiz Fernando Zerbini, PhD, of the International Center for Genetic Engineering and Biotechnology in Cape Town, South Africa, adding that this bioinformatics approach could be a particularly valuable lower-cost model in developing countries.

The authors say their next step will be to evaluate the potential of pentamidine in combination with the current standard-of-care therapies to treat kidney cancer. "Since the drugs we are evaluating are already FDA-approved, successful studies in preclinical animal models may enable us to rapidly move these drugs into clinical trials," adds Libermann.

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Bioinformatics approach helps researchers find new use for old drug

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Personalized Medicine 2.0 Webinar Series - Integrating Key Learnings Across the Organization
This webinar, the second in Diaceutics #39; series on Personalized Medicine (PM), focused on PM education across the pharmaceutical company from the R D team t...

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Personalized Medicine 2.0 Webinar Series - Integrating Key Learnings Across the Organization - Video

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Ron G, C4 SCI, walking at Project Walk Atlanta
C4 SCI, tetraplegic, after months of therapy at Project Walk Atlanta, and surely after being turned away from the Shepherd Center, we have progressed him to walking.

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Ron G, C4 SCI, walking at Project Walk Atlanta - Video

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Amanda #39;s New Life - Promo
Watch the full episode on AttitudeLive. http://attitudelive.com/documentary/amandas-new-life Amanda Lowry had just celebrated her master #39;s degree and birth of her second daughter when a surfing...

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Amanda's New Life - Promo - Video

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Santa Ana Personal Injury Attorney
If you have been seriously injured by the reckless act of another, you have a personal injury claim. At DiMarco Araujo and Montevideo, our attorneys have been helping injured victims of accidents...

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Santa Ana Personal Injury Attorney - Video

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Chair-Leader #39;s 2013
CEO Doug Newson of Charlottetown Airport Authority talks about being a Chair-Leader in 2013.

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Chair-Leader's 2013 - Video

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Pediatric Cardiologist Dr. Abraham Rudolph on Regenerative Medicine
Nationwide Children #39;s was honored to host world-renowned pediatric cardiologist Dr. Abraham Rudolph at our hospital. Hear his comments on future opportunitie...

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Pediatric Cardiologist Dr. Abraham Rudolph on Regenerative Medicine - Video

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Scottsdale, Arizona (PRWEB) May 05, 2014

Top Phoenix and Scottsdale foot and ankle doctors at Valley Foot Surgeons are now offering stem cell procedures for the nonoperative treatment of Achilles tendonitis and tears. The regenerative medicine procedures are typically able to provide exceptional pain relief while allowing patients the ability to avoid surgery. Call (480) 420-3499 for more information and scheduling about the foot and ankle stem cell procedures.

To date, the lead foot and ankle doctor at Valley Foot Surgeons, Dr. Richard Jacoby, has performed close to 100 regenerative medicine procedures. Typically, these are administered for a variety of conditions such as diabetic ulcers, foot and ankle arthritis, plantar fasciitis, and Achilles injuries.

Conditions with the Achilles tendon may include pain due to chronic tendonitis or tears from degeneration. This may occur during a sporting activity, traumatic event, or simply as part of an individual's tendon weakening after taking quinolone antibiotics.

The stem cell procedures are performed as an outpatient, with the injections consisting of amniotic derived stem cells. The material is harvested from consenting donors after scheduled c-section procedures, with no fetal tissue at all being used.

The material is exceptionally rich in stem cells, growth factors, hyaluronic acid, and more. This can dramatically improve pain relief and healing, which is very different from how steroid medications work.

All too often, traditional treatments for Achilles tendonitis and tears fail to provide relief. This may lead to potentially risky surgery, where complications may lead to continued disability.

With the stem cells for Achilles tears and tendonitis, patients go through an outpatient procedure that is low risk and offers the potential for avoiding the risks of surgery while speeding up recovery.

Dr. Jacoby at Valley Foot Surgeons has been a four time Phoenix Top Doc Winner and sees patients out of two offices in the Valley. For the top stem cell treatment for achilles conditions, diabetic wounds, foot and ankle arthritis and more, call (480) 420-3499.

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Valley Foot Surgeons Now Offering Stem Cell Procedures for Achilles Tendonitis and Tears for Pain Relief and Helping ...

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Hip and knee arthritis 5 months after stem cell therapy by Dr Harry Adelson
Richard describes his outcome 5 months after stem cell therapy by Dr Harry Adelson for his hip and knee arthritis http://www.docereclinics.com.

By: Harry Adelson, N.D.

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Hip and knee arthritis 5 months after stem cell therapy by Dr Harry Adelson - Video

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by Andrea Lutz

KTVB.COM

Posted on May 4, 2014 at 9:41 PM

Updated yesterday at 11:04 PM

BOISE -- Modern medicine and early detection are helping women in the fight against breast cancer, but recently a decision in our nation's highest court has made it easier to afford the cost of genetic cancer testing.

The Saint Alphonsus Breast Cancer Center in Boise reports that one in 500 breast cancer cases women have what's called the BRCA gene mutation.

Saint Als Breast Surgeon Elizabeth Prier says knowledge of the BRCA gene has been around for the last decade, and identifying at-risk women has intesified in the last five years.

A lot of women with BRCA1 will end up with breast cancer in their 30s sometimes in their late 20s, said Dr. Prier.

That means women end up starting their fight with the disease earlier.

Annie Pierce, a wife and mother of two, ended her battle with breast cancer before it even started.

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Breast cancer test made famous by Angelina Jolie now more affordable

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The Sims 3: Perfect Genetics Challenge- {Part 1} Meet Khaleesi.
Read Me. *Warning* The first couple of episodes of this LP were recorded all at once, and the audio got kind of weird there for a bit, but still new at this so please don #39;t...

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The Sims 3: Perfect Genetics Challenge- {Part 1} Meet Khaleesi. - Video

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The Sims 3: Perfect Genetics Challenge- {Part 1.5} Got Shot Down!
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The Sims 3: Perfect Genetics Challenge- {Part 1.5} Got Shot Down! - Video

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The Sims 3 | Perfect Genetics Challenge Part 1: One Woohoo Down
Hey guys and welcome to Part 1 of my new lets play! Backstory: "Once upon a time, the Mighty Player sent a Sim to live in the world where all its creations were living happily. But this...

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The Sims 3 | Perfect Genetics Challenge Part 1: One Woohoo Down - Video

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VaderOG Genetics Week 8 HD1080p
VaderOG Genetics Strains : Merlot OG, Witch Brew,Witch Hunt,Bubble Krush,

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VaderOG Genetics Week 8 HD1080p - Video

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Diaceutics Personalized Medicine 2.0 - Integrating Key Learnings Across the Organization
This webinar, the second in Diaceutics #39; series on Personalized Medicine (PM), will focus on PM education across the pharmaceutical company from the R D tea...

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Diaceutics Personalized Medicine 2.0 - Integrating Key Learnings Across the Organization - Video

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Neural Prolotherapy for Carpal Tunnel Syndrome at NYC
VinciHealth.com: Igor Ostrovsky MD, PhD performs neural prolotherapy for carpal tunnel syndrome. Neural Prolotherapy is a powerfully effective new development in the world of regenerative medicine....

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Neural Prolotherapy for Carpal Tunnel Syndrome at NYC - Video

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A new development in fertility treatment scientists have successfully produced early-stage sperm cells from the skin cells of infertile men.

According to the study, Stanford University researchers took skin cells from infertile men, turned them into stem cells known as induced pluripotent stem cellsand then implanted those cells in the tubules of mice testes. (Via Flickr / 7715592@N03,33852688@N08)

Before we move forward, you might be wondering how scientists turned skin cells back into stem cells. This video from Stem Cell Network sums up the process.

"If some adult cell types are taken, grown in plastic dishes and given specific genetic instructions, over time a small number of these cells will reverse from their differentiated state and develop the ability to redifferentiate."(Via Vimeo /Stem Cell Network)

Researchers discovered the stem cells developed into germ cells, the precursor to sperm cells. (Via YouTube / CreekValleyCritters)

But while this new development seemingly bodes well for future fertility treatment, a writer for The Guardian points out one major concern.

"The cells that lodged in the tubules developed into early-stage sperm cells, but others turned into small tumours. The danger of causing cancer in the men is one of the major risks that scientists need to overcome." (Via The Guardian)

And LiveScience reports the research is still in its infancy, noting even though the stem cells produced germ cells, they "did not go on to form mature sperm in the mice."The head researcher for the study told LiveScience this is likely because of the "evolutionary differences between humans and mice."

Despite concerns, Nature World News says this research has potential, because there are various uses for the treatment. "There is also the possibility of using cells from endangered species to help boost their reproduction."

According to the American Society for Reproductive Medicine, about 12 percentof adults suffer from infertility. The study has been published in the journal Cell Reports.

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Human skin cells used to create sperm cells

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Scientists have turned skin tissue from infertile men into early-stage sperm cells in a groundbreaking study that raises hopes for new therapies for the condition.

The unexpected success of the procedure has stunned some scientists, because it was thought to be impossible for the men to make any sperm.

The men who took part in the study had major genetic defects on their Y sex chromosomes, which meant they could not produce healthy adult sperm on their own.

About 1% of men cannot make any sperm, a condition known as azoospermia, while a fifth of men have low sperm counts. Male fertility is a concern for roughly half of couples who seek IVF treatment.

In the latest study, researchers took skin cells from three infertile men and converted them into stem cells, which can grow into almost any tissue in the body. When these cells were transplanted into the testes of mice, they developed into early-stage human sperm cells.

What we found was that cells from men who did not possess sperm at the time of clinical observation were able to produce the precursors for sperm, said Cyril Ramathal, of Stanford University.

Skin cells from infertile men grew into fewer early-stage sperm cells than cells taken from normally fertile men, the study found.

The research is at an early stage, but scientists suspect that the converted skin cells might have grown into mature sperm cells if they had been transplanted into the infertile mens testes.

If further work confirms the suspicion, it may be possible to restore male fertility by taking mens skin cells, turning them into stem cells, and injecting these into their testes. The same might be done for men who are left infertile after having chemotherapy for cancer.

Being able to efficiently convert skin cells into sperm would allow this group to become biologic fathers, said Michael Eisenberg, director of male reproduction and surgery at Stanford, who was not involved in the study. Infertility is one of the most common and devastating complications of cancer treatments, especially for young boys and men.

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Scientists turn tissue from infertile men into sperm cells

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Here is a new development in fertility treatment: Scientists have successfully produced early-stage sperm cells from the skin cells of infertile men.

According to thestudy, Stanford University researchers took skin cells from infertile men, turned them into stem cells known as induced pluripotent stem cells, and then implanted those cells in the tubules of mice testes. (ViaFlickr / 7715592@N03,33852688@N08)

Before we move forward, you might be wondering how scientists turned skin cells back into stem cells. Stem Cell Networksummed up the process: "If some adult cell types are taken, grown in plastic dishes and given specific genetic instructions, over time a small number of these cells will reverse from their differentiated state and develop the ability to redifferentiate."(ViaVimeo /Stem Cell Network)

>> Read more trending stories

Researchers discovered the stem cells developed into germ cells, the precursor to sperm cells. (ViaYouTube /CreekValleyCritters)

But while this new development seemingly bodes well for future fertility treatment, a writer forThe Guardianpoints out one major concern: "The cells that lodged in the (mice) tubules developed into early-stage sperm cells, but others turned into small tumors. The danger of causing cancer in the men is one of the major risks that scientists need to overcome."(ViaThe Guardian)

Despite concerns,Nature World Newssays this research has potential, because there are various uses for the treatment."There is also the possibility of using cells from endangered species to help boost their reproduction," the organization reported.

According to theAmerican Society for Reproductive Medicine, about 12 percentof adults suffer from infertility. The study has been published in the journal Cell Reports.

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Scientists use human skin to create sperm cells

Recommendation and review posted by Bethany Smith

Health authorities on Saturday reissued warnings against health facilities and medical practitioners offering stem-cell therapies or related products, which promise to cure a range of diseases, arrest the aging process or even increase libido.

In an advisory, the Food and Drug Administration stressed that to date not one stem cell or human cells, tissues, and cellular and tissue-based products (HCT/Ps) that applied for registration has been registered by the FDA for compassionate or clinical trial use or for general use.

The use of HCT/Ps without the authorization or permission by the FDA is considered illegal, it said. The agency warned hospitals and health facilities of the provisions of the FDA Act of 2009, which prohibits the manufacture, use, advertisement or sponsorship of unregistered health products.

This warning extends to all unlicensed practitioners from other countries and to tourists who visit the Philippines for leisure and medical needs.

According to FDA acting director general Kenneth Hartigan Go, the FDA recognizes only hematopoietic (pertaining to the formation and development of blood cells) stem-cell transplantation, corneal resurfacing with limbal stem cells and skin regeneration with epidermal stem cells as generally accepted standards of healthcare procedures.

If health institutions are doing these three procedures, they can continue because those are allowed, Go said.

But the efficacy of the use of stem cells for the treatment of other diseases, such as diabetes, cancer and autism, among others, have yet to be proven, he said.

Go noted that while many spa centers and salons are advertising stem-cell therapy treatment and products, none of them have secured the FDAs approval. As of now, we have not accredited any health facility offering stem-cell therapy yet.

Applicants with deficiencies

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FDA: No way spas can do stem-cell therapy

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