2014 Shining Knight Gala: Cole Sydnor #39;s Story
Cole Sydnor wants to share his experience to help others avoid a crippling spinal cord injury.

By: VCU Medical Center

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Cubital Tunnel Post Op: Spinal Cord Injury
This video is a description of my experience of cubital tunnle decompression surgery while a quadriplegic who has a C6/7 spinal cord injury Walk 4 a Cure! Fa...

By: Matt Valente

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Fate Therapeutics

By: Alliance for Regenerative Medicine

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Fate Therapeutics - Video

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Argos Therapeutics

By: Alliance for Regenerative Medicine

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Osiris Therapeutics

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StemCells, Inc.

By: Alliance for Regenerative Medicine

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Regeneus

By: Alliance for Regenerative Medicine

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April 1, 2014

University of Nottingham

Scientists at The University of Nottingham have developed a new substance which could simplify the manufacture of cell therapy in the pioneering world of regenerative medicine.

Cell therapy is an exciting and rapidly developing area of medicine in which stem cells have the potential to repair human tissue and maintain organ function in chronic disease and age-related illnesses. But a major problem with translating current successful research into actual products and treatments is how to mass-produce such a complex living material.

There are two distinct phases in the production of stem cell products; proliferation (making enough cells to form large tissue) and differentiation (turning the basic stem cells into functional cells). The material environment required for these two phases are different and up to now a single substance that does both jobs has not been available.

Now a multi-disciplinary team of researchers at Nottingham has created a new stem cell micro-environment which they have found has allowed both the self-renewal of cells and then their evolution into cardiomyocyte (heart) cells. The material is a hydrogel containing two polymers an alginate-rich environment which allows proliferation of cells with a simple chemical switch to render the environment collagen-rich when the cell population is large enough. This change triggers the next stage of cell growth when cells develop a specific purpose.

Major priority

Professor of Advanced Drug Delivery and Tissue Engineering, Kevin Shakesheff, said:

Our new combination of hydrogels is a first. It allows dense tissue structures to be produced from human pluripotent stem cells (HPSC) in a single step process never achieved before. The discovery has important implications for the future of manufacturing in regenerative medicine. This field of healthcare is a major priority for the UK and we are seeing increasing investment in future manufacturing processes to ensure we are ready to deliver real treatments to patients when HPSC products and treatments go to trial and become standard.

The research, Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation, is published in the Proceedings of the National Academy of Sciences (PNAS).

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Big Breakthrough In Stem Cell Manufacturing Technology

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Graham Parker, 41, from County Durham is one of first to benefit from trial Some participants were given stem cells and the rest placebo Stem cells were taken from bone marrow in his hip and injected into heart Years later Graham feels better - but still classed as having heart failure

By Carol Davis

PUBLISHED: 18:04 EST, 31 March 2014 | UPDATED: 18:25 EST, 31 March 2014

Graham Parker took part in a trial using stem cells to repair heart damage

A major new trial is using patients' own stem cells to treat heart failure. One of the first to benefit is Graham Parker, 41, an archaeology student from Stanley, County Durham. He tells CAROL DAVIS his story.

Working as a supply teacher a few years ago, I started feeling exhausted. I couldn't walk more than 50 metres without pausing, was constantly breathless and would wake at night coughing.

At first I thought it was a cold or flu, or the stress of a house move. But my mum, a retired nurse, pointed out I'd been ill for two months, and sent me to the doctor.

The GP suspected asthma, and gave me an inhaler. But within a week it was worse and I couldn't walk more than a few yards without retching.

So I saw a second GP. She didn't say what she thought it was - she called an ambulance instead. I was admitted to the Queen Elizabeth Hospital in Gateshead, then transferred to the Freeman Hospital in Newcastle while they ran several tests, including an ECG (electrocardiogram) and MRI (magnetic resonance imaging) scan.

Doctors explained I had heart failure: part of my heart muscle was damaged and the lower pumping chamber had become flabby so couldn't pump blood round my body properly. This was why I was so exhausted.

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Revolutionary stem cell op to treat heart failure

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Viruses were traditionally thought to be malicious nanoscopic bearers of death and destruction. But modern science has suggested that while that is sometimes the case, the relationship between viruses and living organisms is a complicated one, as is the question of whether viruses can be truly considered "living" organisms. I. Viruses Can Actually be Useful, Sometimes In case newly discovered mega-viruses -- which rival small bacteria in size, function, and genetic complexity (and are sometimes "infected" by other viruses) -- aren't mind-warping enough, recent evidence suggests that as much of 8 percent of the genetic material found in higher organisms such as humans may be "borrowed" from viral genomes. These pieces of DNA are identifiable, if you know what you're looking for, but long ago lost their ability to depart and jump to new hosts. In that regard, mankind can be viewed as similar in some ways to lichen -- as a collection of multiple fused "organisms" living as one -- as modern man's genetic code consists of virus and traditional eukaryotic genes functioning side by side. The latest wild discovery comes courtesy of Montreal, Quebec, Canada's McGill University.

Professor Bourque states in an interview with National Geographic:

[Acquiring useful genes from viruses] can be faster than just relying on random mutations to get something that might work.

[These genes should be examined] to see if they have also evolved new functional roles, like HERV-H did in stem cells. We suspect that these genes may play important roles in other cell types as well, such as liver, kidney, and brain.

Sources: NATURE STRUCTURAL & MOLECULAR BIOLOGY, National Geographic

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Primate Stem Cell Creation Appears Driven by Genes From Ancient Virus

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I WAS a bit apprehensive when asked to test the La Mer lifting and firming mask. The first time I tried a La Mer product the Lifting Contour Serum it did not give good results.

This was a high-end sculpting serum for face and neck, said to give skin a tighter feel and visibly define and re-shape contours as well as redefine the appearance of the skin.

It is claimed that after using the serum for four weeks, the contours of the jaw line would look more lifted and skin appear firm and more defined.

Unfortunately, I did not get the promised results. In fact, after using it for four days, my skin turned red. I felt a stinging sensation when I applied the serum. Then my skin started to peel, especially on my forehead and cheeks. There was also a small red patch near my right eye. Clearly, some ingredients in the serum did not react well with my skin.

Worried that it would turn worse, I stopped using the serum. La Mer consultant education manager Carina Choo wanted to find out what was wrong.

TOO DRY After discussing my skincare regime, she thought it could be that my skin was dry. The serum tried to repair my skin cells which resulted in the peeling and a stinging sensation.

Well, I do have dry skin. For the past few years, I have been using a moisturiser during the day to ease the problem. Choo said while it is good to do so, it is more important to use skincare products at night.

Our skin is repaired between 10pm and 2am. This is why we need to go to sleep before 10pm so that our skin can get enough rest. Before that, it is important to wash the face, use a toner and apply moisturiser that does not have a sun protection factor.

She suggested that I try the lifting and firming mask which works to repair skin at night. It is a sleep-on mask and works well at night to repair skin.

Choo said the mask boosts skin energy and encourages cell renewal for more radiant and retexturised skin. So, you literally wake up to beautiful skin.

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TRIED & TESTED: Wake up to beautiful skin

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St. Petersburg, FL (PRWEB) April 01, 2014

Sublime Beauty has recently introduced its newest serum which makes a positive impact on aging skin within 30 days.

Cell Renewal | Fibroblast Serum is discounted 35% for 2 days only at the company webstore, SublimeBeautyShop with coupon code CELLRENEW35.

"A key ingredient is Human Fibroblast Conditioned Media, rich in proteins and growth factors, that instruct the skin's fibroblasts to product collagen," says Kathy Heshelow, founder of Sublime Beauty. "The non-embryonic stem cells are powerful indeed - no fillers are used."

The company offers a free brochure about the ingredients on the product page. "We find that our customers want to know about ingredients in the product, what they do and what to expect." says Heshelow. "We offer lots of education on our products."

Sublime Beauty focuses on anti-aging and healthy-skin oriented products, from Skin Brushing and collagen boosters to organic products for the skin. It specializes in serums.

The company offers free standard shipping within the continental U.S and a Sublime Beauty VIP Club. Interested clients can sign up for secret deals and deep discounts as well.

The 35% off sale ends Wednesday at midnight.

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The New Scientific Serum That Helps Skin Become Younger and Healthier on Sale at Sublime Beauty Now

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Just weeks after invalidating a groundbreaking paper describing a simple technique for generating pluripotent stem cells, professor Kenneth Ka Ho Lee now believes he has identified the correct approach.

Lee, chief of stem cell research at the Chinese University of Hong, spoke to Wired.co.uk in March about his tentative excitement when he read the Nature study in question, published at the start of the year. The proposed Stap cells (stimulus-triggered acquisition of pluripotency) in it were a revelation, because they suggested there was a simple way to generate embryonic-like stem cells that could potentially be used in the treatment of diseases such as Parkinson's. The method involved reprogramming a donor's own adult blood and skin cells (in this case, mice) by exposing them to extreme trauma, such as an acid bath.

Lee could see its potential, but like the rest of the community he had his doubts. While reports circulated that the images published in the Nature study also featured in older papers penned by lead researcher Haruko Obokata of Japan's Riken Centre, Lee set about trying to replicate the experiment himself.

It didn't work.

Since then the Riken Centre has launched an investigation into the legitimacy of the trial, and that investigation today revealed Obokata had indeed falsified information, including results and images of DNA fragments used.

"Actions like this completely destroy data credibility," commented Shunsuke Ishii, head of the investigative committee and a Riken molecular geneticist, at a press conference. "There is no doubt that she was fully aware of this danger. We've therefore concluded this was an act of research misconduct involving fabrication." Obokata has denied the allegations, but Riken says its own research team will be the one to verify the results and carry out the experiment again.

In the interim however, a coauthor on the paper at the centre of the debacle,Charles Vacanti published yet another protocol for the Stap technique. Vacanti, of ear-on-a-mouse fame, is a professor at Harvard Medical School and published online what he said was found to be "an effective protocol for generating Stap cells in our lab, regardless of the cell type being studied". It was a combination of the two approaches mentioned in the Naturepaper -- the acid bath, and the trituration process (the application of pressure on the cells using pipettes to induce stress). He describes the latter process as being exerted with force, more so than in the original paper, and over a lengthy period -- twice a day for the first week.

Nature had already rejected Lee's version of experiments for publication last month. Undeterred, he set about applying Vacanti's technique. Liveblogging the experiments on ResearchGate, the open source platform where Lee had published his first set of experiments, the Hong Kong researcher immediately saw the excess stress was leading to rapid cell death among the lung fibroblast cells used.

"We estimated that there was a 50 percent decrease in cell number," Lee wrote four days ago on the blog. "In the original paper reported in Nature, such decrease in cell count was reported for day two, which is inline with our current experiment. Day three will be critical as this was the time Oct4-GFP expression [an indication that stem cells are generating] was reported for Stap cells. If we find that the cell number decreased even more drastically in our cultures, we will harvest some of the cultures and use them directly for qPCR analysis [quantitative polymerase chain reaction,a screening technique for stem cells]."

Nevertheless, things appeared to turn around. In his preliminary studies Lee has concluded that it could be the extreme stress through trituration, and not the acid bath, that was responsible for creating the Stap cells. "I am shocked and amazed by the qPCR results for the three-day-old control and Stap cultures," he wrote on ResearchGate, alongside a graph of the results. "Totally speechless!"

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'Fabricated' stem cell paper may have just been proven valid

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Topics: cancer council queensland, melanoma

AN INTERNATIONAL research project co-funded by Cancer Council Queensland has identified a gene mutation that puts people at an extremely high risk of developing melanoma.

The research team, including scientists from QIMR Berghofer Medical Research Institute, found mutations in the POT1 gene caused a hereditary form of melanoma.

Cancer Council Queensland spokeswoman Kim Ryan said the study would help identify, screen and monitor people who are more susceptible to the disease.

"This discovery will allow people in the high risk category for melanoma to hopefully prevent their chances of getting the disease by being extra vigilant about their health and sun safety," Ms Ryan said.

"We know that many families have a high incidence of melanoma and this gene gives us a better understanding of why.

"Identifying the faulty gene will give people a better chance of preventing, detecting and hopefully treating the disease - with scientists highlighting the gene as a potential drug target.

"In future, this early detection may mean better treatment options."

Scientists have previously identified the genetic mutations responsible for about 40 per cent of all familial cases of melanoma.

This finding accounts for a further 3 per cent of cases, where the mutations inactivate the POT1 gene which would otherwise protect the ends of our chromosomes from damage.

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Scientists identify gene that can increase melanoma risk

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Newswise Right now, options are limited for preventing heart attacks. However, the day may come when treatments target the heart attack gene, myeloid related protein-14 (MRP-14, also known as S100A9) and defang its ability to produce heart attack-inducing blood clots, a process referred to as thrombosis.

Scientists at Case Western Reserve School of Medicine and University Hospitals Case Medical Center have reached a groundbreaking milestone toward this goal. They have studied humans and mice and discovered how MRP-14 generates dangerous clots that could trigger heart attack or stroke, and what happens by manipulating MRP-14. This study describes a previously unrecognized platelet-dependent pathway of thrombosis. The results of this research will appear in the April edition of The Journal for Clinical Investigation (JCI).

This is exciting because we have now closed the loop of our original finding that MRP-14 is a heart attack gene, said Daniel I. Simon, MD, the Herman K. Hellerstein Professor of Cardiovascular Research and Medicine at the School of Medicine and director of the University Hospitals Harrington Heart & Vascular Institute. We now describe a whole new pathway that shows clotting platelets have MRP-14 inside them, that platelets secrete MRP-14 and that MRP-14 binds to a platelet receptor called CD36 to activate platelets.

This translational research has moved back and forth from the cardiac catheterization laboratory investigating patients presenting with heart attack to the basic research lab probing mechanisms of disease. The clinical portion of this research yielded a visually stunning elementblood clots extracted from an occluded heart artery loaded with MRP-14 containing platelets.

It is remarkable that this abundant platelet protein promoting thrombosis could have gone undetected until now, Simon said.

In detailed studies using MRP-14-deficient mice, the investigators discovered MRP-14 in action. One key finding is that, while MRP-14 is required for pathologic blood clotting, it does not appear to be involved in the natural, primary hemostasis response to prevent bleeding.

The practical significance of this research is that it may provide a new target to develop more effective and safer anti-thrombotic agents, Simon said. Current anti-clotting drugs are subject to significant bleeding risk, which is associated with increased mortality.

If we could develop an agent that affects pathologic clotting and not hemostasis, that would be a home run, Simon said. You would have a safer medication to treat pathologic clotting in heart attack and stroke.

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Heart Attack Gene, MRP-14, Triggers Blood Clot Formation

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Genetic Engineering by Nopparat
Genetic Engineering present by Nopparat Chartmontree (Mind) Biology major@Phetchaburi Rajabhat University Smile Bio ... ^^

By: prasert sert

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PUBLIC RELEASE DATE:

1-Apr-2014

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 x2156 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, April 1, 2014 -- Rare, very small embryonic-like stem cells (VSELs) isolated from human adult tissues could provide a new source for developing regenerative therapies to repair complex tissues damaged by disease or trauma. The ability of these most-primitive, multipotent stem cells to differentiate into bone, neurons, connective tissue, and other cell types, and the proper criteria for identifying and isolating VSELs, are described in two articles in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The articles are available on the Stem Cells and Development website.

Russ Taichman and coauthors, University of Michigan (Ann Arbor) and NeoStem (New York, NY), implanted human VSELs into the cavity created by a cranial wound and provided the first demonstration that they could generate tissue structures containing multiple cell types. Their work is presented in "Human and Murine Very Small Embryonic-Like (VSEL) Cells Represent Multipotent Tissue Progenitors, In Vitro and In Vivo."

Malwina Suszynska et al., University of Louisville, KY, and Pomeranian Medical University (Szczecin) and Jagiellonian University (Krakow), Poland, explore the challenges in isolating these rare stem cells and the importance of not confusing VSELs with other types of embryonic or reprogrammed adult pluripotent stem cells, or with monopotent adult stem cells. In the Issues in Development article "The Proper Criteria for Identification and Sorting of Very Small Embryonic-Like Stem Cells (VSELs), and Some Nomenclature Issues," the authors present the most current descriptions and terminology for characterizing VSELs.

"I find the data presented by the Taichman group to be compelling and challenging. However, the current debate as to the significance of the body of publications concerning VSELs can only be resolved by a cooperative investigation across laboratories using identical methodologies and source materials," says Editor-in-Chief Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.

###

About the Journal

Stem Cells and Development is an authoritative peer-reviewed journal published 24 times per year in print and online. The Journal is dedicated to communication and objective analysis of developments in the biology, characteristics, and therapeutic utility of stem cells, especially those of the hematopoietic system. Complete tables of content and a free sample issue may be viewed on the Stem Cells and Development website.

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First evidence that very small embryonic-like stem cells

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15 hours ago

Microbiologists from Trinity College Dublin have discovered that an identical protein is used differently by two species of bacteria to help them cope with distinct types of environmental stress. The discovery reveals an extraordinary level of versatility in the way different genes are 'switched on' in bacteria, which in turn helps to explain how they evolve so quickly.

The microbiologists showed that the same protein, called 'OmpR, which is responsible for binding to specific sections of DNA, governs the way a large cohort of genes function in both a human-friendly strain of Escherichia coli (E. coli) and in the potentially deadly Salmonella enterica serovar Typhimurium (S. Typhimurium).

In E. coli, OmpR is central to the ability of the bacterium to survive sudden stress caused by water moving in and out of its cells due to changing external conditions. In S. Typhimurium, however, OmpR is a key regulator of a series of actions that enable individual bacteria to respond to and survive acid stress. Such conditions are experienced, for example, in the hostile environment found in the bacteria-destroying vacuoles of macrophages, which are cells of the immune system that Salmonella can defeat using specialist pathogenic genes.

The microbiologists identified all the OmpR binding sites in the chromosomes of both species and investigated the features that attracted OmpR to them. The sites were rich in the DNA bases adenine (A) and thymine (T), which bind to one another to help form the classic double helix structure associated with DNA.

Importantly, the DNA of S. Typhimurium alters its shape after a bacterium is exposed to acid. This change in shape, called DNA relaxation, enhances the attractiveness of the OmpR binding sites for the OmpR protein. The same relaxation does not occur in E. coli.

Professor and Head of Microbiology at Trinity, Charles Dorman, said: "This work shows that DNA is not a passive partner when genes are switched on, but that it is an active and dynamic participant in the process. And, among the many OmpR targets possessed by S. Typhimurium that are not present in E. coli are the genes that make Salmonella pathogenic, and problematic for people."

Scientists believe that the pathogenic genes were acquired through horizontal gene transfer. This process is mediated by direct contact between bacteria, by special viruses called bacteriophages, or by direct uptake of DNA from the environment. The transfer essentially represents the passing of DNA's all-important codes between individuals, and is often associated with the development and evolution of antibiotic resistance.

The scientists suspect that this DNA code sharing occurred after Salmonella and E. coli separated from their last common ancestor, earlier in the two species' unique evolutionary journeys, which is why the pathogenic genes are not present in E. coli. The DNA sequences of these genes confirm that they are very rich in A and T bases, which is a key characteristic they share with the OmpR binding sites.

Functionally, this means that these genes have the appropriate structural profile for rapid interaction with the OmpR DNA binding protein, which regulates when, and to what degree, they are 'switched on'. This profile, coupled with the DNA relaxation that accompanies acid stress in Salmonella, may have allowed OmpR to 'tame' these imported genes and embed them in the acid stress response of Salmonella bacteria.

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Versatility in genetic expression aids rapid microbial evolution

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FTB HorizonMinecraft Mod FTB Horizons - 36 - No mas Jetpack! - (Advanced Genetics) (En Espaol)
Buenos dias! Espero que les guste el episodio de hoy, si es asi deja un like! ayuda muchisimo!! Y si aun no estas suscripto al canal, suscribete! y no te pie...

By: Nedrek Games

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FTB HorizonMinecraft Mod FTB Horizons - 36 - No mas Jetpack! - (Advanced Genetics) (En Espaol) - Video

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Accelerated Genetics Cooperative Initiative
Accelerated Genetics Annual Cooperative Business Meeting held every year in January. Hosted by the Board of Directors this event is open to all members of Ac...

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Accelerated Genetics Cooperative Initiative - Video

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Anorexia Nervosa Genetics Initiative (ANGI)
Anorexia Nervosa Genetics Initiative (ANGI) will create the worlds largest database of DNA samples of people with and without eating disorders. Led by UNC Pr...

By: UNC Health Care

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Anorexia Nervosa Genetics Initiative (ANGI) - Video

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VaderOG Genetics Week 3 Flower HD720p
Merlot OG Witch Hunt Witch Brew Bubble Krush.

By: klitzo420

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VaderOG Genetics Week 3 Flower HD720p - Video

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NCEA level 1 Genetics DNA replication and cell division
In this video I review the steps in DNA replication and then show its importance in the process of cell division (Mitosis and Meiosis)

By: MrHughesNZ

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Genetics BodyBuilding, Cardio Routine
http://www.FitnessWithAJ.com CELLUCOR DISCOUNT CODE: ajFitness TWITTER: http://www.twitter.com/fitnesswithaj FACEBOOK: http://www.facebook.com/FitnessWithAJ ...

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Genetics & BodyBuilding, Cardio Routine - Video

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Edgar Martinez con Sparky. International Top Genetics. 6981.5000
Sparky luciendo sus conocimientos y trucos! Jack Russell Terrier (Sparky) Sguenos en nuestras redes sociales: youtube: http://www.youtube.com/user/itopgenetics Goo...

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Edgar Martinez con Sparky. International Top Genetics. 6981.5000 - Video

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