Hunter - T-6 Spinal Cord Injury Pull-Ups
Pressing On client Hunter doing pullups without assistance. Great job! For more info on Pressing On Neuro-Fitness, a non-profit gym for neurological disorder...

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68 1st Spinal Cord Injury
68 1st Spinal Cord Injury.

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PUBLIC RELEASE DATE:

9-Feb-2014

Contact: News & Information Office press.office@admin.ox.ac.uk 44-018-652-80530 University of Oxford

Seven new genetic regions associated with type 2 diabetes have been identified in the largest study to date of the genetic basis of the disease.

DNA data was brought together from more than 48,000 patients and 139,000 healthy controls from four different ethnic groups. The research was conducted by an international consortium of investigators from 20 countries on four continents, co-led by investigators from Oxford University's Wellcome Trust Centre for Human Genetics.

The majority of such 'genome-wide association studies' have been done in populations with European backgrounds. This research is notable for including DNA data from populations of Asian and Hispanic origin as well.

The researchers believe that, as more genetic data increasingly become available from populations of South Asian ancestry and, particularly, African descent, it will be possible to map genes implicated in type 2 diabetes ever more closely.

'One of the striking features of these data is how much of the genetic variation that influences diabetes is shared between major ethnic groups,' says Wellcome Trust Senior Investigator Professor Mark McCarthy from the University of Oxford. 'This has allowed us to combine data from more than 50 studies from across the globe to discover new genetic regions affecting risk of diabetes.'

He adds: 'The overlap in signals between populations of European, Asian and Hispanic origin argues that the risk regions we have found to date do not explain the clear differences in the patterns of diabetes between those groups.'

Among the regions identified by the international research team are two, near the genes ARL15 and RREB1, that also show strong links to elevated levels of insulin and glucose in the body two key characteristics of type 2 diabetes. This finding provides insights into the ways basic biochemical processes are involved in the risk of type 2 diabetes, the scientists say.

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Gym Genetics
If you don #39;t like to go to the gym, it may not be your fault. See how you can overcome "DNA" and stay healthy.

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Interview with Brien Foerster -- Unravelling the Genetics of Elongated Skulls
In this revealing interview, Brien Foerster sheds lights on DNA testing undertaken on one of the Paracas elongated skulls. More than 300 of these elongated s...

By: Ancient Origins

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Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social | Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics Evolutionary psychology Neuroanatomy Neurochemistry Neuroendocrinology Neuroscience Psychoneuroimmunology Physiological Psychology Psychopharmacology (Index, Outline)

Gene therapy is the insertion of genes into an individual's cells and tissues to treat a disease, and hereditary diseases in particular. Gene therapy typically aims to supplement a defective mutant allele with a functional one. Although the technology is still in its infancy, it has been used with some success. Antisense therapy is not strictly a form of gene therapy, but is often lumped together with them.

In the 1980s, advances in molecular biology had already enabled human genes to be sequenced and cloned. Scientists looking for a method of easily producing proteins such as insulin, the protein deficient in diabetes mellitus type 1 investigated introducing human genes to bacterial DNA. The modified bacteria then produce the corresponding protein, which can be harvested and injected in people who cannot produce it naturally.

On September 14, 1990 researchers at the U.S. National Institutes of Health performed the first approved gene therapy procedure on four-year old Ashanti DeSilva. Born with a rare genetic disease called severe combined immunodeficiency (SCID), she lacked a healthy immune system, and was vulnerable to every passing germ. Children with this illness usually develop overwhelming infections and rarely survive to adulthood; a common childhood illness like chickenpox is life-threatening. Ashanti led a cloistered existence--avoiding contact with people outside her family, remaining in the sterile environment of her home, and battling frequent illnesses with massive amounts of antibiotics.

In Ashanti's gene therapy procedure, doctors removed white blood cells from the child's body, let the cells grow in the lab, inserted the missing gene into the cells, and then infused the genetically modified blood cells back into the patient's bloodstream. Laboratory tests have shown that the therapy strengthened Ashanti's immune system; she no longer has recurrent colds, she has been allowed to attend school, and she was immunized against whooping cough. This procedure was not a cure; the white blood cells treated genetically only work for a few months, and the process must be repeated every few months. (VII, Thompson [First] 1993).

Although this simplified explanation of a gene therapy procedure sounds like a happy ending, it is little more than an optimistic first chapter in a long story; the road to the first approved gene therapy procedure was rocky and fraught with controversy. The biology of human gene therapy is very complex, and there are many techniques that still need to be developed and diseases that need to be understood more fully before gene therapy can be used appropriately. The public policy debate surrounding the possible use of genetically engineered material in human subjects has been equally complex. Major participants in the debate have come from the fields of biology, government, law, medicine, philosophy, politics, and religion, each bringing different views to the discussion.

Scientists took the logical step of trying to introduce genes straight into human cells, focusing on diseases caused by single-gene defects, such as cystic fibrosis, hemophilia, muscular dystrophy and sickle cell anemia. However, this has been much harder than modifying simple bacteria, primarily because of the problems involved in carrying large sections of DNA and delivering it to the right site on the genome.

In most gene therapy studies, a "normal" gene is inserted into the genome to replace an "abnormal," disease-causing gene. A carrier molecule called a vector must be used to deliver the therapeutic gene to the patient's target cells. Currently, the most common vector is a virus that has been genetically altered to carry normal human DNA. Viruses have evolved a way of encapsulating and delivering their genes to human cells in a pathogenic manner. Scientists have tried to take advantage of this capability and manipulate the virus genome to remove disease-causing genes and insert therapeutic genes.

Target cells such as the patient's liver or lung cells are infected with the vector. The vector then unloads its genetic material containing the therapeutic human gene into the target cell. The generation of a functional protein product from the therapeutic gene restores the target cell to a normal state.

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Gene therapy - Psychology Wiki

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Diagnosis by DNA: Entering the Era of Personalized Medicine
Personalized medicine is an emerging practice that uses an individual #39;s detailed genomic data to guide decisions made in preventing, diagnosing and treating ...

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MediVet Stem Cell Therapy For Pets
MediVet is the company that created the technology to use stem cell therapy to treat pets with arthritis and hip dysplasia.

By: Newman Veterinary Centers

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Provided by: Wayland Baptist University

PLAINVIEW In honor of Lana Watson, Wayland Baptist University is hosting a bone marrow drive on Monday from 4 to 6 p.m. in Pete's Place, the student lounge in the basement of the McClung University Center, in conjunction with Covenant Health Plainview.

Other screening locations are the hospital lab at 2601 Dimmitt Road from 7 to 9 a.m., the South Plains College nursing lab at 1920 W. 24 from 10 a.m. to 12 p.m., and the First Baptist Church parlor at 205 W. 8th from 1 to 3 p.m.

Lana is the wife of Rodney Watson, Director of the Llano Estacado Museum and a deacon at First Baptist Church. Lana is currently in Dallas undergoing a transplant procedure of her own stem cells and waiting while the search for a bone marrow donor continues.

According to Laurie Hall, Coordinator of Health Services at Wayland, donors should be between the ages of 18-44. People over the age of 44 can be screened, but there is a $100 registration fee. Contact Be the Match at http://www.bethematch.orgfor more information.

No needles are involved in the screening process as donor information is collected through a mouth swab and registration process.

Through a similar drive last year, former Wayland student Scott Langford was identified as a match for a transplant patient. Langford donated his bone marrow to save a life.

Everyone interested in donating bone marrow is encouraged to undergo the screening process.

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Wayland Baptist hosting bone marrow drive

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LONDON: Human skin cells have been turned into stem cells which have the potential to develop into fully-formed embryos, simply by bathing them in weak citric acid for half an hour, a leading scientist has told The Independent on Sunday.

The demonstration that the technique, which was pioneered on mouse cells, also works on human skin cells raises the prospect of new treatments for incurable illnesses, from Parkinson's to heart disease, based on regenerating diseased organs in situ from a patient's own stem cells.

Although there is no intention to create human embryos from skin cells, scientists believe that it could, theoretically, be possible to do so given that entire mouse embryos have already been effectively created from the re-engineered blood cells of laboratory mice.

Creating the mouse embryos was the final proof the scientists needed to demonstrate that the stem cells were "pluripotent", and so capable of developing into any specialised tissue of an adult animal, including the "germ cells" that make sperm and eggs.

Pluripotent stem cells could usher in a new age of medicine based on regenerating diseased organs or tissues with injections of tissue material engineered from a patient's own skin or blood, which would pose few problems in terms of tissue rejection.

However, the technique also has the potential to be misused for cloning babies, although stem cell scientists believe there are formidable technical, legal and ethical obstacles that would make this effectively impossible.

A team of Japanese and American scientists converted human skin cells into stem cells using the same simple approach that had astonished scientists around the world last month when they announced that they had converted blood cells of mice into stem cells by bathing them in a weak solution of citric acid for 30 minutes.

The scientist who instigated the research programme more than a decade ago said that he now has overwhelming evidence that the same technique can be used to create embryonic-like stem cells from human skin cells.

Charles Vacanti, a tissue engineer at Brigham and Women's Hospital in Boston, Massachusetts, said that the same team of researchers has generated stem cells from human dermal fibroblasts skin cells which came from a commercial source of human tissues sold for research purposes.

"The process was very similar to the one we used on mouse cells, but we used human dermal fibroblasts that we purchased commercially," Dr Vacanti said. "I can confirm that stem cells were made when we treated these human cells. They do the same thing [as the mouse cells].

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CTL019 is a clinical trial ofT cell therapyfor patients with B cell cancers such as acute lymphoblastic leukemia (ALL), B cell non-Hodgkin lymphoma (NHL), and the adult disease chronic lymphocytic leukemia (CLL). At this time, The Children's Hospital of Philadelphia is the only hospital enrolling pediatric patientson this trial.

In this clinical trial, immune cells called T cells are taken from a patient's own blood. These cells are genetically modified to express a protein which will recognize and bind to a target called CD19, which is found on cancerous B cells. This is how T cell therapy works:

27 patients with acute lymphoblastic leukemia (22 children and 5 adults) have been treatedusing T cell therapy.Of those patients:

Scientists at The Childrens Hospital of Philadelphia and the University of Pennsylvania are very hopeful that CTL019 could in the future be an effective therapy for patients with B cell cancers. However, because so few patients have been treated, and because those patients have been followed for a relatively shorttime,it is critical that more adult and pediatric patients are enrolled in the study to determine whether a larger group of patients with B cell cancers will have the same response, and maintain that response.

At this point CHOP's capability to enroll patients is limited because of the need to manufacture the T cell product used in this therapy. Our goal is to boost enrollment soon, by increasing our manufacturing capabilities and by broadening this study to other pediatric hospitals.

VIDEO APPEARS HERE

T cell therapyis a treatment for children and adolescents with fairly advanced B cell acute lymphoblastic leukemia (ALL) and B cell lymphomas, but not other leukemias or pediatric cancers.It is an option for those patients who have very resistant ALL.

Roughly 85 percent of ALL cases are treated very successfully with standard chemotherapy. For the remaining 15 percent of cases, representing a substantial number of children in the United States, chemotherapy only works temporarily or not at all. This is not a treatment for newly diagnosed leukemia, only for patients whose leukemia is not responding to chemotherapy,and whose disease has come back after a bone marrow transplant.

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SPIKE gene can boost rice yields in Asia and Southeast Asia significantly and contribute to global food security in coming years, according to Dr. Tsutomu Ishimaru, Plant Breeder of International Rice Research Institute (IRRI)-Japan Collaborative Research Project.

The SPIKE gene is derived from Indonesian landrace, and helps improve yield of rice plants significantly. Dr. Tsutomu Ishimaru says he has achieved yield improvement of around 13-36% compared to IR64 and IRRI146. The SPIKE gene version of IR64 is being tested in several Asian countries including Laos, Indonesia (Java island), India (Tamil Nadu) and Japan. Tests are going on to improve yield in popular rice varieties in South Asia and Southeast Asia using the SPIKE gene. Dr. Tsutomu Ishimaru says, The SPIKE breeding is still in the process for BR11 (popular variety in Bangladesh), Swarna (popular variety in Eastern India), TDK1 (popular variety in Laos), Ciherang (popular variety in Indonesia) and PSBRc18 (popular variety in the Philippines). It will take a few years to finish the transfer of SPIKE to these five varieties.

Though it hasnt been tested yet, the taste, milling quality and cooking properties of traditional rice varieties (such as basmati fragrant rice) are likely to remain same with the introduction of the SPIKE gene through conventional breeding. Increase in yield would also translate into more profit for rice farmers and help in the improvement of the economy of South Asia and Southeast Asia.

Rice is a staple food for almost half of the global population which is growing in Southeast Asia and South Asia. Rice consumption is also increasing in Africa. It is estimated that by 2035, a 26% increase in rice production will be essential to feed the growing population, and according to the International Grains Council (IGC), global rice consumption will surpass rice production in just three years. Dr. Tsutomu Ishimaru hopes SPIKE research will spread to several rice growing countries in future and contribute to global food security.

The IRRI-Japan Collaborative Research Project is supported by the Ministry of Foreign Affairs and the Ministry of Agriculture, Forestry and Fisheries of Japan. The Japan International Research Center for Agricultural Sciences (JIRCAS) is a key partner of the Global Rice Science Partnership (the CGIAR Research Program on Rice), IRRI says.

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Rice Gene 'Spike' Can Boost Yield by 36%, Says IRRI

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Sugar industry can be revived with the help of Tissue Culture Genetic Engineering in UP.
02 February 2014, Shri Narendra Modi highlight the growth of cooperatives in Gujarat which along with focusing on tissue culture, genetic engineering and dri...

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Tissue Culture Genetic Engineering can revive Sugar industry in UP: MODI
SUBSCRIBE this channel for regular updates on Indian Politics at this link http://goo.gl/Qeus8u.

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Genome sequencing holds great potential for diagnosing diseases, finding treatments and ultimately cutting medical costs, experts say, but insurance companies are leery of covering the still-new procedure, preventing it so far from becoming a routine part of medical care.

Boston-based Partners HealthCare is one of just two systems in the country to offer full genome sequencing for clinical patients. The out-of-pocket cost of unlocking your full genetic code, though, is steep: $9,000.

Cost is a barrier, said Heidi Rehm, chief laboratory director at the Partners Center for Personalized Genetic Medicine in Cambridge.

The lab started offering full genome sequencing last August using blood samples to extract information from DNA but it has done the complex analysis for fewer than half a dozen patients since then. Insurance companies didnt cover the costs for any of those patients, Rehm said.

For patients suffering from a range of diseases, from cancer to hearing loss, sequencing can help identify the gene causing the problem and help doctors determine which treatments will be most effective. Genetic sequencing can also tell patients if theyre at risk of developing certain conditions later in life.

The challenge for scientists like Rehm is to prove that this kind of analysis is useful not just for sick patients but for healthy ones.

Can I say every patient should get their genome sequenced? We just dont have the collective evidence and the studies to prove that today, Rehm said. So the insurers are not going to cover everything today.

Insurance companies do pay for some genetic tests those that test specifically for a patients risk of developing breast cancer, for example but theyre still evaluating the benefit of full genome sequencing, which involves much more data and analysis.

We dont have a lot of information yet to make sweeping decisions, said Dr. Neil Minkoff, medical director for the Massachusetts Association of Health Plans. We tend to look at the individual patient or individual physicians request. Its still early in our experience with it.

The states three largest insurers, Blue Cross Blue Shield, Harvard Pilgrim Health Care and Tufts Health Plan, did not respond to requests for comment.

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Gene screen eyes mainstream

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New genetic evidence strengthens the case that one well-known type of cholesterol is a likely suspect in causing heart disease, but also casts further doubt on the causal role played by another type. The findings may guide the search for improved treatments for heart disease.

Most of us have heard of "good cholesterol" and "bad cholesterol" coursing through our bloodstream. In the conventional health wisdom of the past 30 years, having more of the "good" variety (high-density lipoprotein, or HDL) lowers your risk of heart disease, while more of the bad one (low-density lipoprotein, LDL) increases your risk. Indeed, over the years, clinical trials and other studies have found that drugs that lower LDL also lower your probability of heart disease.

On the other hand, drug trials have not shown heart-health benefits to increasing HDL or to lowering triglycerides, a third type of blood lipid. Now a new study co-led by scientists at The Children's Hospital of Philadelphia and Penn Medicine sheds light on the role of genes and blood lipid levels in cardiovascular health. Newer tools for gene analysis show how variations in DNA are underlying actors affecting heart disease -- a major worldwide cause of death and disability.

"Now we are able to pinpoint gene signals that actually cause some of these conditions," says geneticist Brendan J. Keating, D. Phil., of The Center for Applied Genomics at The Children's Hospital of Philadelphia. "Unraveling how genetic variants that influence lipid traits are related to heart disease risk is a step toward designing treatments." Keating and his colleagues, working in large international collaborative groups, are wielding advanced gene-analysis tools to uncover important clues to heart disease.

Keating collaborated with clinical epidemiologist Michael V. Holmes, M.D., Ph.D., of the Perelman School of Medicine at the University of Pennsylvania, in a blood lipid study published online Jan. 27 in the European Heart Journal. Research co-authors were from six countries and various centers, including the University College London in the U.K.

The study team used a recently developed epidemiology tool called Mendelian randomization (MR). MR analyzes genetic variations using a method that identifies genes responsible for particular diseases, independent of confounding factors such as differences in behavior or environmental influences that often limit the conclusions of epidemiology research. This was one of the largest studies to date using MR, as well as the largest to use an allele-score method, described below.

The researchers analyzed DNA data from 17 studies including over 60,000 individuals, of whom more than 12,000 had experienced coronary heart disease, including heart attacks. Because previous studies had found signals from nearly 200 genes to be associated with blood lipid levels, the study team aggregated data into composite groups, called allele scores, for each of three blood lipids: LDL, HDL and triglycerides, then calculated their relationship to coronary heart disease.

As expected, the current study confirmed that higher levels of LDL, the "bad cholesterol," were more likely to cause heart disease. But there were new results: high levels of triglyceride also caused higher risk of heart disease. At the same time, there was little evidence that higher levels of HDL, the "good cholesterol," had a protective effect.

The novelty of their approach, say the authors, lies in their use of a gene score MR analysis using individual participant data. These results build on previous findings and help clarify in further detail the separate roles of triglycerides and HDL in risk for coronary heart disease.

Previous genetic studies, including by Keating and others, found associations among gene variations (single nucleotide polymorphisms, or SNPs) and heart disease, but did not indicate causality, as found in the current study. Holmes said, "These findings are important in understanding which blood lipids cause heart disease, and will enable clinicians to better target those lipids with drugs to reduce the risk of heart disease."

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Genetic signals affecting lipid levels used to investigate heart disease risk

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Unit 8 - Genetics - 2 - Meiosis
Meiosis Main Ideas 1) Two cellular divisions 2) Gamete production 3) Increased Genetic Diversity.

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Genetics - What are the Karyogram and Ideogram? Part 4 of 6
http://www.sicklecellanaemia.org Resource part 4 of 6. Part of the UK Open Education Programme supporting the sharing of educational materials and expertise in sick...

By: Rahmat Setiadi

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Mendel Basic Genetics
Unit 8 - Section 1: Introduction to Gregor Mendel #39;s work, rules, and laws that govern patterns of inheritance.

By: Mr. Kubuske

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Scientific Evidence for Creation CSE BIBLE FORUM Origins 1110 Creation Genetics

By: Seung-Hwa Chung

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Central Dogma of Molecular Genetics, with Russian
This a quick consideration basically of why, metaphorically, we use the terms "transcription" and "translation" to describe these basic concepts of molecular...

By: BiologyasPoetry

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True Genetics
Today i go to Whistler and do a short interview with Phil the owner of True Genetics , a med user who started a seed company in order to breed his own cannab...

By: Bubbleman #39;s World

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True Genetics - Video

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UC Irvine International Imaging Genetics Conference - SOLAR Workshop 2014 part 1
Genetic Analysis of Quantitative Traits * Using SOLAR-Eclipse for genetic, metagenetic and megagenetic analyses - Tenth International Imaging Genetics Prog...

By: Sung Yu

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UC Irvine International Imaging Genetics Conference - SOLAR Workshop 2014 part 1 - Video

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Attack of the B-Team Advanced Genetics Mod Tutorial Ep.1
Attack of the B-Team Advanced Genetics Mod Tutorial: In this very first episode of the new mod pack call Attack of the B-Team i go over most of the machines from the Advanced Genetics mod....

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BLASTED genetics lush led tent
via YouTube Capture.

By: Try Chome

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