Doctor Oz Show, would you guess me to be 41 years old? 60849
http://bit.ly/1i3Ahld Doctor Oz, can you tell how old I REALLY am? Can skin cell therapy make me feel AND LOOK younger again? Doctor Oz Show, would you guess...

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Abandoned dog receives historic stem cell therapy
Veterinarians across the country now have a way to improve the lives of their patients by using a tool to combat osteoarthritis. On Thursday, one dog made hi...

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Autologous Cell Therapy Market
For Details : http://goo.gl/56kgZS Autologous Cell Therapy Market reserach report gives a detailed analysis about state of the art of both autologous stem ce...

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ELLSWORTH Visitors to the Bellaire pet crisis center With a Little help From My Friends get an official welcome from Moka.

The Labrador retriever was found behind a Bellaire restaurant in 2011 and now serves as the centers mascot.

Peforming her duties has been increasingly difficult for the dog, who suffers from severe arthritis in her hips. So recently the center turned to Ellsworth veterinarian Christian Randall of North Country Veterinary Services, the first in northern Michigan to offer in-clinic adipose stem cell therapy.

The procedure uses a pets own blood and tissue to produce plasma-rich platelets and stem cells that proliferate growth in damaged areas.

Dormant stem cells are separated from adipose -- fat tissue -- and activated with an LED technology that uses three different wave lengths of light. Then the cells are injected directly into the affected area or administered intravenously to help promote regeneration. The result is a decrease in pain and lameness and increased range of motion.

Its using the bodys own repair cells to repair damage, said Trey Smith, director of laboratory services for MediVet America, which developed the technology Randall uses.

The therapy is the first treatment to help heal and slow the progression of osteoarthritis and degenerative joint disease rather than just cope with the symptoms, said Randall, who saw the results while studying at Virginia Equine Imaging and now plans to use it on equine as well as canine and feline patients.

It concentrates, speeds up and amplifies the bodys own healing power, he said.

Stem cell therapy has been around for a while, but in-clinic availability of the technology is new. Only a handful of veterinarians in Ann Arbor and Grand Rapids offer the services, said Randall, who charges $1,800 to treat a dog or cat. Repeat injections are possible with banked plasma-rich platelets and stem cells.

Before the one-day procedure, veterinarians had to send blood and tissue to an outside lab for processing, a more costly three-day procedure that requires an animal's return visit to the vet for injection.

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Stem-cell therapy restores faith for arthritic pets

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PUBLIC RELEASE DATE:

26-Jan-2014

Contact: Sue McGreevey smcgreevey@partners.org 617-724-2764 Massachusetts General Hospital

A simple adjustment to a powerful gene-editing tool may be able to improve its specificity. In a report receiving advance online publication in Nature Biotechnology, Massachusetts General Hospital (MGH) investigators describe how adjusting the length of the the guide RNA (gRNA) component of the synthetic enzymes called CRISPR-Cas RNA-guided nucleases (RGNs) can substantially reduce the occurrence of DNA mutations at sites other than the intended target, a limitation the team had previously described just last year.

"Simply by shortening the length of the gRNA targeting region, we saw reductions in the frequencies of unwanted mutations at all of the previously known off-target sites we examined," says J. Keith Joung, MD, PhD, associate chief for Research in the MGH Department of Pathology and senior author of the report. "Some sites showed decreases in mutation frequency of 5,000-fold or more, compared with full length gRNAs, and importantly these truncated gRNAs - which we call tru-gRNAs - are just as efficient as full-length gRNAs at reaching their intended target DNA segments."

CRISPR-Cas RGNs combine a gene-cutting enzyme called Cas9 with a short RNA segment and are used to induce breaks in a complementary DNA segment in order to introduce genetic changes. Last year Joung's team reported finding that, in human cells, CRISPR-Cas RGNs could also cause mutations in DNA sequences with differences of up to five nucleotides from the target, which could seriously limit the proteins' clinical usefulness. The team followed up those findings by investigating a hypothesis that could seem counterintuitive, that shortening the gRNA segment might reduce off-target mutations.

"Some of our experiments from last year suggested that one could mismatch a few nucleotides at one end of the gRNA complementarity region without affecting the targeting activity," Joung explains. "That led us to wonder whether removing these nucleotides could make the system more sensitive to mismatches in the remaining sequence."

Based on a natural system a species of bacteria uses against other pathogens, the CRISPR-Cas RGNs most widely used by researchers includes a 20-nucleotide targeting region within the gRNA. To test their theory, the MGH team constructed RGNs with progressively shorter gRNAs and found that, while gRNAs with targeting segments of 17 or 18 nucleotides were as or more efficient than full-length gRNAs in reaching their targets, those with 15- or 16-nucleotide targeting segments had reduced or no targeting activity. Subsequent experiments found that 17-nucleotide truncated RGNs efficiently induced the desired mutations in human cells with greatly reduced or undetectable off-target effects, even at sites with only one or two mismatches.

"While we don't fully understand the mechanism by which tru-gRNAs reduce off-target effects, our hypothesis is that the original system might have more energy than it needs, enabling it to cleave even imperfectly matched sites," says Joung, who is an associate professor of Pathology at Harvard Medical School. "By shortening the gRNA, we may reduce the energy to a level just sufficient for on-target activity, making the nuclease less able to cleave off-target sites. But more work is needed to define exactly why tru-gRNAs have reduced off-target effects."

###

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Shortening guide RNA markedly improves specificity of CRISPR-Cas nucleases

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Startup Global Bioenergies uses genetic engineering to avoid one of the costliest steps in biofuel production.

Test plant: Global Bioenergies is adapting this test facility, owned by the European research organization Fraunhofer, to produce biofuels using a new process that avoids a costly distillation step.

Audi is investing in a startup, Paris-based Global Bioenergies, that says it can make cheap gasoline from sugar and other renewable sources. The strategic partnership includes stock options and an unspecified amount of funding.

As with conventional biofuel production, Global Bioenergies technology uses microrganisms to ferment sugars to produce fuel. But its process eliminates the second most costly part of producing biofuelsthe energy-intensive distillation step. And by making gasoline instead of making ethanol, the startup skirts a major problem hampering growth in biofuelsthe fact that the market for ethanol is saturated.

Global Bioenergies has demonstrated its technology in the lab and is building two pilot facilities to produce isobutene, a hydrocarbon that a partner will convert into gasoline through an existing chemical process. The larger of the two pilot facilities will be big enough to support the production of over 100,000 liters of gasoline a year.

The process addresses one of the key challenges with conventional biofuels productionthe fuel can kill the microrganisms that make it. In a conventional fermentation process, once the concentration of ethanol gets to about 12 percent, it starts to poison the yeast so that it cant make any more ethanol.

Global Bioenergies has genetically engineered E. coli bacteria to produce a gas (isobutene) that bubbles out of solution, so its concentration in the fermentation tank never reaches toxic levels. As a result the bacteria can go on producing fuel longer than in the conventional process, increasing the output of a plant and reducing capital costs.

The isobutene still needs to be separated from other gases such as carbon dioxide, but Global Energies says this is much cheaper than distillation.

The new process doesnt address the biggest cost of biofuels todaythe cost of the raw materials. Its designed to run on glucose, the type of sugar produced from corn or sugarcane. But the company is adapting it to work with sugars from non-food sources such as wood chips, which include glucose but also other sugars such as xylose.

Audis partnership with Global Bioenergies is part of push by the automaker to reduce greenhouse gas emissions in the face of tightening regulations. Audi recently announced two other investments in cleaner fuels. It funded a project to make methane using renewable energythe methane can be used to run Audis natural-gas fueled cars (see Audi to Make Fuel Using Solar Power). And it funded Joule Unlimited, which is using photosynthetic microrganisms to make ethanol and diesel (see Audi Backs a Biofuels Startup).

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Audi Bets on Bio Gasoline Startup

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Inject a gene from a certain cold-water fish into a strawberry, and the strawberry can withstand colder temperatures. But would you still want to eat it?

Such advances in genetic engineering have implications for helping feed a growing, hungry world but a lot of people aren't too keen on eating those advances just yet.

Others wouldn't hesitate.

The difference reflects the "wild, messy debate" surrounding genetically modified food, with one of the more recent skirmishes centering on whether food labels should contain information about such ingredients, according to Nick George, president of the Midwest Food Processors Association, based in Madison.

Wisconsin's agriculture and food production industries find themselves smack in the middle of the debate.

"This is a big issue," George said. "It's not going away."

Neither, it seems, are genetically engineered crops in the American food chain.

The U.S. Department of Agriculture estimates that 93% of soybean acres and 85% of corn acres in 2013 were planted with genetically modified, herbicide-tolerant crop varieties.

The percentage of insect-resistant corn planted in 2013 stood at 76%, according to the USDA. The insect-resistant corn contains a gene from the soil bacterium Bt Bacillus thuringiensis. The bacteria produce a protein that is toxic to specific insects.

Consider that there are nearly 1.3 million dairy cows in Wisconsin, and some of them are no doubt eating corn with genetically modified ingredients.

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Debate rages over labeling genetically modified food

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GENETICS (But Actually A Rant )
English content is now also on the Facebook page, make sure you give a like, comment like subscribe as always 🙂 https://www.facebook.com/OfekUrbinoFTS.

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Genetics Screencast

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Genetics Screencast - Video

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Genetics- Non-Mendelian Inheritance

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27th Anniversary Sports Spectacular Benefiting Cedars-Sinai Medical Genetics Institute - Red Carpet
New site http://ginacarano.meximas.com/ This channel is dedicated to one of the most prominent figures in the world of martial arts, won the tournament in Th...

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Utopia - S2E17 - Down the Rabbit Hole - Return to Sunshine Genetics Lab
Welcome to the second season of the Utopia Server. Come watch as we check out all that modded Minecraft 1.6.4 has to offer. Our server, our modpack, our rul...

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A guide to herd genetics reports - brought to you by DairyCo
A short presentation on herd genetics reports, how to register and using the reports to evaluate different breeds.

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Human Genome1 Gene Therapy

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Human Genome1 Gene Therapy - Video

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The progression of personalized medicine
The progression of personalized medicine, from concept up to reality. From the one-size-fits-all approach to personalized medicine, where are we today?

By: OracleHealthSciences

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Personalized Medicine: Applying Artificial Intelligence to Mental Healthcare - Session 2
Keynote by Casey Bennett, Research Fellow, CRI; Associate Instructor, Indiana University, Bloomington.

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Wolfpack: The All Military Wheelchair Basketball Team
The San Diego Wolfpack is the only wheelchair basketball team in the United States that is made up of active duty and veteran service members who have sustai...

By: SPORTS N SPOKES .

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Sarah Stroops sit to stand

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tg

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tg - Video

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Chris W lift walk 12/16/2013

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George July 2012

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George July 2012 - Video

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sarah home made twist combo

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Andre on adduction machine SCI recovery

By: ProjectWalkAtlanta Spinal Cord Injury Recovery

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Empower Spinal Cord Injury: 2013 Program
Recap of our 2013 program. Hear from our participants about the heart of Empower SCI!

By: EmpowerSpinal CordInjury

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by Dan Browning

A decade-long Mayo Clinic research project on using stem cells to repair damaged heart tissue has won federal approval for human testing, a step that could have implications for millions of Americans with heart disease.

The U.S. Food and Drug Administration has approved a multistate clinical trial of 240 patients with chronic advanced symptomatic heart failure to see if the new procedure produces a significant improvement in heart function, Mayo officials announced Friday.

Safety testing in humans, completed earlier in Europe, showed a preliminary 25 percent improvement in cardiac outflow, according to Dr. Andre Terzic, director of the Mayo Clinic's Center for Regenerative Medicine.

The procedure could be a "paradigm shift" in the treatment of heart disease, Terzic said.

Going forward, he said, treatments won't just focus on easing the symptoms of heart disease, but rather on curing it.

The process, developed in collaboration with Cardio3 BioSciences of Belgium, involves harvesting stem cells from a patient's bone marrow in the hip, directing the cells to become "cardiopoietic" repair cells, then injecting them back into the heart to do their work.

Mayo researcher Dr. Atta Behfar and other members of Terzic's team isolated hundreds of proteins involved in the "transcription" process that takes place when stem cells are converted to heart cells. They identified eight proteins that were crucial, and used them to convert stem cells into heart cells.

"This is unique in the world," Terzic said.

Dr. Ganesh Raveendran, a cardiologist and co-director of the University of Minnesota's cardiac cell therapy program, called the Mayo research encouraging, but advised caution. Raveendran said a variety of small stem cell studies have shown mixed results, but when the treatments were tested in larger studies, they showed no beneficial effects. "We need to wait and see," he said.

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Mayo Clinic wins FDA approval to test stem-cell heart therapy

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