Stem Cell Therapy for Traumatic Brain Injury
Oswaldo Tapenes received multiple injections of human umbilical cord-derived mesenchymal stem cells and his own bone marrow-derived stem cells over the cours...

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Stem Cell Therapy for Traumatic Brain Injury - Video

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Stemcell treatment for hair and skin, Autologous Adipose Stem Cell Treatment
Through the history of stem cell therapy and stem cell research, animal stem cells have been used, human embryonic stem cells, and now research has led us to...

By: Ojas Aesthetic

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Stemcell treatment for hair and skin, Autologous Adipose Stem Cell Treatment - Video

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Orange County, California (PRWEB) December 16, 2013

Top California stem cell clinic, TeleHealth, is now offering stem cell injections for plantar fasciitis. The condition may lead to chronic pain and may not respond to traditional treatments, with the stem cell therapy often allowing for pain relief and the ability to avoid the need for surgery. For more information and scheduling, call (888) 828-4575.

Planter fasciitis affects millions of Americans. The condition leads to chronic heel pain and may make it difficult to participate in recreational activities and even walk normally. Traditional treatments such as physical therapy, NSAIDS, steroid injections and orthotics are often effective over time. However, the condition may not respond as desired to these options and stem cells for plantar fasciitis may be the answer.

Therefore, stem cell injections that TeleHealth provides may offer an excellent option for healing the inflamed area while at the same time providing considerable pain relief. The conventional pain management treatments tend to mask pain, however, they do not actually heal the condition directly.

Regenerative medicine treatments with stem cells maintain the potential of actually healing the damaged tissue to provide long term relief. Telehealth has multiple US Board Certified doctors who have a long history of providing stem cell therapy for numerous conditions including degenerative arthritis, rotator cuff and Achilles tendonitis, ligament injury, elbow soft tissue tendinitis and more.

For those suffering from planter fasciitis or any of the other arthritic or soft tissue injury conditions, call TeleHealth at (888) 828-4575.

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West Coast Stem Cell Clinic, Telehealth, Now Offering Stem Cell Injections for Plantar Fasciitis

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Phoenix, Arizona (PRWEB) December 16, 2013

The top Phoenix stem cell treatment clinic, Arizona Pain Stem Cell Institute, is now offering stem cell therapy for plantar fasciitis. The treatments are offered by Board Certified pain management doctors in Arizona, and often help patients avoid surgery. For more information and scheduling, call (602) 507-6550.

Plantar fasciitis affects millions of Americans, causing heel pain that may make it difficult to participate in recreational activities and walking in general. Conventional treatments such as steroid injections, NSAIDS, bracing and physical therapy at times do not relieve the pain properly. Surgery for plantar fasciitis unfortunately does not always provide the desired relief.

Regenerative medicine at the Arizona Pain Stem Cell Institute offers a nonoperative option for plantar fasciitis. This may include stem cell injections with bone marrow, fat derived or amniotic derived material. The procedure is outpatient and low risk.

In addition to treatments for plantar fasciitis, the Institute offers stem cell treatments for degenerative arthritis, tennis elbow, rotator cuff symptoms, achilles tendonitis and more. The procedures are performed by Board Certified pain doctors, with four research projects ongoing.

The Institute is a division of Arizona Pain Specialists, the leading pain center in Arizona. Five locations accept over 50 insurance plans including Workers Compensation, Personal Injury, PPO's, some HMO's and self pay. The regenerative medicine treatments are offered as fee for service.

For more information and scheduling to discuss plantar fasciitis options, call (602) 507-6550.

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Arizona Pain Stem Cell Institute Now Offering Stem Cell Therapy for Plantar Fasciitis

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by Jos Domen*, Amy Wagers** and Irving L. Weissman***

Blood and the system that forms it, known as the hematopoietic system, consist of many cell types with specialized functions (see Figure 2.1). Red blood cells (erythrocytes) carry oxygen to the tissues. Platelets (derived from megakaryocytes) help prevent bleeding. Granulocytes (neutrophils, basophils and eosinophils) and macrophages (collectively known as myeloid cells) fight infections from bacteria, fungi, and other parasites such as nematodes (ubiquitous small worms). Some of these cells are also involved in tissue and bone remodeling and removal of dead cells. B-lymphocytes produce antibodies, while T-lymphocytes can directly kill or isolate by inflammation cells recognized as foreign to the body, including many virus-infected cells and cancer cells. Many blood cells are short-lived and need to be replenished continuously; the average human requires approximately one hundred billion new hematopoietic cells each day. The continued production of these cells depends directly on the presence of Hematopoietic Stem Cells (HSCs), the ultimate, and only, source of all these cells.

Figure 2.1. Hematopoietic and stromal cell differentiation.

2001 Terese Winslow (assisted by Lydia Kibiuk)

The search for stem cells began in the aftermath of the bombings in Hiroshima and Nagasaki in 1945. Those who died over a prolonged period from lower doses of radiation had compromised hematopoietic systems that could not regenerate either sufficient white blood cells to protect against otherwise nonpathogenic infections or enough platelets to clot their blood. Higher doses of radiation also killed the stem cells of the intestinal tract, resulting in more rapid death. Later, it was demonstrated that mice that were given doses of whole body X-irradiation developed the same radiation syndromes; at the minimal lethal dose, the mice died from hematopoietic failure approximately two weeks after radiation exposure.1 Significantly, however, shielding a single bone or the spleen from radiation prevented this irradiation syndrome. Soon thereafter, using inbred strains of mice, scientists showed that whole-body-irradiated mice could be rescued from otherwise fatal hematopoietic failure by injection of suspensions of cells from blood-forming organs such as the bone marrow.2 In 1956, three laboratories demonstrated that the injected bone marrow cells directly regenerated the blood-forming system, rather than releasing factors that caused the recipients' cells to repair irradiation damage.35 To date, the only known treatment for hematopoietic failure following whole body irradiation is transplantation of bone marrow cells or HSCs to regenerate the blood-forming system in the host organisms.6,7

The hematopoietic system is not only destroyed by the lowest doses of lethal X-irradiation (it is the most sensitive of the affected vital organs), but also by chemotherapeutic agents that kill dividing cells. By the 1960s, physicians who sought to treat cancer that had spread (metastasized) beyond the primary cancer site attempted to take advantage of the fact that a large fraction of cancer cells are undergoing cell division at any given point in time. They began using agents (e.g., chemical and X-irradiation) that kill dividing cells to attempt to kill the cancer cells. This required the development of a quantitative assessment of damage to the cancer cells compared that inflicted on normal cells. Till and McCulloch began to assess quantitatively the radiation sensitivity of one normal cell type, the bone marrow cells used in transplantation, as it exists in the body. They found that, at sub-radioprotective doses of bone marrow cells, mice that died 1015 days after irradiation developed colonies of myeloid and erythroid cells (see Figure 2.1 for an example) in their spleens. These colonies correlated directly in number with the number of bone marrow cells originally injected (approximately 1 colony per 7,000 bone marrow cells injected).8 To test whether these colonies of blood cells derived from single precursor cells, they pre-irradiated the bone marrow donors with low doses of irradiation that would induce unique chromosome breaks in most hematopoietic cells but allow some cells to survive. Surviving cells displayed radiation-induced and repaired chromosomal breaks that marked each clonogenic (colony-initiating) hematopoietic cell.9 The researchers discovered that all dividing cells within a single spleen colony, which contained different types of blood cells, contained the same unique chromosomal marker. Each colony displayed its own unique chromosomal marker, seen in its dividing cells.9 Furthermore, when cells from a single spleen colony were re-injected into a second set of lethally-irradiated mice, donor-derived spleen colonies that contained the same unique chromosomal marker were often observed, indicating that these colonies had been regenerated from the same, single cell that had generated the first colony. Rarely, these colonies contained sufficient numbers of regenerative cells both to radioprotect secondary recipients (e.g., to prevent their deaths from radiation-induced blood cell loss) and to give rise to lymphocytes and myeloerythroid cells that bore markers of the donor-injected cells.10,11 These genetic marking experiments established the fact that cells that can both self-renew and generate most (if not all) of the cell populations in the blood must exist in bone marrow. At the time, such cells were called pluripotent HSCs, a term later modified to multipotent HSCs.12,13 However, identifying stem cells in retrospect by analysis of randomly chromosome-marked cells is not the same as being able to isolate pure populations of HSCs for study or clinical use.

Achieving this goal requires markers that uniquely define HSCs. Interestingly, the development of these markers, discussed below, has revealed that most of the early spleen colonies visible 8 to 10 days after injection, as well as many of the later colonies, visible at least 12 days after injection, are actually derived from progenitors rather than from HSCs. Spleen colonies formed by HSCs are relatively rare and tend to be present among the later colonies.14,15 However, these findings do not detract from Till and McCulloch's seminal experiments to identify HSCs and define these unique cells by their capacities for self-renewal and multilineage differentiation.

While much of the original work was, and continues to be, performed in murine model systems, strides have been made to develop assays to study human HSCs. The development of Fluorescence Activated Cell Sorting (FACS) has been crucial for this field (see Figure 2.2). This technique enables the recognition and quantification of small numbers of cells in large mixed populations. More importantly, FACS-based cell sorting allows these rare cells (1 in 2000 to less than 1 in 10,000) to be purified, resulting in preparations of near 100% purity. This capability enables the testing of these cells in various assays.

Figure 2.2. Enrichment and purification methods for hematopoietic stem cells. Upper panels illustrate column-based magnetic enrichment. In this method, the cells of interest are labeled with very small iron particles (A). These particles are bound to antibodies that only recognize specific cells. The cell suspension is then passed over a column through a strong magnetic field which retains the cells with the iron particles (B). Other cells flow through and are collected as the depleted negative fraction. The magnet is removed, and the retained cells are collected in a separate tube as the positive or enriched fraction (C). Magnetic enrichment devices exist both as small research instruments and large closed-system clinical instruments.

Lower panels illustrate Fluorescence Activated Cell Sorting (FACS). In this setting, the cell mixture is labeled with fluorescent markers that emit light of different colors after being activated by light from a laser. Each of these fluorescent markers is attached to a different monoclonal antibody that recognizes specific sets of cells (D). The cells are then passed one by one in a very tight stream through a laser beam (blue in the figure) in front of detectors (E) that determine which colors fluoresce in response to the laser. The results can be displayed in a FACS-plot (F). FACS-plots (see figures 3 and 4 for examples) typically show fluorescence levels per cell as dots or probability fields. In the example, four groups can be distinguished: Unstained, red-only, green-only, and red-green double labeling. Each of these groups, e.g., green fluorescence-only, can be sorted to very high purity. The actual sorting happens by breaking the stream shown in (E) into tiny droplets, each containing 1 cell, that then can be sorted using electric charges to move the drops. Modern FACS machines use three different lasers (that can activate different set of fluorochromes), to distinguish up to 8 to 12 different fluorescence colors and sort 4 separate populations, all simultaneously.

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2. Bone Marrow (Hematopoietic) Stem Cells [Stem Cell Information]

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Scientists are hoping to increase the size of future kidneys and believe the resulting organs will boost research and allow cheaper, faster testing of drugs. Within the next three to five years, the artificial organs could be used to allow doctors to repair damaged kidneys within the body, rather than letting diseases develop before proceeding with a transplant.

The engineered kidney was developed by a team of Australian scientists led by the University of Queensland's Institute for Molecular Bioscience.

Professor Wainwright said the process for developing the kidney was "like a scientific approach to cooking". The scientists methodically examined which genes were switched on and off during kidney development and then manipulated the skin cells into embryonic stem cells which could "self-organise" and form complex human structures.

"The [researchers] spent years looking at what happens if you turn this gene off and this one on," he said. "You can eventually coax these stem cells through a journey they [the cells] go through various stages and then think about being a kidney cell and eventually pop together to form a little piece of kidney."

The research could eventually help address the demand for transplant organs and improve medical testing of new drugs for patients with kidney disease.

Human kidneys are particularly susceptible to damage during trials, which makes finding effective medicines costly and time-consuming.

Professor Melissa Little, from the University of Queensland, said scientists could try to grow full-grown kidneys for transplants or even "clusters of mini kidneys" that could be transplanted to boost patients' renal functions. But she told The Australian she believed such developments were still more than a decade away.

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Kidney grown from stem cells by Australian scientists

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stem cell therapy treatment for Quadriplegic Cerebral Palsy by dr alok sharma, mumbai, india short
improvement seen in just 3 months after stem cell therapy treatment for quadriplegic cerebral palsy by dr alok sharma, mumbai, india. Stem Cell Therapy done ...

By: Neurogen Brain and Spine Institute

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stem cell therapy treatment for Quadriplegic Cerebral Palsy by dr alok sharma, mumbai, india short - Video

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stem cell therapy treatment for stroke by dr alok sharma, mumbai, india short
improvement seen in just 3 months after stem cell therapy treatment for stroke by dr alok sharma, mumbai, india. Stem Cell Therapy done date 23rd Jul 2013 Af...

By: Neurogen Brain and Spine Institute

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stem cell therapy treatment for stroke by dr alok sharma, mumbai, india short - Video

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One year after his combination cell therapy by Dr Harry Adelson for his arthritic knee
Dave discusses the outcome of his combination cell therapy performed by Dr Harry Adelson for his arthritic knee.

By: Harry Adelson

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One year after his combination cell therapy by Dr Harry Adelson for his arthritic knee - Video

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Biotech company expert in cell therapy products
3P Biopharmaceuticals specialized in the development and manufacture of biologics and cell therapy products, from proof of concept to commercial phase. http:...

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Biotech company expert in cell therapy products - Video

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Genetic Engineering Pictures
This is a video of pictures to do with Genetic Engineering.

By: cailan13059

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Genetic Engineering Pictures - Video

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Genetic Engineering and Biotechnology | Dr Md Anwarul Azim Akhand | DU
For more inte

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Genetic Engineering and Biotechnology | Dr Md Anwarul Azim Akhand | DU - Video

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B2.6 Genetic engineering: 11Q2 GM Debate
Learning outcomes: Discuss the advantages and disadvantages of genetic engineering to produce GM organisms.

By: TeamScienceTMCS

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B2.6 Genetic engineering: 11Q2 GM Debate - Video

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Alan Watt on The Cloud, Genetic Engineering, Depopulation + Long-Term Conditioning - April 2009
Full interview - http://www.youtube.com/watch?v=WdSj2zaJ-7U Alan Watt #39;s website - http://www.cuttingthroughthematrix.com/ Alan Watt Videos playlist - http://...

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Alan Watt on The Cloud, Genetic Engineering, Depopulation + Long-Term Conditioning - April 2009 - Video

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Scientists poking around Ethiopia's fossil-rich badlands say they have discovered the first pieces of an extinct species of horse that was about the size of a small zebra and lived about 4.4 million years ago.

The specimens were found in what is now an arid desert. But at the time this grass-eating horse roamed the planet, the region would have been covered in grasslands and shrubby woods -- rich grounds for grazing.

Fossilized traces of the horse, which was named Eurygnathohippus woldegabrieli, were uncovered in the archaeologically rich sites of Aramis and Gona in Ethiopia's Middle Awash valley. The region is famed for bearing the world's longest and most continuous record of human evolution.

The extinct horse in this study would have actually been alive at the same time the 4.4-million-year-old human ancestor Ardipithecus ramidus, or "Ardi," walked the region.(Beasts of Burden: Amazing Horse Photos)

"Among the many fossils we found are the two ends of the foreleg bone -- the canon -- brilliant white and well preserved in the red-tinted earth," study researcher Scott Simpson, of Case Western Reserve's School of Medicine, said of the horse discovery.

The leg bone bits indicate this horse had longer legs than its ancestors. The shape and size of the leg suggest the beast was a fast runner, a skill that may have helped it flee predators like lions, sabre-tooth cats, Simpson and colleagues say.

"Grasses are like sandpaper," Simpson explained in a statement. "They wear the teeth down and leave a characteristic signature of pits and scratches on the teeth so we can reliably reconstruct their ancient diets."

The horse's teeth show signs of another departure from more ancient species: With crowns worn flatter than the teeth found on its ancestors, it seems this creature became adapted to a life of grazing. An analysis of the enamel on the fossilized teeth provided further evidence that it subsisted on grass like today's zebras, wildebeests and white rhinoceroses, the scientists say.

The animal belonged to a group of ancient horses called Hipparionines, which had three-toed hooves and arose in North America about 16 million years ago before spreading into Eurasia, presumably over a land bridge that once existed between Alaska and Siberia. The researchers say this discovery helps fill in a blank spot in the evolution of horses, before the animals became even better suited for a life in the grasslands, growing taller and developing longer snouts, for example.

"This horse is one piece of a very complex puzzle that has many, many pieces," Simpson said in a statement.

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Fossils of 4.4-Million-Year-Old Horse Found

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Viral genetics
#39;Viral genetics #39; is video 4 from week 3 of my 2013 Coursera course #39;How viruses work #39;

By: Vincent Racaniello

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Viral genetics - Video

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Genetics and Genomics of Thyroid Neoplasms: Moving Closer towards Personalized Patient Care
December 6, 2013 - The 2013-2014 Genomics in Medicine Lecture Series (Speaker: Electron Kebebew) More: http://www.genome.gov/27553517.

By: GenomeTV

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Genetics and Genomics of Thyroid Neoplasms: Moving Closer towards Personalized Patient Care - Video

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Do Genetics Cause An Unfair Advantage Like Steroid Use?
Just an opinion vid, what #39;s your take? My Training Program + Form Check Service - http://www.canditotraininghq.com/products-services/ Facebook Page - https:/...

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Do Genetics Cause An Unfair Advantage Like Steroid Use? - Video

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Gene therapy using retrovirus vector
This gene therapy video tutorial is to explain the method of gene therapy using retrovirus vector to cure genetic diseases. One example of such retrovirus is...

By: Suman Bhattacharjee

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Gene therapy using retrovirus vector - Video

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New cancer treatment uses patient #39;s cells to attack disease
An experimental gene therapy treatment has shown promise in the fight against leukemia, and doctors will soon start using the sophisticated immunotherapy in ...

By: CBS Evening News

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New cancer treatment uses patient's cells to attack disease - Video

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Francis Collins on Personalized Medicine
Francis Collins is the head of the National Institutes of Health (NIH). We asked him to say a few words about personalized medicine.

By: FriendsofCancerResea

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Francis Collins on Personalized Medicine - Video

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Effective design of multi-marker diagnostic tests for personalized medicine

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Effective design of multi-marker diagnostic tests for personalized medicine - Video

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Beck Lab: Computational Pathology and Personalized Medicine
The system used by pathologists to grade breast tumors hasn #39;t changed much since it was first introduced 80 years ago: Cancerous tissue is stained with dyes ...

By: Beth Israel Deaconess

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Beck Lab: Computational Pathology and Personalized Medicine - Video

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Leroy Hood on Personalized Medicine

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Leroy Hood on Personalized Medicine - Video

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1 Year later after spinal cord injury, lokomat training

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1 Year later after spinal cord injury, lokomat training - Video

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