Genetherapy

Newswise COLUMBUS, Ohio The National Institutes of Health has awarded a $25.4 million grant to The Ohio State University Center for Clinical and Translational Science (CCTS), a collaboration between The Ohio State University and Nationwide Childrens Hospital (NCH) created to accelerate basic science discoveries into life-saving medical advances.

This award is a confirmation that Ohio State has successfully created a strong clinical and translational research environment where basic scientists and clinicians can leverage the resources of a nationally recognized pediatric hospital, Ohio States Wexner Medical Center, seven health science colleges, as well as other resources from one of the largest public universities in the nation, said Charles Lockwood, MD, Dean of the Ohio State University College of Medicine. We find that the barriers to such multidisciplinary research collaboration are virtually non-existent here.

The NIHs endowment is funding of a multi-million dollar Clinical and Translational Science Award (CTSA) that was originally given to the CCTS in 2008. Since then, the Center has helped connect hundreds of researchers across the state of Ohio with the resources needed to discover new techniques and treatments for todays deadliest and costliest diseases including obesity, diabetes, heart disease, cancer, and Alzheimers, as well as a variety of disabling childhood illnesses like muscular dystrophy.

Steven Gabbe, MD, chief executive officer of OSUs Wexner Medical Center, believes one reason that the CCTS program has been successful is that leaders from both Ohio State and Nationwide Childrens Hospital recognize how important translational research and training clinician-scientists is to the evolution of healthcare.

Translational research is critical to our mission of transforming sick care into healthcare, and were committed to creating an environment where discovery fuels innovation in patient care, Gabbe said. The design of the new James Cancer Hospital and Solove Research Institute and Critical Care Center is an excellent example of this. It combines research and education space on every patient care floor, which will accelerate the creation of new diagnostic tools and treatments.

Both the Ohio State and Nationwide Childrens campuses have dedicated substantial resources and infrastructure to grow our translational research capabilities, said John Barnard, MD, President of The Research Institute at Nationwide Childrens . This investment has delivered some major breakthroughs, particularly with gene therapy for some of the most deadly and debilitating muscular diseases. Our partnership is giving us new insights in the continuum of care as children with chronic disease grow into adults , and offering new possibilities for preventing disease altogether.

The CCTS has been also been successful in creating partnerships, infrastructure and programs that drive innovation, training the next generation of scientists, and making the research process more efficient three of the NIHs key goals.

Earlier this year, we signed an historic agreement that includes the two other institutions in the Ohio CTSA network and their partners that centralized our review process, making it dramatically easier for our researchers to collaborate with seven different facilities across the state, noted Rebecca Jackson, MD, director of the Ohio State CCTS. We also joined six other Midwest CTSAs to create a regional consortium that minimizes duplication and makes data capture for multi-site studies more standardized and efficient.

The CCTS facilitated the development of a similar network of institutional partners in Appalachia the Appalachian Translational Research Network which is focused on addressing the significant health challenges and disparities specific to Appalachia.

The CCTS has also helped created shared research resources with sustainability in mind. Two of these resources include the Clinical Research Center, a full service research laboratory, and the Laser Capture Microdissection Core, a lab that collects precise, nano-sized tissue samples. The services were originally fully-funded by the CCTS, but by building them around a sustainable business model, both are close to being self-sufficient operations and are used by researchers across campus.

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$25.4 Million Awarded to Ohio State to Continue Critical "Bench to Bedside" Translational Research

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Sunscreen not only saves skin but 'superhero' within

October 8th, 2013

Topics: skin, skin cancer, sun, sunscreen

NEXT time your kids complain about putting on sunscreen, tell them this: Sunscreen shields a superhero gene that protects them from getting cancer.

It is widely accepted that sunscreen stops you from getting burnt but to date there has been academic debate about the effectiveness of sunscreen in preventing skin cancers.

Now QUT has undertaken a world-first human study to assess the impact of sunscreen at the molecular level.

Researchers found sunscreen provides 100 per cent protection against all three forms of skin cancer: BCC (basal cell carcinoma); SCC (squamous cell carcinoma); and malignant melanoma.

Lead researcher Dr Elke Hacker, from QUT's AusSun Research Lab, said sunscreen not only provided 100 per cent protection against the damage that can lead to skin cancer but it shielded the important p53 gene, a gene that works to prevent cancer.

"As soon as our skin becomes sun damaged, the p53 gene goes to work repairing that damage and thereby preventing skin cancer occurring.

"But over time if skin is burnt regularly the p53 gene mutates and can no longer do the job it was intended for - it no longer repairs sun damaged skin and without this protection skin cancers are far more likely to occur."

The study, published in the Pigment Cell & Melanoma Research journal, looked at the impact of sunlight on human skin, both with and without sunscreen, and found no evidence of UV-induced skin damage when proper application of sunscreen (SPF30+) had been applied to exposed area.

"Melanoma is the most lethal form of skin cancer with research showing damage of melanocytes - the pigment-producing cells of the skin - after sun exposure plays a role in the development of skin cancer," Dr Hacker said.

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Sunscreen not only saves skin but 'superhero' within

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Labeling bill raises modified food debate in Illinois

October 8th, 2013

CHICAGO -- Over the past 16 years, biotechnology has helped Ron Moore grow crops that could survive drought, produce higher-quality grain to feed his livestock and yield sweet corn so plentiful his family has donated extras to the church and local food pantry.

"People have said it's the best sweet corn they've ever eaten," said Moore, 57, whose family farms a few thousand acres near the western Illinois community of Roseville.

But the same scientific advances that have so greatly altered the agriculture industry also have made some consumers nervous about what they are putting in their bodies and what long-term effects it could have.

Now that battle has now come to Moore's home state.

Illinois Sen. David Koehler, a Democrat from Peoria, says those concerns are behind legislation he proposed that would require the labeling of food produced with genetic engineering - often called "GMOs," or genetically modified organisms. Koehler, chairman of the House Agriculture Committee, convened a panel of lawmakers for three hearings on the bill over the summer to try to educate the public and the committee on the issue.

Koehler's bill would require farmers and manufacturers to label any food that's available for retail sale in Illinois and that contains more than 1 percent of genetically engineered ingredients. The front or back of the package must clearly state "Produced with Genetic Engineering" or "Partially Produced with Genetic Engineering." The law would be enforced by the Department of Public Health, and producers could be fined for not properly labeling their products.

"For me it's a consumer transparency issue," Koehler said. "Do consumers have a right to know? I obviously believe they do."

GMOs are plants whose DNA has been manipulated in a lab to resist drought, disease and insects and to increase yields. The European Union largely bans them, but most of the corn, soybean, cotton and sugar beets cultivated in the U.S. today contain plants that were genetically modified. They are particularly common in animal feed and processed foods.

More than 60 countries have GMO labeling laws, according to the Center for Food Safety, a non-profit advocacy group. As efforts to pass a federal law in the U.S. haven't gained much traction, supporters have turned to state legislatures. The Center for Food Safety says labeling measures currently are pending in more than two dozen states. Only two - Maine and Connecticut - have approved them.

Advocates say Illinois is a key piece of the state-by-state approach because it's the nation's fifth most populous state and one of the biggest agricultural producers.

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Labeling bill raises modified food debate in Illinois

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Microbes vs. Genetic Modification

October 8th, 2013

Adapting microbes that dramatically increase crop yields while reducing demand for fertilizers and pesticides through selective breeding or genetic engineering could be cheaper and more flexible than genetically modifying plants themselves, says an author of a report.

Microbes, such as beneficial bacteria, fungi and viruses, could be produced locally for smallholder farmers to significantly improve food security and incomes in developing regions, believes Ann Reid, director of the American Academy of Microbiology and co-author of a report published by the organization last month (27 August).

"Genetic modification of crop plants, which has seen a huge investment, is closed to all but the biggest agricultural companies," she tells SciDev.Net.

"Optimisation of microbes could be done at the level of the local community college and is much more obtainable for a smallholder farmer."

Her comments echo the findings of the report the product of an expert meeting in 2012 which underscored the significant impact microbes could have on food production by increasing crops' absorption of nutrients, resistance to disease and environmental stresses, and even improving flavour.

As well as to accentuate naturally occurring traits such as the secretion of pest-killing toxins or nitrogen-fixation, the modification of microbes is often needed to allow them to be grown in large numbers out of their natural environment.

For example, researchers in Colombia could only produce large quantities of a fungus that improves the nutrient absorption of cassava once they bred a strain of that fungus that was capable of growing on carrot roots.

Recent technological developments in rapid DNA sequencing, imaging and computer modelling can help provide further solutions, as well as building a greater understanding of the complex environment that microbes themselves need to flourish, the report says.

These advances raise the possibility that, within two decades, microbes could increase food production by a fifth and reduce fertiliser demands by the same proportion, it finds.

But to achieve this ambitious goal, the research community must engage in curiosity-driven basic research, develop even cheaper sequencing techniques, and establish a process to move discoveries from the lab to the field, it says.

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Microbes vs. Genetic Modification

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5 Revolutionary Nobel Prizes in Medicine

October 8th, 2013

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5 Revolutionary Nobel Prizes in Medicine

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Regenerative medicine and Stem cells Partnering Terms and Agreements

October 8th, 2013

NEW YORK, Oct. 7, 2013 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Regenerative medicine and Stem cells Partnering Terms and Agreements http://www.reportlinker.com/p01098514/Regenerative-medicine-and-Stem-cells-Partnering-Terms-and-Agreements.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biological_Therapy

The Regenerative Medicine and Stem Cells Partnering Terms and Agreements report provides comprehensive understanding and unprecedented access to the Regenerative medicine and Stem cells partnering deals and agreements entered into by the worlds leading healthcare companies.

Trends in regenerative medicine and stem cells deals Deal terms analysis Partnering agreement structure Partnering contract documents Top deals by value Most active dealmakers Average deal terms for regenerative medicine and stem cells

The report provides a detailed understanding and analysis of how and why companies enter regenerative medicine and stem cells partnering deals. The majority of deals are development stage whereby the licensee obtains a right or an option right to license the licensors regenerative medicine and stem cells technology. These deals tend to be multicomponent, starting with collaborative R&D, and commercialization of outcomes.

This report provides details of the latest regenerative medicine and stem cells agreements including cell therapy agreements announced in the healthcare sector.

Understanding the flexibility of a prospective partner's negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered contract documents provide this insight where press releases and databases do not.

This report contains a comprehensive listing of all regenerative medicine and stem cells partnering deals announced since 2008 including financial terms where available including over 550 links to online deal records as disclosed by the deal parties. In addition, where available, records include contract documents as submitted to the Securities Exchange Commission by companies and their partners.

Contract documents provide the answers to numerous questions about a prospective partner's flexibility on a wide range of important issues, many of which will have a significant impact on each party's ability to derive value from the deal.

For example, analyzing actual company deals and agreements allows assessment of the following: - What is actually granted by the agreement to the partner company? - What exclusivity is granted? - What are the precise rights granted or optioned? - What is the payment structure for the deal? - How aresalesand payments audited? - What is the deal term? - How are the key terms of the agreement defined? - How are IPRs handled and owned? - Who is responsible for commercialization? - Who is responsible for development, supply, and manufacture? - How is confidentiality and publication managed? - How are disputes to be resolved? - Under what conditions can the deal be terminated? - What happens when there is a change of ownership? - What sublicensing and subcontracting provisions have been agreed? - Which boilerplate clauses does the company insist upon? - Which boilerplate clauses appear to differ from partner to partner or deal type to deal type? - Which jurisdiction does the company insist upon for agreement law?

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Regenerative medicine and Stem cells Partnering Terms and Agreements

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Righty? Lefty? Genes' role still unclear

October 8th, 2013

SUNDAY, Oct. 6 (HealthDay News) -- Genetics do not play a major role in determining whether people are right- or left-handed, a new study says.

About 10 percent of people worldwide are left-handed, but the reasons why people favor one hand over the other remain unclear.

In an effort to learn more, researchers conducted genetic analyses of nearly 4,000 twins in the United Kingdom, but were unable to find a strong genetic factor in determining handedness.

The study was published recently in the journal Heredity.

Even though they didn't find a strong genetic influence on handedness, the researchers noted that it is widely believed that handedness is not just the result of choice or learning. Therefore, it's likely that genetic factors play at least a minor role in determining handedness.

Another recent study, published in the journal PLoS Genetics, has found that genetics do play a part in handedness, along with environment.

"It is likely that there are many relatively weak genetic factors in handedness, rather than any strong factors, and much bigger studies than our own will be needed to identify such genes unambiguously," John Armour of the University of Nottingham, co-author of the latest study, said in a university news release.

"As a consequence, even if these genes are identified in the future, it is very unlikely that handedness could be usefully predicted by analysis of human DNA," he added.

More information

The Nemours Foundation has more about being left-handed.

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Righty? Lefty? Genes' role still unclear

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Cell Therapy – Auto Immune Disease – Video

October 7th, 2013

Cell Therapy - Auto Immune Disease
For More Information Visit: http://www.progenacell.com/

By: Charles Studios

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Cell Therapy - Auto Immune Disease - Video

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Cell Therapy – Body Approach – Video

October 7th, 2013

Cell Therapy - Body Approach
For More Information Visit: http://www.progenacell.com/

By: Charles Studios

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Cell Therapy - Body Approach - Video

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Cell Therapy – Lime Disease – Video

October 7th, 2013

Cell Therapy - Lime Disease
For More Information Visit: http://www.progenacell.com/

By: Charles Studios

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Cell Therapy - Lime Disease - Video

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Cell Therapy – Managing Treatments – Video

October 7th, 2013

Cell Therapy - Managing Treatments
For More Information Visit: http://www.progenacell.com/

By: Charles Studios

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Cell Therapy - Managing Treatments - Video

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Open Monoclonal Technology, Inc. Grants Unlimited Platform Access to CNA Development LLC, an Affiliate of Janssen …

October 7th, 2013

PALO ALTO, Calif.--(BUSINESS WIRE)--

Open Monoclonal Technology, Inc. (OMT), a leader in genetic engineering of animals for discovery of human therapeutic antibodies, today announced expansion of its ongoing collaboration with CNA Development LLC, an affiliate of Janssen Pharmaceuticals, Inc. (Janssen).

Following a preliminary collaboration on OmniRat announced in December 2012, OMT has now granted Janssen licenses to use all its genetically engineered animals, OmniRat, OmniMouse and OmniFlic, for an unlimited number of targets and indications. Under the terms of the expanded agreement, Janssen will pay OMT annual platform access fees and success-based development and commercial milestone payments for each product derived from OMTs antibody platforms.

Dr. Roland Buelow, Founder and CEO of OMT, said: "Unlimited, triple-platform access provides OMTs partners with cost-efficient ability to create superior antibodies against some of the most challenging targets. OMT expects to see more and more partners taking such broad access, which will make OMT a profitable biotech company without need for further private or public funding.

OMT offers its collaborators both target-by-target and unlimited platform access. Target-by-target licensing allows the partners to use the technologies in a limited fashion and compare them to existing internal technologies, including humanization of animal-derived antibodies, optimization of display-derived antibodies, and alternative transgenic animal systems. Unlimited platform access provides a more cost-effective long term alternative and gives OMT and its partners more chances at discovery and development of clinically-commercially successful therapeutic antibodies.

Open Monoclonal Technology, Inc.

Open Monoclonal Technology, Inc. (OMT) is a leader in genetic engineering of animals for discovery of human therapeutic antibodies naturally optimized human antibodies.

OMT has created OmniRat, the industrys first fully human monoclonal antibody platform based on rats. It represents a novel and proprietary technology with unrestricted development options. OMT and Pfizer have demonstrated that OmniRat has a complete immune system with a diverse antibody repertoire and generates antibodies with human idiotypes as well as a wild-type animals make rat antibodies (Journal of Immunology 2013 Feb 15; 190(4):1481-90).

OmniMouse is a transgenic mouse designed to complement OmniRat and further increase epitope coverage. Both animals deliver antibodies with great affinity, specificity, expression, solubility and stability, yet with low or no immunogenicity or need for lead optimization. OmniFlic is the industrys first engineered rat with a fixed light chain for development of human bispecific antibodies.

OMTs antibody platforms have broad freedom to operate and use technology protected by new patents and patent applications. They are available for licensing worldwide for all targets and indications and are presently partnered with Merck KGaA, Pfizer, WuXi AppTec and other biopharmaceutical companies.

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Open Monoclonal Technology, Inc. Grants Unlimited Platform Access to CNA Development LLC, an Affiliate of Janssen ...

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Massive DNA study points to new heart drug targets and a key role for triglycerides

October 7th, 2013

Public release date: 6-Oct-2013 [ | E-mail | Share ]

Contact: Kara Gavin kegavin@umich.edu 734-764-2220 University of Michigan Health System

ANN ARBOR, Mich. A global hunt for genes that influence heart disease risk has uncovered 157 changes in human DNA that alter the levels of cholesterol and other blood fats a discovery that could lead to new medications.

Each of the changes points to genes that can modify levels of cholesterol and other blood fats and are potential drug targets. Many of the changes point to genes not previously linked to blood fats, also called lipids. A surprising number of the variations were also associated with coronary artery disease, type 2 diabetes, obesity, and high blood pressure.

The research also reveals that triglycerides another type of blood lipid play a larger role in heart disease risk than previously thought.

The results, published in two new papers appearing simultaneously in the journal Nature Genetics, come from the Global Lipids Genetics Consortium -- a worldwide team of scientists who pooled genetic and clinical information from more than 188,000 people from many countries and heritages.

The analysis of the combined data was led by a team from the University of Michigan Medical School and School of Public Health. They used sophisticated computing and statistical techniques to search for genetic variations that modify blood lipid levels.

The results increase by more than a third the total number of genetic variants linked to blood lipids. All but one of the variants associated with blood lipids are near stretches of DNA that encode proteins.

"These results give us 62 new clues about lipid biology, and more places to look than we had before," says Cristen Willer, Ph.D., the lead author of one paper and an assistant professor of Internal Medicine, Human Genetics and Computational Medicine & Bioinformatics at the U-M Medical School. "Once we take the time to truly understand these clues, we'll have a better understanding of lipid biology and cardiovascular disease -- and potentially new targets for treatment."

But, cautions senior author and U-M School of Public Health Professor Gonalo Abecasis, Ph.D., it will take much further work to study the implicated genes and to find and test potential drugs that could target them. The consortium's "open science" approach will include publishing further detail online for other researchers to use freely toward this goal.

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Massive DNA study points to new heart drug targets and a key role for triglycerides

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Genetics – The Battle Of Epping Forest (Parte 1) @ Teatro Coliseo, Bs As, 21/09/13. – Video

October 7th, 2013

Genetics - The Battle Of Epping Forest (Parte 1) @ Teatro Coliseo, Bs As, 21/09/13.
Genetics - The Battle Of Epping Forest (Parte 1) (Selling England by the Pound, 1973). Teatro Coliseo, Bs As, Argentina. Sábado 21 de Septiembre de 2013. HD ...

By: Gino Zolezzi

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Genetics - The Battle Of Epping Forest (Parte 1) @ Teatro Coliseo, Bs As, 21/09/13. - Video

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Where I’ve been and SK195 Human Genetics and health issues review – Video

October 7th, 2013

Where I #39;ve been and SK195 Human Genetics and health issues review
So this is where I #39;ve been for a while. This is a review of the Open University module SK195 Human Genetics and heath issues review. Some of the information ...

By: 10yeargoals

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Where I've been and SK195 Human Genetics and health issues review - Video

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Myriad's myRisk Hereditary Cancer(TM) Test Improves Colon Cancer Testing by 60 Percent

October 7th, 2013

SALT LAKE CITY, Oct. 7, 2013 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (MYGN) today announced new clinical data from a study with myRisk Hereditary Cancer, a 25-gene hereditary cancer panel, that showed a 60 percent increase in mutations detected in cancer predisposition genes in patients with a prior history of colon cancer and/or polyps. Myriad is presenting this clinical study and data from four other studies this week at the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA) Annual Meeting in Anaheim, Calif.

Patients with a family history of colon cancer also are vulnerable to other cancers including breast, ovarian, endometrial and stomach cancer. The detection of individuals with mutations associated with hereditary colon cancer greatly increases the chances of successful medical management in those at-risk individuals, which will save lives and reduce the downstream healthcare costs. Also, once a patient has been identified as carrying a deleterious mutation that patient's family members can be tested to determine if they have an increased risk of cancer.

"The new data presented at this year's CGA meeting is ground breaking and underscores the importance of using multi-gene panels when testing patients for hereditary colon cancer," said Richard J. Wenstrup, MD, chief medical officer of Myriad. "Importantly, the data suggest that the use of a 25-gene hereditary cancer panel significantly improved the detection of mutations and is a more efficient way for patients to receive appropriate medical management."

Below is a summary of the key data being presented at the CGA annual meeting.

Abstract: Germline Mutations Identified by a 25-Gene Panel in Patients Undergoing Lynch Syndrome Testing

This study evaluated the mutation prevalence among cases referred for Lynch Syndrome (LS), the most common genetic cause of colon cancer, using the myRisk Hereditary Cancer test, a 25-gene hereditary cancer panel. The study presents data from two cohorts representing a total of 1,133 patients diagnosed with colon cancer or colorectal polyps. The results demonstrated that 10 percent of patients had deleterious mutations in the traditional hereditary colon cancer genes, but an additional 6 percent had deleterious mutations in other genes. This represents a 60 percent increase in the number of patients detected with deleterious mutations in cancer predisposing genes

Abstract: Overlap between Lynch Syndrome and Hereditary Breast and Ovarian Cancer Syndrome among Family Histories in Patients Tested for Hereditary Cancer Syndromes

This study investigated the overlap of personal and family histories in hereditary breast and ovarian cancer (HBOC) and hereditary colon cancer in 9,000 patients. Results showed that among patients tested for HBOC, 6.9 percent also had family histories that meet the National Comprehensive Cancer Network (NCCN) criteria for hereditary colon cancer. In addition, 30 percent of patients tested for hereditary colon cancer also met NCCN criteria for HBOC. This analysis demonstrates the overlap among patients with a family history of hereditary breast cancer and those with a family history of colon cancer, suggesting that patients may benefit from multi-gene panels to better improve the diagnosis of hereditary cancer syndromes.

Abstract: MSI-High Histology Is a Predictive Risk Factor for Lynch Syndrome

The objective of this study was to better understand the prevalence of hereditary colon cancer mutations in patients who have abnormal histology, regardless of family history. Approximately 13.9 percent (57/410) of patients with abnormal histology had a deleterious mutation. Importantly, among the patients who tested positive for a deleterious mutation, 77.2 percent (44/57) would not have met Amsterdam II criteria based on personal or family history for hereditary colon cancer testing if histology was not considered. These data support the use of histology to simplify patient selection for hereditary colon cancer testing.

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Myriad's myRisk Hereditary Cancer(TM) Test Improves Colon Cancer Testing by 60 Percent

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Gene therapy set to become future of heart disease treatment

October 7th, 2013

Washington, Oct. 7 (ANI): A global hunt for genes influencing heart disease risk has uncovered 157 changes in human DNA that alter levels of cholesterol and other blood fats - a finding that may lead to new medications.

Each of the changes points to genes that can modify levels of cholesterol and other blood fats and are potential drug targets. Many of the changes point to genes not previously linked to blood fats, also called lipids.

A surprising number of the variations were also associated with coronary artery disease, type 2 diabetes, obesity, and high blood pressure.

The research also reveals that triglycerides - another type of blood lipid - play a larger role in heart disease risk than previously thought.

The results increase by more than a third the total number of genetic variants linked to blood lipids. All but one of the variants associated with blood lipids are near stretches of DNA that encode proteins.

Lead author Cristen Willer, Ph.D., assistant professor of Internal Medicine, Human Genetics and Computational Medicine and Bioinformatics at the U-M Medical School, said that these results give us 62 new clues about lipid biology, and more places to look than we had before.

A further analysis of the massive dataset, published as a letter with lead authors Sekar Kathiresan and Ron Do from Harvard University and the Broad Institute, suggests that triglyceride levels have more impact on cardiovascular disease risk than previously thought.

This analysis found that genetic variations that increase triglyceride or LDL-cholesterol levels are also associated with higher incidence of heart disease. But the analysis also casts further doubt on the role of high density lipoprotein, known commonly as HDL or "good cholesterol", in heart disease risk. In recent years, many drugs that modify HDL cholesterol have failed to show a benefit in preventing heart disease.

The findings have been published in the journal Nature Genetics. (ANI)

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Gene therapy set to become future of heart disease treatment

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