Personalized Medicine in Triple-Negative Breast Cancer
In this segment, panelists discuss research into genomic assays and novel therapeutic approaches that could help personalize the treatment of patients with t...

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Caring for Wounded Warriors with Spinal Cord Injury
During military operations, service members may be exposed to ammunition explosives, fragments, or blasts that can penetrate the spinal cord. If you are cari...

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Cell Therapy - Cancer Treatment
For More Information Visit: http://www.progenacell.com/

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Marilynn Marchione, The Associated Press Published Saturday, October 5, 2013 5:20PM EDT

They were mystery diseases that had stumped doctors for years - adults with strange symptoms and children with neurological problems, mental slowness or muscles too weak to let them stand. Now scientists say they were able to crack a quarter of these cases by decoding the patients' genes.

Their study is the first large-scale effort to move gene sequencing out of the lab and into ordinary medical care, and it shows that high hopes for this technology are finally paying off.

"This is a direct benefit of the Human Genome Project," the big effort to decode our DNA, said Dr. Christine M. Eng of Baylor College of Medicine in Houston. "We're now able to directly benefit patients through more accurate diagnosis."

She led the study, which was published online Wednesday by the New England Journal of Medicine. It gives results on the first 250 patients referred to Baylor for a newer type of sequencing - just the DNA segments that hold the recipes for all the proteins the body needs. That's only about 1 percent of the whole genome.

Baylor has sequenced more patients beyond those in the study - 1,700 so far - and found gene flaws in 1 out of 4, Eng said.

That rate will improve as more genes are linked to diseases, but it's already much higher than the less comprehensive gene tests done now, said Rebecca Nagy, a scientist at Ohio State University and president of the National Society of Genetic Counselors.

"For some of these conditions there could be treatments that are lifesaving," she said.

Already, three people tested at Baylor were found to have a muscle disorder that can cause respiratory problems and even death. The condition is aggravated by infections and stress, and there are drugs to treat those and prevent serious episodes, Eng said.

In other cases, having a diagnosis helped parents like Lindsey and Brandon Collier decide whether to have more children. The Colliers, who live in Georgetown, Texas, about 30 miles north of Austin, searched for years for an answer to what was plaguing their son, Cannon, now 4.

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Genetic Engineering (2000)
Comedy horror music video made to the X-Ray Spex song Genetic Engineering, filmed in 2000. Starring Mike Anino and Alex Dickman, directed by James Nicholas M...

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GNU ECO GENETICS 2014
GNU ECO GENETICS 2014 http://www.board-club.com.ua/?page=productDetails id=7379.

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Genetics problems 5 recessive epistasis
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Genetics problems 9 dominant recessive epistasis
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Genetics problems 12 sex linked inheritance 2
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Genetics - After The Ordeal @ Teatro Coliseo, Bs As, 21/09/13.
Genetics - After The Ordeal (Selling England by the Pound, 1973). Teatro Coliseo, Bs As, Argentina. Sábado 21 de Septiembre de 2013. HD Stereo.

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The Genetics of Multiple Sclerosis
The Genetics of Multiple Sclerosis.

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Dr Pillai (Baba) Reveals His Avatar Part 2 of 3: Soul Genetics - Tarpanam For Your Ancestors
http://www.pillaicenter.com/ Free MP3: http://www.pillaicenter.com/LiveHangout.aspx Subscribe http://www.youtube.com/subscription_center?add_user?=PillaiCent...

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Technology Transfer At VGTI Florida®
Technology Transfer at VGTI Florida® encompasses the process of identification of new discoveries that rise to the level of invention, protection of the resu...

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About VGTI Florida®
The Vaccine and Gene Therapy Institute of Florida is an independent non-profit research institution dedicated to the study of the human immune system. VGTI Florida® #39;s mission is "Translating...

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Freeport, The Bahamas (PRWEB) October 03, 2013

Okyanos Heart Institute, whose mission is to bring a new standard of care and better quality of life to patients with coronary artery disease using cardiac stem cell therapy, has announced that they will be hosting a free educational seminar for the business community and all other interested individuals on Tuesday, October 22nd from 5:30 6:30 pm in the Coral Reef Room of the Pelican Bay Hotel in Lucaya, Grand Bahama Island. Registration is requested to attend as seating is limited.

Howard Walpole, M.D., M.B.A., F.A.C.C., F.S.C.A.I. and chief medical officer and interventional cardiologist for Okyanos Heart Institute will provide an overview of stem cell therapy for heart disease, the source of stem cells, how it is intended to work, and the protocol that will be used by the cath lab for patients once the facility is open in February, 2014. Erika Mangrum, SVP of Communications for the company, will provide an overview of what services will be needed by small businesses on the island, such as janitorial, hospital grade laundry, transportation, catering and more. A preliminary list of jobs that Okyanos Heart Institute will need to fill towards the end of the year will also be shared.

We welcome the local business community to learn about what we will be doing in treating patients with heart disease, said Walpole. Stem cell therapy is a growing field still with some confusion around where stem cells come from, what they do, and how they can potentially help someone with heart disease. We want to answer as many questions as we can.

President of The Grand Bahama Port Authority, Limited (GBPA) Ian Rolle, is pleased with how plans are progressing as the Institute prepares to open its doors locally in early 2014. Legislation has recently been enacted to support stem cell therapy, research and development in The Bahamas. This is of monumental proportions as Grand Bahama Island is now poised to become a leading centre for medical advancement, Rolle said. We heartily welcome the Okyanos Heart Institute and support their efforts towards public education. Additionally, the employment of skilled professionals and outsourcing of ancillary services, mean permanent engagement and greater business opportunities for many of our citizenry.

Okyanos Heart Institute will have a number of service needs from the local business community, said Mangrum. We hope to meet potential suppliers and servicers and share what our needs will be from service providers, and share employment needs once we are close to opening in February. We could not be more enthused about bringing patients to the beautiful island of Grand Bahama in the hopes of improving the quality of their lives by restoring flow to their hearts.

Registration for the seminar is requested as seating is limited. Call 242-688-2667 or email freeseminar(at)okyanos(dot)com by Oct 18.

ABOUT OKYANOS HEART INSTITUTE: (Oh key AH nos) Based in Freeport, The Bahamas, Okyanos Heart Institutes mission is to bring a new standard of care and a better quality of life to patients with coronary artery disease using cardiac stem cell therapy. Okyanos adheres to U.S. surgical center standards and is led by Chief Medical Officer Howard T. Walpole Jr., M.D., M.B.A., F.A.C.C., F.S.C.A.I. Okyanos Treatment utilizes a unique blend of stem and regenerative cells derived from ones own adipose (fat) tissue. The cells, when placed into the heart via a minimally-invasive catheterization, stimulate the growth of new blood vessels, a process known as angiogenesis. The treatment facilitates blood flow in the heart and supports intake and use of oxygen (as demonstrated in rigorous clinical trials such as the PRECISE trial). The literary name Okyanos (Oceanos) symbolizes flow. For more information, go to http://www.okyanos.com.

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Mayo Clinic Researchers Apply Regenerative Medicine to Battlefield Injuries
Mayo Clinic researchers are part of the second phase of a national consortium that focuses on developing innovative medical treatments for wounded veterans. ...

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Pioneering Regenerative Medicine, Dr. Anthony Atala - Andy Anderson - GE FOCUS FORWARD
Subscribe to the GE Channel: http://full.sc/12xcByI Dr. Anthony Atala pioneered the field of regenerative medicine as the first to successfully engineer, gro...

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Oct. 3, 2013 When developing new drugs, monitoring cellular responses to candidate compounds is essential for assessing their efficacy and safety. Researchers from the RIKEN Center for Life Science Technologies report a new method to monitor and quantify the activity of gene promoters during the response to a drug, using the advanced gene expression analysis method CAGE followed by single-molecule sequencing. This research paves the way to a more precise analysis of cellular responses to drugs, at the level of individual promoters.

The study is published this week in the journal CPT: Pharmacometrics & Systems Pharmacology.

Microarray-based technologies are widely used to monitor cellular changes in response to drug administration at the level of genes. However, microarrays have several limitations due to the fact that they rely on pre-designed oligonucleotide probes and detection based on hybridization.

In order to circumvent the limitations imposed by the use of microarray-based technology for the development of new drugs, Dr Harukazu Suzuki and his team at CLST developed a new technique combining Cap Analysis of Gene Expression (CAGE) with 3rd generation, single-molecule sequencing. CAGE is a method developed at RIKEN to comprehensively map human transcription start sites and their promoters, and quantify the set of mRNAs in a cell, also called the transcriptome.

During CAGE the 5'-end of mRNAs is sequenced in order to produce a series of 20-30 nucleotide sequences that can then be mapped onto the genome and provide information about the level of expression of genes. Dr Suzuki and his team used CAGE, combined with a single-molecule sequencer, to monitor the effect of three drugs, U0126, wortmannin and gefitinib on human breast cancer cells.

U0126 and wortmannin are known to inhibit the Ras-ERK and phosphatidylinositol-3-kinase (PI3K)-Akt signalling pathways within cells. Gefinitib is a potent inhibitor of the epidermal growth factor receptor kinase (EGFR kinase) and mainly inhibits the Ras-ERK and PI3K-Akt pathways downstream of EGFR.

The researchers identified a distinct set of promoters that were affected by low doses of the drugs, and therefore showed sensitivity to a weak inhibition of the Ras-ERK and PI3K-Akt signal-transduction pathways. This level of precision would would have been very difficult to achieve using microarray-based profiling.

Furthermore, a quantitative analysis showed that the inhibitory profiles of both U0126 and wortmannin are constitutive components of the transcriptome profile obtained by inhibition of the EGFR kinase. Using a regression model, the researchers were able to quantitatively predict the promoter activity profile of gefitinib, based on the U0126 and wortmannin profiles.

These results demonstrate the potential utility of highly quantitative promoter activity profiling in drug research.

"Quantitative transcriptome analysis is potentially widely applicable to determine the target proteins and action mechanisms of uncharacterized compounds," concludes Dr Suzuki. "Our study paves the way for quantitative analysis of drug responses at the promoter level, and moreover, is potentially applicable for the evaluation of combinatorial or serial drug treatment in a clinical setting," he adds.

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Advanced technology for gene expression analysis can facilitate drug development

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PHILADELPHIA This Sunday, the lifesaving efforts of the University of Pennsylvanias Basser Research Center for BRCA will take root in Congregation Rodeph Shalom at a special event to raise awareness about hereditary breast and ovarian cancers within the Jewish community. The panel discussion, which will gather medical experts and genetic counselors alongside clergy, cancer advocates, survivors and previvors, aims to call attention to a striking statistic: 1 in 40 individuals of Ashkenazi Jewish ancestry who comprise 90 percent of Jews living in the U.S. carries a BRCA mutation, more than ten times the risk of the general population. Men can carry and pass on the gene mutations, too.

Experts will share the latest news on genetic testing for these mutations, which greatly increase carriers lifetime risk of developing breast and ovarian cancers and are also linked to prostate, pancreatic and colon cancers. CBS3/CW Philly 57 Medical Reporter Stephanie Stahl will emcee the event, which will include an opportunity for the audience to ask questions of the panel and for individuals to meet one-on-one with genetic counselors from Penn Medicine.

This event is the first of a three-part educational series co-hosted by Penn Medicines Basser Research Center for BRCA and Living Beyond Breast Cancer, a national nonprofit organization that provides educational resources and support to women affected by breast cancer, their families and caregivers. This partnership, made possible by a grant from Women of Vision, the Jewish Womens Foundation of Greater Philadelphia, also brings together breast and ovarian cancer advocates from FORCE: Facing Our Risk of Cancer Empowered, Sharsheret and Bright Pink.

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Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of theRaymond and Ruth Perelman School of Medicine at the University of Pennsylvania(founded in 1765 as the nation's first medical school) and theUniversity of Pennsylvania Health System, which together form a $4.3 billion enterprise.

The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 16 years, according toU.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $398 million awarded in the 2012 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals byU.S. News & World Report; Penn Presbyterian Medical Center; Chester County Hospital; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Chestnut Hill Hospital and Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2012, Penn Medicine provided$827million to benefit our community.

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San Jose, California (PRWEB) October 04, 2013

Follow us on LinkedIn Predictive diagnostics refer to a series of genetic tests that determine individual susceptibility to diseases, individual response to specific therapies/interventions and the outcome of diseases. Genetic testing has emerged as a lucrative sector in the molecular diagnostics market led by the fact that appropriate and accurate diagnosis is the cornerstone of advanced healthcare. Predictive testing involves identifying the presence or inheritance of faulty gene among members of a family, such as those resulting in Tay-Sachs disease, cystic fibrosis, Lou Gehrig's disease, Huntington's disease and Alzheimer's disease. Predictive diagnostics are also beneficial in examining the gene composition and interaction in diseased tissue/cells to understand and determine progress of the disease as well as the response to treatment.

Though a relatively small market, predictive diagnostics is witnessing steady growth owing to increasing awareness among medical professionals and patients. Proportional to rising life expectancy and mean age, chronic degenerative diseases (CDD) including cardiovascular diseases, neurodegenerative disorders, cancer and autoimmune diseases, have surged globally, translating into demand for predictive testing. The rapidly ageing society in major Western and Eastern economies is therefore a prime driver of demand for predictive diagnostics for age-related disorders. Traditionally offered through physicians, genetic testing kits are now being offered directly to the consumer through web-based stores. However, the security and utility of DTC genetic testing kits is being questioned as several companies tend to circumvent third party reimbursement and regulatory issues.

Decreasing costs coupled with the enhanced efficiency and speed of gene sequencing has resulted in rapidly unfurling information on cancer gene mechanisms. With the cost of sequencing the entire genome falling below US$1,000 in comparison to anti-cancer treatments which cost over US$50,000, physicians are opting to conduct genomic tests to determine patient drug response, following which medications are prescribed to only those patients who are more likely to respond to a specific cancer therapy or treatment option. Technological advancements in genomics such as Next-Generation Sequencing (NGS) are replacing conventional DNA sequencing modalities. Advanced NGS systems offer the capability of sequencing and comparing up to 4 human genomes within a space of two weeks. Demand for genetic tests designed for screening newborn infants, diagnosis of orphan diseases and other rare or fatal disorders, and assessment of the probability of occurrence of conditions such as Huntingtons disease, is expected to expand dramatically in the near term. On the flip side, as the new era of genetic medicine dawns upon the healthcare sector, the need of the hour is a clear and comprehensive framework addressing the medical, economic, ethical and legal aspects of subjecting healthy individuals to genetic testing for disease prevention.

As stated by the new market research report on Predictive Diagnostics, the United States represents the largest market worldwide. Screening for genetic mutations within the CFTR (cystic fibrosis trans-membrane conductance regulator) gene is the most frequently conducted test in the country. While developed economies with advanced healthcare infrastructure are at the forefront in the adoption of predictive genetic testing, population growth and recent government initiatives to improve healthcare delivery to all sections of the population is expected to propel demand in developing countries in the near future. Countries such as China harbor the largest prospects for breast cancer gene testing. Attributed to lifestyle changes as a result of rapid industrialization and increasing urbanization, the country is registering a surge in cases of breast cancer.

Major players covered in the report include Abbott Molecular, Almac Group Ltd., BioGenex, Covance Inc., Dako Denmark A/S, Epistem Plc, F. Hoffmann-La Roche Ltd., Genomic Health, Inc., MDxHEALTH Inc., Myriad Genetics Inc., Precision Therapeutics Inc., Prometheus Laboratories, QIAGEN N.V., among others.

The research report titled "Predictive Diagnostics: A Global Strategic Business Report" announced by Global Industry Analysts Inc., provides a comprehensive review of market trends, drivers, mergers, acquisitions and other strategic industry activities. The report provides market estimates and projections for major geographic markets such as the US, Canada, Japan, Europe (France, Germany, Italy, UK, and Rest of Europe), and Rest of World.

For more details about this comprehensive market research report, please visit http://www.strategyr.com/Predictive_Diagnostics_Market_Report.asp

About Global Industry Analysts, Inc. Global Industry Analysts, Inc., (GIA) is a leading publisher of off-the-shelf market research. Founded in 1987, the company currently employs over 800 people worldwide. Annually, GIA publishes more than 1300 full-scale research reports and analyzes 40,000+ market and technology trends while monitoring more than 126,000 Companies worldwide. Serving over 9500 clients in 27 countries, GIA is recognized today, as one of the world's largest and reputed market research firms.

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Genetics part 1 introduction to advanced genetics
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kush dreams dna genetics
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