Walking with Spinal Cord Injury

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Walking with Spinal Cord Injury - Video

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Aubrey de Grey - Google vs Death: an Anti Aging Initiative - Progress in Regenerative Medicine
Aubrey de Grey of SENS Foundation on #39;Calico #39;, Google #39;s anti-aging initiative. http://sens.org/outreach/outreach-blog/time-feature-cso-aubrey-de-grey-googles...

By: Adam Ford

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Aubrey de Grey - Google vs Death: an Anti Aging Initiative - Progress in Regenerative Medicine - Video

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Professor Arnold Caplan discusses mesenchymal stem cell therapy for multiple sclerosis
Professor Caplan is "The father of the mesenchymal stem cell (MSC)". In this clip, he describes a mouse experiment using human MSCs in a mouse model of MS. T...

By: http://www.cellmedicine.com

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Professor Arnold Caplan discusses mesenchymal stem cell therapy for multiple sclerosis - Video

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Insurance Covered Stem Cell Therapy in California at TeleHealth (888) 828-4575
http://stemcelltherapyincalifornia.com Stem Cell Therapy procedures at TeleHealth are offered for a number of conditions and often covered by insurance. Thes...

By: USPainNetwork

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Insurance Covered Stem Cell Therapy in California at TeleHealth (888) 828-4575 - Video

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MANILA, PhilippinesStem cell therapy should only apply to skin grafting for burn patients and not for anti-aging purposes, according to the Food and Drug Administration (FDA).

Up to now, there is no evidence that stem cell therapy has anti-aging effects, said FDA acting Director General Kenneth Hartigan-Go.

The FDA recognizes only hematopoietic (pertaining to the formation and development of blood cells) stem cell transplantation, corneal resurfacing with limbal stem cells and skin regeneration with epidermal stem cells as generally accepted standards of health care.

Asked if this meant anti-aging stem cell therapies would not be allowed in the Philippines, Go said: It means that if the health claim is for burn patients, requirements that need to be submittedlike clinical trial reportsare expected to be complete, whereas if the claim is for anti-aging, then the requirements may be more extensive and intensive considering that products for anti-aging claims are still controversial.

Facility accreditation

The FDA said it had been continuously collaborating with the Department of Healths Bureau of Health Facilities and Services (BHFS) in accrediting facilities that deal with human cells, tissues, and cellular and tissue-based products (HCT/Ps), laboratory and therapeutic activities or services.

As of Sept. 24, 51 facilities have applied for accreditation, and 11 of these have been inspected by the BHFS, the FDA said.

No automatic approval

Submission of an application, however, does not necessarily result in automatic approval.

The FDA guidelines require that all stem cell and cellular-based treatments offered in the country should first pass the agencys standards for safety, efficacy and quality.

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Stem cell therapy for burns, not aging, says FDA

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Healing With Stem Cell Therapy
http://www.ihealthtube.com http://www.facebook.com/ihealthtube Stem cell treatments have long been controversial, mostly because they started with the use of...

By: iHealthTube.com

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Healing With Stem Cell Therapy - Video

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A research team at the Massachusetts General Hospital have discovered two gene mutations that could cause late onset Alzheimers disease in humans. The good news, according to the researchers, this can help in the prevention and treatment of the disease.

A gene, called ADAM10, is where the new mutations were found. The mutations are similar to the same mutations found in Alzheimers, which is usually founded in people over the age of 60. This is the second gene confirmed to cause late onset Alzheimers as well as the fifth to be linked overall to the disease according to the Massachusetts General Hospital researchers.

The two mutations the researchers found in the ADAM10 gene, showed an increase in producing the beta-amyloid protein. The beta-amyloid protein is founded in people who suffer from Alzheimers. The mutations also stop the creation of new nerve related cells in the hippocampus. The hippocampus is critical as it main purpose is to help with the brains function to learn and retain memory.

This is the first report to document, in animal models, new [disease-causing] gene mutations for Alzheimers since the reports of the original four genes in the 1990s. , study senior author Rudolph Tanzi, director of the genetics and aging unit the Mass General Institute for Neurodegenerative Disease, said at the hospital news release.

What we found regarding the many effects of these two rare mutations in ADAM10 strongly suggests that diminished activity of this enzyme can cause [Alzheimer's disease], and these findings support ADAM10 as a promising therapeutic target for both treatment and prevention. he said.

Similar findings from animal models does not mean it will be founded in humans, but it is a potential help in the fight against Alzheimers. Video via NDN

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Alzheimer’s: A Discovery of Two New Gene Mutations

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Public release date: 29-Sep-2013 [ | E-mail | Share ]

Contact: Glenna Picton picton@bcm.edu 713-798-7973 Baylor College of Medicine

HOUSTON -- (Sep. 29, 2013) As so many genome studies do, this study published online in the journal Nature Genetics began with a single patient and his parents who were in search of a diagnosis.

The parents of this first patient sought genetic testing for Prader-Willi syndrome when he was only a year old, but the test, which was still in its infancy, came back negative. For the next 12 years, his parents were left in limbo. He had many features of the disease including lack of muscle tone, feeding difficulties and failure to thrive early on. Autism spectrum disorder and mild intellectual disability became evident as he grew older.

Dr. C. Thomas Caskey, then with UTHealth and now with Baylor College of Medicine, referred the patient to Dr. Christian Schaaf, an assistant professor of molecular and human genetics at Baylor College of Medicine and a faculty member at the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, for an evaluation. Schaaf agreed that the boy had many of the outward signs consistent with Prader-Willi, but others were lacking, such as the morbid obesity, which is typically caused by a very aggressive appetite.

Dr. Manuel L. Gonzalez-Garay (co-first and co-corresponding author), assistant professor and bioinformatics expert at the University of Texas Health Science Center at Houston's Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, identified a single change (called a point mutation) in the gene MAGEL2 using highly accurate whole genome sequencing information from Complete Genomics, Inc., of Mountain View California. This gene is located in the area of chromosome 15, which researchers knew was involved in Prader-Willi syndrome. The single base deletion found in this GC-rich and difficult to sequence gene is a frame-shift mutation that disrupts activity of the protein product of MAGEL2.

Prader-Willi syndrome is an imprinted disease, which means only one of the two copies of the gene inherited from your parents is working. The other is "silenced," usually during the formation of eggs or sperm. In this case, neither parent had a mutation, meaning that the mutation occurred first in this child. However, it still mattered whether the mutation came from the mother or the father.

The team from UTHealth and Complete Genomics then performed an involved analysis that determined that the mutated gene was on the paternal chromosome 15.

"Because the mom's copy of the gene is silenced and the dad's copy is deficient, there is no functional copy of the gene in his body," said Schaaf. "It was a nice collaboration among Baylor, UTHealth and Complete Genomics. But it was only one patient. When you identify a new gene and want to prove that it is the real cause of disease, you really need to identify several patients with mutations in the same gene, and show that they also have similar clinical manifestations. You also ought to consider the severity of the mutation and how rare the mutation is."

To start, they began to look for other patients. They asked the Baylor Whole Genome Sequencing Laboratory to find out if there had been similar mutations found in patients who had their exomes or protein-coding portions of the genome sequenced. They searched through the records of 1,200 and found three more patients with mutations in the same gene. One of the three had classic Prader-Willi syndrome, the other two were classified as Prader-Willi like. All three children had the standard molecular testing for Prader-Willi when they were infants, with negative results.

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Sequencing studies help pinpoint gene in Prader-Willi syndrome

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Gene is only second linked to late-onset Alzheimer's, fifth overall linked to the disease.

Published: Sept. 28, 2013 at 8:20 PM

Researchers at Massachusetts General Hospital identified two gene mutations that can increase a person's chance of developing late-onset Alzheimer's disease.

The research, published in the October issue of Neuron magazine, found that the two rare mutations are found in the ADAM10 gene, the second gene found to play a role in Alzheimer's developed after the age of 60. It's the fifth gene overall linked to the disease.

"This is the first report to document, in animal models, new [disease-causing] gene mutations for Alzheimer's since the reports of the original four genes in the 1990s," study senior author Rudolph Tanzi, director of the genetics and aging unit at the MassGeneral Institute for Neurodegenerative Disease, said in a hospital news release.

"What we found regarding the many effects of these two rare mutations in ADAM10 strongly suggests that diminished activity of this enzyme can cause [Alzheimer's disease], and these findings support ADAM10 as a promising therapeutic target for both treatment and prevention," Tanzi said.

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Alzheimer's: Two additional gene mutations linked to disease

Recommendation and review posted by Bethany Smith

Gene is only second linked to late-onset Alzheimer's, fifth overall linked to the disease.

Published: Sept. 28, 2013 at 8:20 PM

Researchers at Massachusetts General Hospital identified two gene mutations that can increase a person's chance of developing late-onset Alzheimer's disease.

The research, published in the October issue of Neuron magazine, found that the two rare mutations are found in the ADAM10 gene, the second gene found to play a role in Alzheimer's developed after the age of 60. It's the fifth gene overall linked to the disease.

"This is the first report to document, in animal models, new [disease-causing] gene mutations for Alzheimer's since the reports of the original four genes in the 1990s," study senior author Rudolph Tanzi, director of the genetics and aging unit at the MassGeneral Institute for Neurodegenerative Disease, said in a hospital news release.

"What we found regarding the many effects of these two rare mutations in ADAM10 strongly suggests that diminished activity of this enzyme can cause [Alzheimer's disease], and these findings support ADAM10 as a promising therapeutic target for both treatment and prevention," Tanzi said.

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Alzheimer's: Two new gene mutations linked to disease

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September 2013 Breaking News Genetic engineering
September 2013 Breaking News Genetic engineering.

By: utoob bornagain

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September 2013 Breaking News Genetic engineering - Video

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Asa Mathat | All Things D

Last week more than a dozen companies had IPOs and among them was an interesting bio-tech company called Foundation Medicine.

Foundation offers to the public the kind of in-detailed genetic cancer testing made famous by Steve Jobs. Jobs was the first well-known person to try this sort of thing.

For about $6,000, this test uncovers all the genetic mutations that lead to a persons tumor. It's helping to usher in a new era of "personalized medicine" where doctors choose cancer treatments based on genetic knowledge.

Jobs spent some $100,000 to have this kind of test done, according to Walter Isaacsons biography, and in the end, it obviously didn't save him.

But he believed deeply in the value of the attempt, saying Im either going to be one of the first to be able to outrun a cancer like this, or Im going to be one of the last to die from it, reports Antonio Regalado, MIT Technology Review.

After Jobs died, the doctors who reportedly worked on the test at the Broad Institute of MIT and Harvard, left Broad to start Foundation, Regalado reports. Bill Gates and Larry Page both visited Jobs shortly before his death, according toIsaacson, and while they could do nothing to help him, they did help fund Foundation.

Bill Gates was part of the company's initial $13.5 million round and still owns 4%, according to documents filed with the SEC.

Google Ventures, the venture capital arm of Google, was part of a long list of VCs that later kicked in cash, and still owns 9%. In fact, foundation raised a whopping $251 million from investors in two years.

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Steve Jobs' Final Vision Is Coming True Thanks (In Part) To Bill Gates And Google

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FD Genetics
Why I think psychology is the excuse for genetics.

By: Francis Diet TALKS

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FD Genetics - Video

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AMERICAN GENETICS
http://www.cacciaedintorni.it.

By: Caccia e Dintorni

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AMERICAN GENETICS - Video

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Genetics - Don #39;t Give Up @ Teatro Coliseo, Bs As, 21/09/13.
Genetics - Don #39;t Give Up (Peter Gabriel single, 1986). Teatro Coliseo, Bs As, Argentina. Sábado 21 de Septiembre de 2013. HD Stereo.

By: Gino Zolezzi

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Genetics - Don't Give Up @ Teatro Coliseo, Bs As, 21/09/13. - Video

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Gene therapy relieving chronic pain in pets
9/26 10 pm -- A revolutionary gene therapy developed in Colorado could relieve people #39;s chronic pain, such as arthritis or fibro but first, it is being teste...

By: 7NEWS and TheDenverChannel.com

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Gene therapy relieving chronic pain in pets - Video

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Gene therapy part 2 : ex vivo gene therapy
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html Gene ...

By: Suman Bhattacharjee

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Gene therapy part 2 : ex vivo gene therapy - Video

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Gene therapy part 1 : basics of gene therapy
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html Gene ...

By: Suman Bhattacharjee

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Gene therapy part 1 : basics of gene therapy - Video

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Gene therapy part 3 in vitro gene therapy
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html Gene ...

By: Suman Bhattacharjee

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Gene therapy part 3 in vitro gene therapy - Video

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Gene therapy part 4 applications and future prospects
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html Gene ...

By: Suman Bhattacharjee

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Gene therapy part 4 applications and future prospects - Video

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Human gene therapy, types of gene therapy part 1
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html.

By: Suman Bhattacharjee

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Human gene therapy, types of gene therapy part 1 - Video

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Human gene therapy, types of gene therapy part 2
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html.

By: Suman Bhattacharjee

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Human gene therapy, types of gene therapy part 2 - Video

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Human gene therapy, types of gene therapy part 3
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html Somat...

By: Suman Bhattacharjee

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Human gene therapy, types of gene therapy part 3 - Video

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Human gene therapy, types of gene therapy part 4
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html.

By: Suman Bhattacharjee

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Human gene therapy, types of gene therapy part 4 - Video

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Several gene therapies are or will soon be in late-stage human trials. One of them could be the first to get FDA approval for sale in the U.S.

Though many gene therapies have been tested in patients around the world in hopes of curing hereditary diseases, few governments have approved their sale, and none has been approved in the United States. That could change in coming years as several therapies enter advanced trials.

A big step forward already came in November 2012, when the European Medicines Agency gave the Dutch biotech startup UniQure permission to sell its treatment. That approval came as a relief to many in the field, who had been waiting for a break in the clouds hanging over the technology since failed and fatal trials in the 1990s. You see a resurgence in terms of investors, and in truth, a number of problems have been solved, says Katherine High, a medical researcher at Childrens Hospital of Philadelphia, who is overseeing a late-stage clinical trial for a different gene therapy.

Still, experts say it is likely to be a few years before a treatment is approved in the U.S. With its European approval in hand, UniQure may have good chance of also getting the first U.S. approval, but the company says it has not yet submitted an application to the FDA.

Like most gene therapies, UniQures treatment uses a modified virus to deliver a working copy of a gene to patients who lack a healthy version. In this case, the gene is needed for the body to break down fats; without it, patients can develop painful and even fatal inflammation of the pancreas. UniQure uses a modified version of a virus that most of us already carry. The choice of virus used to deliver a gene therapy depends in part on where the treatment needs to go in the body and whether the viruses are intended to replicate themselves. Some viruses, for instance, are designed to spread throughout the body to kill cancer cells.

There are several groups that could be the first to develop a U.S.-approved gene therapy (see table). Highs team is one; they are enrolling patients in a late-stage trial of a treatment for a disorder that causes blindness at an early age. The patients in this trial have previously been given the gene therapy in one eye, and now the other will be tested.

In the experimental treatment, doctors inject a virus-based particle just behind a patients retina. The treatment improved some patients vision to the point that they were no longer legally blind. Some patients have been stable for nearly six years. The trial is scheduled to end in April 2015.

Another possibility comes from Massachusetts-based Bluebird Bio, which has published results from patients who have seemingly been cured of a genetic blood disease (see Gene Therapy Combats Hereditary Blood Disease). The company is about to start testing its approach in a hereditary neurological disorder that is often fatal in young boys.

In a different form, gene therapy could also become an option for cancer treatment. At a meeting this summer, Amgen announced that it had met its goals for an advanced test of a gene therapy for melanoma that has spread from the skin to other parts of the body. The Amgen treatment, which was engineered from a virus that normally causes cold sores, takes a two-pronged approach to fighting cancer. The virus selectively infects cancer cells, where it replicates until the cell bursts. While growing inside the cell, the virus also produces a protein that rouses the immune system. When the cell explodes, immune cells are attracted to the tumor site to fight the disease.

In a test in patients with late-stage melanoma, 26 percent of patients whose cancer had spread saw a partial or complete tumor response for at least six months. In 11 percent of patients, the cancer completely disappeared, which suggests that the therapy spreads throughout the body, targeting tumors that werent initially injected. Overall survival rates for cancer patients in the trials are expected to be reported in the first half of 2014.

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When Will Gene Therapy Come to the U.S.?

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