Adult Stem Cells Found to Suppress Cancer While Dormant
Posted: December 18, 2013 at 9:43 pm
Contact Information
Available for logged-in reporters only
Newswise Researchers at UCLAs Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have discovered a mechanism in adult stem cells by which the cells suppress their ability to initiate cancer during their dormant phase, an understanding that could be exploited for better cancer prevention strategies. The study was led by Andrew White, post-doctoral fellow, and William Lowry, associate professor of molecular, cell and developmental biology in the life sciences and the Maria Rowena Ross Term Chair in Cell Biology.
The study was published online ahead of print in Nature Cell Biology on December 15, 2013.
Hair follicle stem cells (HFSC), the tissue-specific adult stem cells that generate the hair follicles, are also the cells of origin for cutaneous squamous cell carcinoma (SCC), a common skin cancer. These HFSCs cycle between periods of activation, during which they can grow, and quiescence, when they remain dormant.
Using mouse models, White and Lowry applied known cancer-causing genes (oncogenes) to HFSCs and found that during cell quiescence, the cells could not be made to initiate SCC. Once the HFSC were in their active period, they began growing cancer.
We found that this tumor suppression via adult stem cell quiescence was mediated by Pten, a gene important in regulating the cells response to signaling pathways, White said, therefore, stem cell quiescence is a novel form of tumor suppression in hair follicle stem cells, and Pten must be present for the suppression to work.
Understanding cancer suppression through quiescence could better inform preventative strategies in patients susceptible to SCC, such as organ transplant patients, or those taking the drug vemurafenib for melanoma, another type of skin cancer. This study also may reveal parallels between SCC and other cancers in which stem cells have a quiescent phase. This research was supported by the California Institute of Regenerative Medicine (CIRM), University of California Cancer Research Coordinating Committee (CRCC) and National institutes of Health (NIH).
The stem cell center was launched in 2005 with a UCLA commitment of $20 million over five years. A $20 million gift from the Eli and Edythe Broad Foundation in 2007 resulted in the renaming of the center. With more than 200 members, the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research is committed to a multi-disciplinary, integrated collaboration of scientific, academic and medical disciplines for the purpose of understanding adult and human embryonic stem cells. The center supports innovation, excellence and the highest ethical standards focused on stem cell research with the intent of facilitating basic scientific inquiry directed towards future clinical applications to treat disease. The center is a collaboration of the David Geffen School of Medicine, UCLAs Jonsson Comprehensive Cancer Center, the Henry Samueli School of Engineering and Applied Science and the UCLA College of Letters and Science. To learn more about the center, visit our web site at http://www.stemcell.ucla.edu.
View post:
Adult Stem Cells Found to Suppress Cancer While Dormant
- Secret History of Diamonds Narrated for the Visually Impaired - Part 2 of 4 [Last Updated On: June 24th, 2011] [Originally Added On: June 24th, 2011]
- Skin Stem Cells: Their Biology [Last Updated On: June 24th, 2011] [Originally Added On: June 24th, 2011]
- Emerge Labs New Anti Aging Swiss Apple Stem Cell Skin Care [Last Updated On: June 25th, 2011] [Originally Added On: June 25th, 2011]
- No Avastin for Breast Cancer [Last Updated On: June 25th, 2011] [Originally Added On: June 25th, 2011]
- Signals Skincare System [Last Updated On: June 25th, 2011] [Originally Added On: June 25th, 2011]
- Signals Skincare System [Last Updated On: June 25th, 2011] [Originally Added On: June 25th, 2011]
- Growing Nerve Cells [Last Updated On: June 26th, 2011] [Originally Added On: June 26th, 2011]
- Elaine Fuchs Part 2: Tapping the Potential of Adult Stem Cells, and Summary [Last Updated On: June 26th, 2011] [Originally Added On: June 26th, 2011]
- A Major Breakthrough in Skin Care and Nutrition [Last Updated On: June 27th, 2011] [Originally Added On: June 27th, 2011]
- Stem Cell Facial At Metamorphosis Day Spa Using Emerge Labs Skin Care [Last Updated On: June 27th, 2011] [Originally Added On: June 27th, 2011]
- Come Back Kid [Last Updated On: June 28th, 2011] [Originally Added On: June 28th, 2011]
- PhytoCell.mp4 [Last Updated On: June 28th, 2011] [Originally Added On: June 28th, 2011]
- When Beauty Calls: The Link between Science and Skin Care [Last Updated On: June 29th, 2011] [Originally Added On: June 29th, 2011]
- Skin Stem Cells: Their Biology [Last Updated On: June 29th, 2011] [Originally Added On: June 29th, 2011]
- Come Back Kid [Last Updated On: July 1st, 2011] [Originally Added On: July 1st, 2011]
- PhytoCell.mp4 [Last Updated On: July 1st, 2011] [Originally Added On: July 1st, 2011]
- The Skin Gun stem cell research [Last Updated On: July 1st, 2011] [Originally Added On: July 1st, 2011]
- World's 1st Nutricosmetic with Stem Cell Nutrients [Last Updated On: July 2nd, 2011] [Originally Added On: July 2nd, 2011]
- NG Raccoon Attack [Last Updated On: July 3rd, 2011] [Originally Added On: July 3rd, 2011]
- No Avastin for Breast Cancer [Last Updated On: July 4th, 2011] [Originally Added On: July 4th, 2011]
- E'shee HBA Global Expo 2011, NYC. Skin Care Anti-Aging Symposium [Last Updated On: July 5th, 2011] [Originally Added On: July 5th, 2011]
- Growing Nerve Cells [Last Updated On: July 9th, 2011] [Originally Added On: July 9th, 2011]
- The Skin Gun [Last Updated On: July 9th, 2011] [Originally Added On: July 9th, 2011]
- E'shee HBA Global Expo 2011, NYC. Skin Care Anti-Aging Symposium [Last Updated On: July 14th, 2011] [Originally Added On: July 14th, 2011]
- A Major Breakthrough in Skin Care and Nutrition [Last Updated On: July 17th, 2011] [Originally Added On: July 17th, 2011]
- Elaine Fuchs Part 1: Introduction to Stem Cells [Last Updated On: July 20th, 2011] [Originally Added On: July 20th, 2011]
- World's 1st Nutricosmetic with Stem Cell Nutrients [Last Updated On: July 21st, 2011] [Originally Added On: July 21st, 2011]
- Stem cells acquired from human skin [Last Updated On: August 9th, 2011] [Originally Added On: August 9th, 2011]
- Stem cells acquired from human skin [Last Updated On: August 17th, 2011] [Originally Added On: August 17th, 2011]
- DermaStem Renewal Serum - Stem Cells for Your Skin from STEMTech - New Paradigm in Beauty! [Last Updated On: August 19th, 2011] [Originally Added On: August 19th, 2011]
- DermaStem Renewal Serum - Stem Cells for Your Skin from STEMTech - New Paradigm in Beauty! [Last Updated On: August 30th, 2011] [Originally Added On: August 30th, 2011]
- ReLuma-stemcells- skin rejuvenation [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Dr Nathan Newman- Formulator of Stem Cell Skin Care Line LUMINESCE [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Genetic Skin Disease (EB): Spotlight on Stem Cell Research - Patient Advocate [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Genetic Skin Disease (EB): Spotlight on Stem Cell Research - Patient Advocate [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Stem Cell Skin Care- What is the role of stem cells in Luminesce Featuring Dr Nathan Newman [Last Updated On: September 7th, 2011] [Originally Added On: September 7th, 2011]
- Luminesce Stem Cell Skin Care - Leaders in Jeunesse [Last Updated On: September 7th, 2011] [Originally Added On: September 7th, 2011]
- The Skin Gun (Stem Cell research to replace burnt off skin. Done in 3 days!) [Last Updated On: September 7th, 2011] [Originally Added On: September 7th, 2011]
- Stem Cell Skin Care- What is the role of stem cells in Luminesce Featuring Dr Nathan Newman [Last Updated On: September 7th, 2011] [Originally Added On: September 7th, 2011]
- Isolation and Culture of Adult Epithelial Stem Cells from Human Skin [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- Genetic Skin Disease (EB): Spotlight on Stem Cell Research - Welcome [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- Stem Cells Made From Human Skin [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- Jeunesse Global Business Opportunity with Stem Cell Skin Care Developed by Dr Nathan Newman [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Stem Cell Therapy Skin Repair and Anti-Wrinkle Cream [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Stem Cells Made From Human Skin [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Genetic Skin Disease (EB): Optimizing Embryonic Stem Cell Differentiation Protocols [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Genetic Skin Disease (EB): Spotlight on Stem Cell Research - Introduction [Last Updated On: September 11th, 2011] [Originally Added On: September 11th, 2011]
- Isolation and Culture of Adult Epithelial Stem Cells from Human Skin [Last Updated On: September 11th, 2011] [Originally Added On: September 11th, 2011]
- Stem Cell Therapy - BioLogic Anti-Aging Skin Cream [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- Best natural skin care serum using stem cell technology [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- Jeunesse Global Business Opportunity with Stem Cell Skin Care Developed by Dr Nathan Newman [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- Genetic Skin Disease (EB): Optimizing Embryonic Stem Cell Differentiation Protocols [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- The Skin Gun (Stem Cell research to replace burnt off skin. Done in 3 days!) [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- Research on skin cancer: ERC funds studies on stem cells [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Skin engineering [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Stem Cell Banking: The Perspective of an iPS Donor Family [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Jeunesse Global Opportunity- Stem Cell Skin Care [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Dr Nathan Newman Repairs Laugh Lines With Stem Cell Face Lift [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Dr Nathan Newman MD Stem Cell Face lift On Extra TV.flv [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Dr Nathan Newman Stem Cell Face Lift on Entertainment Tonight [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Dr Nathan Newman MD Stem Cell Face lift On Good Morning LA.flv [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Ellis Martin Report with International Stem Cell Corp [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- Dr Nathan Newman MD Stem Cell Face lift on Channel 7 KABC.flv [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- Stem Cell Face Treatment - What People Are Saying | Beverly Hills | Los Angeles [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- How To Use Your Stem Cells For Facial Skin Rejuvenation [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- StemCellTV - From National Geographic - The Skin Gun - Healing Burns with Stem Cells [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- AMAZING - Stem Cell Skin Cream And Liquid Face Lift Revealed [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Care for Your Skin with Lifeline Skin Care [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- For Damaged Skin - Rejuvenate Your Own Stem Cells [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- Stem Cells: Fulfilling the Promise - 2011 CIRM Grantee Meeting [Last Updated On: September 28th, 2011] [Originally Added On: September 28th, 2011]
- Dr.Thomas Barnes' PRP Hair Growth and Skin Rejuvenation [Last Updated On: September 28th, 2011] [Originally Added On: September 28th, 2011]
- Stem Cell Face Lift - English (Part 5) [Last Updated On: September 28th, 2011] [Originally Added On: September 28th, 2011]
- Dr Amiya Prasad discusses ACell for Hair Regrowth and Skin Rejuvenation with EYES IN Magazine [Last Updated On: September 30th, 2011] [Originally Added On: September 30th, 2011]
- Brussels scientist close to discovering skin cancer origins [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- Cell Reprogramming Transformed [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- Cell Reprogramming Transformed [Last Updated On: October 7th, 2011] [Originally Added On: October 7th, 2011]
- Elaine Fuchs Part 1: Introduction to Stem Cells English Subtitle [Last Updated On: October 10th, 2011] [Originally Added On: October 10th, 2011]
- Elaine Fuchs Part 1: Introduction to Stem Cells English Subtitle [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]
- Elaine Fuchs discusses research on skin and adult stem cells - Video [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]
- Signals Stem Cell Skin Care Anti Aging Skin Care - Video [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]