Physicians Wish More Women Understood They Are Not To Blame

DUBLIN, June 17, 2020 /PRNewswire/ -- Sixty percent (60%) of women surveyed feel it's their fault they have cellulite and 57% feel judged for their cellulite,i according to new Harris Poll survey results released today by Endo Aesthetics LLC, an affiliate of Endo International plc (NASDAQ: ENDP). Conversely, 92% of physicians surveyed wish more women understood having cellulite is not their fault.Although celluliteii is common, many women are unsure about its root causes, lack knowledge about treatment options and feel a sense of blame and judgment for having cellulite.

The Harris Poll survey was conducted online among 2,006 U.S. women and captured feedback from those ages 18-59 who have cellulite, as well as 302 board certified dermatologists and plastic surgeons. Harris polled the women and physicians about their experience with cellulite and current treatment options.

Of aesthetic physicians surveyed, 93% said most women want to know how to improve their cellulite. Additionally, one-third of women surveyed (34%) feel that having information on what does and does not cause cellulite would make it easier to have conversations with their physician about this topic.

"It doesn't surprise me that 60% of women surveyed feel it's their fault they have cellulite," says Lisa Donofrio, MD, a New Orleans based board-certified dermatologist, past president and board member of the American Society for Dermatologic Surgery, and a fellow of the American Academy of Dermatology. "I've consulted with patients who are embarrassed and frustrated with having cellulite; however, I want them to know that they are not alone. In fact, 80% of women surveyed said they have cellulite and over three-quarters of them noted they spend time or effort focused on it. It's a very common issue that can stem from a variety of factors, including but not limited to hormones, genetics, skin structure and skin texture."

Cellulite can have a negative impact on how women perceive themselves. Nearly half of women surveyed (49%) say they are bothered "a great deal" or "a lot" by their cellulite. Women most commonly think about their cellulite at certain times, including when looking in the mirror (65%), at the beach or pool (54%) and during warmer weather (46%).iii

"The Harris Poll survey results reinforce that many women are looking for trusted information and resources from their healthcare professionals," says Robert Catlin, Vice President of Aesthetic Sales and Marketing at Endo. "We undertook this survey to understand how women feel about their cellulite and to help remove the blame and replace it with data and information."

Additional highlights from the Harris Poll survey include:iv

Scientists continue to explore treatments that target the root causes of cellulite in minimally invasive ways.iCurrently, surgical and invasive options get to the bands under the skin's surface that can cause cellulite.iiTheHarris Poll survey showed many of the women surveyed tried to improve their cellulite using various methods, including exercise (71%), diet (58%), topical treatments (36%), massages (25%) and in-office procedures (12%).By releasing the Harris Poll survey results, Endo Aesthetics is seeking to clear up the misinformation that exists around the etiology of cellulite,which may be one of the reasons 74% of women surveyed said that "no matter what I do, I will always have cellulite."v

Research MethodThis survey was conducted online within the U.S. by The Harris Poll between January 2, 2020 and January 26, 2020 on behalf of Endo Pharmaceuticals among two groups: 2,006 women, ages 18-59 who have cellulite; and 302 licensed U.S. healthcare professionals, including 151 dermatologists and 151 plastic surgeons.

Patient data were weighted by age, education, race/ethnicity, region, income, household size, marital status, and employment status to be representative of the broader population. Propensity score weighting was also used to adjust for respondents' propensity to be online. Dermatologist and plastic surgeon data were weighted by gender, years in practice, and region, and a post-weight was applied to the total data to reflect the proportions of dermatologists and plastic surgeons within the U.S. population.

About CelluliteCellulite is a localized alteration in the contour of the skin that has been reported in over 90 percent of post-pubertal females and affects women of all races and ethnicities.vi,vii The presence of cellulite is associated with changes in dermal thickness, and in the fat cells and connective tissue below the skin. A primary factor in the cause of the condition is the collagen containing septae which attach the skin to the underlying fascia layers. The septae tether the skin which, with additional contributing protrusions of subcutaneous fat, causes the surface dimpling characteristic of cellulite.viii,ixThese fibrous septae are oriented differently with varying thickness in females than in males, which helps our understanding of cellulite as a gender-related condition.xi Cellulite clinically presents on the buttocks, thighs, lower abdomen and arms.

It is known that cellulite is different from generalized obesity. In generalized obesity, adipocytes undergo hypertrophy and hyperplasia that is not limited to the pelvis, thighs, and abdomen.xIn areas of cellulite, characteristic large, metabolically stable adipocytes have physiologic and biochemical properties that differ from adipose tissue located elsewhere.An anatomical study in 2019 found that women have increased fat lobule height compared with men, which may also contribute to the mattress-like appearance seen as a result of the tension of the fibrous septae.xi Weight gain can make cellulite more noticeable, but it may be present even in thin subjects.

About The Harris PollThe Harris Poll is a global consulting and market research firm established in 1963 to help support decision making among leaders. Harris workswith clients in three primary areas: crafting brand strategy, building corporate reputation, and earning organic media through public relations research. To learn more, visitwww.theharrispoll.com.

About Endo Aesthetics LLCEndo Aesthetics is embarking on a mission devoted to pushing the boundaries of aesthetic artistry. Driven by world-class research and development, Endo Aesthetics is advancing solutions to address unmet needs beginning with an investigational treatment for cellulite. Headquartered in Malvern, PA, Endo Aesthetics is an affiliate of Endo International plc (NASDAQ: ENDP). Learn more at https://www.endoaesthetics.com.

About Endo International plcEndo International plc (NASDAQ: ENDP) is a highly-focused specialty branded and generics pharmaceutical company delivering quality medicines to patients in need through excellence in development, manufacturing and commercialization. Endo has global headquarters in Dublin, Ireland, and U.S. headquarters in Malvern, PA. Learn more at http://www.endo.com.

Forward Looking StatementsThis press release may contain certain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and Canadian securities legislation, including, but not limited to, the statements by Dr. Donofrioand Mr. Catlin, and other statements regarding the purpose and results of the survey. Statements including words such as "believes," "expects," "anticipates," "intends," "estimates," "plan," "will," "may," "look forward," "intend," "guidance," "future" or similar expressions are forward-looking statements. Because these statements reflect Endo's current views, expectations and beliefs concerning future events, they involve risks and uncertainties. Although Endo believes that these forward-looking statements and information are based upon reasonable assumptions and expectations, readers should not place undue reliance on them, or any other forward-looking statements or information in this news release. Investors should note that many factors, as more fully described in the documents filed by Endo with the Securities and Exchange Commission ("SEC") and with securities regulators in Canada on the System for Electronic Document Analysis and Retrieval ("SEDAR"), including under the caption "Risk Factors" in Endo's Form 10-K, Form 10-Q and Form 8-K filings, and as otherwise enumerated herein or therein, could affect Endo's future results and could cause Endo's actual results to differ materially from those expressed in forward-looking statements contained in this communication. The forward-looking statements in this press release are qualified by these risk factors. Endo assumes no obligation to publicly update any forward-looking statements, whether as a result of new information, future developments or otherwise, except as may be required under applicable securities laws.

References:

iEndo Pharmaceuticals data on file 2020. Cellulite Survey: Women and HCP Survey Results, The Harris Poll online survey, 1/2/20 1/26/20 of2,006 U.S. women ages 18-59 who have cellulite and 302 U.S. licensed physicians aged 18+iiZerini I et al. Cellulite treatment: a comprehensive literature review. J Cosmet Dermatol. 2015 Sep 14(3):224-40 iiiEndo Pharmaceuticals data on file 2020. Cellulite Survey: Women and HCP Survey Results, The Harris Poll online survey, 1/2/20 1/26/20 of2,006 U.S. women ages 18-59 who have cellulite and 302 U.S. licensed physicians aged 18+ivEndo Pharmaceuticals data on file 2020. Cellulite Survey: Women and HCP Survey Results, The Harris Poll online survey, 1/2/20 1/26/20 of2,006 U.S. women ages 18-59 who have cellulite and 302 U.S. licensed physicians aged 18+v Endo Pharmaceuticals data on file 2020. Cellulite Survey: Women and HCP Survey Results, The Harris Poll online survey, 1/2/20 1/26/20 of2,006 U.S. women ages 18-59 who have cellulite and 302 U.S. licensed physicians aged 18+viHexsel, D., & Mazzuco, R. (2013). Cellulite. Update in Cosmetic Dermatology, p.2viiKhan MH et al. Treatment of cellulite: Part I. Pathophysiology. J Am Acad Dermatol. 2010 Mar;62(3):361-70. viiiQuerleux B et al. Anatomy and physiology of subcutaneous adipose tissue by in vivo MRI and spectroscopy: Relationship with sex and presence of cellulite, Skin Research and Technology; 8: 118-124. ixQuerleux B et al. Anatomy and physiology of subcutaneous adipose tissue by in vivo MRI and spectroscopy: Relationship with sex and presence of cellulite, Skin Research and Technology; 8: 118-124. xKhan MH, Victor F, Rao B, Sadick NS. Treatment of cellulite: Part I. Pathophysiology. J Am Acad Dermatol 2010;62(3):361-370xi Rudolph C, Hladik C, Hamade H, Frank K, et al. Structural gender-dimorphism and the biomechanics of the gluteal subcutaneous tissue - implications for the pathophysiology of cellulite. Plast Reconstr Surg 2019; 143: 1077-86.

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New Harris Poll Survey Shows 60% of Women Surveyed Feel It's Their Fault They Have Cellulite - PR Newswire UK

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