The First 3D DNA Structure could advance Stem Cell Therapies – Labiotech.eu (blog)
Posted: March 14, 2017 at 10:45 am
Scientists from the University of Cambridge have determined the first 3D structures of mammalian genomes from individual cells.
For the first time, researchers from the University of Cambridge were able to determine the 3D structure of an active mouse genome in embryonic stem cells. Tim Stevens and his colleagues used a combination of imaging and measurements that reveal DNA interactionsto unravel how the DNA is folded together.This could lead tonew insights into the regulation of gene expression in health and disease.
Every cell in our body contains the same DNA molecules and thusthe same set of genes. Still,our blood cells differ fundamentally from our skin cells. The basis for this isgene regulation, meaning that different cells will not express every gene encoded on our DNA but only a specific subset.
An exciting new avenue for our understanding of gene regulation is the importance of the 3D DNA structure. Regulatory regions within our DNA play a major role in regulating gene expression, but arequirement is that the regions come into spatial contact with the associated genes.
It is well known today, that the way the DNA is folded within the cell is tightlyregulated and determines the contact between different regulatory regions with different genes and thereby determines which genes areswitched on or off.
By looking at individual stem cells, the researchers willnow be able to better understandhowthese master cells are able to differentiate into different cell types of our body, which could revolutionize regenerative medicine.
Knowing where all the genes and control elements are at a given moment will help us understand the molecular mechanisms that control and maintain their expression. () Currently, these mechanisms are poorly understood and understanding them may be key to realizingthe potential of stem cells in medicine.says Prof Ernest Laue, who supervised the study.
A better understanding of how the genome structure determines whether genes are switched on or off could also be important to understand what happens in cancer. Abnormal genomes might cause changes in DNA folding and thereby lead to abnormal gene expression.
Changes in gene expression which are not based on the DNA sequence are calledepigenetic modifications. Epigenetics is definitely one of the recent hypes within the cancer field.The folding of DNA is only one aspect of epigenetic gene regulation, while direct modifications of the DNA or DNA-associated proteins provide another. Cancer cells often make use of the epigenetic machinery to change gene regulation and support their survival.
A recent study,for example, unveiled the role of epigenetic changes in driving pancreatic cancer metastasis. By understanding what happens on the gene regulatorylevel, the researchers were able to find a compound, which specifically inhibits these epigenetic changes and therebycancer cell progression.
Epigenetic mechanisms definitely play a key role not only to advance our understanding of stem cell commitment and regenerative medicine, but also in disease areas such as cancer research. You can findthe identified 3D structures of the DNA below.
Read the rest here:
The First 3D DNA Structure could advance Stem Cell Therapies - Labiotech.eu (blog)
- Secret History of Diamonds Narrated for the Visually Impaired - Part 2 of 4 [Last Updated On: June 24th, 2011] [Originally Added On: June 24th, 2011]
- Skin Stem Cells: Their Biology [Last Updated On: June 24th, 2011] [Originally Added On: June 24th, 2011]
- Emerge Labs New Anti Aging Swiss Apple Stem Cell Skin Care [Last Updated On: June 25th, 2011] [Originally Added On: June 25th, 2011]
- No Avastin for Breast Cancer [Last Updated On: June 25th, 2011] [Originally Added On: June 25th, 2011]
- Signals Skincare System [Last Updated On: June 25th, 2011] [Originally Added On: June 25th, 2011]
- Signals Skincare System [Last Updated On: June 25th, 2011] [Originally Added On: June 25th, 2011]
- Growing Nerve Cells [Last Updated On: June 26th, 2011] [Originally Added On: June 26th, 2011]
- Elaine Fuchs Part 2: Tapping the Potential of Adult Stem Cells, and Summary [Last Updated On: June 26th, 2011] [Originally Added On: June 26th, 2011]
- A Major Breakthrough in Skin Care and Nutrition [Last Updated On: June 27th, 2011] [Originally Added On: June 27th, 2011]
- Stem Cell Facial At Metamorphosis Day Spa Using Emerge Labs Skin Care [Last Updated On: June 27th, 2011] [Originally Added On: June 27th, 2011]
- Come Back Kid [Last Updated On: June 28th, 2011] [Originally Added On: June 28th, 2011]
- PhytoCell.mp4 [Last Updated On: June 28th, 2011] [Originally Added On: June 28th, 2011]
- When Beauty Calls: The Link between Science and Skin Care [Last Updated On: June 29th, 2011] [Originally Added On: June 29th, 2011]
- Skin Stem Cells: Their Biology [Last Updated On: June 29th, 2011] [Originally Added On: June 29th, 2011]
- Come Back Kid [Last Updated On: July 1st, 2011] [Originally Added On: July 1st, 2011]
- PhytoCell.mp4 [Last Updated On: July 1st, 2011] [Originally Added On: July 1st, 2011]
- The Skin Gun stem cell research [Last Updated On: July 1st, 2011] [Originally Added On: July 1st, 2011]
- World's 1st Nutricosmetic with Stem Cell Nutrients [Last Updated On: July 2nd, 2011] [Originally Added On: July 2nd, 2011]
- NG Raccoon Attack [Last Updated On: July 3rd, 2011] [Originally Added On: July 3rd, 2011]
- No Avastin for Breast Cancer [Last Updated On: July 4th, 2011] [Originally Added On: July 4th, 2011]
- E'shee HBA Global Expo 2011, NYC. Skin Care Anti-Aging Symposium [Last Updated On: July 5th, 2011] [Originally Added On: July 5th, 2011]
- Growing Nerve Cells [Last Updated On: July 9th, 2011] [Originally Added On: July 9th, 2011]
- The Skin Gun [Last Updated On: July 9th, 2011] [Originally Added On: July 9th, 2011]
- E'shee HBA Global Expo 2011, NYC. Skin Care Anti-Aging Symposium [Last Updated On: July 14th, 2011] [Originally Added On: July 14th, 2011]
- A Major Breakthrough in Skin Care and Nutrition [Last Updated On: July 17th, 2011] [Originally Added On: July 17th, 2011]
- Elaine Fuchs Part 1: Introduction to Stem Cells [Last Updated On: July 20th, 2011] [Originally Added On: July 20th, 2011]
- World's 1st Nutricosmetic with Stem Cell Nutrients [Last Updated On: July 21st, 2011] [Originally Added On: July 21st, 2011]
- Stem cells acquired from human skin [Last Updated On: August 9th, 2011] [Originally Added On: August 9th, 2011]
- Stem cells acquired from human skin [Last Updated On: August 17th, 2011] [Originally Added On: August 17th, 2011]
- DermaStem Renewal Serum - Stem Cells for Your Skin from STEMTech - New Paradigm in Beauty! [Last Updated On: August 19th, 2011] [Originally Added On: August 19th, 2011]
- DermaStem Renewal Serum - Stem Cells for Your Skin from STEMTech - New Paradigm in Beauty! [Last Updated On: August 30th, 2011] [Originally Added On: August 30th, 2011]
- ReLuma-stemcells- skin rejuvenation [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Dr Nathan Newman- Formulator of Stem Cell Skin Care Line LUMINESCE [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Genetic Skin Disease (EB): Spotlight on Stem Cell Research - Patient Advocate [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Genetic Skin Disease (EB): Spotlight on Stem Cell Research - Patient Advocate [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- Stem Cell Skin Care- What is the role of stem cells in Luminesce Featuring Dr Nathan Newman [Last Updated On: September 7th, 2011] [Originally Added On: September 7th, 2011]
- Luminesce Stem Cell Skin Care - Leaders in Jeunesse [Last Updated On: September 7th, 2011] [Originally Added On: September 7th, 2011]
- The Skin Gun (Stem Cell research to replace burnt off skin. Done in 3 days!) [Last Updated On: September 7th, 2011] [Originally Added On: September 7th, 2011]
- Stem Cell Skin Care- What is the role of stem cells in Luminesce Featuring Dr Nathan Newman [Last Updated On: September 7th, 2011] [Originally Added On: September 7th, 2011]
- Isolation and Culture of Adult Epithelial Stem Cells from Human Skin [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- Genetic Skin Disease (EB): Spotlight on Stem Cell Research - Welcome [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- Stem Cells Made From Human Skin [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- Jeunesse Global Business Opportunity with Stem Cell Skin Care Developed by Dr Nathan Newman [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Stem Cell Therapy Skin Repair and Anti-Wrinkle Cream [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Stem Cells Made From Human Skin [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Genetic Skin Disease (EB): Optimizing Embryonic Stem Cell Differentiation Protocols [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Genetic Skin Disease (EB): Spotlight on Stem Cell Research - Introduction [Last Updated On: September 11th, 2011] [Originally Added On: September 11th, 2011]
- Isolation and Culture of Adult Epithelial Stem Cells from Human Skin [Last Updated On: September 11th, 2011] [Originally Added On: September 11th, 2011]
- Stem Cell Therapy - BioLogic Anti-Aging Skin Cream [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- Best natural skin care serum using stem cell technology [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- Jeunesse Global Business Opportunity with Stem Cell Skin Care Developed by Dr Nathan Newman [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- Genetic Skin Disease (EB): Optimizing Embryonic Stem Cell Differentiation Protocols [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- The Skin Gun (Stem Cell research to replace burnt off skin. Done in 3 days!) [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- Research on skin cancer: ERC funds studies on stem cells [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Skin engineering [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Stem Cell Banking: The Perspective of an iPS Donor Family [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Jeunesse Global Opportunity- Stem Cell Skin Care [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Dr Nathan Newman Repairs Laugh Lines With Stem Cell Face Lift [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Dr Nathan Newman MD Stem Cell Face lift On Extra TV.flv [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Dr Nathan Newman Stem Cell Face Lift on Entertainment Tonight [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Dr Nathan Newman MD Stem Cell Face lift On Good Morning LA.flv [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- Ellis Martin Report with International Stem Cell Corp [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- Dr Nathan Newman MD Stem Cell Face lift on Channel 7 KABC.flv [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- Stem Cell Face Treatment - What People Are Saying | Beverly Hills | Los Angeles [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- How To Use Your Stem Cells For Facial Skin Rejuvenation [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- StemCellTV - From National Geographic - The Skin Gun - Healing Burns with Stem Cells [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- AMAZING - Stem Cell Skin Cream And Liquid Face Lift Revealed [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Care for Your Skin with Lifeline Skin Care [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- For Damaged Skin - Rejuvenate Your Own Stem Cells [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- Stem Cells: Fulfilling the Promise - 2011 CIRM Grantee Meeting [Last Updated On: September 28th, 2011] [Originally Added On: September 28th, 2011]
- Dr.Thomas Barnes' PRP Hair Growth and Skin Rejuvenation [Last Updated On: September 28th, 2011] [Originally Added On: September 28th, 2011]
- Stem Cell Face Lift - English (Part 5) [Last Updated On: September 28th, 2011] [Originally Added On: September 28th, 2011]
- Dr Amiya Prasad discusses ACell for Hair Regrowth and Skin Rejuvenation with EYES IN Magazine [Last Updated On: September 30th, 2011] [Originally Added On: September 30th, 2011]
- Brussels scientist close to discovering skin cancer origins [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- Cell Reprogramming Transformed [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- Cell Reprogramming Transformed [Last Updated On: October 7th, 2011] [Originally Added On: October 7th, 2011]
- Elaine Fuchs Part 1: Introduction to Stem Cells English Subtitle [Last Updated On: October 10th, 2011] [Originally Added On: October 10th, 2011]
- Elaine Fuchs Part 1: Introduction to Stem Cells English Subtitle [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]
- Elaine Fuchs discusses research on skin and adult stem cells - Video [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]
- Signals Stem Cell Skin Care Anti Aging Skin Care - Video [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]